Sant Pau - Institut de Recerca

Main lines of research

Receptor-mediated changes in intracellular calcium homeostasis in atrial fibrillation.
Contribution of genetic variants to electrical remodelling and arrhythmogenesis.
Effects of development and ageing on calcium handling in cardiac myocytes.
Functional effects of lipid accumulation in cardiomyocytes.

Challenges

The goal is to consolidate the group as a reference in research on calcium handling in atrial fibrillation and to establish it within other lines of research by including emerging technology and fields of research. Specifically we aim to:

Develop computational tools and models to improve the analysis and understanding of intracellular calcium handling in cardiac myocytes.
Incorporate emerging technology such as stretching and measurements of force development in single cardiomyocytes.
Consolidate current national and international collaborations and establish new strategic collaborations within emerging fields of research such as the use of super-resolution fluorescence imaging (STORM, STED-techniques), the detection and role of Reactive Oxygen Species in diseased cardiomyocytes, and the role of telomere length in cardiac senescence and regeneration.
Achieve international funding for incorporation of scientific expertise and participation in multidisciplinary international research projects.

Group coordination

HOVE-MADSEN , LEIF CSIC
lmadsen@santpau.cat

Members

Aceituno Fernandez, Cristina CSIC

Publications 2022

(JIF 2022)

Arslanova A, Shafaattalab S, Lin E, Barszczewski T, Hove L, Tibbits GF. Investigating inherited arrhythmias using hiPSC-derived cardiomyocytes. METHODS. 2022; 203. DOI:10.1016/j.ymeth.2021.06.015. PMID:34197925. IF:4,8 (Q1/2D). Document type: Article.
Casabella S, Jimenez V, Tarifa C, Casellas S, Lu TT, Izquierdo P, Gich I, Jimenez M, Ginel A, Guerra JM, Chen SRW, Benitez R, Hove L. Impact of R-Carvedilol on beta 2-Adrenergic Receptor-Mediated Spontaneous Calcium Release in Human Atrial Myocytes. 2022; 10(7):1759. DOI:10.3390/biomedicines10071759. PMID:35885069. IF:4,7 (Q1/3D). Document type: Article.
Garcia C, Dominguez JN, Lodde V, Munk R, Abdelmohsen K, Gorospe M, Jimenez V, Ginel A, Hove L, Aranega AE, Franco D. Identification of atrial-enriched lncRNA Walras linked to cardiomyocyte cytoarchitecture and atrial fibrillation. FASEB JOURNAL. 2022; 36(1):e22051. DOI:10.1096/fj.202100844RR. PMID:34861058. IF:4,8 (Q1/3D). Document type: Article.
Gharanei M, Shafaattalab S, Sangha S, Gunawan M, Laksman Z, Hove L, Tibbits GF. Atrial-specific hiPSC-derived cardiomyocytes in drug discovery and disease modeling. METHODS. 2022; 203. DOI:10.1016/j.ymeth.2021.06.009. PMID:34144175. IF:4,8 (Q1/2D). Document type: Article.
Herraiz A, Tarifa C, Jimenez V, Llach A, Godoy H, Colino H, Nolla C, Casabella S, Izquierdo P, Benitez I, Benitez R, Rosello E, Rodriguez E, Vinolas X, Ciruela F, Cinca J, Hove L. Influence of sex on intracellular calcium homoeostasis in patients with atrial fibrillation. CARDIOVASCULAR RESEARCH. 2022; 118(4). DOI:10.1093/cvr/cvab127. PMID:33788918. IF:10,8 (Q1/1D). Document type: Article.
Nolla C, Casabella S, Jimenez V, Vallmitjana A, Tarifa C, Herraiz A, Llach A, Tauron M, Montiel J, Cinca J, Chen SRW, Benitez R, Hove L. beta 2-adrenergic stimulation potentiates spontaneous calcium release by increasing signal mass and co-activation of ryanodine receptor clusters. Acta Physiologica. 2022; 234(4):e13736. DOI:10.1111/apha.13736. PMID:34709723. IF:6,3 (Q1/1D). Document type: Article.

Publications 2021

Godoy H, Duroux R, Jacobson KA, Soler C, Colino H, Jimenez V, Montiel J, Hove L, Ciruela F. Adenosine A(2A) Receptors Are Upregulated in Peripheral Blood Mononuclear Cells from Atrial Fibrillation Patients. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021; 22(7):3467. DOI:10.3390/ijms22073467. PMID:33801676. IF:6,208.
Herraiz A, Tarifa C, Jimenez V, Llach A, Godoy H, Colino H, Nolla C, Casabella S, Izquierdo P, Benitez I, Benitez R, Rosello E, Rodriguez E, Vinolas X, Ciruela F, Cinca J, Hove L. Influence of sex on intracellular calcium homoeostasis in patients with atrial fibrillation. CARDIOVASCULAR RESEARCH. 2022; 118(4). DOI:10.1093/cvr/cvab127. PMID:33788918. IF:13,081.
Reinhardt F, Beneke K, Pavlidou NG, Conradi L, Reichenspurner H, Hove L, Molina CE. Abnormal Calcium Handling in Atrial Fibrillation Is Linked to Changes in Cyclic AMP Dependent Signaling. Cells. 2021; 10(11):3042. DOI:10.3390/cells10113042. PMID:34831263. IF:7,666.
Rosello E, Hove L, Perez V, Munoz C, Artigas V, Padro JM, Dominguez E. Mitochondrial genetic effect on atrial fibrillation: A case-control study. MITOCHONDRION. 2021; 56. DOI:10.1016/j.mito.2020.11.007. PMID:33171269. IF:4,534.
Senis E, Esgleas M, Najas S, Jimenez V, Bertani C, Gimenez M, Escriche A, Ruiz J, Hergueta M, Jimenez M, Giralt A, Nuciforo P, Alba MM, Peinado H, Toro DD, Hove L, Goetz M, Abad M. TUNAR lncRNA Encodes a Microprotein that Regulates Neural Differentiation and Neurite Formation by Modulating Calcium Dynamics. Frontiers in Cell and Developmental Biology. 2021; 9:747667. DOI:10.3389/fcell.2021.747667. PMID:35036403. IF:6,081.
Sun B, Yao JJ, Ni MK, Wei JH, Zhong XW, Guo WT, Zhang L, Wang RW, Belke D, Chen YX, Lieve KVV, Broendberg AK, Roston TM, Blankoff I, Kammeraad JA, von JC, Lazarte J, Vallmitjana A, Bohne LJ, Rose RA, Benitez R, Hove L, Napolitano C, Hegele RA, Fill M, Sanatani S, Wilde A, Roberts JD, Priori SG, Jensen HK, Chen SRW. Cardiac ryanodine receptor calcium release deficiency syndrome. Science Translational Medicine. 2021; 13(579):eaba7287. DOI:10.1126/scitranslmed.aba7287. PMID:33536282. IF:19,319.
Wei JH, Yao JJ, Belke D, Guo WT, Zhong XW, Sun B, Wang RW, Estillore JP, Vallmitjana A, Benitez R, Hove L, Alvarez E, Echebarria B, Chen SRW. Ca2+-CaM Dependent Inactivation of RyR2 Underlies Ca2+ Alternans in Intact Heart. CIRCULATION RESEARCH. 2021; 128(4). DOI:10.1161/CIRCRESAHA.120.318429. PMID:33375811. IF:23,213.

2017 Scientific Report -Regulation of cardiac

Introduction

Main lines of research

Receptor-mediated changes in intracellular calcium homeostasis in atrial fibrillation.
Contribution of genetic variants to electrical remodelling and arrhythmogenesis.
Effects of development and ageing on calcium handling in cardiac myocytes.
Functional effects of lipid accumulation in cardiomyocytes.

Challenges

Develop computational tools and models to improve the analysis and understanding of intracellular calcium handling in cardiac myocytes.
Incorporate emerging technology such as stretching and measurements of force development in single cardiomyocytes.
Consolidate current national and international collaborations and establish new strategic collaborations within emerging fields of research such as the use of super-resolution fluorescence imaging (STORM, STED-techniques), the detection and role of Reactive Oxygen Species in diseased cardiomyocytes, and the role of telomere length in cardiac senescence and regeneration.
Achieve international funding for incorporation of scientific expertise and participation in multidisciplinary international research projects.

Team

Group coordination

HOVE-MADSEN , LEIF CSIC
lmadsen@santpau.cat

Members

Aceituno Fernandez, Cristina CSIC

Scientific output

Publications 2022

(JIF 2022)

Arslanova A, Shafaattalab S, Lin E, Barszczewski T, Hove L, Tibbits GF. Investigating inherited arrhythmias using hiPSC-derived cardiomyocytes. METHODS. 2022; 203. DOI:10.1016/j.ymeth.2021.06.015. PMID:34197925. IF:4,8 (Q1/2D). Document type: Article.
Casabella S, Jimenez V, Tarifa C, Casellas S, Lu TT, Izquierdo P, Gich I, Jimenez M, Ginel A, Guerra JM, Chen SRW, Benitez R, Hove L. Impact of R-Carvedilol on beta 2-Adrenergic Receptor-Mediated Spontaneous Calcium Release in Human Atrial Myocytes. 2022; 10(7):1759. DOI:10.3390/biomedicines10071759. PMID:35885069. IF:4,7 (Q1/3D). Document type: Article.
Garcia C, Dominguez JN, Lodde V, Munk R, Abdelmohsen K, Gorospe M, Jimenez V, Ginel A, Hove L, Aranega AE, Franco D. Identification of atrial-enriched lncRNA Walras linked to cardiomyocyte cytoarchitecture and atrial fibrillation. FASEB JOURNAL. 2022; 36(1):e22051. DOI:10.1096/fj.202100844RR. PMID:34861058. IF:4,8 (Q1/3D). Document type: Article.
Gharanei M, Shafaattalab S, Sangha S, Gunawan M, Laksman Z, Hove L, Tibbits GF. Atrial-specific hiPSC-derived cardiomyocytes in drug discovery and disease modeling. METHODS. 2022; 203. DOI:10.1016/j.ymeth.2021.06.009. PMID:34144175. IF:4,8 (Q1/2D). Document type: Article.
Herraiz A, Tarifa C, Jimenez V, Llach A, Godoy H, Colino H, Nolla C, Casabella S, Izquierdo P, Benitez I, Benitez R, Rosello E, Rodriguez E, Vinolas X, Ciruela F, Cinca J, Hove L. Influence of sex on intracellular calcium homoeostasis in patients with atrial fibrillation. CARDIOVASCULAR RESEARCH. 2022; 118(4). DOI:10.1093/cvr/cvab127. PMID:33788918. IF:10,8 (Q1/1D). Document type: Article.
Nolla C, Casabella S, Jimenez V, Vallmitjana A, Tarifa C, Herraiz A, Llach A, Tauron M, Montiel J, Cinca J, Chen SRW, Benitez R, Hove L. beta 2-adrenergic stimulation potentiates spontaneous calcium release by increasing signal mass and co-activation of ryanodine receptor clusters. Acta Physiologica. 2022; 234(4):e13736. DOI:10.1111/apha.13736. PMID:34709723. IF:6,3 (Q1/1D). Document type: Article.

Publications 2021

Godoy H, Duroux R, Jacobson KA, Soler C, Colino H, Jimenez V, Montiel J, Hove L, Ciruela F. Adenosine A(2A) Receptors Are Upregulated in Peripheral Blood Mononuclear Cells from Atrial Fibrillation Patients. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021; 22(7):3467. DOI:10.3390/ijms22073467. PMID:33801676. IF:6,208.
Herraiz A, Tarifa C, Jimenez V, Llach A, Godoy H, Colino H, Nolla C, Casabella S, Izquierdo P, Benitez I, Benitez R, Rosello E, Rodriguez E, Vinolas X, Ciruela F, Cinca J, Hove L. Influence of sex on intracellular calcium homoeostasis in patients with atrial fibrillation. CARDIOVASCULAR RESEARCH. 2022; 118(4). DOI:10.1093/cvr/cvab127. PMID:33788918. IF:13,081.
Reinhardt F, Beneke K, Pavlidou NG, Conradi L, Reichenspurner H, Hove L, Molina CE. Abnormal Calcium Handling in Atrial Fibrillation Is Linked to Changes in Cyclic AMP Dependent Signaling. Cells. 2021; 10(11):3042. DOI:10.3390/cells10113042. PMID:34831263. IF:7,666.
Rosello E, Hove L, Perez V, Munoz C, Artigas V, Padro JM, Dominguez E. Mitochondrial genetic effect on atrial fibrillation: A case-control study. MITOCHONDRION. 2021; 56. DOI:10.1016/j.mito.2020.11.007. PMID:33171269. IF:4,534.
Senis E, Esgleas M, Najas S, Jimenez V, Bertani C, Gimenez M, Escriche A, Ruiz J, Hergueta M, Jimenez M, Giralt A, Nuciforo P, Alba MM, Peinado H, Toro DD, Hove L, Goetz M, Abad M. TUNAR lncRNA Encodes a Microprotein that Regulates Neural Differentiation and Neurite Formation by Modulating Calcium Dynamics. Frontiers in Cell and Developmental Biology. 2021; 9:747667. DOI:10.3389/fcell.2021.747667. PMID:35036403. IF:6,081.
Sun B, Yao JJ, Ni MK, Wei JH, Zhong XW, Guo WT, Zhang L, Wang RW, Belke D, Chen YX, Lieve KVV, Broendberg AK, Roston TM, Blankoff I, Kammeraad JA, von JC, Lazarte J, Vallmitjana A, Bohne LJ, Rose RA, Benitez R, Hove L, Napolitano C, Hegele RA, Fill M, Sanatani S, Wilde A, Roberts JD, Priori SG, Jensen HK, Chen SRW. Cardiac ryanodine receptor calcium release deficiency syndrome. Science Translational Medicine. 2021; 13(579):eaba7287. DOI:10.1126/scitranslmed.aba7287. PMID:33536282. IF:19,319.
Wei JH, Yao JJ, Belke D, Guo WT, Zhong XW, Sun B, Wang RW, Estillore JP, Vallmitjana A, Benitez R, Hove L, Alvarez E, Echebarria B, Chen SRW. Ca2+-CaM Dependent Inactivation of RyR2 Underlies Ca2+ Alternans in Intact Heart. CIRCULATION RESEARCH. 2021; 128(4). DOI:10.1161/CIRCRESAHA.120.318429. PMID:33375811. IF:23,213.

CARDIOVASCULAR DISEASES

Regulation of Cardiac Rhythm and Contraction

Main lines of research

Challenges

Group coordination

Members

Publications 2022

Publications 2021

Main lines of research

Challenges

Group coordination

Members

Publications 2022

Publications 2021

Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau