Sant Pau - Institut de Recerca

Principales líneas de investigación

Mecanismos patogénicos de cáncer ginecológico (endometrial/cáncer de ovario).
Mecanismos moleculares de la respuesta del estroma y la inmunosupresión en el cáncer de endometrio.
Aplicación clínica de los factores pronósticos en los cánceres comunes (endometrio, ovario, etc).
Aplicación clínica de los marcadores tumorales.
Biología molecular de los sarcomas de útero y extrauterino.

Retos

Progresar como grupo productivo de investigación traslacional del cáncer ginecológico, capaz de competir con otros grupos altamente visibles en Barcelona que publican regularmente artículos en revistas de prestigio.
Cooperar con otros grupos a nivel nacional e internacional.

Coordinación del grupo

LERMA PUERTAS, ENRIQUE FGS
elerma@santpau.cat

Miembros

Bague Rosell, Silvia FGS
Catasus Cols, Lluis FGS
Clua Gonzalez, Agustin FGS
Espinosa Mariscal, Iñigo FGS
Ferre Figa, Malena FGS
Fumagalli, Caterina FGS
Fuste Chimisana, Victoria FGS
Gallardo Alcañiz, Alberto FGS
Gonzalez Vidal, Alan FGS
Gutierrez Montalban, Raquel FGS
Lopez Vilaro, Laura FGS
Manzotti, Carolina FGS
Mozos Rocafort, Ana FGS
Orellana Fernandez, Ruth Joaquina FGS
Szafranska, Justyna FGS

Publicaciones 2022

(JIF 2022)

Amat V, Yelamos O, Agut E, Dalmau J, Mozos A, Lopez S, Roe E. Spitzoid proliferative nodules arising in a congenital melanocytic naevus: A case report with clinical, dermoscopic and histologic correlation. AUSTRALASIAN JOURNAL OF DERMATOLOGY. 2022; 63(3). DOI:10.1111/ajd.13861. PMID:35510363. IF:2 (Q3/7D). Document type: Article.
Asla Q, Sarda H, Lerma E, Hanzu FA, Rodrigo MT, Urgell E, Perez JI, Webb SM, Aulinas A. 11-Deoxycorticosterone Producing Adrenal Hyperplasia as a Very Unusual Cause of Endocrine Hypertension: Case Report and Systematic Review of the Literature. Frontiers in Endocrinology. 2022; 13:846865. DOI:10.3389/fendo.2022.846865. PMID:35432204. IF:5,2 (Q1/3D). Document type: Review.
Bague S, Leon X, Terra X, Lejeune M, Camacho M, Aviles FX. Prognostic capacity of the transcriptional expression of lactate dehydrogenase A in patients with head and neck squamous cell carcinoma. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK. 2022; 44(11). DOI:10.1002/hed.27161. PMID:36207788. IF:2,9 (Q1/2D). Document type: Article.
Diaz E, Garcia M, Lopez L, Garcia X, Badimon L, Padro T. Urinary Proteomic Signature in Acute Decompensated Heart Failure: Advances into Molecular Pathophysiology. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(4):2344. DOI:10.3390/ijms23042344. PMID:35216460. IF:5,6 (Q1/3D). Document type: Article.
Diaz E, Garcia M, Lopez L, Garcia X, Badimon L, Padro T. Vitamin D Binding Protein and Renal Injury in Acute Decompensated Heart Failure. Frontiers in Cardiovascular Medicine. 2022; 9:829490. DOI:10.3389/fcvm.2022.829490. PMID:35757319. IF:3,6 (Q2/5D). Document type: Article.
Falgàs A, Garcia A, Núñez Y, Serna N, Sánchez L, Unzueta U, Voltà E, Aragó M, Álamo P, Alba L, Sierra J, Gallardo A, Villaverde A, Vázquez E, Mangues R, Casanova I. A diphtheria toxin-based nanoparticle achieves specific cytotoxic effect on CXCR4(+) lymphoma cells without toxicity in immunocompromised and immunocompetent mice. BIOMEDICINE & PHARMACOTHERAPY. 2022; 150:112940. DOI:10.1016/j.biopha.2022.112940. PMID:35421785. IF:7,5 (Q1/1D). Document type: Article.
Garcia C, Morales CE, Dalmau J, Cubiro X, Lopez C, Mozos A, Yelamos O. Extensive lichen planopilaris as exclusive lichenoid reaction secondary to pembrolizumab in a patient with metastatic melanoma. Dermatologic Therapy. 2022; 35(5):e15388. DOI:10.1111/dth.15388. PMID:35174945. IF:3,6 (Q1/3D). Document type: Letter.
Manrique A, Salazar J, Arranz MJ, Bague S, Orellana R, Lopez A, Cerda P, Gracia I, Majercakova K, Peiro A, Trullols L, Fernandez M, Valverde S, Quintana MJ, Bell O, Artigas A, Sebio A. Pharmacogenetic Profiling in High-Risk Soft Tissue Sarcomas Treated with Neoadjuvant Chemotherapy. Journal of Personalized Medicine. 2022; 12(4):618. DOI:10.3390/jpm12040618. PMID:35455734. Document type: Article.
Marsico S, Orellana R, Tizon H, Mas A, Solano A, Zuccarino F. Multimodality imaging evaluation of a primary cardiac epithelioid hemangioendothelioma. ACTA CARDIOLOGICA. 2022; 77(6). DOI:10.1080/00015385.2021.1908704. PMID:33827376. IF:1,6 (Q4/9D). Document type: Editorial material.
Medina E, Cespedes MV, Gallardo A, Rioja E, Pavon MA, Asensio L, Farre L, Alba L, Unzueta U, Villaverde A, Vazquez E, Casanova I, Mangues R. Novel Endometrial Cancer Models Using Sensitive Metastasis Tracing for CXCR4-Targeted Therapy in Advanced Disease. Biomedicines. 2022; 10(7):1680. DOI:10.3390/biomedicines10071680. PMID:35884987. IF:4,7 (Q1/3D). Document type: Article.
Pallares V, Unzueta U, Falgas A, Avino A, Nunez Y, Garcia A, Sanchez L, Serna N, Gallardo A, Alba L, Alamo P, Sierra J, Cedo L, Eritja R, Villaverde A, Vazquez E, Casanova I, Mangues R. A multivalent Ara-C-prodrug nanoconjugate achieves selective ablation of leukemic cells in an acute myeloid leukemia mouse model. 2022; 280:121258. DOI:10.1016/j.biomaterials.2021.121258. PMID:34847435. IF:14 (Q1/1D). Document type: Article.
Palones E, Pajares V, Lopez L, Castillo D, Torrego A. Sarcoidosis following SARS-CoV-2 infection: Cause or consequence?. Respirology Case Reports. 2022; 10(6):e0955. DOI:10.1002/rcr2.955. PMID:35505665. IF:0,8 (Q4/10D). Document type: Article.
Pasquali S, Palmerini E, Quagliuolo V, Martin J, Lopez A, Grignani G, Brunello A, Blay JY, Tendero O, Diaz R, Ferraresi V, Lugowska I, Infante G, Braglia L, Merlo DF, Fontana V, Marchesi E, Donati DM, Palassini E, Bianchi G, Marrari A, Morosi C, Stacchiotti S, Bague S, Coindre JM, Dei AP, Picci P, Bruzzi P, Miceli R, Casali PG, Gronchi A. Neoadjuvant chemotherapy in high-risk soft tissue sarcomas: A Sarculator-based risk stratification analysis of the ISG-STS 1001 randomized trial. CANCER. 2022; 128(1). DOI:10.1002/cncr.33895. PMID:34643947. IF:6,2 (Q1/3D). Document type: Article.
Revilla G,Moral A,Fuste V,Lerma E,Julve J,Escolà JC,Mato E,Pérez JI,Corcoy R,Paez EV. The role of ATP-binding cassette transporter genes in the metastatic process of epithelial thyroid carcinoma with aggressive behavior. In: Unraveling The Complexities Of Metastasis: Transition From A Segmented View To A Conceptual Continuum. Elsevier. 2022. p. 265-275. Document type: Book chapter.
Rioja E, Arroyo I, Alamo P, Casanova I, Gallardo A, Unzueta U, Serna N, Sanchez L, Quer M, Villaverde A, Vazquez E, Leon X, Alba L, Mangues R. CXCR4-targeted nanotoxins induce GSDME-dependent pyroptosis in head and neck squamous cell carcinoma. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2022; 41(1):49. DOI:10.1186/s13046-022-02267-8. PMID:35120582. IF:11,3 (Q1/1D). Document type: Article.
Rioja E, Arroyo I, Álamo P, Casanova I, Gallardo A, Unzueta U, Serna N, Sánchez L, Quer M, Villaverde A, Vázquez E, Mangues R, Alba L, León X. Self-assembling protein nanocarrier for selective delivery of cytotoxic polypeptides to CXCR4(+) head and neck squamous cell carcinoma tumors. Acta Pharmaceutica Sinica B. 2022; 12(5). DOI:10.1016/j.apsb.2021.09.030. PMID:35646535. IF:14,5 (Q1/1D). Document type: Article.
Rioja E, Gallardo A, Arroyo I, Alamo P, Casanova I, Unzueta U, Serna N, Sanchez L, Quer M, Villaverde A, Vazquez E, Leon X, Alba L, Mangues R. A Novel CXCR4-Targeted Diphtheria Toxin Nanoparticle Inhibits Invasion and Metastatic Dissemination in a Head and Neck Squamous Cell Carcinoma Mouse Model. 2022; 14(4):887. DOI:10.3390/pharmaceutics14040887. PMID:35456719. IF:5,4 (Q1/2D). Document type: Article.
Sanchez S, Leganes C, Bianchi F, Goruppi I, Boronat S, Fuste V, Lozano NB. Laparoscopic resection of a paediatric case of solid pseudopapillary tumour of the pancreas. Journal Of Pediatric Surgery Case Reports. 2022; 77:102141. DOI:10.1016/j.epsc.2021.102141. IF:0,4 (Q4/10D). Document type: Article.
Serda PC, Teres R, Sebio A, Bague S, Orellana R, Moreno ME, Riba M, Lopez A. Single-Center Experience with Trabectedin for the Treatment of Non-L-sarcomas. ADVANCES IN THERAPY. 2022; 39(4). DOI:10.1007/s12325-022-02051-2. PMID:35129790. IF:3,8 (Q2/4D). Document type: Article.
Serra C, Torrego A, Pajares V, Millan P, Barril S, Alonso A, Navarro M, Lopez L, Franquet T, Castillo D. Bronchoalveolar lavage complements transbronchial cryobiopsy diagnosis in diffuse interstitial lung diseases. Journal Of Bronchology And Interventional Pulmonology. 2022; 29(1). DOI:10.1097/LBR.0000000000000770. PMID:33828048. IF:3,3 (Q2/5D). Document type: Article.
Torrego A, Muñoz AM, Lucena CM, Castro P, López L, Badía JR, Betbesé A, Ramirez J, Andreo F, Fernández M-T, Fabra M, Pajares V, Agustí C. Safety and Feasibility of Transbronchial Cryobiopsy in Mechanically Ventilated Patients. ARCHIVOS DE BRONCONEUMOLOGIA. 2022; 58(8). DOI:10.1016/j.arbres.2021.11.005. PMID:35312520. IF:8 (Q1/2D). Document type: Letter.
Ventura M, Argemi J, Jones PD, Lackner C, El Hag M, Abraldes JG, Alvarado E, Clemente A, Ravi S, Alves A, Alboraie M, Altamirano J, Barace S, Bosques F, Brown R, Caballeria J, Cabezas J, Carvalhana S, Cortez H, Costa A, Degre D, Fernandez C, Ganne N, Garcia G, Genesca J, Koskinas J, Lanthier N, Louvet A, Lozano JJ, Lucey MR, Masson S, Mathurin P, Mendez N, et al. [Szafranska J]. Clinical, histological and molecular profiling of different stages of alcohol-related liver disease. GUT. 2022; 71(9):324295. DOI:10.1136/gutjnl-2021-324295. PMID:34992134. IF:24,5 (Q1/1D). Document type: Article.

Publicaciones 2021

Aguado C, Teixido C, Román R, Reyes R, Gimenez-Capitan A, Marin E, Cabrera C, Viñolas N, Castillo S, Muñoz S, Arcocha A, Lopez-Vilaro L, Sullivan I, Aldeguer E, Rodriguez S, Moya I, Viteri S, Cardona AF, Palmero R, Sainz C, Mesa-Guzman M, Lozano MD, Aguilar-Hernandez A, Martinez-Bueno A, Gonzalez-Cao M, Gonzalvo E, Leenders WPJ, Rosell R, et al. Multiplex RNA-based detection of clinically relevant MET alterations in advanced non-small cell lung cancer. Molecular Oncology. 202115(2):350-363. DOI:10.1002/1878-0261.12861. PMID: 33236532. IF:7,449.
Alamo P, Cedano J, Conchillo O, Cano O, Alba L, Serna N, Avino A, Carrasco LM, Sanchez A, Martinez C, Gallardo A, Cano M, Eritja R, Villaverde A, Mangues R, Vazquez E, Unzueta U. Rational engineering of a human GFP-like protein scaffold for humanized targeted nanomedicines. Acta Biomaterialia. 2021; 130. DOI:10.1016/j.actbio.2021.06.001. PMID:34116228. IF:10,633.
Campos MC, Tubau C, Segura S, Gonzalez M, Iglesias M, Fernandez MT, Garcia MP, Mozos A. Oral submucous fibrosis presenting with histopathological lichenoid changes as predominant feature: Report of five cases and review of the literature. JOURNAL OF CUTANEOUS PATHOLOGY. 2021; 48(11). DOI:10.1111/cup.14084. PMID:34151457. IF:1,458.
Castillo D, Barril S, Rodrigo A, Millan P, Suarez G, Alonso A, Franquet T, Lopez L, Castellvi I, Plaza V, Sibila O. EARLY HOSPITAL READMISSION INCREASES SHORT AND LONG – TERM MORTALITY IN PATIENTS WITH INTERSTITIAL LUNG DISEASE. SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES. 2021; 38(2):e2021021. DOI:10.36141/svdld.v38i2.10709. PMID:34316260. IF:1,803.
D’Angelo E, Espinosa I, Cipriani V, Szafranska J, Barbareschi M, Prat J. Atypical Endometrial Hyperplasia, Low-grade «Much ADO About Nothing». AMERICAN JOURNAL OF SURGICAL PATHOLOGY. 2021; 45(7). DOI:10.1097/PAS.0000000000001705. PMID:34105519. IF:6,298.
Escuin D, Lopez L, Mora J, Bell O, Moral A, Perez I, Arqueros C, Garcia B, Cajal TRY, Lerma E, Barnadas A. Circulating microRNAs in Early Breast Cancer Patients and Its Association With Lymph Node Metastases. Frontiers in Oncology. 2021; 11:627811. DOI:10.3389/fonc.2021.627811. PMID:34513655. IF:5,738.
Esteve A, Alameda F, Carrato C, Pineda E, Arpi O, Martinez M, Mallo M, Gut M, Dabad M, Tortosa A, Del Barco S, Capellades J, Puig J, Gallego O, Pujol T, Oleaga L, Gil M, de Quintana C, Valduvieco I, Martinez A, Bellosillo B, Munoz AM, Esteve A, Domenech M, Camins A, Craven J, Villa S, Marruecos J, Domenech S, de la Iglesia N, Balana C, Bagué S, Aldecoa I. RNA sequencing and Immunohistochemistry Reveal ZFN7 as a Stronger Marker of Survival than Molecular Subtypes in G-CIMP-negative Glioblastoma. CLINICAL CANCER RESEARCH. 2021; 27(2). DOI:10.1158/1078-0432.CCR-20-2141. PMID:33106291. IF:13,801.
Falgas A, Pallares V, Unzueta U, Nunez Y, Sierra J, Gallardo A, Alba L, Mangues MA, Alamo P, Villaverde A, Vazquez E, Mangues R, Casanova I. Specific Cytotoxic Effect of an Auristatin Nanoconjugate Towards CXCR4(+) Diffuse Large B-Cell Lymphoma Cells. International Journal of Nanomedicine. 2021; 16. DOI:10.2147/IJN.S289733. PMID:33716502. IF:7,033.
Iznardo H, Baselga E, Mozos A, Szafranska J, Orellana R, Roe E. Net-like superficial lymphatic malformation. PEDIATRIC DERMATOLOGY. 2021; 38(2). DOI:10.1111/pde.14526. PMID:33486776. IF:1,997.
Lopez C, Falla LM, Roe E, Arostegui JI, Mozos A, Bernal S, Iznardo H, Baselga E. Excellent response to secukinumab in an infant with severe generalized pustular psoriasis. JOURNAL OF DERMATOLOGY. 2021; 48(6). DOI:10.1111/1346-8138.15673. PMID:33543522. IF:3,468.
Martin J, Lopez M, Moura DS, Ramos R, Collini P, Romagosa C, Bague S, Renne SL, Barisella M, Velasco V, Coindre JM, Lopez D, Dopazo J, Gambarotti M, Braglia L, Merlo DF, Palmerini E, Stacchiotti S, Quagliuolo VL, Lopez A, Grignani G, Blay JY, Brunello A, Gutierrez A, Valverde C, Hindi N, Dei AP, Picci P, Casali PG, Gronchi A. Predictive Value of MRP-1 in Localized High-Risk Soft Tissue Sarcomas: A Translational Research Associated to ISG-STS 1001 Randomized Phase III Trial. MOLECULAR CANCER THERAPEUTICS. 2021; 20(12). DOI:10.1158/1535-7163.MCT-21-0315. PMID:34552008. IF:6,009.
Moura DS, Diaz J, Bague S, Orellana R, Sebio A, Mondaza JL, Salguero C, Rojo F, Hindi N, Fletcher CDM, Martin J. A Novel NFIX-STAT6 Gene Fusion in Solitary Fibrous Tumor: A Case Report. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021; 22(14):7514. DOI:10.3390/ijms22147514. PMID:34299133. IF:6,208.
Moura DS, Pena M, Varela J, Alvarez R, Agra C, Izquierdo F, Ramos R, Ortega L, Martin F, Castilla C, Hernandez CN, Romagosa C, Salgado M, Lavernia J, Bague S, Mayodormo E, Vicioso L, Barcelo J, Rubio J, de Juan A, Fiano MC, Hindi N, Lopez M, Lacerenza S, Dopazo J, Gutierrez A, Alvarez R, Valverde C, Martinez J, Martin J. A DNA damage repair gene-associated signature predicts responses of patients with advanced soft-tissue sarcoma to treatment with trabectedin. Molecular Oncology. 2021; 15(12). DOI:10.1002/1878-0261.12996. PMID:33983674. IF:7,449.
Pallares V, Nunez Y, Sanchez L, Falgas A, Serna N, Unzueta U, Gallardo A, Alba L, Alamo P, Sierra J, Villaverde A, Vazquez E, Casanova I, Mangues R. Antineoplastic effect of a diphtheria toxin-based nanoparticle targeting acute myeloid leukemia cells overexpressing CXCR4. JOURNAL OF CONTROLLED RELEASE. 2021; 335. DOI:10.1016/j.jconrel.2021.05.014. PMID:34004204. IF:11,467.
Revilla G, Cedo L, Tondo M, Moral A, Perez JI, Corcoy R, Lerma E, Fuste V, Reddy TS, Blanco F, Mato E, Escola JC. LDL, HDL and endocrine-related cancer: From pathogenic mechanisms to therapies. SEMINARS IN CANCER BIOLOGY. 2021; 73. DOI:10.1016/j.semcancer.2020.11.012. PMID:33249202. IF:17,012.
Vieites B, Lopez MA, Martin MD, Ramirez CL, Rezola R, Sancho M, Lopez L, Villardell F, Burgues O, Fernandez B, Alfaro L, Peg V. Predictive and prognostic value of total tumor load in sentinel lymph nodes in breast cancer patients after neoadjuvant treatment using one-step nucleic acid amplification: the NEOVATTL study. Clinical & Translational Oncology. 2021; 23(7). DOI:10.1007/s12094-020-02530-4. PMID:33517542. IF:3,340.

2017 Scientific Report – Molecular Pathology of Gynaecologic Cancer

Presentación

Principales líneas de investigación

Mecanismos patogénicos de cáncer ginecológico (endometrial/cáncer de ovario).
Mecanismos moleculares de la respuesta del estroma y la inmunosupresión en el cáncer de endometrio.
Aplicación clínica de los factores pronósticos en los cánceres comunes (endometrio, ovario, etc).
Aplicación clínica de los marcadores tumorales.
Biología molecular de los sarcomas de útero y extrauterino.

Retos

Progresar como grupo productivo de investigación traslacional del cáncer ginecológico, capaz de competir con otros grupos altamente visibles en Barcelona que publican regularmente artículos en revistas de prestigio.
Cooperar con otros grupos a nivel nacional e internacional.

Equipo

Coordinación del grupo

LERMA PUERTAS, ENRIQUE FGS
elerma@santpau.cat

Miembros

Producción científica

Publicaciones 2022

(JIF 2022)

Amat V, Yelamos O, Agut E, Dalmau J, Mozos A, Lopez S, Roe E. Spitzoid proliferative nodules arising in a congenital melanocytic naevus: A case report with clinical, dermoscopic and histologic correlation. AUSTRALASIAN JOURNAL OF DERMATOLOGY. 2022; 63(3). DOI:10.1111/ajd.13861. PMID:35510363. IF:2 (Q3/7D). Document type: Article.
Asla Q, Sarda H, Lerma E, Hanzu FA, Rodrigo MT, Urgell E, Perez JI, Webb SM, Aulinas A. 11-Deoxycorticosterone Producing Adrenal Hyperplasia as a Very Unusual Cause of Endocrine Hypertension: Case Report and Systematic Review of the Literature. Frontiers in Endocrinology. 2022; 13:846865. DOI:10.3389/fendo.2022.846865. PMID:35432204. IF:5,2 (Q1/3D). Document type: Review.
Bague S, Leon X, Terra X, Lejeune M, Camacho M, Aviles FX. Prognostic capacity of the transcriptional expression of lactate dehydrogenase A in patients with head and neck squamous cell carcinoma. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK. 2022; 44(11). DOI:10.1002/hed.27161. PMID:36207788. IF:2,9 (Q1/2D). Document type: Article.
Diaz E, Garcia M, Lopez L, Garcia X, Badimon L, Padro T. Urinary Proteomic Signature in Acute Decompensated Heart Failure: Advances into Molecular Pathophysiology. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(4):2344. DOI:10.3390/ijms23042344. PMID:35216460. IF:5,6 (Q1/3D). Document type: Article.
Diaz E, Garcia M, Lopez L, Garcia X, Badimon L, Padro T. Vitamin D Binding Protein and Renal Injury in Acute Decompensated Heart Failure. Frontiers in Cardiovascular Medicine. 2022; 9:829490. DOI:10.3389/fcvm.2022.829490. PMID:35757319. IF:3,6 (Q2/5D). Document type: Article.
Falgàs A, Garcia A, Núñez Y, Serna N, Sánchez L, Unzueta U, Voltà E, Aragó M, Álamo P, Alba L, Sierra J, Gallardo A, Villaverde A, Vázquez E, Mangues R, Casanova I. A diphtheria toxin-based nanoparticle achieves specific cytotoxic effect on CXCR4(+) lymphoma cells without toxicity in immunocompromised and immunocompetent mice. BIOMEDICINE & PHARMACOTHERAPY. 2022; 150:112940. DOI:10.1016/j.biopha.2022.112940. PMID:35421785. IF:7,5 (Q1/1D). Document type: Article.
Garcia C, Morales CE, Dalmau J, Cubiro X, Lopez C, Mozos A, Yelamos O. Extensive lichen planopilaris as exclusive lichenoid reaction secondary to pembrolizumab in a patient with metastatic melanoma. Dermatologic Therapy. 2022; 35(5):e15388. DOI:10.1111/dth.15388. PMID:35174945. IF:3,6 (Q1/3D). Document type: Letter.
Manrique A, Salazar J, Arranz MJ, Bague S, Orellana R, Lopez A, Cerda P, Gracia I, Majercakova K, Peiro A, Trullols L, Fernandez M, Valverde S, Quintana MJ, Bell O, Artigas A, Sebio A. Pharmacogenetic Profiling in High-Risk Soft Tissue Sarcomas Treated with Neoadjuvant Chemotherapy. Journal of Personalized Medicine. 2022; 12(4):618. DOI:10.3390/jpm12040618. PMID:35455734. Document type: Article.
Marsico S, Orellana R, Tizon H, Mas A, Solano A, Zuccarino F. Multimodality imaging evaluation of a primary cardiac epithelioid hemangioendothelioma. ACTA CARDIOLOGICA. 2022; 77(6). DOI:10.1080/00015385.2021.1908704. PMID:33827376. IF:1,6 (Q4/9D). Document type: Editorial material.
Medina E, Cespedes MV, Gallardo A, Rioja E, Pavon MA, Asensio L, Farre L, Alba L, Unzueta U, Villaverde A, Vazquez E, Casanova I, Mangues R. Novel Endometrial Cancer Models Using Sensitive Metastasis Tracing for CXCR4-Targeted Therapy in Advanced Disease. Biomedicines. 2022; 10(7):1680. DOI:10.3390/biomedicines10071680. PMID:35884987. IF:4,7 (Q1/3D). Document type: Article.
Pallares V, Unzueta U, Falgas A, Avino A, Nunez Y, Garcia A, Sanchez L, Serna N, Gallardo A, Alba L, Alamo P, Sierra J, Cedo L, Eritja R, Villaverde A, Vazquez E, Casanova I, Mangues R. A multivalent Ara-C-prodrug nanoconjugate achieves selective ablation of leukemic cells in an acute myeloid leukemia mouse model. 2022; 280:121258. DOI:10.1016/j.biomaterials.2021.121258. PMID:34847435. IF:14 (Q1/1D). Document type: Article.
Palones E, Pajares V, Lopez L, Castillo D, Torrego A. Sarcoidosis following SARS-CoV-2 infection: Cause or consequence?. Respirology Case Reports. 2022; 10(6):e0955. DOI:10.1002/rcr2.955. PMID:35505665. IF:0,8 (Q4/10D). Document type: Article.
Pasquali S, Palmerini E, Quagliuolo V, Martin J, Lopez A, Grignani G, Brunello A, Blay JY, Tendero O, Diaz R, Ferraresi V, Lugowska I, Infante G, Braglia L, Merlo DF, Fontana V, Marchesi E, Donati DM, Palassini E, Bianchi G, Marrari A, Morosi C, Stacchiotti S, Bague S, Coindre JM, Dei AP, Picci P, Bruzzi P, Miceli R, Casali PG, Gronchi A. Neoadjuvant chemotherapy in high-risk soft tissue sarcomas: A Sarculator-based risk stratification analysis of the ISG-STS 1001 randomized trial. CANCER. 2022; 128(1). DOI:10.1002/cncr.33895. PMID:34643947. IF:6,2 (Q1/3D). Document type: Article.
Revilla G,Moral A,Fuste V,Lerma E,Julve J,Escolà JC,Mato E,Pérez JI,Corcoy R,Paez EV. The role of ATP-binding cassette transporter genes in the metastatic process of epithelial thyroid carcinoma with aggressive behavior. In: Unraveling The Complexities Of Metastasis: Transition From A Segmented View To A Conceptual Continuum. Elsevier. 2022. p. 265-275. Document type: Book chapter.
Rioja E, Arroyo I, Alamo P, Casanova I, Gallardo A, Unzueta U, Serna N, Sanchez L, Quer M, Villaverde A, Vazquez E, Leon X, Alba L, Mangues R. CXCR4-targeted nanotoxins induce GSDME-dependent pyroptosis in head and neck squamous cell carcinoma. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2022; 41(1):49. DOI:10.1186/s13046-022-02267-8. PMID:35120582. IF:11,3 (Q1/1D). Document type: Article.
Rioja E, Arroyo I, Álamo P, Casanova I, Gallardo A, Unzueta U, Serna N, Sánchez L, Quer M, Villaverde A, Vázquez E, Mangues R, Alba L, León X. Self-assembling protein nanocarrier for selective delivery of cytotoxic polypeptides to CXCR4(+) head and neck squamous cell carcinoma tumors. Acta Pharmaceutica Sinica B. 2022; 12(5). DOI:10.1016/j.apsb.2021.09.030. PMID:35646535. IF:14,5 (Q1/1D). Document type: Article.
Rioja E, Gallardo A, Arroyo I, Alamo P, Casanova I, Unzueta U, Serna N, Sanchez L, Quer M, Villaverde A, Vazquez E, Leon X, Alba L, Mangues R. A Novel CXCR4-Targeted Diphtheria Toxin Nanoparticle Inhibits Invasion and Metastatic Dissemination in a Head and Neck Squamous Cell Carcinoma Mouse Model. 2022; 14(4):887. DOI:10.3390/pharmaceutics14040887. PMID:35456719. IF:5,4 (Q1/2D). Document type: Article.
Sanchez S, Leganes C, Bianchi F, Goruppi I, Boronat S, Fuste V, Lozano NB. Laparoscopic resection of a paediatric case of solid pseudopapillary tumour of the pancreas. Journal Of Pediatric Surgery Case Reports. 2022; 77:102141. DOI:10.1016/j.epsc.2021.102141. IF:0,4 (Q4/10D). Document type: Article.
Serda PC, Teres R, Sebio A, Bague S, Orellana R, Moreno ME, Riba M, Lopez A. Single-Center Experience with Trabectedin for the Treatment of Non-L-sarcomas. ADVANCES IN THERAPY. 2022; 39(4). DOI:10.1007/s12325-022-02051-2. PMID:35129790. IF:3,8 (Q2/4D). Document type: Article.
Serra C, Torrego A, Pajares V, Millan P, Barril S, Alonso A, Navarro M, Lopez L, Franquet T, Castillo D. Bronchoalveolar lavage complements transbronchial cryobiopsy diagnosis in diffuse interstitial lung diseases. Journal Of Bronchology And Interventional Pulmonology. 2022; 29(1). DOI:10.1097/LBR.0000000000000770. PMID:33828048. IF:3,3 (Q2/5D). Document type: Article.
Torrego A, Muñoz AM, Lucena CM, Castro P, López L, Badía JR, Betbesé A, Ramirez J, Andreo F, Fernández M-T, Fabra M, Pajares V, Agustí C. Safety and Feasibility of Transbronchial Cryobiopsy in Mechanically Ventilated Patients. ARCHIVOS DE BRONCONEUMOLOGIA. 2022; 58(8). DOI:10.1016/j.arbres.2021.11.005. PMID:35312520. IF:8 (Q1/2D). Document type: Letter.
Ventura M, Argemi J, Jones PD, Lackner C, El Hag M, Abraldes JG, Alvarado E, Clemente A, Ravi S, Alves A, Alboraie M, Altamirano J, Barace S, Bosques F, Brown R, Caballeria J, Cabezas J, Carvalhana S, Cortez H, Costa A, Degre D, Fernandez C, Ganne N, Garcia G, Genesca J, Koskinas J, Lanthier N, Louvet A, Lozano JJ, Lucey MR, Masson S, Mathurin P, Mendez N, et al. [Szafranska J]. Clinical, histological and molecular profiling of different stages of alcohol-related liver disease. GUT. 2022; 71(9):324295. DOI:10.1136/gutjnl-2021-324295. PMID:34992134. IF:24,5 (Q1/1D). Document type: Article.

Publicaciones 2021

Aguado C, Teixido C, Román R, Reyes R, Gimenez-Capitan A, Marin E, Cabrera C, Viñolas N, Castillo S, Muñoz S, Arcocha A, Lopez-Vilaro L, Sullivan I, Aldeguer E, Rodriguez S, Moya I, Viteri S, Cardona AF, Palmero R, Sainz C, Mesa-Guzman M, Lozano MD, Aguilar-Hernandez A, Martinez-Bueno A, Gonzalez-Cao M, Gonzalvo E, Leenders WPJ, Rosell R, et al. Multiplex RNA-based detection of clinically relevant MET alterations in advanced non-small cell lung cancer. Molecular Oncology. 202115(2):350-363. DOI:10.1002/1878-0261.12861. PMID: 33236532. IF:7,449.
Alamo P, Cedano J, Conchillo O, Cano O, Alba L, Serna N, Avino A, Carrasco LM, Sanchez A, Martinez C, Gallardo A, Cano M, Eritja R, Villaverde A, Mangues R, Vazquez E, Unzueta U. Rational engineering of a human GFP-like protein scaffold for humanized targeted nanomedicines. Acta Biomaterialia. 2021; 130. DOI:10.1016/j.actbio.2021.06.001. PMID:34116228. IF:10,633.
Campos MC, Tubau C, Segura S, Gonzalez M, Iglesias M, Fernandez MT, Garcia MP, Mozos A. Oral submucous fibrosis presenting with histopathological lichenoid changes as predominant feature: Report of five cases and review of the literature. JOURNAL OF CUTANEOUS PATHOLOGY. 2021; 48(11). DOI:10.1111/cup.14084. PMID:34151457. IF:1,458.
Castillo D, Barril S, Rodrigo A, Millan P, Suarez G, Alonso A, Franquet T, Lopez L, Castellvi I, Plaza V, Sibila O. EARLY HOSPITAL READMISSION INCREASES SHORT AND LONG – TERM MORTALITY IN PATIENTS WITH INTERSTITIAL LUNG DISEASE. SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES. 2021; 38(2):e2021021. DOI:10.36141/svdld.v38i2.10709. PMID:34316260. IF:1,803.
D’Angelo E, Espinosa I, Cipriani V, Szafranska J, Barbareschi M, Prat J. Atypical Endometrial Hyperplasia, Low-grade «Much ADO About Nothing». AMERICAN JOURNAL OF SURGICAL PATHOLOGY. 2021; 45(7). DOI:10.1097/PAS.0000000000001705. PMID:34105519. IF:6,298.
Escuin D, Lopez L, Mora J, Bell O, Moral A, Perez I, Arqueros C, Garcia B, Cajal TRY, Lerma E, Barnadas A. Circulating microRNAs in Early Breast Cancer Patients and Its Association With Lymph Node Metastases. Frontiers in Oncology. 2021; 11:627811. DOI:10.3389/fonc.2021.627811. PMID:34513655. IF:5,738.
Esteve A, Alameda F, Carrato C, Pineda E, Arpi O, Martinez M, Mallo M, Gut M, Dabad M, Tortosa A, Del Barco S, Capellades J, Puig J, Gallego O, Pujol T, Oleaga L, Gil M, de Quintana C, Valduvieco I, Martinez A, Bellosillo B, Munoz AM, Esteve A, Domenech M, Camins A, Craven J, Villa S, Marruecos J, Domenech S, de la Iglesia N, Balana C, Bagué S, Aldecoa I. RNA sequencing and Immunohistochemistry Reveal ZFN7 as a Stronger Marker of Survival than Molecular Subtypes in G-CIMP-negative Glioblastoma. CLINICAL CANCER RESEARCH. 2021; 27(2). DOI:10.1158/1078-0432.CCR-20-2141. PMID:33106291. IF:13,801.
Falgas A, Pallares V, Unzueta U, Nunez Y, Sierra J, Gallardo A, Alba L, Mangues MA, Alamo P, Villaverde A, Vazquez E, Mangues R, Casanova I. Specific Cytotoxic Effect of an Auristatin Nanoconjugate Towards CXCR4(+) Diffuse Large B-Cell Lymphoma Cells. International Journal of Nanomedicine. 2021; 16. DOI:10.2147/IJN.S289733. PMID:33716502. IF:7,033.
Iznardo H, Baselga E, Mozos A, Szafranska J, Orellana R, Roe E. Net-like superficial lymphatic malformation. PEDIATRIC DERMATOLOGY. 2021; 38(2). DOI:10.1111/pde.14526. PMID:33486776. IF:1,997.
Lopez C, Falla LM, Roe E, Arostegui JI, Mozos A, Bernal S, Iznardo H, Baselga E. Excellent response to secukinumab in an infant with severe generalized pustular psoriasis. JOURNAL OF DERMATOLOGY. 2021; 48(6). DOI:10.1111/1346-8138.15673. PMID:33543522. IF:3,468.
Martin J, Lopez M, Moura DS, Ramos R, Collini P, Romagosa C, Bague S, Renne SL, Barisella M, Velasco V, Coindre JM, Lopez D, Dopazo J, Gambarotti M, Braglia L, Merlo DF, Palmerini E, Stacchiotti S, Quagliuolo VL, Lopez A, Grignani G, Blay JY, Brunello A, Gutierrez A, Valverde C, Hindi N, Dei AP, Picci P, Casali PG, Gronchi A. Predictive Value of MRP-1 in Localized High-Risk Soft Tissue Sarcomas: A Translational Research Associated to ISG-STS 1001 Randomized Phase III Trial. MOLECULAR CANCER THERAPEUTICS. 2021; 20(12). DOI:10.1158/1535-7163.MCT-21-0315. PMID:34552008. IF:6,009.
Moura DS, Diaz J, Bague S, Orellana R, Sebio A, Mondaza JL, Salguero C, Rojo F, Hindi N, Fletcher CDM, Martin J. A Novel NFIX-STAT6 Gene Fusion in Solitary Fibrous Tumor: A Case Report. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021; 22(14):7514. DOI:10.3390/ijms22147514. PMID:34299133. IF:6,208.
Moura DS, Pena M, Varela J, Alvarez R, Agra C, Izquierdo F, Ramos R, Ortega L, Martin F, Castilla C, Hernandez CN, Romagosa C, Salgado M, Lavernia J, Bague S, Mayodormo E, Vicioso L, Barcelo J, Rubio J, de Juan A, Fiano MC, Hindi N, Lopez M, Lacerenza S, Dopazo J, Gutierrez A, Alvarez R, Valverde C, Martinez J, Martin J. A DNA damage repair gene-associated signature predicts responses of patients with advanced soft-tissue sarcoma to treatment with trabectedin. Molecular Oncology. 2021; 15(12). DOI:10.1002/1878-0261.12996. PMID:33983674. IF:7,449.
Pallares V, Nunez Y, Sanchez L, Falgas A, Serna N, Unzueta U, Gallardo A, Alba L, Alamo P, Sierra J, Villaverde A, Vazquez E, Casanova I, Mangues R. Antineoplastic effect of a diphtheria toxin-based nanoparticle targeting acute myeloid leukemia cells overexpressing CXCR4. JOURNAL OF CONTROLLED RELEASE. 2021; 335. DOI:10.1016/j.jconrel.2021.05.014. PMID:34004204. IF:11,467.
Revilla G, Cedo L, Tondo M, Moral A, Perez JI, Corcoy R, Lerma E, Fuste V, Reddy TS, Blanco F, Mato E, Escola JC. LDL, HDL and endocrine-related cancer: From pathogenic mechanisms to therapies. SEMINARS IN CANCER BIOLOGY. 2021; 73. DOI:10.1016/j.semcancer.2020.11.012. PMID:33249202. IF:17,012.
Vieites B, Lopez MA, Martin MD, Ramirez CL, Rezola R, Sancho M, Lopez L, Villardell F, Burgues O, Fernandez B, Alfaro L, Peg V. Predictive and prognostic value of total tumor load in sentinel lymph nodes in breast cancer patients after neoadjuvant treatment using one-step nucleic acid amplification: the NEOVATTL study. Clinical & Translational Oncology. 2021; 23(7). DOI:10.1007/s12094-020-02530-4. PMID:33517542. IF:3,340.

ENFERMEDADES ONCO-HEMATOLóGICAS

Patología Molecular del Cáncer Ginecológico

Principales líneas de investigación

Retos

Coordinación del grupo

Miembros

Publicaciones 2022

Publicaciones 2021

Principales líneas de investigación

Retos

Coordinación del grupo

Miembros

Publicaciones 2022

Publicaciones 2021

Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau