Regulatory Mechanisms of Cardiovascular Remodelling

Our group addresses different aspects of vascular biology, thrombosis, and myocardial pathophysiology aimed at studying the mechanisms underlying the onset, progression, and complication of cardiovascular diseases (CVDs) with high morbidity and mortality, such as atherosclerosis, aortic aneurysms, cardiac hypertrophy, and myocardial infarction. Our ultimate goal is to develop tools for early diagnosis and new therapeutic strategies for these diseases.

Main lines of research

• Pathophysiology of abdominal aortic aneurysm (AAA) and cardiac hypertrophy: new therapeutic opportunities (Rodriguez Sinovas, Cristina).
• The nuclear receptor NOR-1 in coronary artery disease, AAA, and cardiac dysfunction, remodeling, and arrhythmogenesis after myocardial infarction (Martinez Gonzalez, Jose).

Scientific Challenges:

• Analysis of the molecular basis of abdominal aortic aneurysm: Identification of new therapeutic targets.
• Physiopathological mechanisms underlying the development of thoracic aortic aneurysm in syndromic patients.
• Identification of new biomarkers and therapeutic targets in hypertensive cardiac hypertrophy and myocardial infarction.
• Analysis of the molecular mechanisms underlying cardiovascular calcification.
• Identification and validation of novel pharmacological tools in cardiovascular diseases.
• Development and characterization of new animal models in cardiovascular diseases.

Contact

Cristina Rodríguez
crodriguezs@santpau.cat