Genomics of Complex Diseases

Our group is focused on the acquisition, management, and analysis of multi-omics data and its integration with clinical and biological data for the identification of new biomarkers and the generation of risk prediction models to facilitate clinical decision-making in patients with vascular diseases (venous and arterial thrombosis and aneurysms). Furthermore, to the study of biological processes in healthy people exposed to conditions of physiological stress (such as extreme sports). Our multidisciplinary team (Basic/Clinic) has a molecular biology laboratory, including functional analysis and cell cultures, that allows the control of the entire workflow of the process: from the generation of samples and data to the analysis and interpretation of the results.

Main Lines of Research

• Venous Thrombosis. (Soria Fernandez, Jose Manuel).
• Angiology and Vascular Biology. (Camacho Perez De Madrid, Maria Mercedes).
• Genomics of Arterial Vascular Disease. (Sabater Lleal, Maria).
• Genomics in Sport Medicine. (Soria Fernandez, Jose Manuel).
• Interdisciplinary Areas of Bioinformatics and multi-omics Data. (Soria Fernandez, Jose Manuel).

Scientific Challenges

• Analysis of omics data (genomics, transcriptomics, epigenomics) in the field of complex diseases with a translational approach in cooperation with the clinical group.
• Identify new biomarkers (genetic, epigenetic, and/or plasmatic) that determine susceptibility to complex diseases with a sex-specific component.
• Identify new mechanisms involved in the development and progression of complex traits (susceptibility to complex diseases and to healthy status).
• Development of predictive algorithms that integrate the genetic, biological, and clinical information of the patients (Personalized Medicine).
• Development of computational tools based on mathematical models of artificial intelligence for modeling of diseases and physiological processes and patient virtualization from real data.

Contact

José Manuel Soria
jsoria@santpau.cat