GENETIC, METABOLIC AND INFLAMMATORY DISEASES

Inflammatory Diseases

Main lines of research

  • The role of the natural immune system in the development of autoimmune and inflammatory processes.
  • Immunological response and clinical course in immunomodulator treatment.
  • The role of autoantibodies, components of the adaptive immunity system, in the athogenesis of autoimmune processes and their use as diagnostic and prognostic markers in these diseases.
  • Mechanisms involved in immunodeficiency.
  • Study of lymphocyte subpopulations involved in chronic graft rejection in cardiac posttransplant patients.

Challenges

  • Role of cells and molecules of the innate immune response in the development and control of inflammatory processes, in the appearance of autoimmune phenomena, immunodeficiencies, infections, cardiovascular diseases and development of tumours.
  • Role of TLR and STAT signalling in inflammatory diseases.
  • Involvement of STAT family of transcription factors in response to superantigens.
  • Study of mechanisms involved in immunodeficiency caused by alterations of the CD8a molecule.
  • Role of perivascular adipocytes and TLR signalling pathways in the development of atherosclerosis.
  • Inflammation and rejection in heart transplantation.
  • Effects of immunobiological treatments on immunological variables.
  • Analysis of the evolution of immunological parameters and their correlation with clinical response to treatment with immunomodulators.
  • Effects of rituximab, tocilizamab and adalimumab in immunological variables and their correlation with the clinical response in patients with inflammatory diseases.

This website uses cookies to improve the browsing experience and perform analytical tasks. If you continue browsing, we understand that you agree our cookies policy. More information