Sant Pau - Institut de Recerca

Principales líneas de investigación

Mecanismos de la aterosclerosis

Análisis de la Apolipoproteína (ApoJ) como un marcador de RCV.
Uso de péptidos miméticos derivados de ApoJ como herramientas terapéuticas.
Participación de las LDL (-) en la acumulación de lípidos en los cardiomiocitos y la insuficiencia cardiaca.

Mecanismos inflamatorios inducidos por las LDL(-) en monocitos de pacientes con diabetes

Diagnóstico de las enfermedades cardiovasculares crónicos o agudos.
Desarrollo de algoritmos para descartar enfermedad coronaria aguda.
Evaluación de nuevos biomarcadores de enfermedad cardiovascular aguda: troponinas cardíacas, péptidos natriuréticos, ST-2.
Desarrollo de métodos para la medición de punto ofcare biomarcador.
Marcadores de vulnerabilidad a la placa de ateroma: LDL electronegativo, tamaño de las LDL, función de las HDL, mieloperoxidasa, fosfolipasa.

Retos

Determinar los mecanismos intracelulares implicadas en la respuesta inflamatoria inducida por LDL (-) y los componentes de la partícula que implican aterogenicidad.
Analizar el potencial terapéutico de los péptidos miméticos derivados de apo J para retrasar el desarrollo de aterosclerosis en modelos animales.
Demostrar que el LDL electronegativo es un marcador de la placa de ateroma vulnerable.
Encontrar nuevos marcadores de riesgo cardiovascular en enfermedades tales como diabetes, VIH o insuficiencia cardíaca.

Coordinación del grupo

SANCHEZ QUESADA, JOSE LUIS IR
jsanchezq@santpau.cat

Miembros

Benitez Gonzalez, Sonia IR
Freixa Martin, Julia FGS
Garcia Osuna, Alvaro FGS
Grau Agramunt, Margarita FGS
Porcel Jabalera, Inmaculada FGS
Puig Grifol, Nuria IR

Publicaciones 2022

(JIF 2022)

Canyelles M, Perez A, Junza A, Minambres I, Yanes O, Sarda H, Rotllan N, Julve J, Sanchez JL, Tondo M, Escola JC, Blanco F. Divergent Effects of Glycemic Control and Bariatric Surgery on Circulating Concentrations of TMAO in Newly Diagnosed T2D Patients and Morbidly Obese. 2022; 12(11):2783. DOI:10.3390/diagnostics12112783. PMID:36428843. IF:3,6 (Q2/4D). Document type: Article.
Ferrer R, Zhu N, Arranz J, Porcel I, El Bounasri S, Sanchez O, Torres S, Julve J, Lleo A, Blanco F, Alcolea D, Tondo M. Importance of cerebrospinal fluid storage conditions for the Alzheimer’s disease diagnostics on an automated platform. CLINICAL CHEMISTRY AND LABORATORY MEDICINE. 2022; 60(7). DOI:10.1515/cclm-2022-0134. PMID:35405043. IF:6,8 (Q1/2D). Document type: Article.
Garcia A, Sans J, Ferrero A, Alquezar A, Sionis A, Ordonez J. Risk Assessment after ST-Segment Elevation Myocardial Infarction: Can Biomarkers Improve the Performance of Clinical Variables?. Journal of Clinical Medicine. 2022; 11(5):1266. DOI:10.3390/jcm11051266. PMID:35268358. IF:3,9 (Q2/4D). Document type: Article.
Grinan R, Escola JC, Julve J, Benitez S, Rotllan N. Epigenetic Regulation by microRNAs in Hyperhomocysteinemia-Accelerated Atherosclerosis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(20):12452. DOI:10.3390/ijms232012452. PMID:36293305. IF:5,6 (Q1/3D). Document type: Review.
Jayaraman S, Perez A, Minambres I, Sanchez JL, Gursky O. Heparin binding triggers human VLDL remodeling by circulating lipoprotein lipase: Relevance to VLDL functionality in health and disease. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. 2022; 1867(1):159064. DOI:10.1016/j.bbalip.2021.159064. PMID:34610468. IF:4,8 (Q1/2D). Document type: Article.
Minambres I, Sarda H, Urgell E, Genua I, Ramos A, Fernandez S, Balague C, Sanchez JL, Bassas L, Perez A. Obesity Surgery Improves Hypogonadism and Sexual Function in Men without Effects in Sperm Quality. Journal of Clinical Medicine. 2022; 11(17):5126. DOI:10.3390/jcm11175126. PMID:36079056. IF:3,9 (Q2/4D). Document type: Article.
Perez PC, Gonzalez JR, Nuche J, Matute L, Serrano I, Selles MM, Garcia RV, Dolz LM, Gomez M, Figal DP, Crespo MG, Garcia A, Ordonez J, Cuscullola JC, Guerra JM, Delgado JF. Renal Function Impact in the Prognostic Value of Galectin-3 in Acute Heart Failure. Frontiers in Cardiovascular Medicine. 2022; 9:861651. DOI:10.3389/fcvm.2022.861651. PMID:35463785. IF:3,6 (Q2/5D). Document type: Article.
Puig N, Camps P, Camacho M, Aguilera A, Jimenez F, Fernandez A, Marin R, Marti J, Sanchez JL, Jimenez E, Benitez S. Plasma sICAM-1 as a Biomarker of Carotid Plaque Inflammation in Patients with a Recent Ischemic Stroke. Translational Stroke Research. 2022; 13(5). DOI:10.1007/s12975-022-01002-x. PMID:35237947. IF:6,9 (Q1/1D). Document type: Article.
Rivas A, Rotllan N, Santos D, Julve J, Escolà JC, Sanchez JL. Assessment of Ex Vivo Antioxidative Potential of Murine HDL in Atherosclerosis. Methods In Molecular Biology. 2022; 2419. DOI:10.1007/978-1-0716-1924-7_17. Document type: Article.
Rivas A, Rotllan N, Santos D, Julve J, Sanchez JL, Escolà JC. Monitoring Atheroprotective Macrophage Cholesterol Efflux In Vivo. Methods In Molecular Biology. 2022; 2419. DOI:10.1007/978-1-0716-1924-7_35. Document type: Article.
Saumoy M, Sanchez JL, Assoumou L, Gatell JM, Gonzalez A, Guaraldi G, Domingo P, Giacomelli A, Connault J, Katlama C, Masia M, Ordonez J, Pozniak A, Martinez E, Podzamczer D. Atherogenicity of low-density lipoproteins after switching from a protease inhibitor to dolutegravir: a substudy of the NEAT022 study. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. 2022; 77(7). DOI:10.1093/jac/dkac117. PMID:35411401. IF:5,2 (Q1/3D). Document type: Article.

Publicaciones 2021

Aengevaeren VL, van RRJ, Ordonez J, Garcia A, Kaier TE, Marber M, Froeling M, van den Berg S, Hooijmans MT, Monte JR, Hopman M, Strijkers GJ, Nederveen AJ, Bakermans AJ, Eijsvogels TMH. Cardiac Biomarker Kinetics and Their Association With Magnetic Resonance Measures of Cardiomyocyte Integrity Following a Marathon Run: Implications for Postexercise Biomarker Testing. Journal of the American Heart Association. 2021; 10(13):e020039. DOI:10.1161/JAHA.120.020039. PMID:34180243. IF:6,106.
Alvarez J, Garcia A, Vives M, Ferrero A, Martinez M, Vazquez R, Gonzalez JR, Rivera M, Segovia J, Pascual D, Bover R, Bascompte R, Delgado J, Sepulveda AG, Bardaji A, Perez F, Zamorano JL, Crespo M, Sanchez PL, Ordonez J, Cinca J. A 3-Biomarker 2-Point-Based Risk Stratification Strategy in Acute Heart Failure. Frontiers in Physiology. 2021; 12:708890. DOI:10.3389/fphys.2021.708890. PMID:34744758. IF:4,755.
Amaro AB, Curco AS, Garcia E, Julve J, Rives J, Benitez S, Cortes VL. Apolipoprotein and LRP1-Based Peptides as New Therapeutic Tools in Atherosclerosis. Journal of Clinical Medicine. 2021; 10(16):3571. DOI:10.3390/jcm10163571. PMID:34441867. IF:4,964.
Bonaterra A, Fernandez S, Rivas A, Puig N, Benitez S, Pancorbo O, Rodriguez D, Pujadas F, Freijo MD, Tur S, Martinez M, Portela PC, Vera R, Lebrato L, Arenillas JF, Perez S, Montaner J, Sanchez JL, Hernandez M. Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease. Biomedicines. 2021; 9(1):72. DOI:10.3390/biomedicines9010072. PMID:33445800. IF:4,757.
Camps P, Jimenez E, Soler M, Puig N, Aguilera A, Marin R, Prats L, Delgado R, Martinez A, Guisado D, Guasch M, Marti J. Endothelial Progenitor Cells Count after Acute Ischemic Stroke Predicts Functional Outcome in Patients with Carotid Atherosclerosis. Journal of Stroke & Cerebrovascular Diseases. 2021; 30(12):106144. DOI:10.1016/j.jstrokecerebrovasdis.2021.106144. PMID:34649037. IF:2,677.
Canyelles M, Garcia A, Junza A, Yanes O, Puig N, Ordonez J, Sionis A, Sans J, Alquezar A, Santos D, Rotllan N, Julve J, Tondo M, Escola JC, Blanco F. The Capacity of APOB-Depleted Plasma in Inducing ATP-Binding Cassette A1/G1-Mediated Macrophage Cholesterol Efflux-But Not Gut Microbial-Derived Metabolites-Is Independently Associated with Mortality in Patients with ST-Segment Elevation Myocardial Infarction. Biomedicines. 2021; 9(10):1336. DOI:10.3390/biomedicines9101336. PMID:34680453. IF:4,757.
Chen DY, Sawamura T, Dixon R, Sanchez JL, Chen CH. Autoimmune Rheumatic Diseases: An Update on the Role of Atherogenic Electronegative LDL and Potential Therapeutic Strategies. Journal of Clinical Medicine. 2021; 10(9):1992. DOI:10.3390/jcm10091992. PMID:34066436. IF:4,964.
Colom C, Rull A, Sanchez JL, Perez A. Cardiovascular Disease in Type 1 Diabetes Mellitus: Epidemiology and Management of Cardiovascular Risk. Journal of Clinical Medicine. 2021; 10(8):1798. DOI:10.3390/jcm10081798. PMID:33924265. IF:4,964.
Crovetto F, Crispi F, Llurba E, Pascal R, Larroya M, Trilla C, Camacho M, Medina C, Dobano C, Gomez MD, Figueras F, Gratacos E, Garcia A, Mora J. Impact of Severe Acute Respiratory Syndrome Coronavirus 2 Infection on Pregnancy Outcomes: A Population-based Study. CLINICAL INFECTIOUS DISEASES. 2021; 73(10). DOI:10.1093/cid/ciab104. PMID:33556958. IF:20,999.
Diaz SO, Sanchez JL, de Freitas V, Leite A, Barros AS, Reis A. Exploratory analysis of large-scale lipidome in large cohorts: are we any closer of finding lipid-based markers suitable for CVD risk stratification and management?. ANALYTICA CHIMICA ACTA. 2021; 11D42OI:10.1016/j.aca.2020.10.037. PMID:33280696. IF:6,911.
Genua I, Puig N, Minambres I, Benitez S, Gil P, Grau M, Rivas A, Balague C, Fernandez S, Garcia A, Perez A, Sanchez JL. Changes in the Composition and Function of Lipoproteins after Bariatric Surgery in Patients with Severe Obesity. Journal of Clinical Medicine. 2021; 10(8):1716. DOI:10.3390/jcm10081716. PMID:33923393. IF:4,964.
Genua I, Tuneu L, Ramos A, Stantonyonge N, Caimari F, Balague C, Fernandez-Ananin S, Sanchez-Quesada JL, Perez A, Minambres I. Effectiveness of Bariatric Surgery in Patients with the Metabolically Healthy Obese Phenotype. OBESITY SURGERY. 2021; 31(2):517-522. DOI: 10.1007/s11695-020-04967-6. PMID: 32915359. IF:3,479.
Nan MN, Roig R, Martinez S, Rives J, Urgell E, Espinos JJ, Tirado M, Carreras G, Aulinas A, Webb SM, Corcoy R, Blanco F, Tondo M. Comprehensive Genetic Testing of CYP21A2: A Retrospective Analysis in Patients with Suspected Congenital Adrenal Hyperplasia. Journal of Clinical Medicine. 2021; 10(6):1183. DOI:10.3390/jcm10061183. PMID:33809035. IF:4,964.
Rotllan N, Camacho M, Tondo M, Diarte E, Canyelles M, Mendez KA, Benitez S, Alonso N, Mauricio D, Escola JC, Blanco F, Julve J. Therapeutic Potential of Emerging NAD plus -Increasing Strategies for Cardiovascular Diseases. Antioxidants. 2021; 10(12):1939. DOI:10.3390/antiox10121939. IF:7,675.
Saumoy M, Di S, Perez S, Sanchez JL, Valdivielso JM, Subirana I, Imaz A, Tiraboschi JM, Garcia B, Ordonez J, Benitez S, Podzamczer D, Grau M. Carotid atherosclerosis in virologically suppressed HIV patients: comparison with a healthy sample and prediction by cardiovascular risk equations. HIV MEDICINE. 2021; 22(7). DOI:10.1111/hiv.13093. PMID:33817938. IF:3,094.
Saumoy M, Sanchez JL, Ordonez J, Podzamczer D. Do All Integrase Strand Transfer Inhibitors Have the Same Lipid Profile? Review of Randomised Controlled Trials in Naive and Switch Scenarios in HIV-Infected Patients. Journal of Clinical Medicine. 2021; 10(16):3456. DOI:10.3390/jcm10163456. PMID:34441755. IF:4,964.
Ullmo J, Cruz M, Sanchez O, Bos L, De la Llama PF, Calero F, Dominguez C, Garrido C, Trilla C, Carreras F, Sionis A, Mora J, Garcia A, Ordonez J, Llurba E. Cardiac dysfunction and remodeling regulated by anti-angiogenic environment in patients with preeclampsia: the ANGIOCOR prospective cohort study protocol. BMC Pregnancy and Childbirth. 2021; 21(1):816. DOI:10.1186/s12884-021-04263-w. PMID:34879854. IF:3,105.

2017 Scientific Report – Cardiovascular Biochemistry

Presentación

Principales líneas de investigación

Mecanismos de la aterosclerosis

Análisis de la Apolipoproteína (ApoJ) como un marcador de RCV.
Uso de péptidos miméticos derivados de ApoJ como herramientas terapéuticas.
Participación de las LDL (-) en la acumulación de lípidos en los cardiomiocitos y la insuficiencia cardiaca.

Mecanismos inflamatorios inducidos por las LDL(-) en monocitos de pacientes con diabetes

Diagnóstico de las enfermedades cardiovasculares crónicos o agudos.
Desarrollo de algoritmos para descartar enfermedad coronaria aguda.
Evaluación de nuevos biomarcadores de enfermedad cardiovascular aguda: troponinas cardíacas, péptidos natriuréticos, ST-2.
Desarrollo de métodos para la medición de punto ofcare biomarcador.
Marcadores de vulnerabilidad a la placa de ateroma: LDL electronegativo, tamaño de las LDL, función de las HDL, mieloperoxidasa, fosfolipasa.

Retos

Determinar los mecanismos intracelulares implicadas en la respuesta inflamatoria inducida por LDL (-) y los componentes de la partícula que implican aterogenicidad.
Analizar el potencial terapéutico de los péptidos miméticos derivados de apo J para retrasar el desarrollo de aterosclerosis en modelos animales.
Demostrar que el LDL electronegativo es un marcador de la placa de ateroma vulnerable.
Encontrar nuevos marcadores de riesgo cardiovascular en enfermedades tales como diabetes, VIH o insuficiencia cardíaca.

Equipo

Coordinación del grupo

SANCHEZ QUESADA, JOSE LUIS IR
jsanchezq@santpau.cat

Miembros

Benitez Gonzalez, Sonia IR
Freixa Martin, Julia FGS
Garcia Osuna, Alvaro FGS
Grau Agramunt, Margarita FGS
Porcel Jabalera, Inmaculada FGS
Puig Grifol, Nuria IR

Producción científica

Publicaciones 2022

(JIF 2022)

Canyelles M, Perez A, Junza A, Minambres I, Yanes O, Sarda H, Rotllan N, Julve J, Sanchez JL, Tondo M, Escola JC, Blanco F. Divergent Effects of Glycemic Control and Bariatric Surgery on Circulating Concentrations of TMAO in Newly Diagnosed T2D Patients and Morbidly Obese. 2022; 12(11):2783. DOI:10.3390/diagnostics12112783. PMID:36428843. IF:3,6 (Q2/4D). Document type: Article.
Ferrer R, Zhu N, Arranz J, Porcel I, El Bounasri S, Sanchez O, Torres S, Julve J, Lleo A, Blanco F, Alcolea D, Tondo M. Importance of cerebrospinal fluid storage conditions for the Alzheimer’s disease diagnostics on an automated platform. CLINICAL CHEMISTRY AND LABORATORY MEDICINE. 2022; 60(7). DOI:10.1515/cclm-2022-0134. PMID:35405043. IF:6,8 (Q1/2D). Document type: Article.
Garcia A, Sans J, Ferrero A, Alquezar A, Sionis A, Ordonez J. Risk Assessment after ST-Segment Elevation Myocardial Infarction: Can Biomarkers Improve the Performance of Clinical Variables?. Journal of Clinical Medicine. 2022; 11(5):1266. DOI:10.3390/jcm11051266. PMID:35268358. IF:3,9 (Q2/4D). Document type: Article.
Grinan R, Escola JC, Julve J, Benitez S, Rotllan N. Epigenetic Regulation by microRNAs in Hyperhomocysteinemia-Accelerated Atherosclerosis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(20):12452. DOI:10.3390/ijms232012452. PMID:36293305. IF:5,6 (Q1/3D). Document type: Review.
Jayaraman S, Perez A, Minambres I, Sanchez JL, Gursky O. Heparin binding triggers human VLDL remodeling by circulating lipoprotein lipase: Relevance to VLDL functionality in health and disease. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. 2022; 1867(1):159064. DOI:10.1016/j.bbalip.2021.159064. PMID:34610468. IF:4,8 (Q1/2D). Document type: Article.
Minambres I, Sarda H, Urgell E, Genua I, Ramos A, Fernandez S, Balague C, Sanchez JL, Bassas L, Perez A. Obesity Surgery Improves Hypogonadism and Sexual Function in Men without Effects in Sperm Quality. Journal of Clinical Medicine. 2022; 11(17):5126. DOI:10.3390/jcm11175126. PMID:36079056. IF:3,9 (Q2/4D). Document type: Article.
Perez PC, Gonzalez JR, Nuche J, Matute L, Serrano I, Selles MM, Garcia RV, Dolz LM, Gomez M, Figal DP, Crespo MG, Garcia A, Ordonez J, Cuscullola JC, Guerra JM, Delgado JF. Renal Function Impact in the Prognostic Value of Galectin-3 in Acute Heart Failure. Frontiers in Cardiovascular Medicine. 2022; 9:861651. DOI:10.3389/fcvm.2022.861651. PMID:35463785. IF:3,6 (Q2/5D). Document type: Article.
Puig N, Camps P, Camacho M, Aguilera A, Jimenez F, Fernandez A, Marin R, Marti J, Sanchez JL, Jimenez E, Benitez S. Plasma sICAM-1 as a Biomarker of Carotid Plaque Inflammation in Patients with a Recent Ischemic Stroke. Translational Stroke Research. 2022; 13(5). DOI:10.1007/s12975-022-01002-x. PMID:35237947. IF:6,9 (Q1/1D). Document type: Article.
Rivas A, Rotllan N, Santos D, Julve J, Escolà JC, Sanchez JL. Assessment of Ex Vivo Antioxidative Potential of Murine HDL in Atherosclerosis. Methods In Molecular Biology. 2022; 2419. DOI:10.1007/978-1-0716-1924-7_17. Document type: Article.
Rivas A, Rotllan N, Santos D, Julve J, Sanchez JL, Escolà JC. Monitoring Atheroprotective Macrophage Cholesterol Efflux In Vivo. Methods In Molecular Biology. 2022; 2419. DOI:10.1007/978-1-0716-1924-7_35. Document type: Article.
Saumoy M, Sanchez JL, Assoumou L, Gatell JM, Gonzalez A, Guaraldi G, Domingo P, Giacomelli A, Connault J, Katlama C, Masia M, Ordonez J, Pozniak A, Martinez E, Podzamczer D. Atherogenicity of low-density lipoproteins after switching from a protease inhibitor to dolutegravir: a substudy of the NEAT022 study. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. 2022; 77(7). DOI:10.1093/jac/dkac117. PMID:35411401. IF:5,2 (Q1/3D). Document type: Article.

Publicaciones 2021

Aengevaeren VL, van RRJ, Ordonez J, Garcia A, Kaier TE, Marber M, Froeling M, van den Berg S, Hooijmans MT, Monte JR, Hopman M, Strijkers GJ, Nederveen AJ, Bakermans AJ, Eijsvogels TMH. Cardiac Biomarker Kinetics and Their Association With Magnetic Resonance Measures of Cardiomyocyte Integrity Following a Marathon Run: Implications for Postexercise Biomarker Testing. Journal of the American Heart Association. 2021; 10(13):e020039. DOI:10.1161/JAHA.120.020039. PMID:34180243. IF:6,106.
Alvarez J, Garcia A, Vives M, Ferrero A, Martinez M, Vazquez R, Gonzalez JR, Rivera M, Segovia J, Pascual D, Bover R, Bascompte R, Delgado J, Sepulveda AG, Bardaji A, Perez F, Zamorano JL, Crespo M, Sanchez PL, Ordonez J, Cinca J. A 3-Biomarker 2-Point-Based Risk Stratification Strategy in Acute Heart Failure. Frontiers in Physiology. 2021; 12:708890. DOI:10.3389/fphys.2021.708890. PMID:34744758. IF:4,755.
Amaro AB, Curco AS, Garcia E, Julve J, Rives J, Benitez S, Cortes VL. Apolipoprotein and LRP1-Based Peptides as New Therapeutic Tools in Atherosclerosis. Journal of Clinical Medicine. 2021; 10(16):3571. DOI:10.3390/jcm10163571. PMID:34441867. IF:4,964.
Bonaterra A, Fernandez S, Rivas A, Puig N, Benitez S, Pancorbo O, Rodriguez D, Pujadas F, Freijo MD, Tur S, Martinez M, Portela PC, Vera R, Lebrato L, Arenillas JF, Perez S, Montaner J, Sanchez JL, Hernandez M. Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease. Biomedicines. 2021; 9(1):72. DOI:10.3390/biomedicines9010072. PMID:33445800. IF:4,757.
Camps P, Jimenez E, Soler M, Puig N, Aguilera A, Marin R, Prats L, Delgado R, Martinez A, Guisado D, Guasch M, Marti J. Endothelial Progenitor Cells Count after Acute Ischemic Stroke Predicts Functional Outcome in Patients with Carotid Atherosclerosis. Journal of Stroke & Cerebrovascular Diseases. 2021; 30(12):106144. DOI:10.1016/j.jstrokecerebrovasdis.2021.106144. PMID:34649037. IF:2,677.
Canyelles M, Garcia A, Junza A, Yanes O, Puig N, Ordonez J, Sionis A, Sans J, Alquezar A, Santos D, Rotllan N, Julve J, Tondo M, Escola JC, Blanco F. The Capacity of APOB-Depleted Plasma in Inducing ATP-Binding Cassette A1/G1-Mediated Macrophage Cholesterol Efflux-But Not Gut Microbial-Derived Metabolites-Is Independently Associated with Mortality in Patients with ST-Segment Elevation Myocardial Infarction. Biomedicines. 2021; 9(10):1336. DOI:10.3390/biomedicines9101336. PMID:34680453. IF:4,757.
Chen DY, Sawamura T, Dixon R, Sanchez JL, Chen CH. Autoimmune Rheumatic Diseases: An Update on the Role of Atherogenic Electronegative LDL and Potential Therapeutic Strategies. Journal of Clinical Medicine. 2021; 10(9):1992. DOI:10.3390/jcm10091992. PMID:34066436. IF:4,964.
Colom C, Rull A, Sanchez JL, Perez A. Cardiovascular Disease in Type 1 Diabetes Mellitus: Epidemiology and Management of Cardiovascular Risk. Journal of Clinical Medicine. 2021; 10(8):1798. DOI:10.3390/jcm10081798. PMID:33924265. IF:4,964.
Crovetto F, Crispi F, Llurba E, Pascal R, Larroya M, Trilla C, Camacho M, Medina C, Dobano C, Gomez MD, Figueras F, Gratacos E, Garcia A, Mora J. Impact of Severe Acute Respiratory Syndrome Coronavirus 2 Infection on Pregnancy Outcomes: A Population-based Study. CLINICAL INFECTIOUS DISEASES. 2021; 73(10). DOI:10.1093/cid/ciab104. PMID:33556958. IF:20,999.
Diaz SO, Sanchez JL, de Freitas V, Leite A, Barros AS, Reis A. Exploratory analysis of large-scale lipidome in large cohorts: are we any closer of finding lipid-based markers suitable for CVD risk stratification and management?. ANALYTICA CHIMICA ACTA. 2021; 11D42OI:10.1016/j.aca.2020.10.037. PMID:33280696. IF:6,911.
Genua I, Puig N, Minambres I, Benitez S, Gil P, Grau M, Rivas A, Balague C, Fernandez S, Garcia A, Perez A, Sanchez JL. Changes in the Composition and Function of Lipoproteins after Bariatric Surgery in Patients with Severe Obesity. Journal of Clinical Medicine. 2021; 10(8):1716. DOI:10.3390/jcm10081716. PMID:33923393. IF:4,964.
Genua I, Tuneu L, Ramos A, Stantonyonge N, Caimari F, Balague C, Fernandez-Ananin S, Sanchez-Quesada JL, Perez A, Minambres I. Effectiveness of Bariatric Surgery in Patients with the Metabolically Healthy Obese Phenotype. OBESITY SURGERY. 2021; 31(2):517-522. DOI: 10.1007/s11695-020-04967-6. PMID: 32915359. IF:3,479.
Nan MN, Roig R, Martinez S, Rives J, Urgell E, Espinos JJ, Tirado M, Carreras G, Aulinas A, Webb SM, Corcoy R, Blanco F, Tondo M. Comprehensive Genetic Testing of CYP21A2: A Retrospective Analysis in Patients with Suspected Congenital Adrenal Hyperplasia. Journal of Clinical Medicine. 2021; 10(6):1183. DOI:10.3390/jcm10061183. PMID:33809035. IF:4,964.
Rotllan N, Camacho M, Tondo M, Diarte E, Canyelles M, Mendez KA, Benitez S, Alonso N, Mauricio D, Escola JC, Blanco F, Julve J. Therapeutic Potential of Emerging NAD plus -Increasing Strategies for Cardiovascular Diseases. Antioxidants. 2021; 10(12):1939. DOI:10.3390/antiox10121939. IF:7,675.
Saumoy M, Di S, Perez S, Sanchez JL, Valdivielso JM, Subirana I, Imaz A, Tiraboschi JM, Garcia B, Ordonez J, Benitez S, Podzamczer D, Grau M. Carotid atherosclerosis in virologically suppressed HIV patients: comparison with a healthy sample and prediction by cardiovascular risk equations. HIV MEDICINE. 2021; 22(7). DOI:10.1111/hiv.13093. PMID:33817938. IF:3,094.
Saumoy M, Sanchez JL, Ordonez J, Podzamczer D. Do All Integrase Strand Transfer Inhibitors Have the Same Lipid Profile? Review of Randomised Controlled Trials in Naive and Switch Scenarios in HIV-Infected Patients. Journal of Clinical Medicine. 2021; 10(16):3456. DOI:10.3390/jcm10163456. PMID:34441755. IF:4,964.
Ullmo J, Cruz M, Sanchez O, Bos L, De la Llama PF, Calero F, Dominguez C, Garrido C, Trilla C, Carreras F, Sionis A, Mora J, Garcia A, Ordonez J, Llurba E. Cardiac dysfunction and remodeling regulated by anti-angiogenic environment in patients with preeclampsia: the ANGIOCOR prospective cohort study protocol. BMC Pregnancy and Childbirth. 2021; 21(1):816. DOI:10.1186/s12884-021-04263-w. PMID:34879854. IF:3,105.

ENFERMEDADES CARDIOVASCULARES

Bioquímica Cardiovascular

Principales líneas de investigación

Mecanismos de la aterosclerosis

Mecanismos inflamatorios inducidos por las LDL(-) en monocitos de pacientes con diabetes

Retos

Coordinación del grupo

Miembros

Publicaciones 2022

Publicaciones 2021

Principales líneas de investigación

Mecanismos de la aterosclerosis

Mecanismos inflamatorios inducidos por las LDL(-) en monocitos de pacientes con diabetes

Retos

Coordinación del grupo

Miembros

Publicaciones 2022

Publicaciones 2021

Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau