Sant Pau - Institut de Recerca

La recerca del nostre grup estudia la biologia vascular i la fisiopatologia del miocardi orientats a la caracterització dels mecanismes cel·lulars i moleculars implicats en l’inici, la progressió i la complicació de l’aterosclerosi, l’aneurisma d’aorta abdominal i la hipertròfia cardíaca, amb la finalitat última d’identificar noves dianes terapèutiques i biomarcadors que permetin millorar el diagnòstic i el tractament del pacient.

Principals línies de recerca

Remodelat de la matriu extracel·lular en malalties cardiovasculars.
Receptors nuclears en l’aterosclerosi i la biologia vascular.
Noves dianes terapèutiques en la malaltia cardíaca hipertensiva.

Objectius

Estudi de les bases moleculars de l’aneurisma d’aorta abdominal: identificació de noves dianes terapèutiques.
Estudi dels mecanismes fisiopatològics i moleculars del desenvolupament d’aneurisma d’aorta toràcic en pacients sindròmics.
Identificació de nous biomarcadors i dianes terapèutiques en la malaltia arterial perifèrica i la disfunció vascular.
Estudi dels mecanismes moleculars que involucren als receptors nuclears en la regulació de la calcificació vascular.
Identificació i validació de noves eines farmacològiques en malalties cardiovasculars.
Desenvolupament de nous models animals en malaltia cardiovascular.

Coordinació del grup

RODRIGUEZ SINOVAS, MARIA CRISTINA IR
crodriguezs@santpau.cat

Membres

Aguilo Nuñez, Silvia IR
Almendra Peguero, Rafael Antonio IR
Alonso Nieto, Judith CIBERCV
Ballester Servera, Carme CSIC
Blanco Casoliva, Laia CSIC
Martinez Gonzalez, Jose CSIC
Vazquez Sufuentes, Paula CSIC

Publicacions 2022

(JIF 2022)

Ballester C, Canes L, Alonso J, Puertas L, Tauron M, Rodriguez C, Martinez J. Nuclear receptor NOR-1 (Neuron-derived Orphan Receptor-1) in pathological vascular remodelling and vascular remodelling. Clinica E Investigacion En Arteriosclerosis. 2022; 34(4). DOI:10.1016/j.arteri.2022.03.002. PMID:35581107. Document type: Review.
Ballesteros C, Rodrigues R, Beltran LM, Moreno R, Martinez E, Gonzalez M, Martinez J, Rodriguez C, Cachofeiro V, Salaices M, Briones AM. Microsomal prostaglandin E synthase-1 is involved in the metabolic and cardiovascular alterations associated with obesity. BRITISH JOURNAL OF PHARMACOLOGY. 2022; 179(11). DOI:10.1111/bph.15776. PMID:34877656. IF:7,3 (Q1/1D). Document type: Article. Document type: Article.
Blanco R, de la Fuente H, Rodriguez C, Martin L, Sanchez R, Jimenez R, Rodriguez I, Curtabbi A, Garcia MM, Vera A, Rivero F, Cuesta J, Jimenez LJ, Cecconi A, Duran A, Tauron M, Alonso J, Bueno H, Villalba M, Enriquez JA, Robson SC, Alfonso F, Sanchez F, Martinez J, Martin P. CD69 expression on regulatory T cells protects from immune damage after myocardial infarction. JOURNAL OF CLINICAL INVESTIGATION. 2022; 132(21):e152418. DOI:10.1172/JCI152418. PMID:36066993. IF: 15,9 (Q1/1D). Document type: Article.
González M, García AB, Jorge I, Zalba G, Becares M, Ruiz MJ, Rodríguez C, Bermeo H, Rodrigues R, Rios FJ, Montezano AC, Martínez J, Vázquez J, Redondo JM, Touyz RM, Guerra S, Salaices M, Briones AM. Interferon stimulated gene 15 pathway is a novel mediator of endothelial dysfunction and aneurysms development in angiotensin II infused mice through increased oxidative stress. CARDIOVASCULAR RESEARCH. 2022; 118(16). DOI:10.1093/cvr/cvab321. PMID:34672341. IF:10,8 (Q1/1D). Document type: Article.
Jimenez F, Marzi J, Galan M, Dantas AP, Ortega M, Rojas S, Egea G, Schenke K, Jimenez E, Planas AM. Arachnoid membrane as a source of sphingosine-1-phosphate that regulates mouse middle cerebral artery tone. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2022; 42(1):0271678X211033362. DOI:10.1177/0271678X211033362. PMID:34474613. IF:6,3 (Q1/2D). Document type: Article.
Jimenez M, Rodriguez C, Canes L, Ballester C, Vara A, Requena S, de la Fuente H, Martinez J, Sanchez F. CD69-oxLDL ligand engagement induces Programmed Cell Death 1 (PD-1) expression in human CD4+T lymphocytes. CELLULAR AND MOLECULAR LIFE SCIENCES. 2022; 79(8):468. DOI:10.1007/s00018-022-04481-1. PMID:35930205. IF:8 (Q1/2D). Document type: Article.
Lehmann GL, Ginsberg M, Nolan DJ, Rodriguez C, Martinez J, Zeng SM, Voigt AP, Mullins RF, Rafii S, Rodriguez E, Benedicto I. Retinal Pigment Epithelium-Secreted VEGF-A Induces Alpha-2-Macroglobulin Expression in Endothelial Cells. Cells. 2022; 11(19):2975. DOI:10.3390/cells11192975. PMID:36230937. IF:6 (Q2/4D). Document type: Article.
Troncoso C, Petermann F, Lozano M, Perez A, Almendra R, Fernandez T, Nava EJ, Gamero A, Camacho S, Bonillal DA, Perez E, Navarrete EM. A qualitative look at the research in the Spanish Journal of Human Nutrition and Dietetics. Revista Espanola De Nutricion Humana Y Dietetica. 2022; 26(3). DOI:10.14306/renhyd.26.3.1723. Document type: Editorial material.
Valls L, Puertas L, Varona S, Martinez J, Rodriguez C, Rodriguez A. Human Lysyl Oxidase Over-Expression Enhances Baseline Cardiac Oxidative Stress but Does Not Aggravate ROS Generation or Infarct Size Following Myocardial Ischemia-Reperfusion. Antioxidants. 2022; 11(1):75. DOI:10.3390/antiox11010075. PMID:35052579. IF:7 (Q1/1D). Document type: Article.
Vila A, Ramirez C, Apolinar E, Rojas P, Valera D, Almendra R, Navarrete EM. Factors Associated with Dietary Restriction and Emotional and Uncontrolled Eating in Adults from Spanish-Speaking Countries during the COVID-19 Confinement: Results of the CoV-Eat Project. Nutrients. 2022; 14(22):4866. DOI:10.3390/nu14224866. PMID:36432551. IF:5,9 (Q1/2D). Document type: Article.

Publicacions 2021

Canes L, Alonso J, Ballester C, Varona S, Escudero JR, Andres V, Rodriguez C, Martinez J. Targeting Tyrosine Hydroxylase for Abdominal Aortic Aneurysm Impact on Inflammation, Oxidative Stress, and Vascular Remodeling. HYPERTENSION. 2021; 78(3). DOI:10.1161/HYPERTENSIONAHA.121.17517. PMID:34304581. IF:9,897.
Canes L, Marti I, Ballester C, Alonso J, ELENA C, Briones AM, Rodriguez C, Martinez J. High NOR-1 (Neuron-Derived Orphan Receptor 1) Expression Strengthens the Vascular Wall Response to Angiotensin II Leading to Aneurysm Formation in Mice. HYPERTENSION. 2021; 77(2). DOI:10.1161/HYPERTENSIONAHA.120.16078. PMID:33356402. IF:9,897.
Jimenez T, Ballester C, Quetglas M, Morell D, Torres N, Bautista AM, Serra N, Girona E. Cryopreservation of platelets treated with riboflavin and UV light and stored at-80 degrees C for 1 year. TRANSFUSION. 2021; 61(4). DOI:10.1111/trf.16324. PMID:33694171. IF:3,337.
Martinez J, Canes L, Alonso J, Ballester C, Rodriguez A, Corrales I, Rodriguez C. NR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular Remodeling, and Beyond. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021; 22(21):11371. DOI:10.3390/ijms222111371. PMID:34768801. IF:6,208.
Muntsant A, Jimenez F, Puertas L, Jimenez E, Vila E, Gimenez L. Sex-Dependent End-of-Life Mental and Vascular Scenarios for Compensatory Mechanisms in Mice with Normal and AD-Neurodegenerative Aging. Biomedicines. 2021; 9(2):111. DOI:10.3390/biomedicines9020111. PMID:33498895. IF:4,757.
Sanchez D, Nus M, Navas M, Fite J, Perez B, Barros AJ, Soto B, Martinez J, Camacho M, Rodriguez C, Mallat Z, Galan M. Oxidative Stress and Inflammatory Markers in Abdominal Aortic Aneurysm. Antioxidants. 2021; 10(4):602. DOI:10.3390/antiox10040602. PMID:33919749. IF:7,675.
Souza FV, Jimenez S, Delgado B, Jurado R, Genty M, Romero A, Rodriguez C, Nieto ML, Martinez E, Cachofeiro V. The Interplay of Mitochondrial Oxidative Stress and Endoplasmic Reticulum Stress in Cardiovascular Fibrosis in Obese Rats. Antioxidants. 2021; 10(8):1274. DOI:10.3390/antiox10081274. PMID:34439522. IF:7,675.
Varona S, Puertas L, Galan M, Orriols M, Canes L, Aguilo S, Camacho M, Sirvent M, Andres V, Martinez J, Rodriguez C. Rolipram Prevents the Formation of Abdominal Aortic Aneurysm (AAA) in Mice: PDE4B as a Target in AAA. Antioxidants. 2021; 10(3):460. DOI:10.3390/antiox10030460. PMID:33809405. IF:7,675.

presentació

Principals línies de recerca

Remodelat de la matriu extracel·lular en malalties cardiovasculars.
Receptors nuclears en l’aterosclerosi i la biologia vascular.
Noves dianes terapèutiques en la malaltia cardíaca hipertensiva.

Objectius

Estudi de les bases moleculars de l’aneurisma d’aorta abdominal: identificació de noves dianes terapèutiques.
Estudi dels mecanismes fisiopatològics i moleculars del desenvolupament d’aneurisma d’aorta toràcic en pacients sindròmics.
Identificació de nous biomarcadors i dianes terapèutiques en la malaltia arterial perifèrica i la disfunció vascular.
Estudi dels mecanismes moleculars que involucren als receptors nuclears en la regulació de la calcificació vascular.
Identificació i validació de noves eines farmacològiques en malalties cardiovasculars.
Desenvolupament de nous models animals en malaltia cardiovascular.

equip

Coordinació del grup

RODRIGUEZ SINOVAS, MARIA CRISTINA IR
crodriguezs@santpau.cat

Membres

producció científica

Publicacions 2022

(JIF 2022)

Ballester C, Canes L, Alonso J, Puertas L, Tauron M, Rodriguez C, Martinez J. Nuclear receptor NOR-1 (Neuron-derived Orphan Receptor-1) in pathological vascular remodelling and vascular remodelling. Clinica E Investigacion En Arteriosclerosis. 2022; 34(4). DOI:10.1016/j.arteri.2022.03.002. PMID:35581107. Document type: Review.
Ballesteros C, Rodrigues R, Beltran LM, Moreno R, Martinez E, Gonzalez M, Martinez J, Rodriguez C, Cachofeiro V, Salaices M, Briones AM. Microsomal prostaglandin E synthase-1 is involved in the metabolic and cardiovascular alterations associated with obesity. BRITISH JOURNAL OF PHARMACOLOGY. 2022; 179(11). DOI:10.1111/bph.15776. PMID:34877656. IF:7,3 (Q1/1D). Document type: Article. Document type: Article.
Blanco R, de la Fuente H, Rodriguez C, Martin L, Sanchez R, Jimenez R, Rodriguez I, Curtabbi A, Garcia MM, Vera A, Rivero F, Cuesta J, Jimenez LJ, Cecconi A, Duran A, Tauron M, Alonso J, Bueno H, Villalba M, Enriquez JA, Robson SC, Alfonso F, Sanchez F, Martinez J, Martin P. CD69 expression on regulatory T cells protects from immune damage after myocardial infarction. JOURNAL OF CLINICAL INVESTIGATION. 2022; 132(21):e152418. DOI:10.1172/JCI152418. PMID:36066993. IF: 15,9 (Q1/1D). Document type: Article.
González M, García AB, Jorge I, Zalba G, Becares M, Ruiz MJ, Rodríguez C, Bermeo H, Rodrigues R, Rios FJ, Montezano AC, Martínez J, Vázquez J, Redondo JM, Touyz RM, Guerra S, Salaices M, Briones AM. Interferon stimulated gene 15 pathway is a novel mediator of endothelial dysfunction and aneurysms development in angiotensin II infused mice through increased oxidative stress. CARDIOVASCULAR RESEARCH. 2022; 118(16). DOI:10.1093/cvr/cvab321. PMID:34672341. IF:10,8 (Q1/1D). Document type: Article.
Jimenez F, Marzi J, Galan M, Dantas AP, Ortega M, Rojas S, Egea G, Schenke K, Jimenez E, Planas AM. Arachnoid membrane as a source of sphingosine-1-phosphate that regulates mouse middle cerebral artery tone. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2022; 42(1):0271678X211033362. DOI:10.1177/0271678X211033362. PMID:34474613. IF:6,3 (Q1/2D). Document type: Article.
Jimenez M, Rodriguez C, Canes L, Ballester C, Vara A, Requena S, de la Fuente H, Martinez J, Sanchez F. CD69-oxLDL ligand engagement induces Programmed Cell Death 1 (PD-1) expression in human CD4+T lymphocytes. CELLULAR AND MOLECULAR LIFE SCIENCES. 2022; 79(8):468. DOI:10.1007/s00018-022-04481-1. PMID:35930205. IF:8 (Q1/2D). Document type: Article.
Lehmann GL, Ginsberg M, Nolan DJ, Rodriguez C, Martinez J, Zeng SM, Voigt AP, Mullins RF, Rafii S, Rodriguez E, Benedicto I. Retinal Pigment Epithelium-Secreted VEGF-A Induces Alpha-2-Macroglobulin Expression in Endothelial Cells. Cells. 2022; 11(19):2975. DOI:10.3390/cells11192975. PMID:36230937. IF:6 (Q2/4D). Document type: Article.
Troncoso C, Petermann F, Lozano M, Perez A, Almendra R, Fernandez T, Nava EJ, Gamero A, Camacho S, Bonillal DA, Perez E, Navarrete EM. A qualitative look at the research in the Spanish Journal of Human Nutrition and Dietetics. Revista Espanola De Nutricion Humana Y Dietetica. 2022; 26(3). DOI:10.14306/renhyd.26.3.1723. Document type: Editorial material.
Valls L, Puertas L, Varona S, Martinez J, Rodriguez C, Rodriguez A. Human Lysyl Oxidase Over-Expression Enhances Baseline Cardiac Oxidative Stress but Does Not Aggravate ROS Generation or Infarct Size Following Myocardial Ischemia-Reperfusion. Antioxidants. 2022; 11(1):75. DOI:10.3390/antiox11010075. PMID:35052579. IF:7 (Q1/1D). Document type: Article.
Vila A, Ramirez C, Apolinar E, Rojas P, Valera D, Almendra R, Navarrete EM. Factors Associated with Dietary Restriction and Emotional and Uncontrolled Eating in Adults from Spanish-Speaking Countries during the COVID-19 Confinement: Results of the CoV-Eat Project. Nutrients. 2022; 14(22):4866. DOI:10.3390/nu14224866. PMID:36432551. IF:5,9 (Q1/2D). Document type: Article.

Publicacions 2021

Canes L, Alonso J, Ballester C, Varona S, Escudero JR, Andres V, Rodriguez C, Martinez J. Targeting Tyrosine Hydroxylase for Abdominal Aortic Aneurysm Impact on Inflammation, Oxidative Stress, and Vascular Remodeling. HYPERTENSION. 2021; 78(3). DOI:10.1161/HYPERTENSIONAHA.121.17517. PMID:34304581. IF:9,897.
Canes L, Marti I, Ballester C, Alonso J, ELENA C, Briones AM, Rodriguez C, Martinez J. High NOR-1 (Neuron-Derived Orphan Receptor 1) Expression Strengthens the Vascular Wall Response to Angiotensin II Leading to Aneurysm Formation in Mice. HYPERTENSION. 2021; 77(2). DOI:10.1161/HYPERTENSIONAHA.120.16078. PMID:33356402. IF:9,897.
Jimenez T, Ballester C, Quetglas M, Morell D, Torres N, Bautista AM, Serra N, Girona E. Cryopreservation of platelets treated with riboflavin and UV light and stored at-80 degrees C for 1 year. TRANSFUSION. 2021; 61(4). DOI:10.1111/trf.16324. PMID:33694171. IF:3,337.
Martinez J, Canes L, Alonso J, Ballester C, Rodriguez A, Corrales I, Rodriguez C. NR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular Remodeling, and Beyond. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021; 22(21):11371. DOI:10.3390/ijms222111371. PMID:34768801. IF:6,208.
Muntsant A, Jimenez F, Puertas L, Jimenez E, Vila E, Gimenez L. Sex-Dependent End-of-Life Mental and Vascular Scenarios for Compensatory Mechanisms in Mice with Normal and AD-Neurodegenerative Aging. Biomedicines. 2021; 9(2):111. DOI:10.3390/biomedicines9020111. PMID:33498895. IF:4,757.
Sanchez D, Nus M, Navas M, Fite J, Perez B, Barros AJ, Soto B, Martinez J, Camacho M, Rodriguez C, Mallat Z, Galan M. Oxidative Stress and Inflammatory Markers in Abdominal Aortic Aneurysm. Antioxidants. 2021; 10(4):602. DOI:10.3390/antiox10040602. PMID:33919749. IF:7,675.
Souza FV, Jimenez S, Delgado B, Jurado R, Genty M, Romero A, Rodriguez C, Nieto ML, Martinez E, Cachofeiro V. The Interplay of Mitochondrial Oxidative Stress and Endoplasmic Reticulum Stress in Cardiovascular Fibrosis in Obese Rats. Antioxidants. 2021; 10(8):1274. DOI:10.3390/antiox10081274. PMID:34439522. IF:7,675.
Varona S, Puertas L, Galan M, Orriols M, Canes L, Aguilo S, Camacho M, Sirvent M, Andres V, Martinez J, Rodriguez C. Rolipram Prevents the Formation of Abdominal Aortic Aneurysm (AAA) in Mice: PDE4B as a Target in AAA. Antioxidants. 2021; 10(3):460. DOI:10.3390/antiox10030460. PMID:33809405. IF:7,675.

MALALTIES CARDIOVASCULARS

Mecanismes reguladors del remodelat cardiovascular

Principals línies de recerca

Objectius

Coordinació del grup

Membres

Publicacions 2022

Publicacions 2021

Principals línies de recerca

Objectius

Coordinació del grup

Membres

Publicacions 2022

Publicacions 2021

Institut de recerca de l’hospital de la santa creu i sant pau