Sant Pau - Institut de Recerca

Resumen

El Grupo de Fisiopatología de las Enfermedades Relacionadas con Lípidos del Instituto de Investigación del Hospital de la Santa Creu i San Pau, es un equipo interdisiplinario y de investigación traslacional que trabaja en el campo de las enfermedades cardiovasculares relacionadas con alteraciones metabólicas como pueden ser las dislipemias, la diabetes mellitus, la obesidad, las demencias, o la hiperhomocisteinemia, entre otros. La finalidad de los diferentes estudios y líneas de investigación del grupo se centra en encontrar nuevas terapias dirigidas y / o biomarcadores para disminuir el riesgo cardiovascular y enfermedad de Alzheimer en pacientes con dichas alteraciones metabólicas, así como mejorar el diagnóstico y control de los pacientes

Líneas Principales de Investigación e Innovación

Nuevos biomarcadores y terapias relacionados con factores de riesgo cardiometabólicos, que incluyen obesidad, diabetes, esteatohepatitis no alcohólica e hiperhomocisteinemia.
Disfuncionalidad del metabolismo de lípidos y lipoproteínas en la enfermedad.

Coordinación del grupo

ESCOLA GIL, JOAN CARLES IR
jescola@santpau.cat

Miembros

Blanco Vaca, Francisco FGS
Borras Querol, Carla IR
Canyelles Vich, Marina FGS
Griñan Gonzalez, Raquel IR
Illana Camara, Francisco Jose FGS
Martinez Figueroa, Susana FGS
Roig Martinez, Rosa FGS
Rotllan Vila, Noemi IR
Santos Palacios, David CIBERDEM
Sole i Galvez, Arnau CIBERDEM
Tondo Colomer, Mireia FGS

Publicaciones 2022

(JIF 2022)

Antonio V, Franch J, Moreno A, Real J, Orcau A, Mauricio D, Mata M, Julve J, Mendez EN, Treserra RP, de la Puente JB, Millet JP, Garcia JLD, Vlacho B, Cayla JA. Subjects With Diabetes Mellitus Are at Increased Risk for Developing Tuberculosis: A Cohort Study in an Inner-City District of Barcelona (Spain). Frontiers in Public Health. 2022; 10:789952. DOI:10.3389/fpubh.2022.789952. PMID:35677764. IF:5,2 (Q1/3D). Document type: Article.
Blanco F, Rotllan N, Canyelles M, Mauricio D, Escola JC, Julve J. NAD plus -Increasing Strategies to Improve Cardiometabolic Health?. Frontiers in Endocrinology. 2022; 12:815565. DOI:10.3389/fendo.2021.815565. PMID:35173682. IF:5,2 (Q1/3D). Document type: Review.
Borras C, Mercer A, Sirisi S, Alcolea D, Escola JC, Blanco F, Tondo M. HDL-like-Mediated Cell Cholesterol Trafficking in the Central Nervous System and Alzheimer’s Disease Pathogenesis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(16):9356. DOI:10.3390/ijms23169356. PMID:36012637. IF:5,6 (Q1/3D). Document type: Review.
Canyelles M, Perez A, Junza A, Minambres I, Yanes O, Sarda H, Rotllan N, Julve J, Sanchez JL, Tondo M, Escola JC, Blanco F. Divergent Effects of Glycemic Control and Bariatric Surgery on Circulating Concentrations of TMAO in Newly Diagnosed T2D Patients and Morbidly Obese. 2022; 12(11):2783. DOI:10.3390/diagnostics12112783. PMID:36428843. IF:3,6 (Q2/4D). Document type: Article.
Canyelles M, Plaza M, Rotllan N, Llobet D, Julve J, Mojal S, Diaz M, Soria JM, Escola JC, Tondo M, Blanco F, Souto JC. TMAO and Gut Microbial-Derived Metabolites TML and gamma BB Are Not Associated with Thrombotic Risk in Patients with Venous Thromboembolism. Journal of Clinical Medicine. 2022; 11(5):1425. DOI:10.3390/jcm11051425. PMID:35268516. IF:3,9 (Q2/4D). Document type: Article.
Climent E, Bea AM, Benaiges D, Brea A, Pinto X, Suarez M, Perea V, Plana N, Blanco F, Pedro J. LDL Cholesterol Reduction Variability with Different Types and Doses of Statins in Monotherapy or Combined with Ezetimibe. Results from the Spanish Arteriosclerosis Society Dyslipidaemia Registry. CARDIOVASCULAR DRUGS AND THERAPY. 2022; 36(2). DOI:10.1007/s10557-020-07137-z. PMID:33555511. IF:3,4 (Q2/5D). Document type: Article.
Dato VA, Benitez A, Garcia E, Claudi L, Lhoest MTL, Iborra A, Guerra JM, Escola JC, Samouillan V, Enrich C, Chiabrando G, Llorente V. Targeting cholesteryl ester accumulation in the heart improves cardiac insulin response. BIOMEDICINE & PHARMACOTHERAPY. 2022; 152:113270. DOI:10.1016/j.biopha.2022.113270. PMID:35709652. IF:7,5 (Q1/1D). Document type: Article.
Delaby C, Estelles T, Zhu NU, Arranz J, Barroeta I, Carmona M, Illan I, Santos MA, Altuna M, Sala I, Sanchez MB, Videla L, Valldeneu S, Subirana A, Tondo M, Blanco F, Lehmann S, Belbin O, Blesa R, Fortea J, Lleo A, Alcolea D. The A beta 1-42/A beta 1-40 ratio in CSF is more strongly associated to tau markers and clinical progression than A beta 1-42 alone. Alzheimers Research & Therapy. 2022; 14(1):20. DOI:10.1186/s13195-022-00967-z. PMID:35105351. IF:9 (Q1/1D). Document type: Article.
Farras M, Swann JR, Rowland I, Rubio L, Subirana I, Catalan U, Motilva MJ, Sola R, Covas MI, Blanco F, Fito M, Mayneris J. Impact of Phenol-Enriched Olive Oils on Serum Metabonome and Its Relationship with Cardiometabolic Parameters: A Randomized, Double-Blind, Cross-Over, Controlled Trial. 2022; 11(10):1964. DOI:10.3390/antiox11101964. PMID:36290685. IF:7 (Q1/1D). Document type: Article.
Ferrer R, Zhu N, Arranz J, Porcel I, El Bounasri S, Sanchez O, Torres S, Julve J, Lleo A, Blanco F, Alcolea D, Tondo M. Importance of cerebrospinal fluid storage conditions for the Alzheimer’s disease diagnostics on an automated platform. CLINICAL CHEMISTRY AND LABORATORY MEDICINE. 2022; 60(7). DOI:10.1515/cclm-2022-0134. PMID:35405043. IF:6,8 (Q1/2D). Document type: Article.
Granado M, Sola I, Hernandez M, Rojo MI, Julve J, Mauricio D. Effectiveness of medical nutrition therapy in adolescents with type 1 diabetes: a systematic review. Nutrition & Diabetes. 2022; 12(1):24. DOI:10.1038/s41387-022-00201-7. PMID:35459205. IF:6,1 (Q1/2D). Document type: Review.
Grinan R, Escola JC, Julve J, Benitez S, Rotllan N. Epigenetic Regulation by microRNAs in Hyperhomocysteinemia-Accelerated Atherosclerosis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(20):12452. DOI:10.3390/ijms232012452. PMID:36293305. IF:5,6 (Q1/3D). Document type: Review.
Hueso M, Grinan R, Mallen A, Navarro E, Purqueras E, Goma M, Sbraga F, Blasco A, Revilla G, Santos D, Canyelles M, Julve J, Escola JC, Rotllan N. MiR-125b downregulates macrophage scavenger receptor type B1 and reverse cholesterol transport. BIOMEDICINE & PHARMACOTHERAPY. 2022; 146:112596. DOI:10.1016/j.biopha.2021.112596. PMID:35062066. IF:7,5 (Q1/1D). Document type: Article.
Julve J, Escola JC. High-Density Lipoproteins and Cardiovascular Disease: The Good, the Bad, and the Future II. 2022; 10(3):620. DOI:10.3390/biomedicines10030620. PMID:35327422. IF:4,7 (Q1/3D). Document type: Editorial material.
Lee M, Lappalainen J, Kovanen PT, Escola JC. Lipid-Laden Macrophages and Inflammation in Atherosclerosis and Cancer: An Integrative View. Frontiers in Cardiovascular Medicine. 2022; 9:777822. DOI:10.3389/fcvm.2022.777822. PMID:35237673. IF:3,6 (Q2/5D). Document type: Review.
Martos I, del Monte A, Lorenzo C, Busse CE, Delgado P, Mur SM, Cobos L, Escolà JC, Martín JL, Wardemann H, Ramiro AR. MDA-LDL vaccination induces athero-protective germinal-center-derived antibody responses. Cell Reports. 2022; 41(2):111468. DOI:10.1016/j.celrep.2022.111468. PMID:36223741. IF:8,8 (Q1/2D). Document type: Article.
Mauricio D, Vlacho B, de la Puente JB, Mundet X, Real J, Kulisevsky J, Ortega E, Castelblanco E, Julve J, Franch J. Associations Between Diabetic Retinopathy and Parkinson’s Disease: Results From the Catalonian Primary Care Cohort Study. Frontiers in Medicine. 2022; 8:800973. DOI:10.3389/fmed.2021.800973. PMID:35118094. IF:3,9 (Q2/4D). Document type: Article.
Nunez E, Fuster V, Gomez M, Valdivielso JM, Fernandez JM, Martinez D, Rodriguez JM, Bonzon E, Calvo E, Alfayate A, Bermudez M, Escola JC, Fernandez L, Cerro I, Mendiguren JM, Sanchez F, Sanz J, Ordovas JM, Blanco LM, Garcia JM, Ibanez B, Lara E, Fernandez A, Martin JL, Vazquez J. Unbiased plasma proteomics discovery of biomarkers for improved detection of subclinical atherosclerosis. 2022; 76:103874. DOI:10.1016/j.ebiom.2022.103874. PMID:35152150. IF:11,1 (Q1/1D). Document type: Article.
Puig C, Castelblanco E, Falguera M, Hernandez M, Soldevila B, Julian MT, Teis A, Julve J, Barranco M, Franch J, Puig M, Ortega E, Amigo N, Alonso N, Mauricio D. Advanced lipoprotein profile in individuals with normal and impaired glucose metabolism. REVISTA ESPANOLA DE CARDIOLOGIA. 2022; 75(1). DOI:10.1016/j.recesp.2021.02.013. PMID:33785266. IF:5,9 (Q1/3D). Document type: Article.
Revilla G,Moral A,Fuste V,Lerma E,Julve J,Escolà JC,Mato E,Pérez JI,Corcoy R,Paez EV. The role of ATP-binding cassette transporter genes in the metastatic process of epithelial thyroid carcinoma with aggressive behavior. En: Unraveling The Complexities Of Metastasis: Transition From A Segmented View To A Conceptual Continuum. Elsevier. 2022. p. 265-275. DOI: 10.1016/B978-0-12-821789-4.00020-5. Document type: Book chapter.
Rivas A, Rotllan N, Santos D, Julve J, Escolà JC, Sanchez JL. Assessment of Ex Vivo Antioxidative Potential of Murine HDL in Atherosclerosis. Methods In Molecular Biology. 2022; 2419DOI:10.1007/978-1-0716-1924-7_17. Document type: Book chapter.
Rivas A, Rotllan N, Santos D, Julve J, Sanchez JL, Escolà JC. Monitoring Atheroprotective Macrophage Cholesterol Efflux In Vivo. Methods In Molecular Biology. 2022; 2419. DOI:10.1007/978-1-0716-1924-7_35. Document type: Book chapter.
Roldan R, Perez JM, Cerro I, Oller J, Martinez D, Nunez E, Maller SM, Gutierrez C, Mendez N, Escola JC, Michel JB, Mittelbrunn M, Vazquez J, Blanco LM, Rabinovich GA, Martin JL. Galectin-1 prevents pathological vascular remodeling in atherosclerosis and abdominal aortic aneurysm. Science Advances. 2022; 8(11):eabm7322. DOI:10.1126/sciadv.abm7322. PMID:35294231. IF:13,6 (Q1/1D). Document type: Article.
Rotllan N, Zhang XB, Canfran A, Goedeke L, Grinan R, Ramirez CM, Suarez Y, Fernandez C. Antagonism of miR-148a attenuates atherosclerosis progression in APOB(TG )Apobec(-/-)Ldlr(+/-) mice: A brief report. BIOMEDICINE & PHARMACOTHERAPY. 2022; 153:113419. DOI:10.1016/j.biopha.2022.113419. PMID:36076541. IF:7,5 (Q1/1D). Document type: Article.
Rotllan N. The Underlying Pathology of Atherosclerosis: Different Players. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(6):3235. DOI:10.3390/ijms23063235. PMID:35328656. IF:5,6 (Q1/3D). Document type: Editorial material.
Teis A, Castelblanco E, Cediel G, Amigó N, Julve J, Ribalta J, Guardiola M, Franch J, Bermúdez M, Codina P, Lupón J, Mauricio D, Alonso N, Bayés A. (1)H-magnetic resonance spectroscopy lipoprotein profile in patients with chronic heart failure versus matched controls. REVISTA ESPANOLA DE CARDIOLOGIA. 2022; 75(11). DOI:10.1016/j.rec.2021.09.008. PMID:34716123. IF:5,9 (Q1/3D). Document type: Article.
Teis A, Castelblanco E, Cediel G, Amigó N, Julve J, Ribalta J, Guardiola M, Franch J, Bermúdez M, Codina P, Lupón J, Mauricio D, Alonso N, Bayés A. Perfil lipoproteico por espectroscopia nuclear magnética en pacientes con insuficiencia cardiaca crónica comparado con controles emparejados. REVISTA ESPANOLA DE CARDIOLOGIA. 2022; 75(11). DOI:10.1016/j.recesp.2021.09.007. IF:5,9 (Q1/3D). Document type: Article.

Publicaciones 2021

- Amaro AB, Curco AS, Garcia E, Julve J, Rives J, Benitez S, Cortes VL. Apolipoprotein and LRP1-Based Peptides as New Therapeutic Tools in Atherosclerosis. Journal of Clinical Medicine. 2021; 10(16):3571. DOI:10.3390/jcm10163571. PMID:34441867. IF:4,964.
- Arroyo JA, Julve J, Vlacho B, Corcoy R, Ponte P, Roman E, Navas E, Llaurado G, Franch J, Domingo P, Mauricio D. Previous Vitamin D Supplementation and Morbidity and Mortality Outcomes in People Hospitalised for COVID19: A Cross-Sectional Study. Frontiers in Public Health. 2021; 9:758347. DOI:10.3389/fpubh.2021.758347. PMID:34631653. IF:6,461.
- Bellido V, Perez A. COVID-19 and Diabetes. Journal of Clinical Medicine. 2021; 10(22):5341. DOI:10.3390/jcm10225341. PMID:34830623. IF:4,964.
- Bellido V, Perez A. Inpatient Hyperglycemia Management and COVID-19. Diabetes Therapy. 2021; 12(1):121-132. DOI: 10.1007/s13300-020-00966-z. PMID: 33278017. IF:3,595.
- Bonaterra A, Fernandez S, Rivas A, Puig N, Benitez S, Pancorbo O, Rodriguez D, Pujadas F, Freijo MD, Tur S, Martinez M, Portela PC, Vera R, Lebrato L, Arenillas JF, Perez S, Montaner J, Sanchez JL, Hernandez M. Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease. Biomedicines. 2021; 9(1):72. DOI:10.3390/biomedicines9010072. PMID:33445800. IF:4,757.
- Canyelles M, Garcia A, Junza A, Yanes O, Puig N, Ordonez J, Sionis A, Sans J, Alquezar A, Santos D, Rotllan N, Julve J, Tondo M, Escola JC, Blanco F. The Capacity of APOB-Depleted Plasma in Inducing ATP-Binding Cassette A1/G1-Mediated Macrophage Cholesterol Efflux-But Not Gut Microbial-Derived Metabolites-Is Independently Associated with Mortality in Patients with ST-Segment Elevation Myocardial Infarction. Biomedicines. 2021; 9(10):1336. DOI:10.3390/biomedicines9101336. PMID:34680453. IF:4,757.
- Carbo JM, Leon TE, Font J, De la Rosa JV, Castrillo A, Picard FR, Staudenraus D, Huber M, Cedo L, Escola JC, Campos L, Bakiri L, Wagner EF, Caelles C, Stratmann T, Van JA, Valledor AF. Pharmacologic Activation of LXR Alters the Expression Profile of Tumor-Associated Macrophages and the Abundance of Regulatory T Cells in the Tumor Microenvironment. CANCER RESEARCH. 2021; 81(4). DOI:10.1158/0008-5472.CAN-19-3360. PMID:33361391. IF:13,312.
- Castelblanco E, Hernandez M, Ortega E, Amigo N, Real J, Granado M, Minambres I, Lopez C, Lecube A, Bermudez M, Alonso N, Julve J, Mauricio D. Outstanding improvement of the advanced lipoprotein profile in subjects with new-onset type 1 diabetes mellitus after achieving optimal glycemic control. DIABETES RESEARCH AND CLINICAL PRACTICE. 2021; 182:109145. DOI:10.1016/j.diabres.2021.109145. PMID:34785302. IF:8,180.
- Chiva G, Pena E, Cubedo J, Garcia M, Pane A, Gil PA, Perez A, Ortega E, Padro T, Badimon L. Molecular mapping of platelet hyperreactivity in diabetes: the stress proteins complex HSPA8/Hsp90/CSK2 alpha and platelet aggregation in diabetic and normal platelets. Translational Research. 2021; 235. DOI:10.1016/j.trsl.2021.04.003. PMID:33887528. IF:10,171.
- Colom C, Rull A, Sanchez JL, Perez A. Cardiovascular Disease in Type 1 Diabetes Mellitus: Epidemiology and Management of Cardiovascular Risk. Journal of Clinical Medicine. 2021; 10(8):1798. DOI:10.3390/jcm10081798. PMID:33924265. IF:4,964.
- Daban F, Garcia-Subirats I, Porthe V, Lopez M, de-Eyto B, Pasarin MI, Borrell C, Artazcoz L, Perez A, Diez E. Improving mental health and wellbeing in elderly people isolated at home due to architectural barriers: A community health intervention. Atencion Primaria. 2021;53(5):102020. DOI:10.1016/j.aprim.2021.102020. PMID: 33774346. IF: 2,206.
- Delk SC, Chattopadhyay A, Escola JC, Fogelman AM, Reddy ST. Apolipoprotein mimetics in cancer. SEMINARS IN CANCER BIOLOGY. 2021; 73. DOI:10.1016/j.semcancer.2020.11.002. PMID:33188891. IF:17,012.
- Escola JC, Rotllan N, Julve J, Blanco F. Reverse Cholesterol Transport Dysfunction Is a Feature of Familial Hypercholesterolemia. Current Atherosclerosis Reports. 2021; 23(6):29. DOI:10.1007/s11883-021-00928-1. PMID:33914189. IF:5,967.
- Farras M, Almanza E, Hernaez A, Agusti N, Julve J, Fito M, Castaner O. Beneficial effects of olive oil and Mediterranean diet on cancer physio-pathology and incidence. SEMINARS IN CANCER BIOLOGY. 2021; 73. DOI:10.1016/j.semcancer.2020.11.011. PMID:33249203. IF:17,012.
- Fernandez ME, Daimiel L, Villa G, Pavon MV, Busto R, Escola JC, Platt FM, Lasuncion MA, Martinez J, Gomez D. Selective estrogen receptor modulators (SERMs) affect cholesterol homeostasis through the master regulators SREBP and LXR. BIOMEDICINE & PHARMACOTHERAPY. 2021; 141:111871. DOI:10.1016/j.biopha.2021.111871. PMID:34225017. IF:7,419.
- Fernandez S, Pedret A, Catalan U, Valls RM, Farras M, Rubio L, Castaner O, Macia A, Fito M, Motilva MJ, Covas MI, Giera M, Remaley AT, Sola R. Virgin Olive Oil Phenolic Compounds Modulate the HDL Lipidome in Hypercholesterolaemic Subjects: A Lipidomic Analysis of the VOHF Study. MOLECULAR NUTRITION & FOOD RESEARCH. 2021; 65(9):2001192. DOI:10.1002/mnfr.202001192. PMID:33561904. IF:6,575.
- Fuster VP, Perez AP, Gomez JC, Pedragos AC, Gomez R, Perez P. Executive summary: Updates to the dietary treatment of prediabetes and type 2 diabetes mellitus. Endocrinologia Diabetes y Nutricion. 2021; 68(4). DOI:10.1016/j.endinu.2020.10.009. PMID:33593709. IF:1,833.
- Genua I, Puig N, Minambres I, Benitez S, Gil P, Grau M, Rivas A, Balague C, Fernandez S, Garcia A, Perez A, Sanchez JL. Changes in the Composition and Function of Lipoproteins after Bariatric Surgery in Patients with Severe Obesity. Journal of Clinical Medicine. 2021; 10(8):1716. DOI:10.3390/jcm10081716. PMID:33923393. IF:4,964.
- Genua I, Tuneu L, Ramos A, Stantonyonge N, Caimari F, Balague C, Fernandez-Ananin S, Sanchez-Quesada JL, Perez A, Miñambres I. Effectiveness of Bariatric Surgery in Patients with the Metabolically Healthy Obese Phenotype. OBESITY SURGERY. 2021;31(2):517-522. DOI:10.1007/s11695-020-04967-6. PMID: 32915359. IF:3,479.
- Gimeno JA, Rodriguez L, Anguita M, Barrios V, Muniz J, Perez A. Association of the KDIGO Risk Classification with the Prevalence of Heart Failure in Patients with Type 2 Diabetes. Journal of Clinical Medicine. 2021; 10(20):4634. DOI:10.3390/jcm10204634. PMID:34682756. IF:4,964.
- Goedeke L, Canfran A, Rotllan N, Chaube B, Thompson BM, Lee RG, Cline GW, McDonald JG, Shulman GI, Lasuncion MA, Suarez Y, Fernandez C. MMAB promotes negative feedback control of cholesterol homeostasis. Nature Communications. 2021; 12(1):6448. DOI:10.1038/s41467-021-26787-7. PMID:34750386. IF:17,694.
- Granado M, Martinez D, Martinez M, Doria M, Alcubierre N, Valls J, Julve J, Verdu J, Mauricio D. Psychometric Validation of the Cardiff Wound Impact Schedule Questionnaire in a Spanish Population with Diabetic Foot Ulcer. Journal of Clinical Medicine. 2021; 10(17):4023. DOI:10.3390/jcm10174023. PMID:34501471. IF:4,964.
- Julián MT, Pera G, Soldevila B, Caballería L, Julve J, Puig C, Morillas R, Torán P, Expósito C, Puig M, Castelblanco E, Franch J, Cusi K, Mauricio D, Alonso N. Atherogenic dyslipidemia, but not hyperglycemia, is an independent factor associated with liver fibrosis in subjects with type 2 diabetes and NAFLD: A population-based study. EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2021; 184(4). DOI:10.1530/EJE-20-1240. PMID:33606661. IF:6,558.
- Mendez KA, Rodriguez E, Sebastian D, Blanco R, Camacho M, Nan MN, Diarte E, Mato E, Lope S, Roglans N, Laguna JC, Alonso N, Mauricio D, Zorzano A, Villarroya F, Villena JA, Blanco F, Julve J. Nicotinamide Protects Against Diet-Induced Body Weight Gain, Increases Energy Expenditure, and Induces White Adipose Tissue Beiging. MOLECULAR NUTRITION & FOOD RESEARCH. 2021; 65(11):2100111. DOI:10.1002/mnfr.202100111. PMID:33870623. IF:6,575.
- Minambres I, Sanchez J, Cuixart G, Sanchez A, Sarroca J, Perez A. Characterization of the hypertriglyceridemic waist phenotype in patients with type 2 diabetes mellitus in Spain: an epidemiological study. REVISTA CLINICA ESPANOLA. 2021; 221(10). PMID:34839890. IF:3,064.
- Nan MN, Roig R, Martinez S, Rives J, Urgell E, Espinos JJ, Tirado M, Carreras G, Aulinas A, Webb SM, Corcoy R, Blanco F, Tondo M. Comprehensive Genetic Testing of CYP21A2: A Retrospective Analysis in Patients with Suspected Congenital Adrenal Hyperplasia. Journal of Clinical Medicine. 2021; 10(6):1183. DOI:10.3390/jcm10061183. PMID:33809035. IF:4,964.
- Oyaguez I, Gomez F, Artola S, Carrasco FJ, Carretero J, Garcia J, Gomez R, Merino JF, Perez A. Cost Analysis of FreeStyle Libre(R) 2 System in Type 2 Diabetes Mellitus Population. Diabetes Therapy. 2021; 12(9). DOI:10.1007/s13300-021-01064-4. PMID:33948909. IF:6,706.
- Papotti B, Escola JC, Julve J, Poti F, Zanotti I. Impact of Dietary Lipids on the Reverse Cholesterol Transport: What We Learned from Animal Studies. Nutrients. 2021; 13(8):2643. DOI:10.3390/nu13082643. PMID:34444804. IF:6,706.
- Revilla G, Cedo L, Tondo M, Moral A, Perez JI, Corcoy R, Lerma E, Fuste V, Reddy TS, Blanco F, Mato E, Escola JC. LDL, HDL and endocrine-related cancer: From pathogenic mechanisms to therapies. SEMINARS IN CANCER BIOLOGY. 2021; 73. DOI:10.1016/j.semcancer.2020.11.012. PMID:33249202. IF:17,012.
- Ribo S, Sanchez D, Martinez L, Garcia I, Ramon M, Tondo M, Arning E, Nofrarias M, Osorio O, Fernandez A, Gonzalez P, Cebria J, Gavalda A, Chenoll E, Isganaitis E, Villarroya F, Vallejo M, Segales J, Jimenez JC, Bottiglieri T, Demerath EW, Fields DA, Collado MC, Lerin C. Increasing breast milk betaine modulates Akkermansia abundance in mammalian neonates and improves long-term metabolic health. Science Translational Medicine. 2021; 13(587):eabb0322. DOI:10.1126/scitranslmed.abb0322. PMID:33790021. IF:19,319.
- Rodriguez J, Cerro I, Lindholt JS, Bonzon E, Martinez D, Roldan R, Escola JC, Michel JB, Blanco LM, Vazquez J, Suraez A, Martin JL. Malondialdehyde-modified HDL particles elicit a specific IgG response in abdominal aortic aneurysm. FREE RADICAL BIOLOGY AND MEDICINE. 2021; 174. DOI:10.1016/j.freeradbiomed.2021.08.004. PMID:34364980. IF:8,101.
- Rojo MI, Castelblanco E, Real J, Hernandez M, Falguera M, Amigo N, Julve J, Alonso N, Franch J, Granado M, Mauricio D. Advanced Quantitative Lipoprotein Characteristics Do Not Relate to Healthy Dietary Patterns in Adults from a Mediterranean Area. Nutrients. 2021; 13(12):4369. DOI:10.3390/nu13124369. PMID:34959921. IF:6,706.
- Rotllan N, Camacho M, Tondo M, Diarte E, Canyelles M, Mendez KA, Benitez S, Alonso N, Mauricio D, Escola JC, Blanco F, Julve J. Therapeutic Potential of Emerging NAD plus -Increasing Strategies for Cardiovascular Diseases. Antioxidants. 2021; 10(12):1939. DOI:10.3390/antiox10121939. IF:7,675.
- Singh AK, Chaube B, Zhang XB, Sun J, Citrin KM, Canfran A, Aryal B, Rotllan N, Varela L, Lee RG, Horvath TL, Price NL, Suarez Y, Fernandez C. Hepatocyte-specific suppression of ANGPTL4 improves obesity-associated diabetes and mitigates atherosclerosis in mice. JOURNAL OF CLINICAL INVESTIGATION. 2021; 131(17):e140989. DOI:10.1172/JCI140989. PMID:34255741. IF:19,456.
- Teis A, Cediel G, Amigo N, Julve J, Aranyo J, Andres J, Puig C, Castelblanco E, Gual F, Ferrer E, Vallejo N, Junca G, Lopez J, De Antonio M, Domingo M, Santiago E, Codina P, Mauricio D, Lupon J, Alonso N, Bayes A. Particle size and cholesterol content of circulating HDL correlate with cardiovascular death in chronic heart failure. Scientific Reports. 2021; 11(1):3141. DOI:10.1038/s41598-021-82861-6. PMID:33542459. IF:4,996.
- Uribe KB, Benito A, Martin C, Blanco F, Rotllan N. (r)HDL in theranostics: how do we apply HDL’s biology for precision medicine in atherosclerosis management?dagger. Biomaterials Science. 2021; 9(9). DOI:10.1039/d0bm01838d. PMID:33949389. IF:7,590.

MEMORIA CIENTIFICA

2020-Scientific Report

PUBLICACIONES RELEVANTES DESDE 2018

Cedo L., Plana N., Metso J., Lee-Rueckert M., Sanchez-Quesada J.L., Kovanen P.T. et al. Altered HDL Remodeling and Functionality in Familial Hypercholesterolemia. Journal of the American College of Cardiology. 2018;71(4):466-468.
Cedo L., Metso J., Santos D., Garcia-Leon A., Plana N., Sabate-Soler S. et al. LDL receptor regulates the reverse transport of macrophage-derived unesterified cholesterol via concerted action of the HDL-LDL Axis: Insight from mouse models. Circulation Research. 2020;:778-792.
Revilla G., Cedo L., Tondo M., Moral A., Perez J.I., Corcoy R. et al. LDL, HDL and endocrine-related cancer: From pathogenic mechanisms to therapies. Seminars in Cancer Biology. 2020;.
Benitez-Amaro A., Revuelta-Lopez E., Bornachea O., Cedo L., Vea A., Herrero L. et al. Low-density lipoprotein receptor-related protein 1 deficiency in cardiomyocytes reduces susceptibility to insulin resistance and obesity. Metabolism: Clinical and Experimental. 2020;106.
Méndez-Lara KA, Letelier N, Farré N, Diarte-Añazco EMG, Nieto-Nicolau N, Rodríguez-Millán E et al. Nicotinamide Prevents Apolipoprotein B-Containing Lipoprotein Oxidation, Inflammation and Atherosclerosis in Apolipoprotein E-Deficient Mice.Antioxidants (Basel, Switzerland). 2020;9(11).
Martinez-Lopez D., Camafeita E., Cedo L., Roldan-Montero R., Jorge I., Garcia-Marques F. et al. APOA1 oxidation is associated to dysfunctional high-density lipoproteins in human abdominal aortic aneurysm. EBioMedicine. 2019;.
Martínez-López D, Cedó L, Metso J, Burillo E, García-León A, Canyelles M et al. Impaired HDL (High-Density Lipoprotein)-Mediated Macrophage Cholesterol Efflux in Patients With Abdominal Aortic Aneurysm-Brief Report. Arteriosclerosis, thrombosis, and vascular biology. 2018;38(11):2750-2754.
Méndez-Lara KA, Rodríguez-Millán E, Sebastián D, Blanco-Soto R, Camacho M, Nan MN, et al. Nicotinamide Protects Against Diet-Induced Body Weight Gain, Increases Energy Expenditure, and Induces White Adipose Tissue Beiging. Mol Nutr Food Res. 2021 Jun;65(11):e2100111

Página web Ciberdem Grup Dr. Blanco-Vaca

https://www.ciberdem.org/grupos/grupo-de-investigacion?id=3280

Presentación

Resumen

Líneas Principales de Investigación e Innovación

Nuevos biomarcadores y terapias relacionados con factores de riesgo cardiometabólicos, que incluyen obesidad, diabetes, esteatohepatitis no alcohólica e hiperhomocisteinemia.
Disfuncionalidad del metabolismo de lípidos y lipoproteínas en la enfermedad.

Equipo

Coordinación del grupo

ESCOLA GIL, JOAN CARLES IR
jescola@santpau.cat

Miembros

Producción científica

Publicaciones 2022

(JIF 2022)

Antonio V, Franch J, Moreno A, Real J, Orcau A, Mauricio D, Mata M, Julve J, Mendez EN, Treserra RP, de la Puente JB, Millet JP, Garcia JLD, Vlacho B, Cayla JA. Subjects With Diabetes Mellitus Are at Increased Risk for Developing Tuberculosis: A Cohort Study in an Inner-City District of Barcelona (Spain). Frontiers in Public Health. 2022; 10:789952. DOI:10.3389/fpubh.2022.789952. PMID:35677764. IF:5,2 (Q1/3D). Document type: Article.
Blanco F, Rotllan N, Canyelles M, Mauricio D, Escola JC, Julve J. NAD plus -Increasing Strategies to Improve Cardiometabolic Health?. Frontiers in Endocrinology. 2022; 12:815565. DOI:10.3389/fendo.2021.815565. PMID:35173682. IF:5,2 (Q1/3D). Document type: Review.
Borras C, Mercer A, Sirisi S, Alcolea D, Escola JC, Blanco F, Tondo M. HDL-like-Mediated Cell Cholesterol Trafficking in the Central Nervous System and Alzheimer’s Disease Pathogenesis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(16):9356. DOI:10.3390/ijms23169356. PMID:36012637. IF:5,6 (Q1/3D). Document type: Review.
Canyelles M, Perez A, Junza A, Minambres I, Yanes O, Sarda H, Rotllan N, Julve J, Sanchez JL, Tondo M, Escola JC, Blanco F. Divergent Effects of Glycemic Control and Bariatric Surgery on Circulating Concentrations of TMAO in Newly Diagnosed T2D Patients and Morbidly Obese. 2022; 12(11):2783. DOI:10.3390/diagnostics12112783. PMID:36428843. IF:3,6 (Q2/4D). Document type: Article.
Canyelles M, Plaza M, Rotllan N, Llobet D, Julve J, Mojal S, Diaz M, Soria JM, Escola JC, Tondo M, Blanco F, Souto JC. TMAO and Gut Microbial-Derived Metabolites TML and gamma BB Are Not Associated with Thrombotic Risk in Patients with Venous Thromboembolism. Journal of Clinical Medicine. 2022; 11(5):1425. DOI:10.3390/jcm11051425. PMID:35268516. IF:3,9 (Q2/4D). Document type: Article.
Climent E, Bea AM, Benaiges D, Brea A, Pinto X, Suarez M, Perea V, Plana N, Blanco F, Pedro J. LDL Cholesterol Reduction Variability with Different Types and Doses of Statins in Monotherapy or Combined with Ezetimibe. Results from the Spanish Arteriosclerosis Society Dyslipidaemia Registry. CARDIOVASCULAR DRUGS AND THERAPY. 2022; 36(2). DOI:10.1007/s10557-020-07137-z. PMID:33555511. IF:3,4 (Q2/5D). Document type: Article.
Dato VA, Benitez A, Garcia E, Claudi L, Lhoest MTL, Iborra A, Guerra JM, Escola JC, Samouillan V, Enrich C, Chiabrando G, Llorente V. Targeting cholesteryl ester accumulation in the heart improves cardiac insulin response. BIOMEDICINE & PHARMACOTHERAPY. 2022; 152:113270. DOI:10.1016/j.biopha.2022.113270. PMID:35709652. IF:7,5 (Q1/1D). Document type: Article.
Delaby C, Estelles T, Zhu NU, Arranz J, Barroeta I, Carmona M, Illan I, Santos MA, Altuna M, Sala I, Sanchez MB, Videla L, Valldeneu S, Subirana A, Tondo M, Blanco F, Lehmann S, Belbin O, Blesa R, Fortea J, Lleo A, Alcolea D. The A beta 1-42/A beta 1-40 ratio in CSF is more strongly associated to tau markers and clinical progression than A beta 1-42 alone. Alzheimers Research & Therapy. 2022; 14(1):20. DOI:10.1186/s13195-022-00967-z. PMID:35105351. IF:9 (Q1/1D). Document type: Article.
Farras M, Swann JR, Rowland I, Rubio L, Subirana I, Catalan U, Motilva MJ, Sola R, Covas MI, Blanco F, Fito M, Mayneris J. Impact of Phenol-Enriched Olive Oils on Serum Metabonome and Its Relationship with Cardiometabolic Parameters: A Randomized, Double-Blind, Cross-Over, Controlled Trial. 2022; 11(10):1964. DOI:10.3390/antiox11101964. PMID:36290685. IF:7 (Q1/1D). Document type: Article.
Ferrer R, Zhu N, Arranz J, Porcel I, El Bounasri S, Sanchez O, Torres S, Julve J, Lleo A, Blanco F, Alcolea D, Tondo M. Importance of cerebrospinal fluid storage conditions for the Alzheimer’s disease diagnostics on an automated platform. CLINICAL CHEMISTRY AND LABORATORY MEDICINE. 2022; 60(7). DOI:10.1515/cclm-2022-0134. PMID:35405043. IF:6,8 (Q1/2D). Document type: Article.
Granado M, Sola I, Hernandez M, Rojo MI, Julve J, Mauricio D. Effectiveness of medical nutrition therapy in adolescents with type 1 diabetes: a systematic review. Nutrition & Diabetes. 2022; 12(1):24. DOI:10.1038/s41387-022-00201-7. PMID:35459205. IF:6,1 (Q1/2D). Document type: Review.
Grinan R, Escola JC, Julve J, Benitez S, Rotllan N. Epigenetic Regulation by microRNAs in Hyperhomocysteinemia-Accelerated Atherosclerosis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(20):12452. DOI:10.3390/ijms232012452. PMID:36293305. IF:5,6 (Q1/3D). Document type: Review.
Hueso M, Grinan R, Mallen A, Navarro E, Purqueras E, Goma M, Sbraga F, Blasco A, Revilla G, Santos D, Canyelles M, Julve J, Escola JC, Rotllan N. MiR-125b downregulates macrophage scavenger receptor type B1 and reverse cholesterol transport. BIOMEDICINE & PHARMACOTHERAPY. 2022; 146:112596. DOI:10.1016/j.biopha.2021.112596. PMID:35062066. IF:7,5 (Q1/1D). Document type: Article.
Julve J, Escola JC. High-Density Lipoproteins and Cardiovascular Disease: The Good, the Bad, and the Future II. 2022; 10(3):620. DOI:10.3390/biomedicines10030620. PMID:35327422. IF:4,7 (Q1/3D). Document type: Editorial material.
Lee M, Lappalainen J, Kovanen PT, Escola JC. Lipid-Laden Macrophages and Inflammation in Atherosclerosis and Cancer: An Integrative View. Frontiers in Cardiovascular Medicine. 2022; 9:777822. DOI:10.3389/fcvm.2022.777822. PMID:35237673. IF:3,6 (Q2/5D). Document type: Review.
Martos I, del Monte A, Lorenzo C, Busse CE, Delgado P, Mur SM, Cobos L, Escolà JC, Martín JL, Wardemann H, Ramiro AR. MDA-LDL vaccination induces athero-protective germinal-center-derived antibody responses. Cell Reports. 2022; 41(2):111468. DOI:10.1016/j.celrep.2022.111468. PMID:36223741. IF:8,8 (Q1/2D). Document type: Article.
Mauricio D, Vlacho B, de la Puente JB, Mundet X, Real J, Kulisevsky J, Ortega E, Castelblanco E, Julve J, Franch J. Associations Between Diabetic Retinopathy and Parkinson’s Disease: Results From the Catalonian Primary Care Cohort Study. Frontiers in Medicine. 2022; 8:800973. DOI:10.3389/fmed.2021.800973. PMID:35118094. IF:3,9 (Q2/4D). Document type: Article.
Nunez E, Fuster V, Gomez M, Valdivielso JM, Fernandez JM, Martinez D, Rodriguez JM, Bonzon E, Calvo E, Alfayate A, Bermudez M, Escola JC, Fernandez L, Cerro I, Mendiguren JM, Sanchez F, Sanz J, Ordovas JM, Blanco LM, Garcia JM, Ibanez B, Lara E, Fernandez A, Martin JL, Vazquez J. Unbiased plasma proteomics discovery of biomarkers for improved detection of subclinical atherosclerosis. 2022; 76:103874. DOI:10.1016/j.ebiom.2022.103874. PMID:35152150. IF:11,1 (Q1/1D). Document type: Article.
Puig C, Castelblanco E, Falguera M, Hernandez M, Soldevila B, Julian MT, Teis A, Julve J, Barranco M, Franch J, Puig M, Ortega E, Amigo N, Alonso N, Mauricio D. Advanced lipoprotein profile in individuals with normal and impaired glucose metabolism. REVISTA ESPANOLA DE CARDIOLOGIA. 2022; 75(1). DOI:10.1016/j.recesp.2021.02.013. PMID:33785266. IF:5,9 (Q1/3D). Document type: Article.
Revilla G,Moral A,Fuste V,Lerma E,Julve J,Escolà JC,Mato E,Pérez JI,Corcoy R,Paez EV. The role of ATP-binding cassette transporter genes in the metastatic process of epithelial thyroid carcinoma with aggressive behavior. En: Unraveling The Complexities Of Metastasis: Transition From A Segmented View To A Conceptual Continuum. Elsevier. 2022. p. 265-275. DOI: 10.1016/B978-0-12-821789-4.00020-5. Document type: Book chapter.
Rivas A, Rotllan N, Santos D, Julve J, Escolà JC, Sanchez JL. Assessment of Ex Vivo Antioxidative Potential of Murine HDL in Atherosclerosis. Methods In Molecular Biology. 2022; 2419DOI:10.1007/978-1-0716-1924-7_17. Document type: Book chapter.
Rivas A, Rotllan N, Santos D, Julve J, Sanchez JL, Escolà JC. Monitoring Atheroprotective Macrophage Cholesterol Efflux In Vivo. Methods In Molecular Biology. 2022; 2419. DOI:10.1007/978-1-0716-1924-7_35. Document type: Book chapter.
Roldan R, Perez JM, Cerro I, Oller J, Martinez D, Nunez E, Maller SM, Gutierrez C, Mendez N, Escola JC, Michel JB, Mittelbrunn M, Vazquez J, Blanco LM, Rabinovich GA, Martin JL. Galectin-1 prevents pathological vascular remodeling in atherosclerosis and abdominal aortic aneurysm. Science Advances. 2022; 8(11):eabm7322. DOI:10.1126/sciadv.abm7322. PMID:35294231. IF:13,6 (Q1/1D). Document type: Article.
Rotllan N, Zhang XB, Canfran A, Goedeke L, Grinan R, Ramirez CM, Suarez Y, Fernandez C. Antagonism of miR-148a attenuates atherosclerosis progression in APOB(TG )Apobec(-/-)Ldlr(+/-) mice: A brief report. BIOMEDICINE & PHARMACOTHERAPY. 2022; 153:113419. DOI:10.1016/j.biopha.2022.113419. PMID:36076541. IF:7,5 (Q1/1D). Document type: Article.
Rotllan N. The Underlying Pathology of Atherosclerosis: Different Players. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(6):3235. DOI:10.3390/ijms23063235. PMID:35328656. IF:5,6 (Q1/3D). Document type: Editorial material.
Teis A, Castelblanco E, Cediel G, Amigó N, Julve J, Ribalta J, Guardiola M, Franch J, Bermúdez M, Codina P, Lupón J, Mauricio D, Alonso N, Bayés A. (1)H-magnetic resonance spectroscopy lipoprotein profile in patients with chronic heart failure versus matched controls. REVISTA ESPANOLA DE CARDIOLOGIA. 2022; 75(11). DOI:10.1016/j.rec.2021.09.008. PMID:34716123. IF:5,9 (Q1/3D). Document type: Article.
Teis A, Castelblanco E, Cediel G, Amigó N, Julve J, Ribalta J, Guardiola M, Franch J, Bermúdez M, Codina P, Lupón J, Mauricio D, Alonso N, Bayés A. Perfil lipoproteico por espectroscopia nuclear magnética en pacientes con insuficiencia cardiaca crónica comparado con controles emparejados. REVISTA ESPANOLA DE CARDIOLOGIA. 2022; 75(11). DOI:10.1016/j.recesp.2021.09.007. IF:5,9 (Q1/3D). Document type: Article.

Publicaciones 2021

- Amaro AB, Curco AS, Garcia E, Julve J, Rives J, Benitez S, Cortes VL. Apolipoprotein and LRP1-Based Peptides as New Therapeutic Tools in Atherosclerosis. Journal of Clinical Medicine. 2021; 10(16):3571. DOI:10.3390/jcm10163571. PMID:34441867. IF:4,964.
- Arroyo JA, Julve J, Vlacho B, Corcoy R, Ponte P, Roman E, Navas E, Llaurado G, Franch J, Domingo P, Mauricio D. Previous Vitamin D Supplementation and Morbidity and Mortality Outcomes in People Hospitalised for COVID19: A Cross-Sectional Study. Frontiers in Public Health. 2021; 9:758347. DOI:10.3389/fpubh.2021.758347. PMID:34631653. IF:6,461.
- Bellido V, Perez A. COVID-19 and Diabetes. Journal of Clinical Medicine. 2021; 10(22):5341. DOI:10.3390/jcm10225341. PMID:34830623. IF:4,964.
- Bellido V, Perez A. Inpatient Hyperglycemia Management and COVID-19. Diabetes Therapy. 2021; 12(1):121-132. DOI: 10.1007/s13300-020-00966-z. PMID: 33278017. IF:3,595.
- Bonaterra A, Fernandez S, Rivas A, Puig N, Benitez S, Pancorbo O, Rodriguez D, Pujadas F, Freijo MD, Tur S, Martinez M, Portela PC, Vera R, Lebrato L, Arenillas JF, Perez S, Montaner J, Sanchez JL, Hernandez M. Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease. Biomedicines. 2021; 9(1):72. DOI:10.3390/biomedicines9010072. PMID:33445800. IF:4,757.
- Canyelles M, Garcia A, Junza A, Yanes O, Puig N, Ordonez J, Sionis A, Sans J, Alquezar A, Santos D, Rotllan N, Julve J, Tondo M, Escola JC, Blanco F. The Capacity of APOB-Depleted Plasma in Inducing ATP-Binding Cassette A1/G1-Mediated Macrophage Cholesterol Efflux-But Not Gut Microbial-Derived Metabolites-Is Independently Associated with Mortality in Patients with ST-Segment Elevation Myocardial Infarction. Biomedicines. 2021; 9(10):1336. DOI:10.3390/biomedicines9101336. PMID:34680453. IF:4,757.
- Carbo JM, Leon TE, Font J, De la Rosa JV, Castrillo A, Picard FR, Staudenraus D, Huber M, Cedo L, Escola JC, Campos L, Bakiri L, Wagner EF, Caelles C, Stratmann T, Van JA, Valledor AF. Pharmacologic Activation of LXR Alters the Expression Profile of Tumor-Associated Macrophages and the Abundance of Regulatory T Cells in the Tumor Microenvironment. CANCER RESEARCH. 2021; 81(4). DOI:10.1158/0008-5472.CAN-19-3360. PMID:33361391. IF:13,312.
- Castelblanco E, Hernandez M, Ortega E, Amigo N, Real J, Granado M, Minambres I, Lopez C, Lecube A, Bermudez M, Alonso N, Julve J, Mauricio D. Outstanding improvement of the advanced lipoprotein profile in subjects with new-onset type 1 diabetes mellitus after achieving optimal glycemic control. DIABETES RESEARCH AND CLINICAL PRACTICE. 2021; 182:109145. DOI:10.1016/j.diabres.2021.109145. PMID:34785302. IF:8,180.
- Chiva G, Pena E, Cubedo J, Garcia M, Pane A, Gil PA, Perez A, Ortega E, Padro T, Badimon L. Molecular mapping of platelet hyperreactivity in diabetes: the stress proteins complex HSPA8/Hsp90/CSK2 alpha and platelet aggregation in diabetic and normal platelets. Translational Research. 2021; 235. DOI:10.1016/j.trsl.2021.04.003. PMID:33887528. IF:10,171.
- Colom C, Rull A, Sanchez JL, Perez A. Cardiovascular Disease in Type 1 Diabetes Mellitus: Epidemiology and Management of Cardiovascular Risk. Journal of Clinical Medicine. 2021; 10(8):1798. DOI:10.3390/jcm10081798. PMID:33924265. IF:4,964.
- Daban F, Garcia-Subirats I, Porthe V, Lopez M, de-Eyto B, Pasarin MI, Borrell C, Artazcoz L, Perez A, Diez E. Improving mental health and wellbeing in elderly people isolated at home due to architectural barriers: A community health intervention. Atencion Primaria. 2021;53(5):102020. DOI:10.1016/j.aprim.2021.102020. PMID: 33774346. IF: 2,206.
- Delk SC, Chattopadhyay A, Escola JC, Fogelman AM, Reddy ST. Apolipoprotein mimetics in cancer. SEMINARS IN CANCER BIOLOGY. 2021; 73. DOI:10.1016/j.semcancer.2020.11.002. PMID:33188891. IF:17,012.
- Escola JC, Rotllan N, Julve J, Blanco F. Reverse Cholesterol Transport Dysfunction Is a Feature of Familial Hypercholesterolemia. Current Atherosclerosis Reports. 2021; 23(6):29. DOI:10.1007/s11883-021-00928-1. PMID:33914189. IF:5,967.
- Farras M, Almanza E, Hernaez A, Agusti N, Julve J, Fito M, Castaner O. Beneficial effects of olive oil and Mediterranean diet on cancer physio-pathology and incidence. SEMINARS IN CANCER BIOLOGY. 2021; 73. DOI:10.1016/j.semcancer.2020.11.011. PMID:33249203. IF:17,012.
- Fernandez ME, Daimiel L, Villa G, Pavon MV, Busto R, Escola JC, Platt FM, Lasuncion MA, Martinez J, Gomez D. Selective estrogen receptor modulators (SERMs) affect cholesterol homeostasis through the master regulators SREBP and LXR. BIOMEDICINE & PHARMACOTHERAPY. 2021; 141:111871. DOI:10.1016/j.biopha.2021.111871. PMID:34225017. IF:7,419.
- Fernandez S, Pedret A, Catalan U, Valls RM, Farras M, Rubio L, Castaner O, Macia A, Fito M, Motilva MJ, Covas MI, Giera M, Remaley AT, Sola R. Virgin Olive Oil Phenolic Compounds Modulate the HDL Lipidome in Hypercholesterolaemic Subjects: A Lipidomic Analysis of the VOHF Study. MOLECULAR NUTRITION & FOOD RESEARCH. 2021; 65(9):2001192. DOI:10.1002/mnfr.202001192. PMID:33561904. IF:6,575.
- Fuster VP, Perez AP, Gomez JC, Pedragos AC, Gomez R, Perez P. Executive summary: Updates to the dietary treatment of prediabetes and type 2 diabetes mellitus. Endocrinologia Diabetes y Nutricion. 2021; 68(4). DOI:10.1016/j.endinu.2020.10.009. PMID:33593709. IF:1,833.
- Genua I, Puig N, Minambres I, Benitez S, Gil P, Grau M, Rivas A, Balague C, Fernandez S, Garcia A, Perez A, Sanchez JL. Changes in the Composition and Function of Lipoproteins after Bariatric Surgery in Patients with Severe Obesity. Journal of Clinical Medicine. 2021; 10(8):1716. DOI:10.3390/jcm10081716. PMID:33923393. IF:4,964.
- Genua I, Tuneu L, Ramos A, Stantonyonge N, Caimari F, Balague C, Fernandez-Ananin S, Sanchez-Quesada JL, Perez A, Miñambres I. Effectiveness of Bariatric Surgery in Patients with the Metabolically Healthy Obese Phenotype. OBESITY SURGERY. 2021;31(2):517-522. DOI:10.1007/s11695-020-04967-6. PMID: 32915359. IF:3,479.
- Gimeno JA, Rodriguez L, Anguita M, Barrios V, Muniz J, Perez A. Association of the KDIGO Risk Classification with the Prevalence of Heart Failure in Patients with Type 2 Diabetes. Journal of Clinical Medicine. 2021; 10(20):4634. DOI:10.3390/jcm10204634. PMID:34682756. IF:4,964.
- Goedeke L, Canfran A, Rotllan N, Chaube B, Thompson BM, Lee RG, Cline GW, McDonald JG, Shulman GI, Lasuncion MA, Suarez Y, Fernandez C. MMAB promotes negative feedback control of cholesterol homeostasis. Nature Communications. 2021; 12(1):6448. DOI:10.1038/s41467-021-26787-7. PMID:34750386. IF:17,694.
- Granado M, Martinez D, Martinez M, Doria M, Alcubierre N, Valls J, Julve J, Verdu J, Mauricio D. Psychometric Validation of the Cardiff Wound Impact Schedule Questionnaire in a Spanish Population with Diabetic Foot Ulcer. Journal of Clinical Medicine. 2021; 10(17):4023. DOI:10.3390/jcm10174023. PMID:34501471. IF:4,964.
- Julián MT, Pera G, Soldevila B, Caballería L, Julve J, Puig C, Morillas R, Torán P, Expósito C, Puig M, Castelblanco E, Franch J, Cusi K, Mauricio D, Alonso N. Atherogenic dyslipidemia, but not hyperglycemia, is an independent factor associated with liver fibrosis in subjects with type 2 diabetes and NAFLD: A population-based study. EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2021; 184(4). DOI:10.1530/EJE-20-1240. PMID:33606661. IF:6,558.
- Mendez KA, Rodriguez E, Sebastian D, Blanco R, Camacho M, Nan MN, Diarte E, Mato E, Lope S, Roglans N, Laguna JC, Alonso N, Mauricio D, Zorzano A, Villarroya F, Villena JA, Blanco F, Julve J. Nicotinamide Protects Against Diet-Induced Body Weight Gain, Increases Energy Expenditure, and Induces White Adipose Tissue Beiging. MOLECULAR NUTRITION & FOOD RESEARCH. 2021; 65(11):2100111. DOI:10.1002/mnfr.202100111. PMID:33870623. IF:6,575.
- Minambres I, Sanchez J, Cuixart G, Sanchez A, Sarroca J, Perez A. Characterization of the hypertriglyceridemic waist phenotype in patients with type 2 diabetes mellitus in Spain: an epidemiological study. REVISTA CLINICA ESPANOLA. 2021; 221(10). PMID:34839890. IF:3,064.
- Nan MN, Roig R, Martinez S, Rives J, Urgell E, Espinos JJ, Tirado M, Carreras G, Aulinas A, Webb SM, Corcoy R, Blanco F, Tondo M. Comprehensive Genetic Testing of CYP21A2: A Retrospective Analysis in Patients with Suspected Congenital Adrenal Hyperplasia. Journal of Clinical Medicine. 2021; 10(6):1183. DOI:10.3390/jcm10061183. PMID:33809035. IF:4,964.
- Oyaguez I, Gomez F, Artola S, Carrasco FJ, Carretero J, Garcia J, Gomez R, Merino JF, Perez A. Cost Analysis of FreeStyle Libre(R) 2 System in Type 2 Diabetes Mellitus Population. Diabetes Therapy. 2021; 12(9). DOI:10.1007/s13300-021-01064-4. PMID:33948909. IF:6,706.
- Papotti B, Escola JC, Julve J, Poti F, Zanotti I. Impact of Dietary Lipids on the Reverse Cholesterol Transport: What We Learned from Animal Studies. Nutrients. 2021; 13(8):2643. DOI:10.3390/nu13082643. PMID:34444804. IF:6,706.
- Revilla G, Cedo L, Tondo M, Moral A, Perez JI, Corcoy R, Lerma E, Fuste V, Reddy TS, Blanco F, Mato E, Escola JC. LDL, HDL and endocrine-related cancer: From pathogenic mechanisms to therapies. SEMINARS IN CANCER BIOLOGY. 2021; 73. DOI:10.1016/j.semcancer.2020.11.012. PMID:33249202. IF:17,012.
- Ribo S, Sanchez D, Martinez L, Garcia I, Ramon M, Tondo M, Arning E, Nofrarias M, Osorio O, Fernandez A, Gonzalez P, Cebria J, Gavalda A, Chenoll E, Isganaitis E, Villarroya F, Vallejo M, Segales J, Jimenez JC, Bottiglieri T, Demerath EW, Fields DA, Collado MC, Lerin C. Increasing breast milk betaine modulates Akkermansia abundance in mammalian neonates and improves long-term metabolic health. Science Translational Medicine. 2021; 13(587):eabb0322. DOI:10.1126/scitranslmed.abb0322. PMID:33790021. IF:19,319.
- Rodriguez J, Cerro I, Lindholt JS, Bonzon E, Martinez D, Roldan R, Escola JC, Michel JB, Blanco LM, Vazquez J, Suraez A, Martin JL. Malondialdehyde-modified HDL particles elicit a specific IgG response in abdominal aortic aneurysm. FREE RADICAL BIOLOGY AND MEDICINE. 2021; 174. DOI:10.1016/j.freeradbiomed.2021.08.004. PMID:34364980. IF:8,101.
- Rojo MI, Castelblanco E, Real J, Hernandez M, Falguera M, Amigo N, Julve J, Alonso N, Franch J, Granado M, Mauricio D. Advanced Quantitative Lipoprotein Characteristics Do Not Relate to Healthy Dietary Patterns in Adults from a Mediterranean Area. Nutrients. 2021; 13(12):4369. DOI:10.3390/nu13124369. PMID:34959921. IF:6,706.
- Rotllan N, Camacho M, Tondo M, Diarte E, Canyelles M, Mendez KA, Benitez S, Alonso N, Mauricio D, Escola JC, Blanco F, Julve J. Therapeutic Potential of Emerging NAD plus -Increasing Strategies for Cardiovascular Diseases. Antioxidants. 2021; 10(12):1939. DOI:10.3390/antiox10121939. IF:7,675.
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ENFERMEDADES CARDIOVASCULARES

Fisiopatología de las enfermedades caracterizadas por alteraciones lipídicas

Resumen

Líneas Principales de Investigación e Innovación

Coordinación del grupo

Miembros

Publicaciones 2022

Publicaciones 2021

Resumen

Líneas Principales de Investigación e Innovación

Coordinación del grupo

Miembros

Publicaciones 2022

Publicaciones 2021

Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau