ONCOHEMATOLOGIC DISEASES

Oncology/Haematology and Transplantation

Main lines of research

  • Study of the molecular and cellular pathophysiology of haematological cancers.
  • Study of the prognostic value of clinical and biological parameters in haematological malignancies.
  • Design of new modalities of chemotherapy, biotherapy and drug treatment targeting molecular mechanisms.
  • Design of new modalities of haematopoietic stem-cell transplantation and cell therapy.
  • Psychological intervention and quality of life in patients with haematological malignancies.

Challenges

  • Identify new prognostic parameters for risk and therapeutic stratification.
  • Evaluate targeted therapy in cell lines and animal models (with the Oncogenesis and Antitumour Drugs group).
  • Reduce toxicity and increase availability of allogeneic transplants.
  • Molecularly characterize acute myeloid leukaemia and determine the prognostic value of known genes and other genes of uncertain significance (with the Haematology Laboratory).
  • Model leukaemia and lymphoma in animals to better understand cell physiopathology and test new drugs (with the Oncogenesis and Antitumour Drugs group).
  • Molecularly characterize and determine the prognostic significance of cell physiopathology and immunotherapy for lymphoproliferative diseases and evaluate antitumour immunotherapy in animals and humans.

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