Cell Therapy and Angiogenesis in Ischemic Pathology

This group is dedicated to investigating the vascular effects of ischemia and angiogenesis. The group focuses on exploring the therapeutic potential of adipose-derived stem cells (ASCs) to promote blood vessel formation and repair damaged tissues in ischemic conditions. By combining advanced techniques in cell therapy and molecular biology, the group aims to develop novel treatments that improve clinical outcomes for patients with cardiovascular diseases. Its research seeks not only to understand the underlying mechanisms of angiogenesis, but also to translate these findings into clinical applications, offering new opportunities for more effective and personalized therapies. Ultimately, the group’s goal is to advance the diagnosis, treatment, and prevention of ischemic diseases through innovative approaches.

Main Lines of Research

• Cell therapy and angiogenesis: application of adipose-derived stem cells (ASCs) to promote blood vessel formation (angiogenesis) in ischemic conditions. (Arderiu Marques, Gemma).
• Endothelial dysfunction and cardiovascular disease: study of impaired vascular function as a key factor in the development of atherosclerosis, hypertension, and other cardiovascular disorders. (Arderiu Marques, Gemma).
• Tissue factor and angiogenesis: study of the role of thrombogenic tissue factor (TF) in vascular remodeling and pathological angiogenesis. (Arderiu Marques, Gemma).

Scientific Challenges

• Characterize ASCs (adipose-derived stem cells) obtained from different tissues of individuals with various pathologies and determine their angiogenic capacity for use in cell therapy.
• Enhance the angiogenic capacity of ASCs through differentiation, genetic manipulation, and/or the use of their derivatives, such as microvesicles.

Contacto

Gemma Arderiu
garderiu@santpau.cat