Multiple Sclerosis and Central Nervous System Autoimmune Diseases

Developing interdisciplinary research is essential to advance knowledge, optimize therapeutic strategies in multiple sclerosis and other autoimmune diseases of the central nervous system, and ultimately improve patients’ quality of life. Our group comprises a multidisciplinary team with broad expertise in neurology, immunology, neuro-ophthalmology, and clinical research. Each member brings a unique and complementary perspective, enabling a comprehensive approach to neuroimmunological diseases.

Main Lines of Research

• Study of biological and imaging biomarkers in MS and other demyelinating diseases. (Vidal Jordana, Angela; Martin Aguilar, Lorena).
• Study of neurological complications of systemic diseases and immunotherapy (CAR-T cells and immune checkpoint inhibitors). (Martin Aguilar, Lorena; Vidal Jordana, Angela).
• Clinical trials in MS and related disorders and patient-reported outcomes studies. (Vidal Jordana, Angela).

Scientific Challenges

• Available biological and imaging biomarkers, when used in isolation, provide limited accuracy for diagnosing and monitoring autoimmune CNS diseases; there is a critical need to integrate and validate combined biomarkers that can reliably guide early and personalized treatment decisions.
• Neurological complications of emerging immunotherapies such as CAR-T cells and immune checkpoint inhibitors remain unpredictable and poorly characterized, representing a major challenge for early detection, risk stratification, and effective clinical management.

Contact

Àngela Vidal Jordana
avidalj@santpau.cat