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01/11/2025
Novel approaches for the discovery of pharmacogenetic biomarkers of chemotoxicity in patients with colorectal cancer
Simoes, AR, González, SC, Lopez-Doldan, MD, Duran, G, Fernández-Montes, A, Fernandez, MP, Fernandez, MS, Mata, JG, Paez, D, Riera, P, Guino, E, Lopez-Fernandez, L, de Santiago, BG, Aspiroz, EL, Rojas, A, Castells, A, Castellvi-Bel, S, Ponte, CR, Vymetalkova, V, Carracedo, A, Fernandez-Rozadilla, C. Novel approaches for the discovery of pharmacogenetic biomarkers of chemotoxicity in patients with colorectal cancer. BRITISH JOURNAL OF PHARMACOLOGY. 2025; 182(21)DOI:10.1111/bph.70051. PMID:40624839. IF:7.700(Q1/1D).
01/11/2025
Durvalumab plus platinum-etoposide in the first-line treatment of extensive-stage small cell lung cancer (CANTABRICO): A single-arm clinical trial
Isla, D, Zugazagoitia, J, Arriola, E, García-Campelo, R, Blanco, CM, Diz-Taín, MP, Lopez-Brea, M, Moreno-Vega, AL, León-Mateos, L, Oramás, J, Gutiérrez-Calderón, V, Majem, M, Sánchez-Hernández, A, Aguado, C, Alvarez-Cabellos, R, Massutí, B, Moreno, A, Fírvida-Pérez, JL, Valdivia, J, González-Cordero, M, Zafra-Poves, M, Dómine, M, Garcia-Navalon, FJ, Villanueva, N, Provencio, M, Juan-Vidal, O, Rivas-Corredor, C, García, MEO, Palmero, R, López-Castro, R, Carcereny, E, Lechuga, JL, Domínguez, M, Callejo, A, Paz-Ares, L. Durvalumab plus platinum-etoposide in the first-line treatment of extensive-stage small cell lung cancer (CANTABRICO): A single-arm clinical trial. LUNG CANCER. 2025; 209DOI:10.1016/j.lungcan.2025.108763. PMID:41033130. IF:4.400(Q1/2D).
01/11/2025
Predictive factors of efficacy for FTD/TPI plus bevacizumab in refractory metastatic colorectal cancer patients: a subanalysis of the Spanish cohort from the SUNLIGHT phase III trial
Soler, G, Grávalos, C, Rivera, F, Safont, MJ, Virgili, AC, Valladares-Ayerbes, M, Ferreiro-Monteagudo, R, Ortiz-Morales, MJ, Polo-Marques, E, Kornusova-Bersheva, I, Soustre, E, Yao, WY, Élez, E. Predictive factors of efficacy for FTD/TPI plus bevacizumab in refractory metastatic colorectal cancer patients: a subanalysis of the Spanish cohort from the SUNLIGHT phase III trial. Clinical & Translational Oncology. 2025; 27(11)DOI:10.1007/s12094-025-03907-z. PMID:40338282. IF:2.500(Q3/6D).
01/11/2025
Long-term outcomes from pembrolizumab monotherapy in patients with advanced NSCLC, PD-L1 expression = 50 %, and poor performance status: Transformer-based AI to characterize prognostic complexity
Cortellini, A, Garbo, E, La Cava, G, Citarella, F, Santo, V, Brunetti, L, Pinato, DJ, Naidoo, J, Loza, M, Genova, C, Gettinger, S, Kim, SY, Jayakrishnan, R, El Zarif, T, Russano, M, Pecci, F, Di Federico, A, Montrone, M, Owen, DH, Signorelli, D, Li, MJ, Camerini, A, Halmos, B, Vincenzi, B, Metro, G, Yendamuri, S, Grossi, F, Josephides, E, Tomasik, B, Giusti, R, Bria, E, Sebastian, M, Rost, M, Acker, F, Landi, L, Mazzoni, F, Morabito, A, Leonetti, A, Cantini, L, Mountzios, G, Kalvapudi, S, O'Reilly, D, Karapanagiotou, E, Monnet, I, Baena, J, Macerelli, M, Majem, M, Piedra, A, Cortinovis, DL, Tonini, G, Minuti, G, Mezquita, L, Gorria, T, Beninato, T, Lo Russo, G, Prelaj, A, De Giglio, A, Biello, F, Nana, FA, Dingemans, AMC, Aerts, JG, Ferrara, R, Abu Hejleh, T, Takada, K, Naqash, AR, Garassino, MC, Wakelee, HA, Nassar, A, Ricciuti, B, Soda, P, Caruso, CM, Guarrasi, V. Long-term outcomes from pembrolizumab monotherapy in patients with advanced NSCLC, PD-L1 expression = 50 %, and poor performance status: Transformer-based AI to characterize prognostic complexity. LUNG CANCER. 2025; 209DOI:10.1016/j.lungcan.2025.108799. PMID:41108882. IF:4.400(Q1/2D).
01/11/2025
Self-disintegrating protein-leaking microparticles for topical protein delivery
Volta-Durán, E, Sánchez, JM, Favaro, MTP, Martinez-Cuentra, G, Contreras, E, di Somma, A, López-Laguna, H, Unzueta, U, Casanova, I, Mangues, R, Villaverde, A, Vázquez, E. Self-disintegrating protein-leaking microparticles for topical protein delivery. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2025; 329DOI:10.1016/j.ijbiomac.2025.147730. PMID:40967544. IF:8.500(Q1/1D).
01/11/2025
Nanotoxin induces in situ pyroptosis to sensitize aPD1 to ablate metastases in microsattellite stable colorectal cancer
Carrasco-Díaz, LM, Otero-Mateo, M, Alamo, P, Gallardo, A, Virgili, AC, Páez, D, Voltà-Durán, E, Villaverde, A, Vázquez, E, Unzueta, U, Casanova, I, Alba-Castellon, L, Mangues, R. Nanotoxin induces in situ pyroptosis to sensitize aPD1 to ablate metastases in microsattellite stable colorectal cancer. PHARMACOLOGICAL RESEARCH. 2025; 221DOI:10.1016/j.phrs.2025.107982. PMID:41083088. IF:10.500(Q1/1D).
01/11/2025
Prognostic value of pretreatment peripheral blood biomarkers in patients with head and neck squamous cell carcinoma treated with chemo/bioradiotherapy
Sansa, A, Vásquez, R, Valero, C, Vázquez, C, Holgado, A, Gayà, J, Rubio, D, León, X. Prognostic value of pretreatment peripheral blood biomarkers in patients with head and neck squamous cell carcinoma treated with chemo/bioradiotherapy. Clinical & Translational Oncology. 2025; 27(11)DOI:10.1007/s12094-025-03897-y. PMID:40323571. IF:2.500(Q3/6D).
01/11/2025
Wolf's isotopic phenomenon in a patient with T-cell lymphoblastic lymphoma
Vilaseca, VG, Perez, ES, Fabrego, IE, Peral, IL, Prat, AM. Wolf's isotopic phenomenon in a patient with T-cell lymphoblastic lymphoma. MEDICINA CLINICA. 2025; 165(5)DOI:10.1016/j.medcli.2025.107073. PMID:40543401. IF:2.100(Q2/3D).
01/11/2025
Defining the Patient Journey and Identifying Digital Health Solutions in Treatment-Resistant Schizophrenia
Grasa, E, Forment, A, Alonso-Solís, A, Ramalho, L, Roldán, A, Pousa, E, Aussó, S, Berdun, J, Tesoro, AG, Escudero, J, Corripio, I. Defining the Patient Journey and Identifying Digital Health Solutions in Treatment-Resistant Schizophrenia. ACTAS ESPANOLAS DE PSIQUIATRIA. 2025; 53(6)DOI:10.62641/aep.v53i6.1959. PMID:41437755. IF:1.600(Q3/7D).
01/11/2025
Clinical practice guide for nurses that optimizes nurse's comprehensive care of patients undergoing immunotherapy
Serra-Lopez, J, Miranda, A, Soria, A, Lopez, N, Castañon, E, Majem, M. Clinical practice guide for nurses that optimizes nurse's comprehensive care of patients undergoing immunotherapy. Enfermeria Clinica. 2025; 35(6)DOI:10.1016/j.enfcle.2025.502193. PMID:40204238. IF:(Q/D).
01/11/2025
Use of nebulized bronchodilators in acute heart failure: impact on outcomes
Miró, O, Ivars, N, Espinosa, B, Jacob, J, Alquézar-Arbé, A, Gil, V, Bellido, A, Serrano, L, Herrero-Puente, P, Fortuny, MJ, Mir, M, Soy, E, Esquivias, MA, Tost, J, Travería, L, Domingo, E, Noceda, J, López-Diez, MP, Aguirre, A, Alonso, H, Romero, M, López-Grima, ML, López, ML, Mueller, C, Peacock, WF, Puente, PH. Use of nebulized bronchodilators in acute heart failure: impact on outcomes. Internal and Emergency Medicine. 2025; 20(8)DOI:10.1007/s11739-025-04123-x. PMID:41162690. IF:3.800(Q1/2D).
01/11/2025
The MULTISENT Study: A Multicenter Study on the Detection Rate of Sentinel Lymph Node Mapping in Endometrial Cancer Across Spain
Gómez-Hidalgo, NR, Cabrera, S, Bebia, V, García-Pineda, V, Padilla-Iserte, P, Fabregas, FF, Fuste, P, Alonso, P, Rodriguez, TG, Fernandez-Gonzalez, S, Chacon, E, Alvarez, JAP, Oliver, R, Gil-Moreno, A. The MULTISENT Study: A Multicenter Study on the Detection Rate of Sentinel Lymph Node Mapping in Endometrial Cancer Across Spain. ANNALS OF SURGICAL ONCOLOGY. 2025; 32(12)DOI:10.1245/s10434-025-17836-2. PMID:40702200. IF:3.500(Q1/2D).
01/11/2025
Executive summary. Screening, staging and follow-up of type 1 diabetes in preclinical stages: consensus of the scientific societies SED, SEEN and SEEP.
Martinez-Brocca, Maria Asuncion, Bellido, Virginia, Cardona-Hernandez, Roque, Castaño, Luis, Conget, Ignacio, Fernandez, Alberto, Gomez Gila, Ana Lucia, Leiva-Gea, Isabel, Mauricio, Didac. Executive summary. Screening, staging and follow-up of type 1 diabetes in preclinical stages: consensus of the scientific societies SED, SEEN and SEEP.. Anales De Pediatria. 2025; 103(5)DOI:10.1016/j.anpede.2025.503944. PMID:. IF:(Q/D).
01/11/2025
Addition of pulse corticosteroids to oral prednisone in moderately active ulcerative colitis: a randomized, multicentre, open-label study by GETECCU
Llao, J, Mañosa, M, Martín-Arranz, E, Zabana, Y, Navarro-Llavat, M, Téller, M, Garcia-Planella, E, Busquets, D, Monfort, D, Pineda, JR, Gutiérrez, A, Villoria, A, Menchén, L, Bastida, G, García-Alonso, FJ, Rivero, M, Chaparro, M, de Francisco, R, Merino, O, Rodríguez-Lago, I, Acosta, MBD, Rodríguez-Fortúnez, P, Rodríguez-Jiménez, C, Calafat, M, Domènech, E. Addition of pulse corticosteroids to oral prednisone in moderately active ulcerative colitis: a randomized, multicentre, open-label study by GETECCU. Journal of Crohns & Colitis. 2025; 19(11)DOI:10.1093/ecco-jcc/jjaf182. PMID:41258993. IF:8.700(Q1/1D).
01/11/2025
A Metagenomics Approach to Frailty in Patients With Cirrhosis Undergoing a Multifactorial Intervention
Vega-Abellaneda, S, Román, E, Soler, Z, Ortiz, MA, Rossi, G, Biagini, L, Sánchez, E, Pons-Tarin, M, Laghi, L, Mengucci, C, Kaur, N, Poca, M, Cuyàs, B, Serrano-Gomez, G, Alvarado, E, Manichanh, C, Soriano, G. A Metagenomics Approach to Frailty in Patients With Cirrhosis Undergoing a Multifactorial Intervention. LIVER INTERNATIONAL. 2025; 45(12)DOI:10.1111/liv.70418. PMID:41174950. IF:5.200(Q1/2D).
01/11/2025
Consensus on acromegaly therapeutic outcomes: an update
Melmed, S, di Filippo, L, Fleseriu, M, Mercado, M, Karavitaki, N, Gurnell, M, Salvatori, R, Tsagarakis, S, Losa, M, Maffei, P, Pereira, AM, Geer, EB, Katznelson, L, van der Lely, AJ, Bollerslev, J, Esposito, D, Webb, SM, Zatelli, MC, Valassi, E, Neggers, S, Chanson, P, Ho, KKY, Ioachimescu, AG, Biller, BMK, Samson, SL, Kaiser, UB, Schilbach, K, Luque, RM, Casanueva, FF, Shimon, I, Boguszewski, CL, Biermasz, N, Colao, A, Pirchio, R, Lamberts, SWJ, Kadioglu, P, Buchfelder, M, Frara, S, Chiloiro, S, Petersenn, S, Gadelha, MR, Puig-Domingo, M, Luger, A, Brue, T, Beckers, A, Ferone, D, Clemmons, DR, Greenman, Y, Marazuela, M, Mortini, P, Strasburger, CJ, Giustina, A. Consensus on acromegaly therapeutic outcomes: an update. Nature Reviews Endocrinology. 2025; 21(11)DOI:10.1038/s41574-025-01148-2. PMID:40804505. IF:40.000(Q1/1D).
01/11/2025
First-Line Osimertinib in a Patient Having NSCLC With a Rare Duplication Mutation in the EGFR Exon 19 Region (NM_005228.5:c.2214_2231dup p.(Ile740_Lys745dup))
Portu, M, Martinez-Recio, S, Barba, A, Gonzalez, A, López, L, Catasús, L, Majem, M. First-Line Osimertinib in a Patient Having NSCLC With a Rare Duplication Mutation in the EGFR Exon 19 Region (NM_005228.5:c.2214_2231dup p.(Ile740_Lys745dup)). Clinical Lung Cancer. 2025; 26(7)DOI:10.1016/j.clic.2025.07.013. PMID:40774920. IF:3.300(Q2/4D).
01/11/2025
Assessing outcomes emerging after confirmatory trials of accelerated approval drugs, 1992-2021
Cardozo, AR, Tibau, A, Liu, I, Han, J, Cliff, E, Kesselheim, A. Assessing outcomes emerging after confirmatory trials of accelerated approval drugs, 1992-2021. ANNALS OF ONCOLOGY. 2025; 36DOI:10.1016/j.annonc.2025.08.2894. PMID:. IF:65.400(Q1/1D).
01/11/2025
Magnitude of clinical benefit demonstrated in trials supporting FDA and EMA Approval of drugs for hematological malignancies, 2020-2024
Cardozo, AR, Kesselheim, A, Tibau, A. Magnitude of clinical benefit demonstrated in trials supporting FDA and EMA Approval of drugs for hematological malignancies, 2020-2024. ANNALS OF ONCOLOGY. 2025; 36DOI:10.1016/j.annonc.2025.08.1886. PMID:. IF:65.400(Q1/1D).
01/11/2025
CIRTUSARC: A multicenter, open-label phase II trial of cirtuvivint as second-line therapy in selected advanced soft-tissue sarcomas
Martin-Broto, J, Ospina, GM, Garcia, AS, Trufero, JM, Martinez-Garcia, J, Fidalgo, JAP, Morales, CMV, Jurado, JC, Ledesma, P, Grifman, M, Moura, DD, Muñiz, NH. CIRTUSARC: A multicenter, open-label phase II trial of cirtuvivint as second-line therapy in selected advanced soft-tissue sarcomas. ANNALS OF ONCOLOGY. 2025; 36DOI:10.1016/j.annonc.2025.08.3354. PMID:. IF:65.400(Q1/1D).