Mitochondrial antioxidants have a beneficial effect on metabolic alterations associated with obesity such as weight gain and insulin resistance, and may have consequences on heart function, according to researchers from the CIBER Cardiovascular Diseases (CIBERCV) of different research groups such as “Mechanisms regulating cardiovascular remodeling” coordinated by Dra. Cristina Rodríguez from the Research Institute of the Hospital de Sant Pau- IIB Sant Pau; researchers from the Universidad Complutense de Madrid-Instituto de Investigación Sanitaria Gregorio Marañón; from the Instituto de Investigaciones Biomédicas de Barcelona (IIBB-CSIC) and from the Instituto de Biología y Genética Molecular (IBGM-CSIC / UV).
In this work col – elaborated, published in the FASEB Journal, the interest of developing antioxidant drugs aimed at blocking mitochondrial oxidative stress for the improvement of metabolic alterations observed in obese patients is emphasized. Therefore, the role of oxidative stress in metabolic alterations has been evaluated in rats, fed a diet high in fat or low for 7 weeks that were treated with MitoQ, a mitochondrial antioxidant, and also the mitochondrial protein profile of visceral adipose tissue of obese patients has been analyzed.
Link to the reference article:
The role of Mitochondrial oxidative stress in the Metabolic alteration in diet-induced Obesity in rats
Gemma Marín-Royo, Cristina Rodríguez, Aliaume Le Pape, Raquel Jurado-López, María Luaces, Alfonso Antequera, José Martínez-González, Francisco V Souza-Net, María Luisa Nieto, Ernesto Martínez-Martínez, Victoria Cachofeiro.