Sant Pau - Institut de Recerca

Main lines of researchThe Group of “Regulatory mechanisms of cardiovascular remodeling” investigates key aspects of vascular biology, atherothrombosis and myocardial pathophysiology geared towards the characterization of the cellular and molecular mechanisms involved in the onset, progression and complication of ischemic heart disease, abdominal aortic aneurysm (AAA) and cardiac hypertrophy. The ultimate goal of the group is to identify novel therapeutic targets and biomarkers to better manage these highly prevalent cardiovascular diseases.

Main lines of research

Extracellular matrix remodeling in cardiovascular diseases.
Nuclear receptors in ischemic heart disease, vascular biology and cardiac hypertrophy.
Novel therapeutic targets in hypertensive disease

Objectives:
To analyze the molecular basis of abdominal aortic aneurysm and to identify novel therapeutic targets.
To study the pathophysiological and molecular mechanisms underlying the development of thoracic aortic aneurysm in syndromic patients.
To identify novel biomarkers and therapeutic targets for peripheral artery disease and vascular dysfunction.
To analyze the molecular mechanisms that involve nuclear receptors in the regulation of vascular calcification.
To identify and validate novel pharmacological tools in cardiovascular diseases.
To develop new animal models in cardiovascular disease.

Group coordination

RODRIGUEZ SINOVAS, MARIA CRISTINA IR
crodriguezs@santpau.cat

Members

Aguilo Nuñez, Silvia IR
Almendra Peguero, Rafael Antonio IR
Alonso Nieto, Judith CIBERCV
Ballester Servera, Carme CSIC
Blanco Casoliva, Laia CSIC
Martinez Gonzalez, Jose CSIC
Vazquez Sufuentes, Paula CSIC

Publications 2022

(JIF 2022)

Ballester C, Canes L, Alonso J, Puertas L, Tauron M, Rodriguez C, Martinez J. Nuclear receptor NOR-1 (Neuron-derived Orphan Receptor-1) in pathological vascular remodelling and vascular remodelling. Clinica E Investigacion En Arteriosclerosis. 2022; 34(4). DOI:10.1016/j.arteri.2022.03.002. PMID:35581107. Document type: Review.
Ballesteros C, Rodrigues R, Beltran LM, Moreno R, Martinez E, Gonzalez M, Martinez J, Rodriguez C, Cachofeiro V, Salaices M, Briones AM. Microsomal prostaglandin E synthase-1 is involved in the metabolic and cardiovascular alterations associated with obesity. BRITISH JOURNAL OF PHARMACOLOGY. 2022; 179(11). DOI:10.1111/bph.15776. PMID:34877656. IF:7,3 (Q1/1D). Document type: Article. Document type: Article.
Blanco R, de la Fuente H, Rodriguez C, Martin L, Sanchez R, Jimenez R, Rodriguez I, Curtabbi A, Garcia MM, Vera A, Rivero F, Cuesta J, Jimenez LJ, Cecconi A, Duran A, Tauron M, Alonso J, Bueno H, Villalba M, Enriquez JA, Robson SC, Alfonso F, Sanchez F, Martinez J, Martin P. CD69 expression on regulatory T cells protects from immune damage after myocardial infarction. JOURNAL OF CLINICAL INVESTIGATION. 2022; 132(21):e152418. DOI:10.1172/JCI152418. PMID:36066993. IF: 15,9 (Q1/1D). Document type: Article.
González M, García AB, Jorge I, Zalba G, Becares M, Ruiz MJ, Rodríguez C, Bermeo H, Rodrigues R, Rios FJ, Montezano AC, Martínez J, Vázquez J, Redondo JM, Touyz RM, Guerra S, Salaices M, Briones AM. Interferon stimulated gene 15 pathway is a novel mediator of endothelial dysfunction and aneurysms development in angiotensin II infused mice through increased oxidative stress. CARDIOVASCULAR RESEARCH. 2022; 118(16). DOI:10.1093/cvr/cvab321. PMID:34672341. IF:10,8 (Q1/1D). Document type: Article.
Jimenez F, Marzi J, Galan M, Dantas AP, Ortega M, Rojas S, Egea G, Schenke K, Jimenez E, Planas AM. Arachnoid membrane as a source of sphingosine-1-phosphate that regulates mouse middle cerebral artery tone. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2022; 42(1):0271678X211033362. DOI:10.1177/0271678X211033362. PMID:34474613. IF:6,3 (Q1/2D). Document type: Article.
Jimenez M, Rodriguez C, Canes L, Ballester C, Vara A, Requena S, de la Fuente H, Martinez J, Sanchez F. CD69-oxLDL ligand engagement induces Programmed Cell Death 1 (PD-1) expression in human CD4+T lymphocytes. CELLULAR AND MOLECULAR LIFE SCIENCES. 2022; 79(8):468. DOI:10.1007/s00018-022-04481-1. PMID:35930205. IF:8 (Q1/2D). Document type: Article.
Lehmann GL, Ginsberg M, Nolan DJ, Rodriguez C, Martinez J, Zeng SM, Voigt AP, Mullins RF, Rafii S, Rodriguez E, Benedicto I. Retinal Pigment Epithelium-Secreted VEGF-A Induces Alpha-2-Macroglobulin Expression in Endothelial Cells. Cells. 2022; 11(19):2975. DOI:10.3390/cells11192975. PMID:36230937. IF:6 (Q2/4D). Document type: Article.
Troncoso C, Petermann F, Lozano M, Perez A, Almendra R, Fernandez T, Nava EJ, Gamero A, Camacho S, Bonillal DA, Perez E, Navarrete EM. A qualitative look at the research in the Spanish Journal of Human Nutrition and Dietetics. Revista Espanola De Nutricion Humana Y Dietetica. 2022; 26(3). DOI:10.14306/renhyd.26.3.1723. Document type: Editorial material.
Valls L, Puertas L, Varona S, Martinez J, Rodriguez C, Rodriguez A. Human Lysyl Oxidase Over-Expression Enhances Baseline Cardiac Oxidative Stress but Does Not Aggravate ROS Generation or Infarct Size Following Myocardial Ischemia-Reperfusion. Antioxidants. 2022; 11(1):75. DOI:10.3390/antiox11010075. PMID:35052579. IF:7 (Q1/1D). Document type: Article.
Vila A, Ramirez C, Apolinar E, Rojas P, Valera D, Almendra R, Navarrete EM. Factors Associated with Dietary Restriction and Emotional and Uncontrolled Eating in Adults from Spanish-Speaking Countries during the COVID-19 Confinement: Results of the CoV-Eat Project. Nutrients. 2022; 14(22):4866. DOI:10.3390/nu14224866. PMID:36432551. IF:5,9 (Q1/2D). Document type: Article.

Publications 2021

Canes L, Alonso J, Ballester C, Varona S, Escudero JR, Andres V, Rodriguez C, Martinez J. Targeting Tyrosine Hydroxylase for Abdominal Aortic Aneurysm Impact on Inflammation, Oxidative Stress, and Vascular Remodeling. HYPERTENSION. 2021; 78(3). DOI:10.1161/HYPERTENSIONAHA.121.17517. PMID:34304581. IF:9,897.
Canes L, Marti I, Ballester C, Alonso J, ELENA C, Briones AM, Rodriguez C, Martinez J. High NOR-1 (Neuron-Derived Orphan Receptor 1) Expression Strengthens the Vascular Wall Response to Angiotensin II Leading to Aneurysm Formation in Mice. HYPERTENSION. 2021; 77(2). DOI:10.1161/HYPERTENSIONAHA.120.16078. PMID:33356402. IF:9,897.
Jimenez T, Ballester C, Quetglas M, Morell D, Torres N, Bautista AM, Serra N, Girona E. Cryopreservation of platelets treated with riboflavin and UV light and stored at-80 degrees C for 1 year. TRANSFUSION. 2021; 61(4). DOI:10.1111/trf.16324. PMID:33694171. IF:3,337.
Martinez J, Canes L, Alonso J, Ballester C, Rodriguez A, Corrales I, Rodriguez C. NR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular Remodeling, and Beyond. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021; 22(21):11371. DOI:10.3390/ijms222111371. PMID:34768801. IF:6,208.
Muntsant A, Jimenez F, Puertas L, Jimenez E, Vila E, Gimenez L. Sex-Dependent End-of-Life Mental and Vascular Scenarios for Compensatory Mechanisms in Mice with Normal and AD-Neurodegenerative Aging. Biomedicines. 2021; 9(2):111. DOI:10.3390/biomedicines9020111. PMID:33498895. IF:4,757.
Sanchez D, Nus M, Navas M, Fite J, Perez B, Barros AJ, Soto B, Martinez J, Camacho M, Rodriguez C, Mallat Z, Galan M. Oxidative Stress and Inflammatory Markers in Abdominal Aortic Aneurysm. Antioxidants. 2021; 10(4):602. DOI:10.3390/antiox10040602. PMID:33919749. IF:7,675.
Souza FV, Jimenez S, Delgado B, Jurado R, Genty M, Romero A, Rodriguez C, Nieto ML, Martinez E, Cachofeiro V. The Interplay of Mitochondrial Oxidative Stress and Endoplasmic Reticulum Stress in Cardiovascular Fibrosis in Obese Rats. Antioxidants. 2021; 10(8):1274. DOI:10.3390/antiox10081274. PMID:34439522. IF:7,675.
Varona S, Puertas L, Galan M, Orriols M, Canes L, Aguilo S, Camacho M, Sirvent M, Andres V, Martinez J, Rodriguez C. Rolipram Prevents the Formation of Abdominal Aortic Aneurysm (AAA) in Mice: PDE4B as a Target in AAA. Antioxidants. 2021; 10(3):460. DOI:10.3390/antiox10030460. PMID:33809405. IF:7,675.

Introduction

Main lines of research

Extracellular matrix remodeling in cardiovascular diseases.
Nuclear receptors in ischemic heart disease, vascular biology and cardiac hypertrophy.
Novel therapeutic targets in hypertensive disease

Objectives:
To analyze the molecular basis of abdominal aortic aneurysm and to identify novel therapeutic targets.
To study the pathophysiological and molecular mechanisms underlying the development of thoracic aortic aneurysm in syndromic patients.
To identify novel biomarkers and therapeutic targets for peripheral artery disease and vascular dysfunction.
To analyze the molecular mechanisms that involve nuclear receptors in the regulation of vascular calcification.
To identify and validate novel pharmacological tools in cardiovascular diseases.
To develop new animal models in cardiovascular disease.

Team

Group coordination

RODRIGUEZ SINOVAS, MARIA CRISTINA IR
crodriguezs@santpau.cat

Members

Scientific output

Publications 2022

(JIF 2022)

Ballester C, Canes L, Alonso J, Puertas L, Tauron M, Rodriguez C, Martinez J. Nuclear receptor NOR-1 (Neuron-derived Orphan Receptor-1) in pathological vascular remodelling and vascular remodelling. Clinica E Investigacion En Arteriosclerosis. 2022; 34(4). DOI:10.1016/j.arteri.2022.03.002. PMID:35581107. Document type: Review.
Ballesteros C, Rodrigues R, Beltran LM, Moreno R, Martinez E, Gonzalez M, Martinez J, Rodriguez C, Cachofeiro V, Salaices M, Briones AM. Microsomal prostaglandin E synthase-1 is involved in the metabolic and cardiovascular alterations associated with obesity. BRITISH JOURNAL OF PHARMACOLOGY. 2022; 179(11). DOI:10.1111/bph.15776. PMID:34877656. IF:7,3 (Q1/1D). Document type: Article. Document type: Article.
Blanco R, de la Fuente H, Rodriguez C, Martin L, Sanchez R, Jimenez R, Rodriguez I, Curtabbi A, Garcia MM, Vera A, Rivero F, Cuesta J, Jimenez LJ, Cecconi A, Duran A, Tauron M, Alonso J, Bueno H, Villalba M, Enriquez JA, Robson SC, Alfonso F, Sanchez F, Martinez J, Martin P. CD69 expression on regulatory T cells protects from immune damage after myocardial infarction. JOURNAL OF CLINICAL INVESTIGATION. 2022; 132(21):e152418. DOI:10.1172/JCI152418. PMID:36066993. IF: 15,9 (Q1/1D). Document type: Article.
González M, García AB, Jorge I, Zalba G, Becares M, Ruiz MJ, Rodríguez C, Bermeo H, Rodrigues R, Rios FJ, Montezano AC, Martínez J, Vázquez J, Redondo JM, Touyz RM, Guerra S, Salaices M, Briones AM. Interferon stimulated gene 15 pathway is a novel mediator of endothelial dysfunction and aneurysms development in angiotensin II infused mice through increased oxidative stress. CARDIOVASCULAR RESEARCH. 2022; 118(16). DOI:10.1093/cvr/cvab321. PMID:34672341. IF:10,8 (Q1/1D). Document type: Article.
Jimenez F, Marzi J, Galan M, Dantas AP, Ortega M, Rojas S, Egea G, Schenke K, Jimenez E, Planas AM. Arachnoid membrane as a source of sphingosine-1-phosphate that regulates mouse middle cerebral artery tone. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2022; 42(1):0271678X211033362. DOI:10.1177/0271678X211033362. PMID:34474613. IF:6,3 (Q1/2D). Document type: Article.
Jimenez M, Rodriguez C, Canes L, Ballester C, Vara A, Requena S, de la Fuente H, Martinez J, Sanchez F. CD69-oxLDL ligand engagement induces Programmed Cell Death 1 (PD-1) expression in human CD4+T lymphocytes. CELLULAR AND MOLECULAR LIFE SCIENCES. 2022; 79(8):468. DOI:10.1007/s00018-022-04481-1. PMID:35930205. IF:8 (Q1/2D). Document type: Article.
Lehmann GL, Ginsberg M, Nolan DJ, Rodriguez C, Martinez J, Zeng SM, Voigt AP, Mullins RF, Rafii S, Rodriguez E, Benedicto I. Retinal Pigment Epithelium-Secreted VEGF-A Induces Alpha-2-Macroglobulin Expression in Endothelial Cells. Cells. 2022; 11(19):2975. DOI:10.3390/cells11192975. PMID:36230937. IF:6 (Q2/4D). Document type: Article.
Troncoso C, Petermann F, Lozano M, Perez A, Almendra R, Fernandez T, Nava EJ, Gamero A, Camacho S, Bonillal DA, Perez E, Navarrete EM. A qualitative look at the research in the Spanish Journal of Human Nutrition and Dietetics. Revista Espanola De Nutricion Humana Y Dietetica. 2022; 26(3). DOI:10.14306/renhyd.26.3.1723. Document type: Editorial material.
Valls L, Puertas L, Varona S, Martinez J, Rodriguez C, Rodriguez A. Human Lysyl Oxidase Over-Expression Enhances Baseline Cardiac Oxidative Stress but Does Not Aggravate ROS Generation or Infarct Size Following Myocardial Ischemia-Reperfusion. Antioxidants. 2022; 11(1):75. DOI:10.3390/antiox11010075. PMID:35052579. IF:7 (Q1/1D). Document type: Article.
Vila A, Ramirez C, Apolinar E, Rojas P, Valera D, Almendra R, Navarrete EM. Factors Associated with Dietary Restriction and Emotional and Uncontrolled Eating in Adults from Spanish-Speaking Countries during the COVID-19 Confinement: Results of the CoV-Eat Project. Nutrients. 2022; 14(22):4866. DOI:10.3390/nu14224866. PMID:36432551. IF:5,9 (Q1/2D). Document type: Article.

Publications 2021

Canes L, Alonso J, Ballester C, Varona S, Escudero JR, Andres V, Rodriguez C, Martinez J. Targeting Tyrosine Hydroxylase for Abdominal Aortic Aneurysm Impact on Inflammation, Oxidative Stress, and Vascular Remodeling. HYPERTENSION. 2021; 78(3). DOI:10.1161/HYPERTENSIONAHA.121.17517. PMID:34304581. IF:9,897.
Canes L, Marti I, Ballester C, Alonso J, ELENA C, Briones AM, Rodriguez C, Martinez J. High NOR-1 (Neuron-Derived Orphan Receptor 1) Expression Strengthens the Vascular Wall Response to Angiotensin II Leading to Aneurysm Formation in Mice. HYPERTENSION. 2021; 77(2). DOI:10.1161/HYPERTENSIONAHA.120.16078. PMID:33356402. IF:9,897.
Jimenez T, Ballester C, Quetglas M, Morell D, Torres N, Bautista AM, Serra N, Girona E. Cryopreservation of platelets treated with riboflavin and UV light and stored at-80 degrees C for 1 year. TRANSFUSION. 2021; 61(4). DOI:10.1111/trf.16324. PMID:33694171. IF:3,337.
Martinez J, Canes L, Alonso J, Ballester C, Rodriguez A, Corrales I, Rodriguez C. NR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular Remodeling, and Beyond. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021; 22(21):11371. DOI:10.3390/ijms222111371. PMID:34768801. IF:6,208.
Muntsant A, Jimenez F, Puertas L, Jimenez E, Vila E, Gimenez L. Sex-Dependent End-of-Life Mental and Vascular Scenarios for Compensatory Mechanisms in Mice with Normal and AD-Neurodegenerative Aging. Biomedicines. 2021; 9(2):111. DOI:10.3390/biomedicines9020111. PMID:33498895. IF:4,757.
Sanchez D, Nus M, Navas M, Fite J, Perez B, Barros AJ, Soto B, Martinez J, Camacho M, Rodriguez C, Mallat Z, Galan M. Oxidative Stress and Inflammatory Markers in Abdominal Aortic Aneurysm. Antioxidants. 2021; 10(4):602. DOI:10.3390/antiox10040602. PMID:33919749. IF:7,675.
Souza FV, Jimenez S, Delgado B, Jurado R, Genty M, Romero A, Rodriguez C, Nieto ML, Martinez E, Cachofeiro V. The Interplay of Mitochondrial Oxidative Stress and Endoplasmic Reticulum Stress in Cardiovascular Fibrosis in Obese Rats. Antioxidants. 2021; 10(8):1274. DOI:10.3390/antiox10081274. PMID:34439522. IF:7,675.
Varona S, Puertas L, Galan M, Orriols M, Canes L, Aguilo S, Camacho M, Sirvent M, Andres V, Martinez J, Rodriguez C. Rolipram Prevents the Formation of Abdominal Aortic Aneurysm (AAA) in Mice: PDE4B as a Target in AAA. Antioxidants. 2021; 10(3):460. DOI:10.3390/antiox10030460. PMID:33809405. IF:7,675.

CARDIOVASCULAR DISEASES

Regulatory Mechanisms of Cardiovascular Remodelling

Main lines of research

Objectives:

Group coordination

Members

Publications 2022

Publications 2021

Main lines of research

Objectives:

Group coordination

Members

Publications 2022

Publications 2021

Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau