Publications - IR Sant Pau

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01/12/2022 Dissociable contribution of plasma NfL and p-tau181 to cognitive impairment in Parkinson's disease

Pagonabarraga, J, Perez-Gonzalez, R, Bejr-kasem, H, Marin-Lahoz, J, Horta-Barba, A, Martinez-Horta, S, Aracil-Bolanos, I, Sampedro, F, Campolongo, A, Rivas, E, Puig-Davi, A, Ruiz-Barrios, I, Perez-Perez, J, Pascual-Sedano, B, Kulisevsky, J. Dissociable contribution of plasma NfL and p-tau181 to cognitive impairment in Parkinson's disease. PARKINSONISM & RELATED DISORDERS. 2022; 105DOI:10.1016/j.parkreldis.2022.05.020. PMID:35752549. IF:4.100(Q2/3D).

01/12/2022 Trial of Deferiprone in Parkinson's Disease

Devos, D, Labreuche, J, Rascol, O, Corvol, JC, Duhamel, A, Delannoy, PG, Poewe, W, Compta, Y, Pavese, N, Ruzicka, E, Dusek, P, Post, B, Bloem, BR, Berg, D, Maetzler, W, Otto, M, Habert, MO, Lehericy, S, Ferreira, J, Dodel, R, Tranchant, C, Eusebio, A, Thobois, S, Marques, AR, Meissner, WG, Ory-Magne, F, Walter, U, de Bie, RMA, Gago, M, Vilas, D, Kulisevsky, J, Januario, C, Coelho, MVS, Behnke, S, Worth, P, Seppi, K, Ouk, T, Potey, C, Leclercq, C, Viard, R, Kuchcinski, G, Lopes, R, Pruvo, JP, Pigny, P, Garcon, G, Simonin, O, Carpentier, J, Rolland, AS, Nyholm, D, Scherfler, C, Mangin, JF, Chupin, M, Bordet, R, Dexter, DT, Fradette, C, Spino, M, Tricta, F, Ayton, S, Bush, AI, Devedjian, JC, Duce, JA, Cabantchik, I, Defebvre, L, Deplanque, D, Moreau, C. Trial of Deferiprone in Parkinson's Disease. NEW ENGLAND JOURNAL OF MEDICINE. 2022; 387(22)DOI:10.1056/NEJMoa2209254. PMID:36449420. IF:158.500(Q1/1D).

16/05/2022 Comparison of the Results of a Parkinson's Holter Monitor With Patient Diaries, in Real Conditions of Use: A Sub-analysis of the MoMoPa-EC Clinical Trial

Pérez-López C., Hernández-Vara J., Caballol N., Bayes À., Buongiorno M., Lopez-Ariztegui N., Gironell A., López-Sánchez J., Martínez-Castrillo J.C., Sauco M A., López-Manzanares L., Escalante-Arroyo S., Pérez-Martínez D.A., Rodríguez-Molinero A.. Comparison of the Results of a Parkinson's Holter Monitor With Patient Diaries, in Real Conditions of Use: A Sub-analysis of the MoMoPa-EC Clinical Trial. Frontiers in Neurology. 2022; 13DOI:10.3389/fneur.2022.835249. PMID:35651347. IF:3.400(Q2/5D).

01/01/2022 Functional changes in prefrontal cortex following frequency-specific training

Bach-Morrow L., Boccalatte F., DeRosa A., Devos D., Garcia-Sanchez C., Inglese M., Droby A.. Functional changes in prefrontal cortex following frequency-specific training. Scientific Reports. 2022; 12(1)DOI:10.1038/s41598-022-24088-7. PMID:36434008. IF:4.600(Q2/4D).

01/01/2022 Le risque de maladie de Parkinson dans une population méditerranéenne de patients goutteux : étude cas-témoins

Pou M.A., Orfila F., Pagonabarraga J., Ferrer-Moret S., Corominas H., Diaz-Torne C.. Le risque de maladie de Parkinson dans une population méditerranéenne de patients goutteux : étude cas-témoins. Revue Du Rhumatisme (edition Francaise). 2022; 89(6)DOI:10.1016/j.rhum.2022.09.019. PMID:. IF:(Q/D).

01/01/2022 Pharmacological management of Parkinson's disease motor symptoms: update and recommendations from an expert

Kulisevsky J.. Pharmacological management of Parkinson's disease motor symptoms: update and recommendations from an expert. REVISTA DE NEUROLOGIA. 2022; 75(s04)DOI:10.33588/rn.75s04.2022217. PMID:36342310. IF:1.200(Q4/10D).

01/01/2022 Efficacy and safety of high doses of safinamide in advanced Parkinson disease

Rodríguez-Jorge F., Beltrán-Corbellini Á., Chico-García J.L., Parra-Díaz P., Baena-Álvarez B., Pagonabarraga J., Pérez-Torre P., Pareés I., López-Sendón J.L., Martínez-Castrillo J.C., Alonso-Cánovas A.. Efficacy and safety of high doses of safinamide in advanced Parkinson disease. PARKINSONISM & RELATED DISORDERS. 2022; 97DOI:10.1016/j.parkreldis.2022.03.010. PMID:35344893. IF:(Q/D).

18/11/2025 Structured clinical diagnostic assessment reveals autism spectrum disorder in adults with functional neurological disorder

Gonzalez-Herrero, B, Coebergh, J, Pagonabarraga, J, Morgante, F, Deeley, Q, Edwards, MJ. Structured clinical diagnostic assessment reveals autism spectrum disorder in adults with functional neurological disorder. Scientific Reports. 2025; 15(1)DOI:10.1038/s41598-025-20508-6. PMID:41253885. IF:3.900(Q1/2D).

01/10/2025 Update on Genetic Chorea

Pérez-Pérez, J, Olmedo-Saura, G, Martínez-Horta, S, Bernal, S, Pagonabarraga, J, Kulisevsky, J. Update on Genetic Chorea. EUROPEAN JOURNAL OF NEUROLOGY. 2025; 32(10)DOI:10.1111/ene.70357. PMID:41104576. IF:3.900(Q1/3D).

01/10/2025 Consolidation deficits in episodic memory define distinct clinical and neurodegenerative profiles in Huntington's disease

Martinez-Horta, S, Quevedo-García, A, Puig-Davi, A, Sampedro, F, Oltra-Cucarella, J, Pérez-Pérez, J, Franch-Martí, C, Olmedo-Saura, G, Rivas-Asensio, E, Vazquez-Oliver, A, Pérez-Carasol, L, Horta-Barba, A, Pagonabarraga, J, Kulisevsky, J. Consolidation deficits in episodic memory define distinct clinical and neurodegenerative profiles in Huntington's disease. NeuroImage-Clinical. 2025; 48DOI:10.1016/j.nicl.2025.103894. PMID:41172859. IF:3.600(Q1/1D).

16/08/2025 Preventing Cisplatin-Induced Neuropathy and Related Emotional Disorders with the Coadministration of Duloxetine and Hydrogen-Rich Water in Male and Female Mice

Martínez-Martel, I, Negrini-Ferrari, SE, Pol, O. Preventing Cisplatin-Induced Neuropathy and Related Emotional Disorders with the Coadministration of Duloxetine and Hydrogen-Rich Water in Male and Female Mice. Antioxidants. 2025; 14(8)DOI:10.3390/antiox14081004. PMID:40867900. IF:6.600(Q1/1D).

01/02/2025 MCC950 Reduces the Anxiodepressive-like Behaviors and Memory Deficits Related to Paclitaxel-Induced Peripheral Neuropathy in Mice

Martínez-Martel, I, Negrini-Ferrari, SE, Pol, O. MCC950 Reduces the Anxiodepressive-like Behaviors and Memory Deficits Related to Paclitaxel-Induced Peripheral Neuropathy in Mice. Antioxidants. 2025; 14(2)DOI:10.3390/antiox14020143. PMID:40002330. IF:6.600(Q1/1D).

01/07/2024 The Combination of Molecular Hydrogen and Heme Oxygenase 1 Effectively Inhibits Neuropathy Caused by Paclitaxel in Mice

Martínez-Martel, I, Bai, X, Kordikowski, R, Leite-Panissi, CRA, Pol, O. The Combination of Molecular Hydrogen and Heme Oxygenase 1 Effectively Inhibits Neuropathy Caused by Paclitaxel in Mice. Antioxidants. 2024; 13(7)DOI:10.3390/antiox13070856. PMID:39061924. IF:6.600(Q1/1D).

01/12/2023 The Impact of UFP-512 in Mice with Osteoarthritis Pain: The Role of Hydrogen Sulfide

Batallé, G, Bai, X, Balboni, G, Pol, O. The Impact of UFP-512 in Mice with Osteoarthritis Pain: The Role of Hydrogen Sulfide. Antioxidants. 2023; 12(12)DOI:10.3390/antiox12122085. PMID:38136204. IF:6.000(Q1/2D).

01/12/2023 A Novel Therapy for Cisplatin-Induced Allodynia and Dysfunctional and Emotional Impairments in Male and Female Mice

Martinez-Martel, I, Pol, O. A Novel Therapy for Cisplatin-Induced Allodynia and Dysfunctional and Emotional Impairments in Male and Female Mice. Antioxidants. 2023; 12(12)DOI:10.3390/antiox12122063. PMID:38136183. IF:6.000(Q1/2D).

01/10/2023 Novel Heme Oxygenase-1 Inducers Palliate Inflammatory Pain and Emotional Disorders by Regulating NLRP3 Inflammasome and Activating the Antioxidant Pathway

Pérez-Fernández, M, Suárez-Rojas, I, Bai, X, Martínez-Martel, I, Ciaffaglione, V, Pittalà, V, Salerno, L, Pol, O. Novel Heme Oxygenase-1 Inducers Palliate Inflammatory Pain and Emotional Disorders by Regulating NLRP3 Inflammasome and Activating the Antioxidant Pathway. Antioxidants. 2023; 12(10)DOI:10.3390/antiox12101794. PMID:37891874. IF:6.000(Q1/2D).

01/10/2023 The Inhibition of Neuropathic Pain Incited by Nerve Injury and Accompanying Mood Disorders by New Heme Oxygenase-1 Inducers: Mechanisms Implicated

Suárez-Rojas, I, Pérez-Fernández, M, Bai, X, Martínez-Martel, I, Intagliata, S, Pittalà, V, Salerno, L, Pol, O. The Inhibition of Neuropathic Pain Incited by Nerve Injury and Accompanying Mood Disorders by New Heme Oxygenase-1 Inducers: Mechanisms Implicated. Antioxidants. 2023; 12(10)DOI:10.3390/antiox12101859. PMID:37891937. IF:6.000(Q1/2D).

01/06/2023 Hydrogen Sulfide Interacting with Cannabinoid 2 Receptors during Sciatic Nerve Injury-Induced Neuropathic Pain

Bai, X, Batalle, G, Martinez-Martel, I, Pol, O. Hydrogen Sulfide Interacting with Cannabinoid 2 Receptors during Sciatic Nerve Injury-Induced Neuropathic Pain. Antioxidants. 2023; 12(6)DOI:10.3390/antiox12061179. PMID:37371911. IF:6.000(Q1/2D).

01/12/2022 New Treatment for the Cognitive and Emotional Deficits Linked with Paclitaxel-Induced Peripheral Neuropathy in Mice

Martinez-Martel, I, Bai, X, Batalle, G, Pol, O. New Treatment for the Cognitive and Emotional Deficits Linked with Paclitaxel-Induced Peripheral Neuropathy in Mice. Antioxidants. 2022; 11(12)DOI:10.3390/antiox11122387. PMID:36552595. IF:7.000(Q1/1D).

01/11/2022 Treatment with Hydrogen-Rich Water Improves the Nociceptive and Anxio-Depressive-like Behaviors Associated with Chronic Inflammatory Pain in Mice

Coral-Perez, S, Martinez-Martel, I, Martinez-Serrat, M, Batalle, G, Bai, X, Leite-Panissi, CRA, Pol, O. Treatment with Hydrogen-Rich Water Improves the Nociceptive and Anxio-Depressive-like Behaviors Associated with Chronic Inflammatory Pain in Mice. Antioxidants. 2022; 11(11)DOI:10.3390/antiox11112153. PMID:36358525. IF:7.000(Q1/1D).

01/10/2022 Effects of treatment with a carbon monoxide donor and an activator of heme oxygenase 1 on the nociceptive, apoptotic and/or oxidative alterations induced by persistent inflammatory pain in the central nervous system of mice

Cazuza, RA, Batalle, G, Bai, X, Leite-Panissi, CRA, Pol, O. Effects of treatment with a carbon monoxide donor and an activator of heme oxygenase 1 on the nociceptive, apoptotic and/or oxidative alterations induced by persistent inflammatory pain in the central nervous system of mice. BRAIN RESEARCH BULLETIN. 2022; 188DOI:10.1016/j.brainresbull.2022.08.004. PMID:35952846. IF:3.800(Q2/5D).

01/09/2022 Hydrogen-Rich Water as a Novel Therapeutic Strategy for the Affective Disorders Linked with Chronic Neuropathic Pain in Mice

Martinez-Serrat, M, Martinez-Martel, I, Coral-Perez, S, Bai, X, Batalle, G, Pol, O. Hydrogen-Rich Water as a Novel Therapeutic Strategy for the Affective Disorders Linked with Chronic Neuropathic Pain in Mice. Antioxidants. 2022; 11(9)DOI:10.3390/antiox11091826. PMID:36139900. IF:7.000(Q1/1D).

01/07/2022 Hydrogen Sulfide Increases the Analgesic Effects of mu- and delta-Opioid Receptors during Neuropathic Pain: Pathways Implicated

Bai, X, Batalle, G, Balboni, G, Pol, O. Hydrogen Sulfide Increases the Analgesic Effects of mu- and delta-Opioid Receptors during Neuropathic Pain: Pathways Implicated. Antioxidants. 2022; 11(7)DOI:10.3390/antiox11071321. PMID:. IF:7.000(Q1/1D).

01/07/2022 The Interaction between Carbon Monoxide and Hydrogen Sulfide during Chronic Joint Pain in Young Female Mice

Batallé G., Bai X., Pol O.. The Interaction between Carbon Monoxide and Hydrogen Sulfide during Chronic Joint Pain in Young Female Mice. Antioxidants. 2022; 11(7)DOI:10.3390/antiox11071271. PMID:35883761. IF:7.000(Q1/1D).

01/05/2022 Effects of heme oxygenase 1 in the molecular changes and neuropathy associated with type 2 diabetes in mice

Pouso-Vázquez E., Bai X., Batallé G., Roch G., Pol O.. Effects of heme oxygenase 1 in the molecular changes and neuropathy associated with type 2 diabetes in mice. BIOCHEMICAL PHARMACOLOGY. 2022; 199DOI:10.1016/j.bcp.2022.114987. PMID:35276215. IF:5.800(Q1/2D).

01/01/2022 The Beneficial Effects of Heme Oxygenase 1 and Hydrogen Sulfide Activation in the Management of Neuropathic Pain, Anxiety- and Depressive-like Effects of Paclitaxel in Mice

Roch, G, Batalle, G, Bai, X, Pouso-Vazquez, E, Rodriguez, L, Pol, O. The Beneficial Effects of Heme Oxygenase 1 and Hydrogen Sulfide Activation in the Management of Neuropathic Pain, Anxiety- and Depressive-like Effects of Paclitaxel in Mice. Antioxidants. 2022; 11(1)DOI:10.3390/antiox11010122. PMID:35052626. IF:7.000(Q1/1D).

01/01/2022 CO and pain management

Pol O.. CO and pain management. Carbon Monoxide In Drug Discovery: Basics, Pharmacology, And Therapeutic Potential. 2022; DOI:10.1002/9781119783435.ch29. PMID:. IF:(Q/D).

01/12/2021 Hydrogen Sulfide Inhibits Inflammatory Pain and Enhances the Analgesic Properties of Delta Opioid Receptors

Porta, A, Rodriguez, L, Bai, X, Batalle, G, Roch, G, Pouso-Vazquez, E, Balboni, G, Pol, O. Hydrogen Sulfide Inhibits Inflammatory Pain and Enhances the Analgesic Properties of Delta Opioid Receptors. Antioxidants. 2021; 10(12)DOI:10.3390/antiox10121977. PMID:34943080. IF:7.675(Q1/1D).

01/10/2021 The Recovery of Cognitive and Affective Deficiencies Linked with Chronic Osteoarthritis Pain and Implicated Pathways by Slow-Releasing Hydrogen Sulfide Treatment

Batalle, G, Bai, X, Pouso-Vazquez, E, Roch, G, Rodriguez, L, Pol, O. The Recovery of Cognitive and Affective Deficiencies Linked with Chronic Osteoarthritis Pain and Implicated Pathways by Slow-Releasing Hydrogen Sulfide Treatment. Antioxidants. 2021; 10(10)DOI:10.3390/antiox10101632. PMID:34679766. IF:7.675(Q1/1D).

01/07/2021 Treatment with 5-fluoro-2-oxindole Increases the Antinociceptive Effects of Morphine and Inhibits Neuropathic Pain

Ferreira-Chamorro, P, Redondo, A, Riego, G, Pol, O. Treatment with 5-fluoro-2-oxindole Increases the Antinociceptive Effects of Morphine and Inhibits Neuropathic Pain. CELLULAR AND MOLECULAR NEUROBIOLOGY. 2021; 41(5)DOI:10.1007/s10571-020-00952-w. PMID:32880099. IF:4.231(Q2/5D).

01/07/2021 The Anxiolytic and Antidepressant Effects of Diallyl Disulfide and GYY4137 in Animals with Chronic Neuropathic Pain

Bai, X, Batalle, G, Pol, O. The Anxiolytic and Antidepressant Effects of Diallyl Disulfide and GYY4137 in Animals with Chronic Neuropathic Pain. Antioxidants. 2021; 10(7)DOI:10.3390/antiox10071074. PMID:34356307. IF:7.675(Q1/1D).

01/01/2022 Impact of pre-admission antithrombotic therapy on disease severity and mortality in patients hospitalized for COVID-19

Corrochano, M, Acosta-Isaac, R, Mojal, S, Miqueleiz, S, Rodriguez, D, Quijada-Manuitt, MA, Fraga, E, Castillo-Ocana, M, Amaro-Hosey, K, Albiol, N, Soria, JM, Antonijoan, RM, Souto, JC. Impact of pre-admission antithrombotic therapy on disease severity and mortality in patients hospitalized for COVID-19. JOURNAL OF THROMBOSIS AND THROMBOLYSIS. 2022; 53(1)DOI:10.1007/s11239-021-02507-2. PMID:34138399. IF:4.000(Q2/4D).

01/10/2021 Dopamine modulations of reward-driven music memory consolidation

Ferreri, L, Mas-Herrero, E, Cardona, G, Zatorre, RJ, Antonijoan, RM, Valle, M, Riba, J, Ripolles, P, Rodriguez-Fornells, A. Dopamine modulations of reward-driven music memory consolidation. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2021; 1502(1)DOI:10.1111/nyas.14656. PMID:34247392. IF:6.499(Q1/2D).

01/12/2025 Melatonin as a Possible Stimulus to Unmask an Oxytocin-Deficient State in Hypopituitarism and Hypothalamic Damage

Asla, Q, Garrido, M, Urgell, E, Terzan, S, Santos, A, Varghese, N, Atila, C, Biagetti, B, Plessow, F, Christ-Crain, M, Eckert, A, Webb, SM, Lawson, EA, Aulinas, A. Melatonin as a Possible Stimulus to Unmask an Oxytocin-Deficient State in Hypopituitarism and Hypothalamic Damage. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2025; 110(12)DOI:10.1210/clinem/dgaf201. PMID:40166823. IF:5.100(Q1/2D).

01/09/2025 Introduction of Biopharmaceuticals in Europe: A Cross-Sectional Study of Early Diffusion Patterns and Data Availability

Veszelei, I, Godman, B, Aaltonen, K, Selke, GW, Garuoliene, K, Cangini, A, Kurdi, A, Rodrigues, AT, Pontes, C, Torre, C, Lunghi, C, Burton, E, Poplavska, E, Jónsdóttir, F, Petrova, G, Langner, I, Iaru, I, Odnoletkova, I, Slaby, J, Gvozdanovic, K, Saastamoinen, L, Laius, O, Benkö, R, Ziogaite, S, McTaggart, S, Mueller, T, de Pando, T, Tesar, T, Mitkova, Z, Wettermark, B. Introduction of Biopharmaceuticals in Europe: A Cross-Sectional Study of Early Diffusion Patterns and Data Availability. BIODRUGS. 2025; 39(5)DOI:10.1007/s40259-025-00732-2. PMID:40779010. IF:6.900(Q1/1D).

12/08/2025 Update on the Prevalence, Incidence, Mortality, and Trends in Treatment of Inflammatory Bowel Disease in a Population-Based Registry in Catalonia Between 2017 and 2023

Brunet-Mas, E, Garcia-Sagué, B, Vela, E, Pontes, C, Melcarne, L, Frisancho, LE, Llovet, LP, Pedregal-Pascual, P, Lario, S, Ramírez-Lázaro, MJ, Villoria, A, Calvet, X. Update on the Prevalence, Incidence, Mortality, and Trends in Treatment of Inflammatory Bowel Disease in a Population-Based Registry in Catalonia Between 2017 and 2023. Journal of Clinical Medicine. 2025; 14(16)DOI:10.3390/jcm14165711. PMID:40869536. IF:2.900(Q1/2D).

01/04/2025 Safety, Tolerability and Pharmacokinetics of Sodium Tungstate (OXO-001) in Healthy Female Volunteers of Childbearing Age: A Randomized, Double-Blind, Dose-Finding, and Placebo-Controlled Phase I Study

Arbat, A, Canals, I, Coimbra, J, Molina-Perelló, P, Llorens, M, Torres, R, Perello, J, Moral-Blanch, M, Antonijoan, RM, Calaf, J. Safety, Tolerability and Pharmacokinetics of Sodium Tungstate (OXO-001) in Healthy Female Volunteers of Childbearing Age: A Randomized, Double-Blind, Dose-Finding, and Placebo-Controlled Phase I Study. International Journal of Fertility & Sterility. 2025; 19(2)DOI:10.22074/ijfs.2024.2013704.1554. PMID:40200776. IF:0.471(Q4/10D).

25/03/2025 Use of Bayesian approaches in oncology clinical trials: A cross-sectional analysis

Lopez-Rey, BG, Carot-Sans, G, Ouchi, D, Torres, F, Pontes, C. Use of Bayesian approaches in oncology clinical trials: A cross-sectional analysis. Frontiers in Pharmacology. 2025; 16DOI:10.3389/fphar.2025.1548997. PMID:40201693. IF:4.800(Q1/2D).

13/12/2024 A cross-sectional study of Phase I Clinical Trials authorized in Spain: An analysis of characteristics and times of execution based on experience

Filippi-Arriaga, F, Molina, P, Delgado-Espinoza, CE, Antonijoan, R. A cross-sectional study of Phase I Clinical Trials authorized in Spain: An analysis of characteristics and times of execution based on experience. MEDICINA CLINICA. 2024; 163(11)DOI:10.1016/j.medcli.2024.06.001. PMID:39043476. IF:2.100(Q2/3D).

18/11/2024 A 25-Year Retrospective of Health IT Infrastructure Building: The Example of the Catalonia Region

Piera-Jiménez, J, Carot-Sans, G, Ramiro-Pareta, M, Nogueras, MM, Folguera-Ródenas, J, Ródenas, P, Jiménez-Rueda, A, Navarro, TD, Palacios, JAM, Fajardo, JC, Campillo, JU, Vela, E, Monterde, D, Valero-Bover, D, Bonet, T, Tarrasó-Urios, G, Cantenys-Saba, R, Fabregat-Fabregat, P, Oliveros, BG, Berdún, J, Michelena, X, Cano, I, González-Colom, R, Roca, J, Solans, O, Pontes, C, Pérez-Sust, P. A 25-Year Retrospective of Health IT Infrastructure Building: The Example of the Catalonia Region. JOURNAL OF MEDICAL INTERNET RESEARCH. 2024; 26DOI:10.2196/58933. PMID:39556831. IF:6.000(Q1/1D).