Sant Pau - Institut de Recerca

Resumen

Las alteraciones en los lípidos y las lipoproteínas no solo son factores causales clave en la enfermedad cardiovascular aterosclerótica y el riesgo cardiovascular global, sino que también están estrechamente vinculadas al desarrollo de otras patologías de gran impacto sanitario, como la diabetes tipo 2, el síndrome metabólico, la obesidad, la enfermedad de Alzheimer y determinadas formas de cáncer.

En este contexto, las líneas de investigación de nuestro grupo se orientan a profundizar en el papel de las alteraciones lipídicas en estas enfermedades, con el objetivo de identificar y desarrollar nuevos biomarcadores y potenciales terapias dirigidas que contribuyan a mejorar el diagnóstico, la estratificación del riesgo y el manejo clínico de los pacientes.

Principales líneas de Investigación e Innovación

La actividad del grupo se centra en dos líneas principales y una línea emergente, estrechamente interrelacionadas:

Metabolismeo de las lipoproteínas i riesgo cardiovascular

Nos centramos en el estudio de las lipoproteínas, especialmente las lipoproteínas remanentes, lipoproteínas de baja densidad y de alta densidad (LDL y HDL) y su papel como potenciales biomarcadores pronósticos. Investigamos su utilidad para fundamentar intervenciones farmacológicas y nutricionales dirigidas a corregir disfunciones lipoproteicas en pacientes con alto riesgo cardiovascular, así como en pacientes con cánceres endocrinos y enfermedad de Alzheimer.

Asimismo, investigamos el rol de nuevos microARN como reguladores del metabolismo lipoproteico y la aterosclerosis, y evaluamos su potencial terapéutico in vivo mediante el uso de HDL recombinantes.

Diagnóstico y caracterización molecular de trastornos metabólicos

Desarrollamos y validamos métodos analíticos innovadores para el estudio de trastornos metabólicos y endocrinológicos. Gracias al elevado volumen de muestras procesadas y a nuestra producción científica, nuestro laboratorio se ha consolidado como centro de referencia nacional para el diagnóstico de dislipemias hereditarias.

Biomarcadores en enfermedades neurodegenerativas (línea emergente)

En colaboración con la Unidad de Memoria del Servicio de Neurología del Hospital de Sant Pau, trabajamos en el desarrollo e implementación de biomarcadores sanguíneos para el diagnóstico de enfermedades neurodegenerativas como el Alzheimer, el Parkinson y otras demencias. Estos marcadores permiten detectar procesos fisiopatológicos clave, apoyar el diagnóstico, monitorizar la progresión de la enfermedad y evaluar la respuesta a tratamientos.

Retos

Desarrollar y validar biomarcadores predictivos relacionados con lipoproteínas para la diabetes y la enfermedad cardiovascular en poblaciones con alto riesgo metabólico, con el fin de mejorar la estratificación del riesgo y la prevención personalizada.
Profundizar en los mecanismos moleculares que regulan las alteraciones del metabolismo de las lipoproteínas en la diabetes tipo 1 y tipo 2, con especial atención al papel de proteínas clave como ANGPTL3 y APOC3.
Evaluar el potencial terapéutico de HDL sintéticas y terapias dirigidas basadas en rHDL-miARN en la regresión de la aterosclerosis.
Desentrañar la compleja interacción entre el metabolismo lipídico y la progresión de la enfermedad de Alzheimer en el síndrome de Down, con el objetivo de identificar nuevos mecanismos patogénicos y posibles dianas terapéuticas.

Coordinación del grupo

ESCOLA GIL, JOAN CARLES IR
jescola@santpau.cat

Miembros

Antonijoan Pares, Assumpta FGS
Blanco Vaca, Francisco FGS
Borras Querol, Carla IR
Cabello Femenias, Isaac FGS
Canyelles Vich, Marina FGS
Companys Armengol, Eva Maria FGS
Costa Pallaruelo, Maria FGS
Cubero Hernandez, Esther FGS
Dong, Chen UAB
El Allam Kanice, Aya IR
Erazo Paredes, Katherine M. UAB
Ferrer Perez, Rosa IR
Font Firvida, Montserrat FGS
Guiñon Muñoz, Leonor FGS
Illana Camara, Francisco Jose FGS
Lazaro Peña, Laura FGS
Liras Garcia, Esther FGS
Martinez Figueroa, Susana FGS
Orantes Gallego, Vanesa FGS
Perez Bolancel, Cristina FGS
Roig Martinez, Rosa FGS
Rotllan Vila, Noemi IR
Santos Palacios, David CIBER
Sole i Galvez, Arnau CIBER
Sospedra Arnau, Maria FGS
Terzan Molina, Silvia FGS
Tondo Colomer, Mireia FGS
Urgell Rull, Eulalia FGS
Velasco Reniu, Lorena IR
Zapico Muñiz, Edgar FGS
Zhao, Qi UAB

Publicaciones 2024

(JIF 2024)

-Arranz J, Zhu NL, Rubio S, Rodríguez I, Ferrer R, Carmona M, Barroeta I, Illan I, Santos M, Fortea J, Lleó A, Tondo M, Alcolea D. Diagnostic performance of plasma pTau₂₁₇, pTau₁₈₁, Aß_1-42 and Aß_1-40 in the LUMIPULSE automated platform for the detection of Alzheimer disease. Alzheimers Research & Therapy. 2024; 16(1):139. DOI:10.1186/s13195-024-01513-9. PMID:38926773. IF:7,600 (Q1/1D). Document type: Article.

-Ballester C, Alonso J, Taurón M, Rotllán N, Rodríguez C, Martínez J. Lysyl oxidase expression in smooth muscle cells determines the level of intima calcification in hypercholesterolemia-induced atherosclerosis. Clinica E Investigacion En Arteriosclerosis. 2024; 36(5). DOI:10.1016/j.arteri.2024.01.003. PMID:38402026. IF:1,900 (Q3/7D). Document type: Article.

-Borràs C, Canyelles M, Girona J, Ibarretxe D, Santos D, Revilla G, Llorente-Cortes V, Rotllan N, Kovanen PT, Jauhiainen M, Lee-Rueckert M, Masana L, Arrieta F, Martínez-Botas J, Gómez-Coronado D, Ribalta J, Tondo M, Blanco-Vaca F, Escolà-Gil JC. PCSK9 Antibodies Treatment Specifically Enhances the Macrophage-specific Reverse Cholesterol Transport Pathway in Heterozygous Familial Hypercholesterolemia. JACC Basic Transl Sci. 2024 Aug 28;9(10):1195-1210. doi: 10.1016/j.jacbts.2024.06.008. PMID: 39534644; IF:7,200 (Q1/2D). Document type: Article.

-Delgado J, Mostaza JM, Arrobas T, Blanco F, Masana L, Pedro J, Perez P, Civeira F, Cuende JI, Gomez JJ, Lahoz C, Pinto X, Suarez M, Lopez J, Guijarro C. Consensus on lipoprotein(a) of the Spanish Society of Arteriosclerosis. Literature review and recommendations for clinical practice. Clinica E Investigacion En Arteriosclerosis. 2024; 36(4). DOI:10.1016/j.arteri.2024.03.002. PMID:38599943. IF:1,900 (Q3/7D). Document type: Article.

-Fernandez S, Canyelles M, Martín A, Borràs C, Nuñez E, Palacio L, Del Rio PR, Betancor D, Gómez A, Brescó MS, Laguna JJ, Méndez N, Rotllan N, Escolà JC, Esteban V. Impaired high-density lipoprotein function and endothelial barrier stability in severe anaphylaxis. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2024; 154(3). DOI:10.1016/j.jaci.2024.03.031. PMID:38718948. IF:11,200 (Q1/1D). Document type: Article.

-Illana FJ, García A, Sospedra M, Ferrer R, Martínez C, Guiñón L. Quality assurance of add-on testing in plasma samples: stability limit for 29 biochemical analytes. Biochemia Medica. 2024; 34(2):020704. DOI:10.11613/BM.2024.020704. PMID:38665870. IF:1,800 (Q3/6D). Document type: Article.

-La Lhoëst MTL, Martinez A, Claudi L, Garcia E, Benitez A, Polishchuk A, Piñero J, Vilades D, Guerra JM, Sanz F, Rotllan N, Escolà JC, Llorente V. Mechanisms modulating foam cell formation in the arterial intima: exploring new therapeutic opportunities in atherosclerosis. Frontiers in Cardiovascular Medicine. 2024; 11:1381520. DOI:10.3389/fcvm.2024.1381520. PMID:38952543. IF:2,900 (Q2/4D). Document type: Review.

-Laghi L, Ortiz MA, Rossi G, Román E, Mengucci C, Cantó E, Biagini L, Sánchez E, Mulet M, García A, Urgell E, Kaur N, Poca M, Padrós J, Nadal MJ, Cuyàs B, Alvarado E, Vidal S, Juanes E, Ferrero A, Escorsell A, Soriano G. Biomarkers of Frailty in Patients with Advanced Chronic Liver Disease Undergoing a Multifactorial Intervention Consisting of Home Exercise, Branched-Chain Amino Acids, and Probiotics. Biomolecules. 2024; 14(11):1410. DOI:10.3390/biom14111410. PMID:39595586. IF:4,800 (Q1/3D). Document type: Article.

-López de Las Hazas MC, Del Saz-Lara A, Cedó L, Crespo MC, Tomé-Carneiro J, Chapado LA, Macià A, Visioli F, Escola-Gil JC, Dávalos A. Hydroxytyrosol Induces Dyslipidemia in an ApoB100 Humanized Mouse Model. Mol Nutr Food Res. 2024; 68(1):e2300508. DOI:10.1002/mnfr.202300508. PMID:37933702. IF:4,200 (Q2/3D). Document type: Article.

-Minguez B, de Los Santos M, Garcia C, Molera C, Paredes AJ, Oliva C, Arias A, Rodriguez H, Yubero D, Tondo M, Santos C, Meavilla S, Artuch R. Exploring Plasma Coenzyme Q₁₀ Status in Paediatric Dyslipidaemia. Antioxidants. 2024; 13(8):966. DOI:10.3390/antiox13080966. PMID:39199213. IF:6,600 (Q1/2D). Document type: Article.

-Oliveras A, Vázquez S, Vega MV, Camps C, Illana FJ, Armario P, Crespo M, de la Sierra A. Improvement of non-adherence and reduction of BP values in patients with difficult-to-treat hypertension: the ATHAN clinical trial. HYPERTENSION RESEARCH. 2024; DOI:10.1038/s41440-024-01748-x. PMID:39085464. IF:4,600 (Q1/2D). Document type: Article.

-Redondo S, Costa M, Moreno ME, Arguello M, Riba M, Aso O, Iranzo E, Esquirol A, Sierra J, Briones J, Martino R, Zapico E, Garcia I. Development and Clinical Validation of Liquid Chromatography-Tandem Mass Spectrometry for Measuring Ruxolitinib in Steroid-Refractory Graft-Versus-Host Disease: A First Step Towards Optimized Treatment. EUROPEAN JOURNAL OF HAEMATOLOGY. 2024; DOI:10.1111/ejh.14349. PMID:39545520. IF:2,300 (Q2/5D). Document type: Article.

-Rotllan N, Escolà JC. Apolipoproteins and Lipoproteins in Health and Disease 2.0. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024; 25(11):6183. DOI:10.3390/ijms25116183. PMID:38892369. IF:4,900 (Q1/3D). Document type: Article.

-Rotllan N, Julve J, Escolà JC. Type 2 Diabetes and HDL dysfunction: a key contributor to Glycemic Control. CURRENT MEDICINAL CHEMISTRY. 2024; 31(3). DOI:10.2174/0929867330666230201124125. PMID:36722477. IF:3,500 (Q2/4D). Document type: Review.

-Sardà H, Colom C, Benitez S, Carreras G, Amigó J, Miñambres I, Viladés D, Blanco F, Sanchez JL, Pérez A. PCSK9 plasma concentration is associated with epicardial adipose tissue volume and metabolic control in patients with type 1 diabetes. Scientific Reports. 2024; 14(1):7195. DOI:10.1038/s41598-024-57708-5. PMID:38532033. IF:3,900 (Q1/2D). Document type: Article.

Publicaciones 2023

(JIF 2023)

-Asla Q, Sarda H, Segui N, de Pinillos GM, Mazarico I, Capel I, Rives J, Suarez J, avila V, Torres MM, Saigi I, Palacios N, Urgell E, Webb SM, Fernandez M, Oriola J, Mora M, Tondo M, Aulinas A. Clinical and outcome comparison of genetically positive vs. negative patients in a large cohort of suspected familial hypocalciuric hypercalcemia. ENDOCRINE. 2023. DOI:10.1007/s12020-023-03560-y. PMID:38214877. IF:3,000 (Q2/5D). Document type: Article.

-Canyelles M, Blanco F, Pérez A, Escolà JC. Comment on Huh et al. Remnant Cholesterol Is an Independent Predictor of Type 2 Diabetes: A Nationwide Population-Based Cohort Study. Diabetes Care 2023;46:305-312. DIABETES CARE. 2023; 46(10):e203. DOI:10.2337/dc23-0774. PMID:37729500. IF:14,800 (Q1/1D). Document type: Letter.

-Canyelles M, Borràs C, Rotllan N, Tondo M, Escolà JC, Blanco F. Gut Microbiota-Derived TMAO: A Causal Factor Promoting Atherosclerotic Cardiovascular Disease?. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023; 24(3):1940. DOI:10.3390/ijms24031940. PMID:36768264. IF:4,900 (Q1/3D). Document type: Review.

-de las Hazas MCL, del Saz A, Cedó L, Crespo MC, Tomé J, Chapado LA, Macià A, Visioli F, Escola JC, Dávalos A. Hydroxytyrosol Induces Dyslipidemia in an ApoB100 Humanized Mouse Model. MOLECULAR NUTRITION & FOOD RESEARCH. 2023; 68(1). DOI:10.1002/mnfr.202300508. PMID:37933702. IF:4,500 (Q1/3D). Document type: Article.

-Ferrer R, Mansilla A, Tondo M, Blanco F. Remnant cholesterol: new outcomes highlight its potential as a clinically useful cardiovascular risk factor. Journal Of Laboratory And Precision Medicine. 2023; 8:A5. DOI:10.21037/jlpm-22-70. Document type: Note.

-Frutos MFD, Pardo V, Torrecilla M, Rada P, Perez A, Martin Y, de la Pena G, Gomez A, Toledano A, Gomez D, Casarejos MJ, Solis JM, Rotllan N, Pastor O, Ledesma MD, Valverde AM, Busto R, Ramirez CM. «MiR-7 controls cholesterol biosynthesis through posttranscriptional regulation of DHCR24 expression». Biochimica et Biophysica Acta-Gene Regulatory Mechanisms. 2023; 1866(2):194938. DOI:10.1016/j.bbagrm.2023.194938. PMID:37086967. IF:2,600 (Q3/6D). Document type: Article.

-García A, Muñoz LG, Pallaruelo MC, Usero AM, Eduardo BC, Ramos JL, Canyelles M, Brú CM, Cámara F. Characterization of add-on testing before and after automation at a core laboratory. Heliyon. 2023; 9(11):e22096. DOI:10.1016/j.heliyon.2023.e22096. PMID:38034602. IF:3,400 (Q1/3D). Document type: Article.

-Guiñón L, Illana FJ, Cuevas B, Canyelles M, Martínez C, García Á. Periodic verification of results’ comparability between several analyzers: Experience in the application of the EP31-A-IR guideline. CLINICAL CHEMISTRY AND LABORATORY MEDICINE. 2023; 62(3). DOI:10.1515/cclm-2023-0994. PMID:37819627. IF:3,800 (Q1/2D). Document type: Article.

-Hueso M, Rotllan N, Escolà JC, Vellido A. Systems biology and data-driven machine learning-based models in personalized cardiovascular medicine. Frontiers in Cardiovascular Medicine. 2023; 10:1320110. DOI:10.3389/fcvm.2023.1320110. PMID:37965080. IF:2,800 (Q2/4D). Document type: Editorial Material.

-Lee M, Canyelles M, Tondo M, Rotllan N, Kovanen PT, Llorente V, Escola JC. Obesity-induced changes in cancer cells and their microenvironment: Mechanisms and therapeutic perspectives to manage dysregulated lipid metabolism. SEMINARS IN CANCER BIOLOGY. 2023; 93. DOI:10.1016/j.semcancer.2023.05.002. PMID:37156344. IF:12,100 (Q1/1D). Document type: Article.

-Mansilla A, Canyelles M, Ferrer R, Arranz J, Rodriguez I, Zhu N, Rubio S, El Bounasri S, Sanchez O, Torres S, Fortea J, Lleo A, Alcolea D, Tondo M. Effects of storage conditions on the stability of blood-based markers for the diagnosis of Alzheimer’s disease. CLINICAL CHEMISTRY AND LABORATORY MEDICINE. 2023; 61(9). DOI:10.1515/cclm-2023-0245. PMID:37083158. IF:3,800 (Q1/2D). Document type: Article.

-Martinez MC, Cortés M, Moreno A, Han L, Ninfali C, Domínguez V, Andrés MJ, Farràs M, Esteve A, Enrich C, Diaz FJ, Pintado B, Escolà JC, de Frutos PG, Andrés V, Melgar P, Postigo A. Atherosclerotic plaque development in mice is enhanced by myeloid ZEB1 downregulation. Nature Communications. 2023; 14(1):8316. DOI:10.1038/s41467-023-43896-7. PMID:38097578. IF:14,700 (Q1/1D). Document type: Article.

-Munoz JP, Sanchez P, Diarte E, Zorzano A, Blanco F, Julve J. FTY720-P, a Biased S1PR Ligand, Increases Mitochondrial Function through STAT3 Activation in Cardiac Cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023; 24(8):7374. DOI:10.3390/ijms24087374. PMID:37108539. IF:4,900 (Q1/3D). Document type: Article.

-Nan MN, Garcia A, Mora J, Trilla C, Antonijuan A, Orantes V, Cruz M, Blanco F, Llurba E. Impact of Angiogenic and Cardiovascular Biomarkers for Prediction of Placental Dysfunction in the First Trimester of Pregnancy. Biomedicines. 2023; 11(5):1327. DOI:10.3390/biomedicines11051327. PMID:37238997. IF:3,900 (Q1/3D). Document type: Article.

-Puig N, Rives J, Estruch M, Aguilera A, Rotllan N, Camacho M, Colomé N, Canals F, Sánchez JL, Benitez S. Presence of Ceramidase Activity in Electronegative LDL. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023; 24(1):165. DOI:10.3390/ijms24010165. PMID:36613609. IF:4,900 (Q1/3D). Document type: Article.

-Puig N, Solé A, Aguilera A, Griñán R, Rotllan N, Camps P, Benitez S. Novel Therapeutic Approaches to Prevent Atherothrombotic Ischemic Stroke in Patients with Carotid Atherosclerosis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023; 24(18):14325. DOI:10.3390/ijms241814325. PMID:37762627. IF:4,900 (Q1/3D). Document type: Review.

-Revilla G, Al Qtaish N, Caruana P, Sainz M, Lopez T, Rodriguez F, Paez V, Li CD, Vallverdú NF, Edwards M, Moral A, Pérez JI, Escolà JC, Pedraz JL, Gallego I, Corcoy R, Céspedes MV, Puras G, Mato E. Lenvatinib-Loaded Poly(lactic-co-glycolic acid) Nanoparticles with Epidermal Growth Factor Receptor Antibody Conjugation as a Preclinical Approach to Therapeutically Improve Thyroid Cancer with Aggressive Behavior. Biomolecules. 2023; 13(11):1647. DOI:10.3390/biom13111647. PMID:38002329. IF:4,800 (Q1/3D). Document type: Article.

-Revilla G, Ruiz L, Vallverdu NF, Santamaria P, Moral A, Perez JI, Li CD, Fuste V, Lerma E, Corcoy R, Pitoia F, Escola JC, Mato E. Low-Density Lipoprotein Receptor Is a Key Driver of Aggressiveness in Thyroid Tumor Cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023; 24(13):11153. DOI:10.3390/ijms241311153. PMID:37446330. IF:4,900 (Q1/3D). Document type: Article.

-Rossi G, Belmonte T, Rivas A, Benitez S, Rotllan N, Crespo J, Llorente V, Sanchez JL, de Gonzalo D. Circulating lipoprotein-carried miRNome analysis reveals novel VLDL-enriched microRNAs that strongly correlate with the HDL-microRNA profile. BIOMEDICINE & PHARMACOTHERAPY. 2023; 162:114623. DOI:10.1016/j.biopha.2023.114623. PMID:37023624. IF:6,900 (Q1/1D). Document type: Article.

-Roth L, Dogan S, Tuna BG, Aranyi T, Benitez S, Borrell M, Bozaykut P, De Meyer GRY, Duca L, Durmus N, Fonseca D, Fraenkel E, Gillery P, Giudici A, Jaisson S, Johansson M, Julve J, Lucas AK, Martinet W, Maurice P, McDonnell BJ, Ozbek EN, Pucci G, Pugh C, Rochfort KD, Roks A, Rotllan N, Shadiow J, Sohrabi Y, Spronck B, Szeri F, Terentes D, Aydin ET, Tura O, Ucar E, Yetik G. Pharmacological modulation of vascular ageing: A review from VascAgeNet. AGEING RESEARCH REVIEWS. 2023; 92:102122. DOI:10.1016/j.arr.2023.102122. PMID:37956927. IF:12,500 (Q1/1D). Document type: Review.

-Samouillan V, Garcia E, Benitez A, Lhoest MTLC, Dandurand J, Dato VA, Guerra JM, Escola JC, Chiabrando G, Enrich C, Llorente V. Inhibitory Effects of LRP1-Based Immunotherapy on Cardiac Extracellular Matrix Biophysical Alterations Induced by Hypercholesterolemia. JOURNAL OF MEDICINAL CHEMISTRY. 2023; 66(9). DOI:10.1021/acs.jmedchem.2c02103. PMID:37116069. IF:6,800 (Q1/1D). Document type: Article.

-Soler MC, Romero MD, Todorcevic M, Delgado K, Calatayud C, Benitez A, Lhoest MTL, Mera P, Zagmutt S, Bastias M, Ibeas K, Casals N, Escola JC, Llorente V, Consiglio A, Serra D, Herrero L. Implantation of CPT1AM-expressing adipocytes reduces obesity and glucose intolerance in mice. METABOLIC ENGINEERING. 2023; 77. DOI:10.1016/j.ymben.2023.04.010. PMID:37088334. IF:6,800 (Q1/1D). Document type: Article.

-Sprankel L, Vizarraga D, Martín J, Manger S, Meier J, Marcos M, Julve J, Rotllan N, Scheffer MP, Escolà JC, Langer JD, Piñol J, Fita I, Frangakis AS. Essential protein P116 extracts cholesterol and other indispensable lipids for Mycoplasmas. NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2023; 30(3). DOI:10.1038/s41594-023-00922-y. PMID:36782049. IF:12,500 (Q1/1D). Document type: Article.

-Torres JK, Niño J, Martinez P, Diarte EMG, Méndez KA, del Olmo TV, Rotllan N, Julián MT, Alonso N, Mauricio D, Camacho M, Muñoz JP, Rossell J, Julve J. Nicotinamide Prevents Diabetic Brain Inflammation via NAD+-Dependent Deacetylation Mechanisms. Nutrients. 2023; 15(14):3083. DOI:10.3390/nu15143083. PMID:37513501. IF:4,800 (Q1/2D). Document type: Article.

-Villanueva T, Cedo L, Madeira A, Ceperuelo V, Rodriguez MM, Nunez C, Maymo E, Repolles M, Badia J, Keiran N, Mirasierra M, Pimenta C, Sabadell J, Bosch R, Caubet L, Escola JC, Fernandez JM, Vilarrasa N, Ventura F, Vallejo M, Vendrell J, Fernandez S. SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression. Cell Metabolism. 2023; 35(4):601-619.e10. DOI:10.1016/j.cmet.2023.03.004. PMID:36977414. IF:27,700 (Q1/1D). Document type: Article.

Publicaciones 2022

(JIF 2022)

Antonio V, Franch J, Moreno A, Real J, Orcau A, Mauricio D, Mata M, Julve J, Mendez EN, Treserra RP, de la Puente JB, Millet JP, Garcia JLD, Vlacho B, Cayla JA. Subjects With Diabetes Mellitus Are at Increased Risk for Developing Tuberculosis: A Cohort Study in an Inner-City District of Barcelona (Spain). Frontiers in Public Health. 2022; 10:789952. DOI:10.3389/fpubh.2022.789952. PMID:35677764. IF:5,2 (Q1/3D). Document type: Article.
Blanco F, Rotllan N, Canyelles M, Mauricio D, Escola JC, Julve J. NAD plus -Increasing Strategies to Improve Cardiometabolic Health?. Frontiers in Endocrinology. 2022; 12:815565. DOI:10.3389/fendo.2021.815565. PMID:35173682. IF:5,2 (Q1/3D). Document type: Review.
Borras C, Mercer A, Sirisi S, Alcolea D, Escola JC, Blanco F, Tondo M. HDL-like-Mediated Cell Cholesterol Trafficking in the Central Nervous System and Alzheimer’s Disease Pathogenesis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(16):9356. DOI:10.3390/ijms23169356. PMID:36012637. IF:5,6 (Q1/3D). Document type: Review.
Canyelles M, Perez A, Junza A, Minambres I, Yanes O, Sarda H, Rotllan N, Julve J, Sanchez JL, Tondo M, Escola JC, Blanco F. Divergent Effects of Glycemic Control and Bariatric Surgery on Circulating Concentrations of TMAO in Newly Diagnosed T2D Patients and Morbidly Obese. 2022; 12(11):2783. DOI:10.3390/diagnostics12112783. PMID:36428843. IF:3,6 (Q2/4D). Document type: Article.
Canyelles M, Plaza M, Rotllan N, Llobet D, Julve J, Mojal S, Diaz M, Soria JM, Escola JC, Tondo M, Blanco F, Souto JC. TMAO and Gut Microbial-Derived Metabolites TML and gamma BB Are Not Associated with Thrombotic Risk in Patients with Venous Thromboembolism. Journal of Clinical Medicine. 2022; 11(5):1425. DOI:10.3390/jcm11051425. PMID:35268516. IF:3,9 (Q2/4D). Document type: Article.
Climent E, Bea AM, Benaiges D, Brea A, Pinto X, Suarez M, Perea V, Plana N, Blanco F, Pedro J. LDL Cholesterol Reduction Variability with Different Types and Doses of Statins in Monotherapy or Combined with Ezetimibe. Results from the Spanish Arteriosclerosis Society Dyslipidaemia Registry. CARDIOVASCULAR DRUGS AND THERAPY. 2022; 36(2). DOI:10.1007/s10557-020-07137-z. PMID:33555511. IF:3,4 (Q2/5D). Document type: Article.
Dato VA, Benitez A, Garcia E, Claudi L, Lhoest MTL, Iborra A, Guerra JM, Escola JC, Samouillan V, Enrich C, Chiabrando G, Llorente V. Targeting cholesteryl ester accumulation in the heart improves cardiac insulin response. BIOMEDICINE & PHARMACOTHERAPY. 2022; 152:113270. DOI:10.1016/j.biopha.2022.113270. PMID:35709652. IF:7,5 (Q1/1D). Document type: Article.
Delaby C, Estelles T, Zhu NU, Arranz J, Barroeta I, Carmona M, Illan I, Santos MA, Altuna M, Sala I, Sanchez MB, Videla L, Valldeneu S, Subirana A, Tondo M, Blanco F, Lehmann S, Belbin O, Blesa R, Fortea J, Lleo A, Alcolea D. The A beta 1-42/A beta 1-40 ratio in CSF is more strongly associated to tau markers and clinical progression than A beta 1-42 alone. Alzheimers Research & Therapy. 2022; 14(1):20. DOI:10.1186/s13195-022-00967-z. PMID:35105351. IF:9 (Q1/1D). Document type: Article.
Farras M, Swann JR, Rowland I, Rubio L, Subirana I, Catalan U, Motilva MJ, Sola R, Covas MI, Blanco F, Fito M, Mayneris J. Impact of Phenol-Enriched Olive Oils on Serum Metabonome and Its Relationship with Cardiometabolic Parameters: A Randomized, Double-Blind, Cross-Over, Controlled Trial. 2022; 11(10):1964. DOI:10.3390/antiox11101964. PMID:36290685. IF:7 (Q1/1D). Document type: Article.
Ferrer R, Zhu N, Arranz J, Porcel I, El Bounasri S, Sanchez O, Torres S, Julve J, Lleo A, Blanco F, Alcolea D, Tondo M. Importance of cerebrospinal fluid storage conditions for the Alzheimer’s disease diagnostics on an automated platform. CLINICAL CHEMISTRY AND LABORATORY MEDICINE. 2022; 60(7). DOI:10.1515/cclm-2022-0134. PMID:35405043. IF:6,8 (Q1/2D). Document type: Article.
Granado M, Sola I, Hernandez M, Rojo MI, Julve J, Mauricio D. Effectiveness of medical nutrition therapy in adolescents with type 1 diabetes: a systematic review. Nutrition & Diabetes. 2022; 12(1):24. DOI:10.1038/s41387-022-00201-7. PMID:35459205. IF:6,1 (Q1/2D). Document type: Review.
Grinan R, Escola JC, Julve J, Benitez S, Rotllan N. Epigenetic Regulation by microRNAs in Hyperhomocysteinemia-Accelerated Atherosclerosis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(20):12452. DOI:10.3390/ijms232012452. PMID:36293305. IF:5,6 (Q1/3D). Document type: Review.
Hueso M, Grinan R, Mallen A, Navarro E, Purqueras E, Goma M, Sbraga F, Blasco A, Revilla G, Santos D, Canyelles M, Julve J, Escola JC, Rotllan N. MiR-125b downregulates macrophage scavenger receptor type B1 and reverse cholesterol transport. BIOMEDICINE & PHARMACOTHERAPY. 2022; 146:112596. DOI:10.1016/j.biopha.2021.112596. PMID:35062066. IF:7,5 (Q1/1D). Document type: Article.
Julve J, Escola JC. High-Density Lipoproteins and Cardiovascular Disease: The Good, the Bad, and the Future II. 2022; 10(3):620. DOI:10.3390/biomedicines10030620. PMID:35327422. IF:4,7 (Q1/3D). Document type: Editorial material.
Lee M, Lappalainen J, Kovanen PT, Escola JC. Lipid-Laden Macrophages and Inflammation in Atherosclerosis and Cancer: An Integrative View. Frontiers in Cardiovascular Medicine. 2022; 9:777822. DOI:10.3389/fcvm.2022.777822. PMID:35237673. IF:3,6 (Q2/5D). Document type: Review.
Martos I, del Monte A, Lorenzo C, Busse CE, Delgado P, Mur SM, Cobos L, Escolà JC, Martín JL, Wardemann H, Ramiro AR. MDA-LDL vaccination induces athero-protective germinal-center-derived antibody responses. Cell Reports. 2022; 41(2):111468. DOI:10.1016/j.celrep.2022.111468. PMID:36223741. IF:8,8 (Q1/2D). Document type: Article.
Mauricio D, Vlacho B, de la Puente JB, Mundet X, Real J, Kulisevsky J, Ortega E, Castelblanco E, Julve J, Franch J. Associations Between Diabetic Retinopathy and Parkinson’s Disease: Results From the Catalonian Primary Care Cohort Study. Frontiers in Medicine. 2022; 8:800973. DOI:10.3389/fmed.2021.800973. PMID:35118094. IF:3,9 (Q2/4D). Document type: Article.
Nunez E, Fuster V, Gomez M, Valdivielso JM, Fernandez JM, Martinez D, Rodriguez JM, Bonzon E, Calvo E, Alfayate A, Bermudez M, Escola JC, Fernandez L, Cerro I, Mendiguren JM, Sanchez F, Sanz J, Ordovas JM, Blanco LM, Garcia JM, Ibanez B, Lara E, Fernandez A, Martin JL, Vazquez J. Unbiased plasma proteomics discovery of biomarkers for improved detection of subclinical atherosclerosis. 2022; 76:103874. DOI:10.1016/j.ebiom.2022.103874. PMID:35152150. IF:11,1 (Q1/1D). Document type: Article.
Puig C, Castelblanco E, Falguera M, Hernandez M, Soldevila B, Julian MT, Teis A, Julve J, Barranco M, Franch J, Puig M, Ortega E, Amigo N, Alonso N, Mauricio D. Advanced lipoprotein profile in individuals with normal and impaired glucose metabolism. REVISTA ESPANOLA DE CARDIOLOGIA. 2022; 75(1). DOI:10.1016/j.recesp.2021.02.013. PMID:33785266. IF:5,9 (Q1/3D). Document type: Article.
Revilla G,Moral A,Fuste V,Lerma E,Julve J,Escolà JC,Mato E,Pérez JI,Corcoy R,Paez EV. The role of ATP-binding cassette transporter genes in the metastatic process of epithelial thyroid carcinoma with aggressive behavior. En: Unraveling The Complexities Of Metastasis: Transition From A Segmented View To A Conceptual Continuum. Elsevier. 2022. p. 265-275. DOI: 10.1016/B978-0-12-821789-4.00020-5. Document type: Book chapter.
Rivas A, Rotllan N, Santos D, Julve J, Escolà JC, Sanchez JL. Assessment of Ex Vivo Antioxidative Potential of Murine HDL in Atherosclerosis. Methods In Molecular Biology. 2022; 2419DOI:10.1007/978-1-0716-1924-7_17. Document type: Book chapter.
Rivas A, Rotllan N, Santos D, Julve J, Sanchez JL, Escolà JC. Monitoring Atheroprotective Macrophage Cholesterol Efflux In Vivo. Methods In Molecular Biology. 2022; 2419. DOI:10.1007/978-1-0716-1924-7_35. Document type: Book chapter.
Roldan R, Perez JM, Cerro I, Oller J, Martinez D, Nunez E, Maller SM, Gutierrez C, Mendez N, Escola JC, Michel JB, Mittelbrunn M, Vazquez J, Blanco LM, Rabinovich GA, Martin JL. Galectin-1 prevents pathological vascular remodeling in atherosclerosis and abdominal aortic aneurysm. Science Advances. 2022; 8(11):eabm7322. DOI:10.1126/sciadv.abm7322. PMID:35294231. IF:13,6 (Q1/1D). Document type: Article.
Rotllan N, Zhang XB, Canfran A, Goedeke L, Grinan R, Ramirez CM, Suarez Y, Fernandez C. Antagonism of miR-148a attenuates atherosclerosis progression in APOB(TG )Apobec(-/-)Ldlr(+/-) mice: A brief report. BIOMEDICINE & PHARMACOTHERAPY. 2022; 153:113419. DOI:10.1016/j.biopha.2022.113419. PMID:36076541. IF:7,5 (Q1/1D). Document type: Article.
Rotllan N. The Underlying Pathology of Atherosclerosis: Different Players. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(6):3235. DOI:10.3390/ijms23063235. PMID:35328656. IF:5,6 (Q1/3D). Document type: Editorial material.
Teis A, Castelblanco E, Cediel G, Amigó N, Julve J, Ribalta J, Guardiola M, Franch J, Bermúdez M, Codina P, Lupón J, Mauricio D, Alonso N, Bayés A. (1)H-magnetic resonance spectroscopy lipoprotein profile in patients with chronic heart failure versus matched controls. REVISTA ESPANOLA DE CARDIOLOGIA. 2022; 75(11). DOI:10.1016/j.rec.2021.09.008. PMID:34716123. IF:5,9 (Q1/3D). Document type: Article.
Teis A, Castelblanco E, Cediel G, Amigó N, Julve J, Ribalta J, Guardiola M, Franch J, Bermúdez M, Codina P, Lupón J, Mauricio D, Alonso N, Bayés A. Perfil lipoproteico por espectroscopia nuclear magnética en pacientes con insuficiencia cardiaca crónica comparado con controles emparejados. REVISTA ESPANOLA DE CARDIOLOGIA. 2022; 75(11). DOI:10.1016/j.recesp.2021.09.007. IF:5,9 (Q1/3D). Document type: Article.

Publicaciones 2021

- Amaro AB, Curco AS, Garcia E, Julve J, Rives J, Benitez S, Cortes VL. Apolipoprotein and LRP1-Based Peptides as New Therapeutic Tools in Atherosclerosis. Journal of Clinical Medicine. 2021; 10(16):3571. DOI:10.3390/jcm10163571. PMID:34441867. IF:4,964.
- Arroyo JA, Julve J, Vlacho B, Corcoy R, Ponte P, Roman E, Navas E, Llaurado G, Franch J, Domingo P, Mauricio D. Previous Vitamin D Supplementation and Morbidity and Mortality Outcomes in People Hospitalised for COVID19: A Cross-Sectional Study. Frontiers in Public Health. 2021; 9:758347. DOI:10.3389/fpubh.2021.758347. PMID:34631653. IF:6,461.
- Bellido V, Perez A. COVID-19 and Diabetes. Journal of Clinical Medicine. 2021; 10(22):5341. DOI:10.3390/jcm10225341. PMID:34830623. IF:4,964.
- Bellido V, Perez A. Inpatient Hyperglycemia Management and COVID-19. Diabetes Therapy. 2021; 12(1):121-132. DOI: 10.1007/s13300-020-00966-z. PMID: 33278017. IF:3,595.
- Bonaterra A, Fernandez S, Rivas A, Puig N, Benitez S, Pancorbo O, Rodriguez D, Pujadas F, Freijo MD, Tur S, Martinez M, Portela PC, Vera R, Lebrato L, Arenillas JF, Perez S, Montaner J, Sanchez JL, Hernandez M. Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease. Biomedicines. 2021; 9(1):72. DOI:10.3390/biomedicines9010072. PMID:33445800. IF:4,757.
- Canyelles M, Garcia A, Junza A, Yanes O, Puig N, Ordonez J, Sionis A, Sans J, Alquezar A, Santos D, Rotllan N, Julve J, Tondo M, Escola JC, Blanco F. The Capacity of APOB-Depleted Plasma in Inducing ATP-Binding Cassette A1/G1-Mediated Macrophage Cholesterol Efflux-But Not Gut Microbial-Derived Metabolites-Is Independently Associated with Mortality in Patients with ST-Segment Elevation Myocardial Infarction. Biomedicines. 2021; 9(10):1336. DOI:10.3390/biomedicines9101336. PMID:34680453. IF:4,757.
- Carbo JM, Leon TE, Font J, De la Rosa JV, Castrillo A, Picard FR, Staudenraus D, Huber M, Cedo L, Escola JC, Campos L, Bakiri L, Wagner EF, Caelles C, Stratmann T, Van JA, Valledor AF. Pharmacologic Activation of LXR Alters the Expression Profile of Tumor-Associated Macrophages and the Abundance of Regulatory T Cells in the Tumor Microenvironment. CANCER RESEARCH. 2021; 81(4). DOI:10.1158/0008-5472.CAN-19-3360. PMID:33361391. IF:13,312.
- Castelblanco E, Hernandez M, Ortega E, Amigo N, Real J, Granado M, Minambres I, Lopez C, Lecube A, Bermudez M, Alonso N, Julve J, Mauricio D. Outstanding improvement of the advanced lipoprotein profile in subjects with new-onset type 1 diabetes mellitus after achieving optimal glycemic control. DIABETES RESEARCH AND CLINICAL PRACTICE. 2021; 182:109145. DOI:10.1016/j.diabres.2021.109145. PMID:34785302. IF:8,180.
- Chiva G, Pena E, Cubedo J, Garcia M, Pane A, Gil PA, Perez A, Ortega E, Padro T, Badimon L. Molecular mapping of platelet hyperreactivity in diabetes: the stress proteins complex HSPA8/Hsp90/CSK2 alpha and platelet aggregation in diabetic and normal platelets. Translational Research. 2021; 235. DOI:10.1016/j.trsl.2021.04.003. PMID:33887528. IF:10,171.
- Colom C, Rull A, Sanchez JL, Perez A. Cardiovascular Disease in Type 1 Diabetes Mellitus: Epidemiology and Management of Cardiovascular Risk. Journal of Clinical Medicine. 2021; 10(8):1798. DOI:10.3390/jcm10081798. PMID:33924265. IF:4,964.
- Daban F, Garcia-Subirats I, Porthe V, Lopez M, de-Eyto B, Pasarin MI, Borrell C, Artazcoz L, Perez A, Diez E. Improving mental health and wellbeing in elderly people isolated at home due to architectural barriers: A community health intervention. Atencion Primaria. 2021;53(5):102020. DOI:10.1016/j.aprim.2021.102020. PMID: 33774346. IF: 2,206.
- Delk SC, Chattopadhyay A, Escola JC, Fogelman AM, Reddy ST. Apolipoprotein mimetics in cancer. SEMINARS IN CANCER BIOLOGY. 2021; 73. DOI:10.1016/j.semcancer.2020.11.002. PMID:33188891. IF:17,012.
- Escola JC, Rotllan N, Julve J, Blanco F. Reverse Cholesterol Transport Dysfunction Is a Feature of Familial Hypercholesterolemia. Current Atherosclerosis Reports. 2021; 23(6):29. DOI:10.1007/s11883-021-00928-1. PMID:33914189. IF:5,967.
- Farras M, Almanza E, Hernaez A, Agusti N, Julve J, Fito M, Castaner O. Beneficial effects of olive oil and Mediterranean diet on cancer physio-pathology and incidence. SEMINARS IN CANCER BIOLOGY. 2021; 73. DOI:10.1016/j.semcancer.2020.11.011. PMID:33249203. IF:17,012.
- Fernandez ME, Daimiel L, Villa G, Pavon MV, Busto R, Escola JC, Platt FM, Lasuncion MA, Martinez J, Gomez D. Selective estrogen receptor modulators (SERMs) affect cholesterol homeostasis through the master regulators SREBP and LXR. BIOMEDICINE & PHARMACOTHERAPY. 2021; 141:111871. DOI:10.1016/j.biopha.2021.111871. PMID:34225017. IF:7,419.
- Fernandez S, Pedret A, Catalan U, Valls RM, Farras M, Rubio L, Castaner O, Macia A, Fito M, Motilva MJ, Covas MI, Giera M, Remaley AT, Sola R. Virgin Olive Oil Phenolic Compounds Modulate the HDL Lipidome in Hypercholesterolaemic Subjects: A Lipidomic Analysis of the VOHF Study. MOLECULAR NUTRITION & FOOD RESEARCH. 2021; 65(9):2001192. DOI:10.1002/mnfr.202001192. PMID:33561904. IF:6,575.
- Fuster VP, Perez AP, Gomez JC, Pedragos AC, Gomez R, Perez P. Executive summary: Updates to the dietary treatment of prediabetes and type 2 diabetes mellitus. Endocrinologia Diabetes y Nutricion. 2021; 68(4). DOI:10.1016/j.endinu.2020.10.009. PMID:33593709. IF:1,833.
- Genua I, Puig N, Minambres I, Benitez S, Gil P, Grau M, Rivas A, Balague C, Fernandez S, Garcia A, Perez A, Sanchez JL. Changes in the Composition and Function of Lipoproteins after Bariatric Surgery in Patients with Severe Obesity. Journal of Clinical Medicine. 2021; 10(8):1716. DOI:10.3390/jcm10081716. PMID:33923393. IF:4,964.
- Genua I, Tuneu L, Ramos A, Stantonyonge N, Caimari F, Balague C, Fernandez-Ananin S, Sanchez-Quesada JL, Perez A, Miñambres I. Effectiveness of Bariatric Surgery in Patients with the Metabolically Healthy Obese Phenotype. OBESITY SURGERY. 2021;31(2):517-522. DOI:10.1007/s11695-020-04967-6. PMID: 32915359. IF:3,479.
- Gimeno JA, Rodriguez L, Anguita M, Barrios V, Muniz J, Perez A. Association of the KDIGO Risk Classification with the Prevalence of Heart Failure in Patients with Type 2 Diabetes. Journal of Clinical Medicine. 2021; 10(20):4634. DOI:10.3390/jcm10204634. PMID:34682756. IF:4,964.
- Goedeke L, Canfran A, Rotllan N, Chaube B, Thompson BM, Lee RG, Cline GW, McDonald JG, Shulman GI, Lasuncion MA, Suarez Y, Fernandez C. MMAB promotes negative feedback control of cholesterol homeostasis. Nature Communications. 2021; 12(1):6448. DOI:10.1038/s41467-021-26787-7. PMID:34750386. IF:17,694.
- Granado M, Martinez D, Martinez M, Doria M, Alcubierre N, Valls J, Julve J, Verdu J, Mauricio D. Psychometric Validation of the Cardiff Wound Impact Schedule Questionnaire in a Spanish Population with Diabetic Foot Ulcer. Journal of Clinical Medicine. 2021; 10(17):4023. DOI:10.3390/jcm10174023. PMID:34501471. IF:4,964.
- Julián MT, Pera G, Soldevila B, Caballería L, Julve J, Puig C, Morillas R, Torán P, Expósito C, Puig M, Castelblanco E, Franch J, Cusi K, Mauricio D, Alonso N. Atherogenic dyslipidemia, but not hyperglycemia, is an independent factor associated with liver fibrosis in subjects with type 2 diabetes and NAFLD: A population-based study. EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2021; 184(4). DOI:10.1530/EJE-20-1240. PMID:33606661. IF:6,558.
- Mendez KA, Rodriguez E, Sebastian D, Blanco R, Camacho M, Nan MN, Diarte E, Mato E, Lope S, Roglans N, Laguna JC, Alonso N, Mauricio D, Zorzano A, Villarroya F, Villena JA, Blanco F, Julve J. Nicotinamide Protects Against Diet-Induced Body Weight Gain, Increases Energy Expenditure, and Induces White Adipose Tissue Beiging. MOLECULAR NUTRITION & FOOD RESEARCH. 2021; 65(11):2100111. DOI:10.1002/mnfr.202100111. PMID:33870623. IF:6,575.
- Minambres I, Sanchez J, Cuixart G, Sanchez A, Sarroca J, Perez A. Characterization of the hypertriglyceridemic waist phenotype in patients with type 2 diabetes mellitus in Spain: an epidemiological study. REVISTA CLINICA ESPANOLA. 2021; 221(10). PMID:34839890. IF:3,064.
- Nan MN, Roig R, Martinez S, Rives J, Urgell E, Espinos JJ, Tirado M, Carreras G, Aulinas A, Webb SM, Corcoy R, Blanco F, Tondo M. Comprehensive Genetic Testing of CYP21A2: A Retrospective Analysis in Patients with Suspected Congenital Adrenal Hyperplasia. Journal of Clinical Medicine. 2021; 10(6):1183. DOI:10.3390/jcm10061183. PMID:33809035. IF:4,964.
- Oyaguez I, Gomez F, Artola S, Carrasco FJ, Carretero J, Garcia J, Gomez R, Merino JF, Perez A. Cost Analysis of FreeStyle Libre(R) 2 System in Type 2 Diabetes Mellitus Population. Diabetes Therapy. 2021; 12(9). DOI:10.1007/s13300-021-01064-4. PMID:33948909. IF:6,706.
- Papotti B, Escola JC, Julve J, Poti F, Zanotti I. Impact of Dietary Lipids on the Reverse Cholesterol Transport: What We Learned from Animal Studies. Nutrients. 2021; 13(8):2643. DOI:10.3390/nu13082643. PMID:34444804. IF:6,706.
- Revilla G, Cedo L, Tondo M, Moral A, Perez JI, Corcoy R, Lerma E, Fuste V, Reddy TS, Blanco F, Mato E, Escola JC. LDL, HDL and endocrine-related cancer: From pathogenic mechanisms to therapies. SEMINARS IN CANCER BIOLOGY. 2021; 73. DOI:10.1016/j.semcancer.2020.11.012. PMID:33249202. IF:17,012.
- Ribo S, Sanchez D, Martinez L, Garcia I, Ramon M, Tondo M, Arning E, Nofrarias M, Osorio O, Fernandez A, Gonzalez P, Cebria J, Gavalda A, Chenoll E, Isganaitis E, Villarroya F, Vallejo M, Segales J, Jimenez JC, Bottiglieri T, Demerath EW, Fields DA, Collado MC, Lerin C. Increasing breast milk betaine modulates Akkermansia abundance in mammalian neonates and improves long-term metabolic health. Science Translational Medicine. 2021; 13(587):eabb0322. DOI:10.1126/scitranslmed.abb0322. PMID:33790021. IF:19,319.
- Rodriguez J, Cerro I, Lindholt JS, Bonzon E, Martinez D, Roldan R, Escola JC, Michel JB, Blanco LM, Vazquez J, Suraez A, Martin JL. Malondialdehyde-modified HDL particles elicit a specific IgG response in abdominal aortic aneurysm. FREE RADICAL BIOLOGY AND MEDICINE. 2021; 174. DOI:10.1016/j.freeradbiomed.2021.08.004. PMID:34364980. IF:8,101.
- Rojo MI, Castelblanco E, Real J, Hernandez M, Falguera M, Amigo N, Julve J, Alonso N, Franch J, Granado M, Mauricio D. Advanced Quantitative Lipoprotein Characteristics Do Not Relate to Healthy Dietary Patterns in Adults from a Mediterranean Area. Nutrients. 2021; 13(12):4369. DOI:10.3390/nu13124369. PMID:34959921. IF:6,706.
- Rotllan N, Camacho M, Tondo M, Diarte E, Canyelles M, Mendez KA, Benitez S, Alonso N, Mauricio D, Escola JC, Blanco F, Julve J. Therapeutic Potential of Emerging NAD plus -Increasing Strategies for Cardiovascular Diseases. Antioxidants. 2021; 10(12):1939. DOI:10.3390/antiox10121939. IF:7,675.
- Singh AK, Chaube B, Zhang XB, Sun J, Citrin KM, Canfran A, Aryal B, Rotllan N, Varela L, Lee RG, Horvath TL, Price NL, Suarez Y, Fernandez C. Hepatocyte-specific suppression of ANGPTL4 improves obesity-associated diabetes and mitigates atherosclerosis in mice. JOURNAL OF CLINICAL INVESTIGATION. 2021; 131(17):e140989. DOI:10.1172/JCI140989. PMID:34255741. IF:19,456.
- Teis A, Cediel G, Amigo N, Julve J, Aranyo J, Andres J, Puig C, Castelblanco E, Gual F, Ferrer E, Vallejo N, Junca G, Lopez J, De Antonio M, Domingo M, Santiago E, Codina P, Mauricio D, Lupon J, Alonso N, Bayes A. Particle size and cholesterol content of circulating HDL correlate with cardiovascular death in chronic heart failure. Scientific Reports. 2021; 11(1):3141. DOI:10.1038/s41598-021-82861-6. PMID:33542459. IF:4,996.
- Uribe KB, Benito A, Martin C, Blanco F, Rotllan N. (r)HDL in theranostics: how do we apply HDL’s biology for precision medicine in atherosclerosis management?dagger. Biomaterials Science. 2021; 9(9). DOI:10.1039/d0bm01838d. PMID:33949389. IF:7,590.

Memoria científica

Accede a la memoria científica 2024

Artículos destacados

Circ Res. 2020 Aug 28;127(6):778-792. https://doi.org/10.1161/CIRCRESAHA.119.316424
Semin Cancer Biol. 2023 Aug;93:36-51. https://doi.org/10.1016/j.semcancer.2023.05.002
JACC Basic Transl Sci. 2024 Aug 28;9(10):1195-1210. https://doi.org/10.1016/j.jacbts.2024.06.008
Biomed Pharmacother. 2025 Jul;188:118178. https://doi.org/10.1016/j.biopha.2025.118178
Nat Comm 2025, 16(1):1115. https://doi.org/10.1038/s41467-025-66129-5
J Lipid Res. 2025 Aug;66(8):100865. https://doi.org/10.1016/j.jlr.2025.100865

Proyectos y contractos competitivos activos

JR22/00003, Contratos Juan Rodés (ISCIII, 2023–2026). PI: Dr. Canyelles.
PID2022-137186OB-I00 (MICIIN): ”Celulas Vasculares Lisas, Transporte Reverso De Colesterol Y Mirnas: Mecanismos Patofisiologicos Y Nuevas Dianas Para Prevenir La Enfermedad Cardiovascular” (2023-2025). PI: Dr. Rotllan.
PI23/00232 (ISCIII): “Impacto de las lipoproteínas remanentes y HDL en el riesgo cardiovascular: evaluación de biomarcadores predictivos en el estudio prospectivo Di@bet.es y un estudio longitudinal en sujetos con diabetes tipo 2” (2024–2026). PIs: Drs. Canyelles and Escolà-Gil.
FI24/00013, Contratos PFIS (ISCIII, 2025-2029). Lorena Velasco Reniu.
CNS2023-144119 (MICIIN): Proyecto de Incentivación de la consolidación investigadora: “Recombinant HDL: A novel Therapeutic approach for LNA-antimiRs treatment in atherogenesis” (2024-2026). PI: Dr. Rotllan.
MARATÓ 202312-31 (Fundació La Marató de TV3): «Role of HDL miRNA in coronary heart disease incidence; Customised miR-sHDL as strategy for atherosclerosis treatment» (2024-2027). PI: Dr. Rotllan.
CM24/00089, Contratos Río Hortega (ISCIII, 2025-2027). Rosa Ferrer Pérez.
PI24/00513 (ISCIII): «Implicaciones del transporte de colesterol mediado por lipoproteínas de alta densidad en la demencia por enfermedad de Alzheimer en adultos con síndrome de Down (cohorte DABNI). Proyecto DOWNLIP» (2025-2027). PIs: Drs. Tondo and Blanco-Vaca.
FI25/00113, Contratos PFIS (ISCIII, 2026-2030). Aya El Allam Kanice.

Página web y redes sociales

Ciberdem: https://www.ciberdem.org/grupos/grupo-de-investigacion?id=17009

Linkedin: http://www.linkedin.com/in/patholipid-santpau

Instagram: @patholipid_santpau

Presentación

Resumen

Principales líneas de Investigación e Innovación

La actividad del grupo se centra en dos líneas principales y una línea emergente, estrechamente interrelacionadas:

Metabolismeo de las lipoproteínas i riesgo cardiovascular

Diagnóstico y caracterización molecular de trastornos metabólicos

Biomarcadores en enfermedades neurodegenerativas (línea emergente)

Retos

Desarrollar y validar biomarcadores predictivos relacionados con lipoproteínas para la diabetes y la enfermedad cardiovascular en poblaciones con alto riesgo metabólico, con el fin de mejorar la estratificación del riesgo y la prevención personalizada.
Profundizar en los mecanismos moleculares que regulan las alteraciones del metabolismo de las lipoproteínas en la diabetes tipo 1 y tipo 2, con especial atención al papel de proteínas clave como ANGPTL3 y APOC3.
Evaluar el potencial terapéutico de HDL sintéticas y terapias dirigidas basadas en rHDL-miARN en la regresión de la aterosclerosis.
Desentrañar la compleja interacción entre el metabolismo lipídico y la progresión de la enfermedad de Alzheimer en el síndrome de Down, con el objetivo de identificar nuevos mecanismos patogénicos y posibles dianas terapéuticas.

Equipo

Coordinación del grupo

ESCOLA GIL, JOAN CARLES IR
jescola@santpau.cat

Miembros

Producción científica

Antonio V, Franch J, Moreno A, Real J, Orcau A, Mauricio D, Mata M, Julve J, Mendez EN, Treserra RP, de la Puente JB, Millet JP, Garcia JLD, Vlacho B, Cayla JA. Subjects With Diabetes Mellitus Are at Increased Risk for Developing Tuberculosis: A Cohort Study in an Inner-City District of Barcelona (Spain). Frontiers in Public Health. 2022; 10:789952. DOI:10.3389/fpubh.2022.789952. PMID:35677764. IF:5,2 (Q1/3D). Document type: Article.
Blanco F, Rotllan N, Canyelles M, Mauricio D, Escola JC, Julve J. NAD plus -Increasing Strategies to Improve Cardiometabolic Health?. Frontiers in Endocrinology. 2022; 12:815565. DOI:10.3389/fendo.2021.815565. PMID:35173682. IF:5,2 (Q1/3D). Document type: Review.
Borras C, Mercer A, Sirisi S, Alcolea D, Escola JC, Blanco F, Tondo M. HDL-like-Mediated Cell Cholesterol Trafficking in the Central Nervous System and Alzheimer’s Disease Pathogenesis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(16):9356. DOI:10.3390/ijms23169356. PMID:36012637. IF:5,6 (Q1/3D). Document type: Review.
Canyelles M, Perez A, Junza A, Minambres I, Yanes O, Sarda H, Rotllan N, Julve J, Sanchez JL, Tondo M, Escola JC, Blanco F. Divergent Effects of Glycemic Control and Bariatric Surgery on Circulating Concentrations of TMAO in Newly Diagnosed T2D Patients and Morbidly Obese. 2022; 12(11):2783. DOI:10.3390/diagnostics12112783. PMID:36428843. IF:3,6 (Q2/4D). Document type: Article.
Canyelles M, Plaza M, Rotllan N, Llobet D, Julve J, Mojal S, Diaz M, Soria JM, Escola JC, Tondo M, Blanco F, Souto JC. TMAO and Gut Microbial-Derived Metabolites TML and gamma BB Are Not Associated with Thrombotic Risk in Patients with Venous Thromboembolism. Journal of Clinical Medicine. 2022; 11(5):1425. DOI:10.3390/jcm11051425. PMID:35268516. IF:3,9 (Q2/4D). Document type: Article.
Climent E, Bea AM, Benaiges D, Brea A, Pinto X, Suarez M, Perea V, Plana N, Blanco F, Pedro J. LDL Cholesterol Reduction Variability with Different Types and Doses of Statins in Monotherapy or Combined with Ezetimibe. Results from the Spanish Arteriosclerosis Society Dyslipidaemia Registry. CARDIOVASCULAR DRUGS AND THERAPY. 2022; 36(2). DOI:10.1007/s10557-020-07137-z. PMID:33555511. IF:3,4 (Q2/5D). Document type: Article.
Dato VA, Benitez A, Garcia E, Claudi L, Lhoest MTL, Iborra A, Guerra JM, Escola JC, Samouillan V, Enrich C, Chiabrando G, Llorente V. Targeting cholesteryl ester accumulation in the heart improves cardiac insulin response. BIOMEDICINE & PHARMACOTHERAPY. 2022; 152:113270. DOI:10.1016/j.biopha.2022.113270. PMID:35709652. IF:7,5 (Q1/1D). Document type: Article.
Delaby C, Estelles T, Zhu NU, Arranz J, Barroeta I, Carmona M, Illan I, Santos MA, Altuna M, Sala I, Sanchez MB, Videla L, Valldeneu S, Subirana A, Tondo M, Blanco F, Lehmann S, Belbin O, Blesa R, Fortea J, Lleo A, Alcolea D. The A beta 1-42/A beta 1-40 ratio in CSF is more strongly associated to tau markers and clinical progression than A beta 1-42 alone. Alzheimers Research & Therapy. 2022; 14(1):20. DOI:10.1186/s13195-022-00967-z. PMID:35105351. IF:9 (Q1/1D). Document type: Article.
Farras M, Swann JR, Rowland I, Rubio L, Subirana I, Catalan U, Motilva MJ, Sola R, Covas MI, Blanco F, Fito M, Mayneris J. Impact of Phenol-Enriched Olive Oils on Serum Metabonome and Its Relationship with Cardiometabolic Parameters: A Randomized, Double-Blind, Cross-Over, Controlled Trial. 2022; 11(10):1964. DOI:10.3390/antiox11101964. PMID:36290685. IF:7 (Q1/1D). Document type: Article.
Ferrer R, Zhu N, Arranz J, Porcel I, El Bounasri S, Sanchez O, Torres S, Julve J, Lleo A, Blanco F, Alcolea D, Tondo M. Importance of cerebrospinal fluid storage conditions for the Alzheimer’s disease diagnostics on an automated platform. CLINICAL CHEMISTRY AND LABORATORY MEDICINE. 2022; 60(7). DOI:10.1515/cclm-2022-0134. PMID:35405043. IF:6,8 (Q1/2D). Document type: Article.
Granado M, Sola I, Hernandez M, Rojo MI, Julve J, Mauricio D. Effectiveness of medical nutrition therapy in adolescents with type 1 diabetes: a systematic review. Nutrition & Diabetes. 2022; 12(1):24. DOI:10.1038/s41387-022-00201-7. PMID:35459205. IF:6,1 (Q1/2D). Document type: Review.
Grinan R, Escola JC, Julve J, Benitez S, Rotllan N. Epigenetic Regulation by microRNAs in Hyperhomocysteinemia-Accelerated Atherosclerosis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(20):12452. DOI:10.3390/ijms232012452. PMID:36293305. IF:5,6 (Q1/3D). Document type: Review.
Hueso M, Grinan R, Mallen A, Navarro E, Purqueras E, Goma M, Sbraga F, Blasco A, Revilla G, Santos D, Canyelles M, Julve J, Escola JC, Rotllan N. MiR-125b downregulates macrophage scavenger receptor type B1 and reverse cholesterol transport. BIOMEDICINE & PHARMACOTHERAPY. 2022; 146:112596. DOI:10.1016/j.biopha.2021.112596. PMID:35062066. IF:7,5 (Q1/1D). Document type: Article.
Julve J, Escola JC. High-Density Lipoproteins and Cardiovascular Disease: The Good, the Bad, and the Future II. 2022; 10(3):620. DOI:10.3390/biomedicines10030620. PMID:35327422. IF:4,7 (Q1/3D). Document type: Editorial material.
Lee M, Lappalainen J, Kovanen PT, Escola JC. Lipid-Laden Macrophages and Inflammation in Atherosclerosis and Cancer: An Integrative View. Frontiers in Cardiovascular Medicine. 2022; 9:777822. DOI:10.3389/fcvm.2022.777822. PMID:35237673. IF:3,6 (Q2/5D). Document type: Review.
Martos I, del Monte A, Lorenzo C, Busse CE, Delgado P, Mur SM, Cobos L, Escolà JC, Martín JL, Wardemann H, Ramiro AR. MDA-LDL vaccination induces athero-protective germinal-center-derived antibody responses. Cell Reports. 2022; 41(2):111468. DOI:10.1016/j.celrep.2022.111468. PMID:36223741. IF:8,8 (Q1/2D). Document type: Article.
Mauricio D, Vlacho B, de la Puente JB, Mundet X, Real J, Kulisevsky J, Ortega E, Castelblanco E, Julve J, Franch J. Associations Between Diabetic Retinopathy and Parkinson’s Disease: Results From the Catalonian Primary Care Cohort Study. Frontiers in Medicine. 2022; 8:800973. DOI:10.3389/fmed.2021.800973. PMID:35118094. IF:3,9 (Q2/4D). Document type: Article.
Nunez E, Fuster V, Gomez M, Valdivielso JM, Fernandez JM, Martinez D, Rodriguez JM, Bonzon E, Calvo E, Alfayate A, Bermudez M, Escola JC, Fernandez L, Cerro I, Mendiguren JM, Sanchez F, Sanz J, Ordovas JM, Blanco LM, Garcia JM, Ibanez B, Lara E, Fernandez A, Martin JL, Vazquez J. Unbiased plasma proteomics discovery of biomarkers for improved detection of subclinical atherosclerosis. 2022; 76:103874. DOI:10.1016/j.ebiom.2022.103874. PMID:35152150. IF:11,1 (Q1/1D). Document type: Article.
Puig C, Castelblanco E, Falguera M, Hernandez M, Soldevila B, Julian MT, Teis A, Julve J, Barranco M, Franch J, Puig M, Ortega E, Amigo N, Alonso N, Mauricio D. Advanced lipoprotein profile in individuals with normal and impaired glucose metabolism. REVISTA ESPANOLA DE CARDIOLOGIA. 2022; 75(1). DOI:10.1016/j.recesp.2021.02.013. PMID:33785266. IF:5,9 (Q1/3D). Document type: Article.
Revilla G,Moral A,Fuste V,Lerma E,Julve J,Escolà JC,Mato E,Pérez JI,Corcoy R,Paez EV. The role of ATP-binding cassette transporter genes in the metastatic process of epithelial thyroid carcinoma with aggressive behavior. En: Unraveling The Complexities Of Metastasis: Transition From A Segmented View To A Conceptual Continuum. Elsevier. 2022. p. 265-275. DOI: 10.1016/B978-0-12-821789-4.00020-5. Document type: Book chapter.
Rivas A, Rotllan N, Santos D, Julve J, Escolà JC, Sanchez JL. Assessment of Ex Vivo Antioxidative Potential of Murine HDL in Atherosclerosis. Methods In Molecular Biology. 2022; 2419DOI:10.1007/978-1-0716-1924-7_17. Document type: Book chapter.
Rivas A, Rotllan N, Santos D, Julve J, Sanchez JL, Escolà JC. Monitoring Atheroprotective Macrophage Cholesterol Efflux In Vivo. Methods In Molecular Biology. 2022; 2419. DOI:10.1007/978-1-0716-1924-7_35. Document type: Book chapter.
Roldan R, Perez JM, Cerro I, Oller J, Martinez D, Nunez E, Maller SM, Gutierrez C, Mendez N, Escola JC, Michel JB, Mittelbrunn M, Vazquez J, Blanco LM, Rabinovich GA, Martin JL. Galectin-1 prevents pathological vascular remodeling in atherosclerosis and abdominal aortic aneurysm. Science Advances. 2022; 8(11):eabm7322. DOI:10.1126/sciadv.abm7322. PMID:35294231. IF:13,6 (Q1/1D). Document type: Article.
Rotllan N, Zhang XB, Canfran A, Goedeke L, Grinan R, Ramirez CM, Suarez Y, Fernandez C. Antagonism of miR-148a attenuates atherosclerosis progression in APOB(TG )Apobec(-/-)Ldlr(+/-) mice: A brief report. BIOMEDICINE & PHARMACOTHERAPY. 2022; 153:113419. DOI:10.1016/j.biopha.2022.113419. PMID:36076541. IF:7,5 (Q1/1D). Document type: Article.
Rotllan N. The Underlying Pathology of Atherosclerosis: Different Players. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(6):3235. DOI:10.3390/ijms23063235. PMID:35328656. IF:5,6 (Q1/3D). Document type: Editorial material.
Teis A, Castelblanco E, Cediel G, Amigó N, Julve J, Ribalta J, Guardiola M, Franch J, Bermúdez M, Codina P, Lupón J, Mauricio D, Alonso N, Bayés A. (1)H-magnetic resonance spectroscopy lipoprotein profile in patients with chronic heart failure versus matched controls. REVISTA ESPANOLA DE CARDIOLOGIA. 2022; 75(11). DOI:10.1016/j.rec.2021.09.008. PMID:34716123. IF:5,9 (Q1/3D). Document type: Article.
Teis A, Castelblanco E, Cediel G, Amigó N, Julve J, Ribalta J, Guardiola M, Franch J, Bermúdez M, Codina P, Lupón J, Mauricio D, Alonso N, Bayés A. Perfil lipoproteico por espectroscopia nuclear magnética en pacientes con insuficiencia cardiaca crónica comparado con controles emparejados. REVISTA ESPANOLA DE CARDIOLOGIA. 2022; 75(11). DOI:10.1016/j.recesp.2021.09.007. IF:5,9 (Q1/3D). Document type: Article.

Publicaciones 2021

- Amaro AB, Curco AS, Garcia E, Julve J, Rives J, Benitez S, Cortes VL. Apolipoprotein and LRP1-Based Peptides as New Therapeutic Tools in Atherosclerosis. Journal of Clinical Medicine. 2021; 10(16):3571. DOI:10.3390/jcm10163571. PMID:34441867. IF:4,964.
- Arroyo JA, Julve J, Vlacho B, Corcoy R, Ponte P, Roman E, Navas E, Llaurado G, Franch J, Domingo P, Mauricio D. Previous Vitamin D Supplementation and Morbidity and Mortality Outcomes in People Hospitalised for COVID19: A Cross-Sectional Study. Frontiers in Public Health. 2021; 9:758347. DOI:10.3389/fpubh.2021.758347. PMID:34631653. IF:6,461.
- Bellido V, Perez A. COVID-19 and Diabetes. Journal of Clinical Medicine. 2021; 10(22):5341. DOI:10.3390/jcm10225341. PMID:34830623. IF:4,964.
- Bellido V, Perez A. Inpatient Hyperglycemia Management and COVID-19. Diabetes Therapy. 2021; 12(1):121-132. DOI: 10.1007/s13300-020-00966-z. PMID: 33278017. IF:3,595.
- Bonaterra A, Fernandez S, Rivas A, Puig N, Benitez S, Pancorbo O, Rodriguez D, Pujadas F, Freijo MD, Tur S, Martinez M, Portela PC, Vera R, Lebrato L, Arenillas JF, Perez S, Montaner J, Sanchez JL, Hernandez M. Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease. Biomedicines. 2021; 9(1):72. DOI:10.3390/biomedicines9010072. PMID:33445800. IF:4,757.
- Canyelles M, Garcia A, Junza A, Yanes O, Puig N, Ordonez J, Sionis A, Sans J, Alquezar A, Santos D, Rotllan N, Julve J, Tondo M, Escola JC, Blanco F. The Capacity of APOB-Depleted Plasma in Inducing ATP-Binding Cassette A1/G1-Mediated Macrophage Cholesterol Efflux-But Not Gut Microbial-Derived Metabolites-Is Independently Associated with Mortality in Patients with ST-Segment Elevation Myocardial Infarction. Biomedicines. 2021; 9(10):1336. DOI:10.3390/biomedicines9101336. PMID:34680453. IF:4,757.
- Carbo JM, Leon TE, Font J, De la Rosa JV, Castrillo A, Picard FR, Staudenraus D, Huber M, Cedo L, Escola JC, Campos L, Bakiri L, Wagner EF, Caelles C, Stratmann T, Van JA, Valledor AF. Pharmacologic Activation of LXR Alters the Expression Profile of Tumor-Associated Macrophages and the Abundance of Regulatory T Cells in the Tumor Microenvironment. CANCER RESEARCH. 2021; 81(4). DOI:10.1158/0008-5472.CAN-19-3360. PMID:33361391. IF:13,312.
- Castelblanco E, Hernandez M, Ortega E, Amigo N, Real J, Granado M, Minambres I, Lopez C, Lecube A, Bermudez M, Alonso N, Julve J, Mauricio D. Outstanding improvement of the advanced lipoprotein profile in subjects with new-onset type 1 diabetes mellitus after achieving optimal glycemic control. DIABETES RESEARCH AND CLINICAL PRACTICE. 2021; 182:109145. DOI:10.1016/j.diabres.2021.109145. PMID:34785302. IF:8,180.
- Chiva G, Pena E, Cubedo J, Garcia M, Pane A, Gil PA, Perez A, Ortega E, Padro T, Badimon L. Molecular mapping of platelet hyperreactivity in diabetes: the stress proteins complex HSPA8/Hsp90/CSK2 alpha and platelet aggregation in diabetic and normal platelets. Translational Research. 2021; 235. DOI:10.1016/j.trsl.2021.04.003. PMID:33887528. IF:10,171.
- Colom C, Rull A, Sanchez JL, Perez A. Cardiovascular Disease in Type 1 Diabetes Mellitus: Epidemiology and Management of Cardiovascular Risk. Journal of Clinical Medicine. 2021; 10(8):1798. DOI:10.3390/jcm10081798. PMID:33924265. IF:4,964.
- Daban F, Garcia-Subirats I, Porthe V, Lopez M, de-Eyto B, Pasarin MI, Borrell C, Artazcoz L, Perez A, Diez E. Improving mental health and wellbeing in elderly people isolated at home due to architectural barriers: A community health intervention. Atencion Primaria. 2021;53(5):102020. DOI:10.1016/j.aprim.2021.102020. PMID: 33774346. IF: 2,206.
- Delk SC, Chattopadhyay A, Escola JC, Fogelman AM, Reddy ST. Apolipoprotein mimetics in cancer. SEMINARS IN CANCER BIOLOGY. 2021; 73. DOI:10.1016/j.semcancer.2020.11.002. PMID:33188891. IF:17,012.
- Escola JC, Rotllan N, Julve J, Blanco F. Reverse Cholesterol Transport Dysfunction Is a Feature of Familial Hypercholesterolemia. Current Atherosclerosis Reports. 2021; 23(6):29. DOI:10.1007/s11883-021-00928-1. PMID:33914189. IF:5,967.
- Farras M, Almanza E, Hernaez A, Agusti N, Julve J, Fito M, Castaner O. Beneficial effects of olive oil and Mediterranean diet on cancer physio-pathology and incidence. SEMINARS IN CANCER BIOLOGY. 2021; 73. DOI:10.1016/j.semcancer.2020.11.011. PMID:33249203. IF:17,012.
- Fernandez ME, Daimiel L, Villa G, Pavon MV, Busto R, Escola JC, Platt FM, Lasuncion MA, Martinez J, Gomez D. Selective estrogen receptor modulators (SERMs) affect cholesterol homeostasis through the master regulators SREBP and LXR. BIOMEDICINE & PHARMACOTHERAPY. 2021; 141:111871. DOI:10.1016/j.biopha.2021.111871. PMID:34225017. IF:7,419.
- Fernandez S, Pedret A, Catalan U, Valls RM, Farras M, Rubio L, Castaner O, Macia A, Fito M, Motilva MJ, Covas MI, Giera M, Remaley AT, Sola R. Virgin Olive Oil Phenolic Compounds Modulate the HDL Lipidome in Hypercholesterolaemic Subjects: A Lipidomic Analysis of the VOHF Study. MOLECULAR NUTRITION & FOOD RESEARCH. 2021; 65(9):2001192. DOI:10.1002/mnfr.202001192. PMID:33561904. IF:6,575.
- Fuster VP, Perez AP, Gomez JC, Pedragos AC, Gomez R, Perez P. Executive summary: Updates to the dietary treatment of prediabetes and type 2 diabetes mellitus. Endocrinologia Diabetes y Nutricion. 2021; 68(4). DOI:10.1016/j.endinu.2020.10.009. PMID:33593709. IF:1,833.
- Genua I, Puig N, Minambres I, Benitez S, Gil P, Grau M, Rivas A, Balague C, Fernandez S, Garcia A, Perez A, Sanchez JL. Changes in the Composition and Function of Lipoproteins after Bariatric Surgery in Patients with Severe Obesity. Journal of Clinical Medicine. 2021; 10(8):1716. DOI:10.3390/jcm10081716. PMID:33923393. IF:4,964.
- Genua I, Tuneu L, Ramos A, Stantonyonge N, Caimari F, Balague C, Fernandez-Ananin S, Sanchez-Quesada JL, Perez A, Miñambres I. Effectiveness of Bariatric Surgery in Patients with the Metabolically Healthy Obese Phenotype. OBESITY SURGERY. 2021;31(2):517-522. DOI:10.1007/s11695-020-04967-6. PMID: 32915359. IF:3,479.
- Gimeno JA, Rodriguez L, Anguita M, Barrios V, Muniz J, Perez A. Association of the KDIGO Risk Classification with the Prevalence of Heart Failure in Patients with Type 2 Diabetes. Journal of Clinical Medicine. 2021; 10(20):4634. DOI:10.3390/jcm10204634. PMID:34682756. IF:4,964.
- Goedeke L, Canfran A, Rotllan N, Chaube B, Thompson BM, Lee RG, Cline GW, McDonald JG, Shulman GI, Lasuncion MA, Suarez Y, Fernandez C. MMAB promotes negative feedback control of cholesterol homeostasis. Nature Communications. 2021; 12(1):6448. DOI:10.1038/s41467-021-26787-7. PMID:34750386. IF:17,694.
- Granado M, Martinez D, Martinez M, Doria M, Alcubierre N, Valls J, Julve J, Verdu J, Mauricio D. Psychometric Validation of the Cardiff Wound Impact Schedule Questionnaire in a Spanish Population with Diabetic Foot Ulcer. Journal of Clinical Medicine. 2021; 10(17):4023. DOI:10.3390/jcm10174023. PMID:34501471. IF:4,964.
- Julián MT, Pera G, Soldevila B, Caballería L, Julve J, Puig C, Morillas R, Torán P, Expósito C, Puig M, Castelblanco E, Franch J, Cusi K, Mauricio D, Alonso N. Atherogenic dyslipidemia, but not hyperglycemia, is an independent factor associated with liver fibrosis in subjects with type 2 diabetes and NAFLD: A population-based study. EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2021; 184(4). DOI:10.1530/EJE-20-1240. PMID:33606661. IF:6,558.
- Mendez KA, Rodriguez E, Sebastian D, Blanco R, Camacho M, Nan MN, Diarte E, Mato E, Lope S, Roglans N, Laguna JC, Alonso N, Mauricio D, Zorzano A, Villarroya F, Villena JA, Blanco F, Julve J. Nicotinamide Protects Against Diet-Induced Body Weight Gain, Increases Energy Expenditure, and Induces White Adipose Tissue Beiging. MOLECULAR NUTRITION & FOOD RESEARCH. 2021; 65(11):2100111. DOI:10.1002/mnfr.202100111. PMID:33870623. IF:6,575.
- Minambres I, Sanchez J, Cuixart G, Sanchez A, Sarroca J, Perez A. Characterization of the hypertriglyceridemic waist phenotype in patients with type 2 diabetes mellitus in Spain: an epidemiological study. REVISTA CLINICA ESPANOLA. 2021; 221(10). PMID:34839890. IF:3,064.
- Nan MN, Roig R, Martinez S, Rives J, Urgell E, Espinos JJ, Tirado M, Carreras G, Aulinas A, Webb SM, Corcoy R, Blanco F, Tondo M. Comprehensive Genetic Testing of CYP21A2: A Retrospective Analysis in Patients with Suspected Congenital Adrenal Hyperplasia. Journal of Clinical Medicine. 2021; 10(6):1183. DOI:10.3390/jcm10061183. PMID:33809035. IF:4,964.
- Oyaguez I, Gomez F, Artola S, Carrasco FJ, Carretero J, Garcia J, Gomez R, Merino JF, Perez A. Cost Analysis of FreeStyle Libre(R) 2 System in Type 2 Diabetes Mellitus Population. Diabetes Therapy. 2021; 12(9). DOI:10.1007/s13300-021-01064-4. PMID:33948909. IF:6,706.
- Papotti B, Escola JC, Julve J, Poti F, Zanotti I. Impact of Dietary Lipids on the Reverse Cholesterol Transport: What We Learned from Animal Studies. Nutrients. 2021; 13(8):2643. DOI:10.3390/nu13082643. PMID:34444804. IF:6,706.
- Revilla G, Cedo L, Tondo M, Moral A, Perez JI, Corcoy R, Lerma E, Fuste V, Reddy TS, Blanco F, Mato E, Escola JC. LDL, HDL and endocrine-related cancer: From pathogenic mechanisms to therapies. SEMINARS IN CANCER BIOLOGY. 2021; 73. DOI:10.1016/j.semcancer.2020.11.012. PMID:33249202. IF:17,012.
- Ribo S, Sanchez D, Martinez L, Garcia I, Ramon M, Tondo M, Arning E, Nofrarias M, Osorio O, Fernandez A, Gonzalez P, Cebria J, Gavalda A, Chenoll E, Isganaitis E, Villarroya F, Vallejo M, Segales J, Jimenez JC, Bottiglieri T, Demerath EW, Fields DA, Collado MC, Lerin C. Increasing breast milk betaine modulates Akkermansia abundance in mammalian neonates and improves long-term metabolic health. Science Translational Medicine. 2021; 13(587):eabb0322. DOI:10.1126/scitranslmed.abb0322. PMID:33790021. IF:19,319.
- Rodriguez J, Cerro I, Lindholt JS, Bonzon E, Martinez D, Roldan R, Escola JC, Michel JB, Blanco LM, Vazquez J, Suraez A, Martin JL. Malondialdehyde-modified HDL particles elicit a specific IgG response in abdominal aortic aneurysm. FREE RADICAL BIOLOGY AND MEDICINE. 2021; 174. DOI:10.1016/j.freeradbiomed.2021.08.004. PMID:34364980. IF:8,101.
- Rojo MI, Castelblanco E, Real J, Hernandez M, Falguera M, Amigo N, Julve J, Alonso N, Franch J, Granado M, Mauricio D. Advanced Quantitative Lipoprotein Characteristics Do Not Relate to Healthy Dietary Patterns in Adults from a Mediterranean Area. Nutrients. 2021; 13(12):4369. DOI:10.3390/nu13124369. PMID:34959921. IF:6,706.
- Rotllan N, Camacho M, Tondo M, Diarte E, Canyelles M, Mendez KA, Benitez S, Alonso N, Mauricio D, Escola JC, Blanco F, Julve J. Therapeutic Potential of Emerging NAD plus -Increasing Strategies for Cardiovascular Diseases. Antioxidants. 2021; 10(12):1939. DOI:10.3390/antiox10121939. IF:7,675.
- Singh AK, Chaube B, Zhang XB, Sun J, Citrin KM, Canfran A, Aryal B, Rotllan N, Varela L, Lee RG, Horvath TL, Price NL, Suarez Y, Fernandez C. Hepatocyte-specific suppression of ANGPTL4 improves obesity-associated diabetes and mitigates atherosclerosis in mice. JOURNAL OF CLINICAL INVESTIGATION. 2021; 131(17):e140989. DOI:10.1172/JCI140989. PMID:34255741. IF:19,456.
- Teis A, Cediel G, Amigo N, Julve J, Aranyo J, Andres J, Puig C, Castelblanco E, Gual F, Ferrer E, Vallejo N, Junca G, Lopez J, De Antonio M, Domingo M, Santiago E, Codina P, Mauricio D, Lupon J, Alonso N, Bayes A. Particle size and cholesterol content of circulating HDL correlate with cardiovascular death in chronic heart failure. Scientific Reports. 2021; 11(1):3141. DOI:10.1038/s41598-021-82861-6. PMID:33542459. IF:4,996.
- Uribe KB, Benito A, Martin C, Blanco F, Rotllan N. (r)HDL in theranostics: how do we apply HDL’s biology for precision medicine in atherosclerosis management?dagger. Biomaterials Science. 2021; 9(9). DOI:10.1039/d0bm01838d. PMID:33949389. IF:7,590.

ENFERMEDADES CARDIOVASCULARES

Fisiopatología de las enfermedades caracterizadas por alteraciones lipídicas

Resumen

Principales líneas de Investigación e Innovación

Metabolismeo de las lipoproteínas i riesgo cardiovascular

Diagnóstico y caracterización molecular de trastornos metabólicos

Biomarcadores en enfermedades neurodegenerativas (línea emergente)

Retos

Coordinación del grupo

Miembros

Publicaciones 2024

Publicaciones 2023

Publicaciones 2022

Publicaciones 2021

Memoria científica

Artículos destacados

Proyectos y contractos competitivos activos

Página web y redes sociales

Resumen

Principales líneas de Investigación e Innovación

Metabolismeo de las lipoproteínas i riesgo cardiovascular

Diagnóstico y caracterización molecular de trastornos metabólicos

Biomarcadores en enfermedades neurodegenerativas (línea emergente)

Retos

Coordinación del grupo

Miembros

Publicaciones 2024

Publicaciones 2023

Publicaciones 2022

Publicaciones 2021

Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau