Sant Pau - Institut de Recerca

Molecular and cellular analyses of the vertebrate synapse.
Molecular and cellular dysfunctions underlying intellectual disability and autism.
Research into animal models of mental and behavioural disorders.
Development of new biochemical methods to study the synapse.

Characterize the molecular roots of cognition and behaviour.
Identify the synaptic molecules and mechanisms involved in mental and behavioural disorders, mainly intellectual disabilities and autism spectrum disorders.
Identify drugs which might help treat mental and behavioural disorders.
Study the reversibility after birth of neurodevelopmental disorders affecting cognition.

BAYES PUIG, ALEJANDRO IR
abayesp@santpau.cat

Del Castillo Berges, Diego IR
Viñola Renart, Carla IR

(JIF 2022)

Kilinc M, Arora V, Creson TK, Rojas C, Le AA, Lauterborn J, Wilkinson B, Hartel N, Graham N, Reich A, Gou G, Araki Y, ALEX B, Coba M, Lynch G, Miller CA, Rumbaugh G. Endogenous Syngap1 alpha splice forms promote cognitive function and seizure protection. eLife. 2022; 11:e75707. DOI:10.7554/eLife.75707. PMID:35394425. IF:7,7 (Q1/1D). Document type: Article.
Trubetskoy V, Pardiñas AF, Qi T, Panagiotaropoulou G, Awasthi S, Bigdeli TB, Chen C-Y, Dennison CA, Hall LS, Lam M, Watanabe K, Frei O, Ge T, Harwood JC, Magnusson S, Richards AL, Sidorenko J, Wu Y, Zeng J, Grove J, Kim M, Li Z, Voloudakis G, Zhang W, Adams M, Agartz I, Atkinson EG, Agerbo E, Al Eissa M, Albus M, Alexander M, Alizadeh BZ, Alptekin K, Als TD, et al. [Bayés A]. Mapping genomic loci implicates genes and synaptic biology in schizophrenia. NATURE. 2022; 604(7906). DOI:10.1038/s41586-022-04434-5. PMID:35396580. IF:64,8 (Q1/1D). Document type: Article.

Cazurro A, Marce A, Correa M, Salazar A, Vanegas MI, Macaya A, Alex B, Perez B. epsilon-Sarcoglycan: Unraveling the Myoclonus-Dystonia Gene. MOLECULAR NEUROBIOLOGY. 2021; 58(8). DOI:10.1007/s12035-021-02391-0. PMID:33886091. IF:5,682.
Cid E, Marquez A, Valero M, Gal B, Medeiros DC, Navarron CM, Ballesteros L, Reig R, Morales AV, Fernandez I, Gomez D, Sato M, Hayashi Y, Alex B, Barco A, Lopez JP, de la Prida LM. Sublayer- and cell-type-specific neurodegenerative transcriptional trajectories in hippocampal sclerosis. Cell Reports. 2021; 35(10):109229. DOI:10.1016/j.celrep.2021.109229. PMID:34107264. IF:9,995.
Ramos D, Grant SGN, Alex B. Metazoan evolution and diversity of glutamate receptors and their auxiliary subunits. NEUROPHARMACOLOGY. 2021; 195:108640. DOI:10.1016/j.neuropharm.2021.108640. PMID:34116111. IF:5,273.
Watkins JC, Evans RH, Alex B, Booker SA, Gibb A, Mabb AM, Mayer M, Mellor JR, Molnar E, Niu L, Ortega A, Pankratov Y, Ramos D, Rodriguez A, Rodriguez A, Wang LY, Wang YT, Wollmuth L, Wyllie D, Zhuo M, Frenguelli BG. 21st century excitatory amino acid research: A Q & A with Jeff Watkins and Dick Evans. NEUROPHARMACOLOGY. 2021; 198:108743. DOI:10.1016/j.neuropharm.2021.108743. PMID:34363811. IF:5,273.

New schedule for 2016/17 academic year comming soon!!

Introduction

Molecular and cellular analyses of the vertebrate synapse.
Molecular and cellular dysfunctions underlying intellectual disability and autism.
Research into animal models of mental and behavioural disorders.
Development of new biochemical methods to study the synapse.

Characterize the molecular roots of cognition and behaviour.
Identify the synaptic molecules and mechanisms involved in mental and behavioural disorders, mainly intellectual disabilities and autism spectrum disorders.
Identify drugs which might help treat mental and behavioural disorders.
Study the reversibility after birth of neurodevelopmental disorders affecting cognition.

Team

BAYES PUIG, ALEJANDRO IR
abayesp@santpau.cat

Del Castillo Berges, Diego IR
Viñola Renart, Carla IR

Scientific output

(JIF 2022)

Kilinc M, Arora V, Creson TK, Rojas C, Le AA, Lauterborn J, Wilkinson B, Hartel N, Graham N, Reich A, Gou G, Araki Y, ALEX B, Coba M, Lynch G, Miller CA, Rumbaugh G. Endogenous Syngap1 alpha splice forms promote cognitive function and seizure protection. eLife. 2022; 11:e75707. DOI:10.7554/eLife.75707. PMID:35394425. IF:7,7 (Q1/1D). Document type: Article.
Trubetskoy V, Pardiñas AF, Qi T, Panagiotaropoulou G, Awasthi S, Bigdeli TB, Chen C-Y, Dennison CA, Hall LS, Lam M, Watanabe K, Frei O, Ge T, Harwood JC, Magnusson S, Richards AL, Sidorenko J, Wu Y, Zeng J, Grove J, Kim M, Li Z, Voloudakis G, Zhang W, Adams M, Agartz I, Atkinson EG, Agerbo E, Al Eissa M, Albus M, Alexander M, Alizadeh BZ, Alptekin K, Als TD, et al. [Bayés A]. Mapping genomic loci implicates genes and synaptic biology in schizophrenia. NATURE. 2022; 604(7906). DOI:10.1038/s41586-022-04434-5. PMID:35396580. IF:64,8 (Q1/1D). Document type: Article.

Cazurro A, Marce A, Correa M, Salazar A, Vanegas MI, Macaya A, Alex B, Perez B. epsilon-Sarcoglycan: Unraveling the Myoclonus-Dystonia Gene. MOLECULAR NEUROBIOLOGY. 2021; 58(8). DOI:10.1007/s12035-021-02391-0. PMID:33886091. IF:5,682.
Cid E, Marquez A, Valero M, Gal B, Medeiros DC, Navarron CM, Ballesteros L, Reig R, Morales AV, Fernandez I, Gomez D, Sato M, Hayashi Y, Alex B, Barco A, Lopez JP, de la Prida LM. Sublayer- and cell-type-specific neurodegenerative transcriptional trajectories in hippocampal sclerosis. Cell Reports. 2021; 35(10):109229. DOI:10.1016/j.celrep.2021.109229. PMID:34107264. IF:9,995.
Ramos D, Grant SGN, Alex B. Metazoan evolution and diversity of glutamate receptors and their auxiliary subunits. NEUROPHARMACOLOGY. 2021; 195:108640. DOI:10.1016/j.neuropharm.2021.108640. PMID:34116111. IF:5,273.
Watkins JC, Evans RH, Alex B, Booker SA, Gibb A, Mabb AM, Mayer M, Mellor JR, Molnar E, Niu L, Ortega A, Pankratov Y, Ramos D, Rodriguez A, Rodriguez A, Wang LY, Wang YT, Wollmuth L, Wyllie D, Zhuo M, Frenguelli BG. 21st century excitatory amino acid research: A Q & A with Jeff Watkins and Dick Evans. NEUROPHARMACOLOGY. 2021; 198:108743. DOI:10.1016/j.neuropharm.2021.108743. PMID:34363811. IF:5,273.

NEUROLOGICAL DISEASES, NEUROSCIENCE & MENTAL HEALTH