CARDIOVASCULAR DISEASES

Molecular Pathology and Therapeutic of Ischaemic and Atherothrombotic Diseases

Main lines of research

  • Physiopathological role of LRP family proteins
    in chronic diseases.
  • Identification and characterization of transcription factors and genetic targets. Role of lipids and inflammation.
  • Vascular impact of ischaemia and angiogenesis in heart disease. Cell therapy.
  • Research into new targets to inhibit the transformation of silent atherosclerosis into ischaemic syndromes: tissue-factormediated angiogenic switch.

Challenges

  • Broaden the experimental focus to include transgenic animal models with/without cardiovascular risk factors in order to proceed to in-depth analysis of molecules involved in the modulation of new proteins identified by post-genomic technologies and systems biology approaches.
  • Maintain present scientific networks and establish new multidisciplinary collaborations.
  • Increase international funding for the extension of new and established platforms in order to implement proposed activities.

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