TRANSLATIONAL MEDICINE

Multi-organ Damage and Rheumatology

Main lines of research

Bone Metabolism and Osteoporosis

  • Analysis of genetic influence on osteoporosis by means of aggregation studies in families of three or more generations with a minimum of 15 members.
  • Bone structure study with quantitative CT of hip and spine, analysing the contribution of trabecular and cortical components using HRCT.
  • Description of fat values and percentages in a normal population (in collaboration with the HIV Unit and CETIR Medical Group).
  • Analysis of the influence of an intervention (physical exercise) on changes in the muscle compartment of patients with cirrhosis measured by DXA and HRQCT (in collaboration with the Gastroenterology Department).
  • Description of bone structure in patients with a history of acromegaly assessed by DXA and HRQCT.

Hypertension and Vascular Risk

  • Hypertension and quality of life.
  • Refractory hypertension.
  • Use of alirocumab in hypercholesterolaemia.

Clinical Management, Internal Medicine and Geriatrics

  • Health care quality indexes (mortality, readmissions, etc).
  • Perioperative medicine.
  • Potentially inappropriate prescribing to older patients admitted to hospital.

Rheumatology and Rheumatoid Arthritis

  • Early rheumatoid arthritis
  • Rheumatoid arthritis biomarkers
  • Interstitial lung disease associated with rheumatoid arthritis

Systemic sclerosis

  • Capillaroscopy patterns and correlation with auto-antibodies and pulmonary function tests.
  • Evidence-based detection of pulmonary arterial hypertension in systemic sclerosis: the DETECT study.
  • Use of endothelin receptor antagonism to prevent pulmonary arterial hypertension (in collaboration with Vall d’Hebron University Hospital, Barcelona, Spain).
  • Genetic studies in systemic sclerosis and collaboration with DUO Registry and LAUDES study.
  • Study of capillaroscopy patterns in diffuse connective tissue diseases: QuantiCAP study.

Gout

  • Epidemiology of hyperuricaemia and gout.

Sjögren syndrome

  • TClinical and epidemiological findings in Spanish patients with primary Sjögren syndrome (in collaboration with Spanish Society of Rheumatology).

Challenges

  • To establish stable work relations between the HSCSP Bone Metabolism and Genomics of Complex Diseases Groups and the Bone Metabolism Unit of Hospital del Mar-Municipal Institute for Medical Research and the Faculty of Biology of the University of Barcelona.
  • To strengthen ties between Sant Pau’s Rheumatology and Immunology departments regarding the study of immunological diseases.

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