Sant Pau - Institut de Recerca

Main Lines of Research

Molecular Pathology of Gynaecologic Cancer

Pathogenic mechanisms of gynaecological cancer (endometrial/ovarian cancer).
Molecular mechanisms of stromal response and immunosuppression in endometrial cancer.
Clinical application of prognostic factors in common cancers (endometrial, ovarian, etc).
Clinical application of tumour markers.
Molecular biology of uterine and extra-uterine sarcomas.

Pathology of Lung Tumors

Challenges

Progress as a productive translational gynaecological cancer research group, capable of competing with other highly visible groups in Barcelona that publish regular articles in reputable journals.
Cooperate with other groups at the national and international levels.

Group coordination

PIJUAN ANDUJAR, LARA FGS
lpijuan@santpau.cat

Members

Anglas Garcia, Anna FGS
Bague Rosell, Silvia FGS
Cabanas Llado, Mariona FGS
Campazas Herrera, Irma FGS
Catasus Cols, Lluis FGS
Chabla Jaramillo, Julio Fabriccio FGS
Clua Gonzalez, Agustin FGS
Di Muro, Antonietta FGS
Diaz Sanchez, Lorena FGS
Espadaler Fabrego, Ignasi FGS
Espinosa Mariscal, Iñigo FGS
Ferre Figa, Malena FGS
Fumagalli, Caterina FGS
Fuste Chimisana, Victoria FGS
Gallardo Alcañiz, Alberto FGS
Gonzalez Vidal, Alan FGS
Gutierrez Montalban, Raquel FGS
Lopez Vilaro, Laura FGS
Manzotti, Carolina FGS
Martinez Montolla, Daniel FGS
Mozos Rocafort, Ana FGS
Noguero Dominguez, Blanca FGS
Orellana Fernandez, Ruth Joaquina FGS
Restrepo Arango, Sara M. FGS
Scevola Metralle, Sofia C. FGS
Serrat Clavijos, Meritxell FGS
Szafranska, Justyna FGS
Vazquez Del Olmo, Tania FGS

Publications 2024

(JIF 2024)

-Aibar JA, Salgado L, Anka MO, Mirapeix RM, Alcañiz AG, Alvarado JDP, Pereira MR, Rodríguez RR, Munoz F, Quintana CD. Navigated intraoperative ultrasound in neuro-oncology: volumetric accuracy and correlation with high-field MRI. JOURNAL OF NEUROSURGERY. 2024; 141(1). DOI:10.3171/2023.10.JNS231244. PMID:38181499. IF:3,600 (Q1/2D). Document type: Article.

-Alvarado E, Martí D, Gómez C, Ferrero A, Szafranska J, Brujats A, Osuna R, Guinart A, Alfaro C, Pose E, Ventura M, Clemente A, Fernández C, Contreras C, Cabezas J, López H, Arab J, Argemi J, Bataller R. Binge drinking at time of bariatric surgery is associated with liver disease, suicides, and increases long-term mortality. Hepatology Communications. 2024; 8(8):e0490. DOI:10.1097/HC9.0000000000000490. IF:4,600 (Q1/2D). Document type: Article.

-Arqueros C, Gallardo A, Vidal S, Osuna R, Tibau A, Bell OL, Cajal T, Lerma E, Lobato B, Salazar J, Barnadas A. Clinical Relevance of Tumour-Infiltrating Immune Cells in HER2-Negative Breast Cancer Treated with Neoadjuvant Therapy. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024; 25(5):2627. DOI:10.3390/ijms25052627. PMID:38473874. IF:4,900 (Q1/3D). Document type: Article.

-Barba A, López L, Ferre M, Majem M, Martinez S, Bell O, Arranz MJ, Salazar J, Sullivan I. ERCC1 and ERCC2 Polymorphisms Predict the Efficacy and Toxicity of Platinum-Based Chemotherapy in Small Cell Lung Cancer. Pharmaceutics. 2024; 16(9):1121. DOI:10.3390/pharmaceutics16091121. PMID:39339159. IF:5,500 (Q1/1D). Document type: Article.

-Carmona E, Rusiñol L, Garcia C, Iznardo H, Mozos A, López C, Yélamos O. Lentigo maligna: a comprehensive review on diagnosis and treatment. Italian Journal of Dermatology and Venereology. 2024; 159(4). DOI:10.23736/S2784-8671.24.07837-X. PMID:39069838. IF:2,600 (Q2/4D). Document type: Review.

-Carrillo J, Hindi N, Conceicao M, Sala MA, Ugalde A, López A, Bagué S, Sevilla I, Vicioso L, Ramos R, Martínez J, Mateo MCG, Cruz J, Hernández CN, Redondo A, Mendiola M, García JM, Hernández JE, Alvarez R, Agra C, de Juan A, Valverde C, Cano JM, de Sande LM, Pérez JA, Lavernia J, Marcilla D, Gutiérrez A, Moura DS, Martín J. Prognostic impact of tumor location and gene expression profile in sporadic desmoid tumor. EUROPEAN JOURNAL OF CANCER. 2024; 209:114270. DOI:10.1016/j.ejca.2024.114270. PMID:39142211. IF:7,100 (Q1/2D). Document type: Article.

-Conde E, Hernandez S, Carrillo JLR, Martinez R, Alonso M, Curto D, Jimenez B, Caminoa A, Benito A, Garrido P, Clave S, Arriola E, Esteban I, De Castro J, Sansano I, Felip E, Rojo F, Dómine M, Abdulkader I, Garcia J, Teixido C, Reguart N, Compañ D, Insa A, Mancheño N, Palanca S, Juan O, Baixeras N, Nadal E, Cebollero M, Calles A, Martin P, Salas C, Provencio M, Aranda I, Massuti B, Lopez L, Majem M, Paz L, Lopez F. RET Fusion Testing in Patients With NSCLC: The RETING Study. Jto Clinical And Research Reports. 2024; 5(4):100653. DOI:10.1016/j.jtocrr.2024.100653. PMID:38525319. IF:3,500 (Q1/3D). Document type: Article.

-Escuin D, Bell O, García B, Clos M, Larrañaga I, López L, Mora J, Andrés M, Arqueros C, Barnadas A. Small Non-Coding RNAs and Their Role in Locoregional Metastasis and Outcomes in Early-Stage Breast Cancer Patients. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024; 25(7):3982. DOI:10.3390/ijms25073982. PMID:38612790. IF:4,900 (Q1/3D). Document type: Article.

-Espinosa I, D’Angelo E, Prat J. Endometrial carcinoma: 10 years of TCGA (the cancer genome atlas): A critical reappraisal with comments on FIGO 2023 staging. GYNECOLOGIC ONCOLOGY. 2024; 186DOI:10.1016/j.ygyno.2024.04.008. PMID:38615479. IF:4,100 (Q1/1D). Document type: Article.

-Feltrer-Martínez L, Orozco S, Alonso A, Millan-Billi P, Barril S, Ruibal G, Francesqui J, Lobo-Prat D, Gimenez A, Lopez L, Martinez-Martinez L, Castellvi I, Castillo D. Older Patients With Interstitial Lung Disease Feature a Distinct Clinical Profile. Open Respir Arch. 2024; 6(4):100374. DOI:10.1016/j.opresp.2024.100374. PMID:39697831. Document type: Article.

-Gras-Cabrerizo JR, Martel-Martin M, Casasayas-Plass M, Kolanczak K, Lopez-Vilaró L, Szafranska J, Massegur-Solench H, León-Vintró X. Surgical treatment of 186 sinonasal inverted papillomas and analysis of the immunohistochemical and molecular features associated with recurrences. Am J Otolaryngol. 2024; 45(2):104129. DOI:10.1016/j.amjoto.2023.104129. PMID:38070378. IF:1,700 (Q2/4D). Document type: Article.

-Gronchi A, Palmerini E, Quagliuolo V, Broto JM, Pousa AL, Grignani G, Brunello A, Blay JY, Tendero O, Beveridge RD, Ferraresi V, Lugowska I, Pizzamiglio S, Verderio P, Fontana V, Donati DM, Palassini E, Sanfilippo R, Bianchi G, Bertuzzi A, Morosi C, Pasquali S, Stacchiotti S, Bagué S, Coindre JM, Miceli R, Dei AP, Casali PG. Neoadjuvant Chemotherapy in High-Grade Myxoid Liposarcoma: Results of the Expanded Cohort of a Randomized Trial From Italian (ISG), Spanish (GEIS), French (FSG), and Polish Sarcoma Groups (PSG). JOURNAL OF CLINICAL ONCOLOGY. 2024; 42(8). DOI:10.1200/JCO.23.00908. PMID:38232337. IF:41,900 (Q1/1D). Document type: Article.

-Mármol MCC, Aguado M, Cajal TRY, Gallardo A, Catasus L, Gonzalez A, Mendez JE, Lasa A, Arumi M, Rubio OG, Serra JB, Hernandez FM, von A, Kommoss FKF, Espinosa I. Non-C19MC-altered embryonal tumor with multilayered rosettes in a young woman with DICER1 syndrome: case report and review of the literature. Pathologica. 2024; 116(3). DOI:10.32074/1591-951X-970. PMID:38979591. IF:2,900 (Q2/4D). Document type: Review.

-Martín B, Virgili AC, Riera P, Fumagalli C, Mirallas O, Pelegrín FJ, Sánchez S, Molina V, Szafranska J, Páez D. Histopathological, Clinical, And Molecular (HICAM) score for patients with colorectal liver metastases. BRITISH JOURNAL OF SURGERY. 2024; 111(3):znae016. DOI:10.1093/bjs/znae016. PMID:38488528. IF:8,800 (Q1/1D). Document type: Article.

-Moura DS, Mondaza JL, Sanchez P, Peña M, Cordero JA, Lopez M, Carrillo J, Martin M, Romero P, Renshaw M, Ramos R, Marcilla D, Alvarez R, Agra C, Izquierdo F, Ortega L, Martin F, Hernandez CN, Romagosa C, Salgado M, Lavernia J, Bagué S, Mayodormo E, Alvarez R, Valverde C, Martinez J, Castilla C, Gutierrez A, Dopazo J, Hindi N, Garcia J, Martin J. HMGA1 regulates trabectedin sensitivity in advanced soft-tissue sarcoma (STS): A Spanish Group for Research on Sarcomas (GEIS) study. CELLULAR AND MOLECULAR LIFE SCIENCES. 2024; 81(1):219. DOI:10.1007/s00018-024-05250-y. PMID:38758230. IF:6,200 (Q1/2D). Document type: Article.

-Pasquali S, Vallacchi V, Lalli L, Collini P, Barisella M, Romagosa C, Bague S, Coindre JM, Dei AP, Palmerini E, Quagliuolo V, Martin J, Lopez A, Grignani G, Blay JY, Beveridge RD, Casiraghi E, Brich S, Renne SL, Bergamaschi L, Vergani B, Sbaraglia M, Casali PG, Rivoltini L, Stacchiotti S, Gronchi A. Spatial distribution of tumour immune in fi ltrate predicts outcomes of patients with high-risk soft tissue sarcomas after neoadjuvant chemotherapy. EBioMedicine. 2024; 106:105220. DOI:10.1016/j.ebiom.2024.105220. PMID:39018755. IF:10,800 (Q1/1D). Document type: Article.

-Virgili AC, Salazar J, Gallardo A, López A, Terés R, Bagué S, Orellana R, Fumagalli C, Mangues R, Alba L, Unzueta U, Casanova I, Sebio A. CXCR4 Expression as a Prognostic Biomarker in Soft Tissue Sarcomas. Diagnostics. 2024; 14(11):1195. DOI:10.3390/diagnostics14111195. PMID:38893721. IF:3,300 (Q1/2D). Document type: Article.

Publications 2023

(JIF 2023)

-Álamo P, Parladé E, Favaro MTP, Gallardo A, Mendoza R, Ferreira LCS, Roher N, Mangues R, Villaverde A, Vázquez E. Probing the Biosafety of Implantable Artificial Secretory Granules for the Sustained Release of Bioactive Proteins. ACS Applied Materials & Interfaces. 2023; 15(33). DOI:10.1021/acsami.3c08643. PMID:37614001. IF:8,500 (Q1/2D). Document type: Article.

-Álvarez Álvarez R, Manzano A, Agra Pujol C, Artigas Raventós V, Correa R, Cruz Jurado J, Fernandez JA, Garcia Del Muro X, Gonzalez JA, Hindi N, Lozano Lominchar P, Martínez-Trufero J, Méndez R, Muñoz M, Muñoz Casares C, Orbis Castellanos F, Orellana Fernandez R, Paniagua González M, Redondo A, Valverde Morales C, Asencio JM. Updated Review and Clinical Recommendations for the Diagnosis and Treatment of Patients with Retroperitoneal Sarcoma by the Spanish Sarcoma Research Group (GEIS). Cancers. 2023; 15(12):3194. DOI: 10.3390/cancers15123194. PMID: 37370803. IF:4,500 (Q1/3D). Document type: Review.

-Álvarez R, Dols O, El Bounasri S, López L, Trujillo JC, Reyes D, Suárez X, Cortés E, Illa I, Gallardo E. Reduced Number of Thymoma CTLA4-Positive Cells Is Associated With a Higher Probability of Developing Myasthenia Gravis. Neurology-Neuroimmunology & Neuroinflammation. 2023; 10(2):e200085. DOI:10.1212/NXI.0000000000200085. PMID:36697230. IF:8,300 (Q1/1D). Document type: Article.

-Arqueros C, Salazar J, Gallardo A, Andrés M, Tibau A, Bell OL, Artigas A, Lasa A, Cajal T, Lerma E, Barnadas A. Secreted Protein Acidic and Rich in Cysteine (SPARC) Polymorphisms in Response to Neoadjuvant Chemotherapy in HER2-Negative Breast Cancer Patients. Biomedicines. 2023; 11(12):3231. DOI:10.3390/biomedicines11123231. PMID:38137452. IF:3,900 (Q1/3D). Document type: Article.

-Barca EG, Tomas L, Esteve A, Rodriguez M, Gato L, Alonso R, Garcia AM, Cordoba R, Monter A, Bastos M, Burgues JMB, Sayas MJ, Alegria MCV, Sanchez JJ, Pellicer MR, Henriquez HDL, de Ona R, Cabezudo ME, Infante MS, Hernandez J, Sanz R, Blanco O, Mozos A, Climent F, Piris MA. Extranodal natural killer/T-cell lymphoma nasal type in a western population: Molecular profiling identifies new therapeutic targets. AMERICAN JOURNAL OF HEMATOLOGY. 2023; 98(6):E134-E138. DOI:10.1002/ajh.26904. PMID:36882876. IF:10,100 (Q1/1D). Document type: Letter.

-Barrabes C, Arandes J, Armillas L, Posada RA, Koptseva I, Fumagalli C, Pinol D, Salleras M. Sarcomatoid transformation of a basal cell carcinoma following treatment with hedgehog inhibitors. BRITISH JOURNAL OF DERMATOLOGY. 2023; 189(4). DOI:10.1093/bjd/ljad206. PMID:37378960. IF:11,000 (Q1/1D). Document type: Letter.

-Carmona E, Aguado M, Tubau C, Sánchez S, Mozos A, Sullivan I, Spertino J. Epidermolysis bullosa acquisita induced by atezolizumab. JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT. 2023; DOI:10.1111/ddg.15203. PMID:37658659. IF:5,500 (Q1/1D). Document type: Letter.

-Cosio BG, Shafiek H, Iglesias A, Mosteiro M, Gonzalez A, Rodríguez M, García M, Busto E, Martin J, Mejías L, Benito A, López L, Gómez C. Validation of a Pathological Score for the Assessment of Bronchial Biopsies in Severe Uncontrolled Asthma: Beyond Blood Eosinophils. ARCHIVOS DE BRONCONEUMOLOGIA. 2023; 59(8). DOI:10.1016/j.arbres.2023.05.014. PMID:37414638. IF:8,700 (Q1/1D). Document type: Article.

-D’Angelo E, Espinosa I, Felicioni L, Buttitta F, Prat J. Ovarian high-grade serous carcinoma with transitional-like (SET) morphology: a homologous recombination-deficient tumor. HUMAN PATHOLOGY. 2023; 141. DOI:10.1016/j.humpath.2023.08.010. PMID:37673346. IF:2,700 (Q2/4D). Document type: Article.

-Escuin D, López L, Bell O, Mora J, García B, Moral A, Clos M, Boronat L, Arqueros C, Barnadas A. Circulating miRNA Expression Is Inversely Correlated with Tumor Tissue or Sentinel Lymph Nodes in Estrogen Receptor-Positive Early Breast Cancer Patients. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023; 24(17):13293. DOI:10.3390/ijms241713293. PMID:37686099. IF:4,900 (Q1/3D). Document type: Article.

-Español P, Rovira R, Caruana P, Luna-Guibourg R, Soler C, Teixeira N, Rodríguez F, Gallardo A, Edwards M, Porta O, Gámez M, Sánchez O, Llurba E, Corchero JL, Céspedes MV. Dopamine receptors D1 and D2 show prognostic significance and potential therapeutic applications for endometrial cancer patients. Gynecol Oncol. 2023 ;176:25-35. DOI:10.1016/j.ygyno.2023.06.019. PMID: 37437489. IF:4,500 (Q1/1D). Document Type: Article.

-Espinosa I, D’Angelo E, De Brot L, Prat J. Malignant rhabdoid tumors of the vulva versus epithelioid sarcomas: a clinicopathologic, immunohistochemical, and molecular genetics study. HUMAN PATHOLOGY. 2023; 135. DOI:10.1016/j.humpath.2023.02.006. PMID:36863690. IF:2,700 (Q2/4D). Document type: Article.

-Frezza AM, Stacchiotti S, Chibon F, Coindre JM, Italiano A, Romagnosa C, Bagué S, Dei AP, Braglia L, Palmerini E, Quagliuolo V, Broto JM, Pousa AL, Grignani G, Brunello A, Blay JY, Beveridge RD, Lugowska I, Lesluyes T, Maestro R, Merlo FD, Casali PG, Gronchi A. CINSARC in high-risk soft tissue sarcoma patients treated with neoadjuvant chemotherapy: Results from the ISG-STS 1001 study. Cancer Medicine. 2023; 12(2). DOI:10.1002/cam4.5015. PMID:35848358. IF:2,900 (Q2/5D). Document type: Article.

-Fumagalli C, Orellana R, Ferre M, Gonzalez A, Catasus L, Vazquez T, Sebio A, Lopez A, Llauger J, Peiro A, Antonescu CR. Expanding the molecular landscape of undifferentiated sarcomas of bone with a novel EWSR1-SSX3 gene fusion. GENES CHROMOSOMES & CANCER. 2023; 63(1). DOI:10.1002/gcc.23215. PMID:38050902. IF:3,100 (Q2/4D). Document type: Article.

-Gené M, Cuatrecasas M, Amat I, Veiga JA, Fernández MJ, Fusté V, Tarragona J, Jurado I, Fernández R, Martínez C, Alenda C, Zac C, Ortega de la Obra P, Fernández MT, Esteller M, Musulen E. Alterations in p53, Microsatellite Stability and Lack of MUC5AC Expression as Molecular Features of Colorectal Carcinoma Associated with Inflammatory Bowel Disease. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023; 24(10):8655. DOI:10.3390/ijms24108655. PMID:37240002. IF:4,900 (Q1/3D). Document type: Article.

-León X, Bague S, Holgado A, Quer M, Terra X, Camacho M, Aviltes FX. Relationship between transcriptional expression of pyruvate dehydrogenase and local control of disease in patients with oral cavity carcinomas. Acta Otorrinolaringologica Espanola. 2023; 74(6). DOI:10.1016/j.otorri.2023.05.001. IF:0,900 (Q3/8D). Document type: Article.

-Marti D, Gougol A, Gomez C, Jamali A, Abo A, Morales D, Jimenez A, Burns K, Bawa A, Hernandez A, Pujol C, Alvarado E, Szafranska J, Chiu WK, Villagrasa A, Ventura M, Gandicheruvu H, Lluch P, Chen HW, Rachakonda V, Duarte A, Bataller R. Prevalence and clinical impact of alcohol withdrawal syndrome in alcohol-associated hepatitis and the potential role of prophylaxis: a multinational, retrospective cohort study. Eclinicalmedicine. 2023; 61:102046. DOI:10.1016/j.eclinm.2023.102046. PMID:37415844. IF:9,600 (Q1/1D). Document type: Article.

-Martinez C, Alba L, Carrasco LI, Serna N, Imedio L, Gallardo A, Casanova I, Unzueta U, Vazquez E, Mangues R, Villaverde A. Lymphocyte infiltration and antitumoral effect promoted by cytotoxic inflammatory proteins formulated as self-assembling, protein-only nanoparticles. BIOMEDICINE & PHARMACOTHERAPY. 2023; 164:114976. DOI:10.1016/j.biopha.2023.114976. PMID:37276641. IF:6,900 (Q1/1D). Document type: Article.

-Medina E, García A, Gallardo A, Álamo P, Alba L, Unzueta U, Villaverde A, Vázquez E, Casanova I, Mangues R. Potent Anticancer Activity of CXCR4-Targeted Nanostructured Toxins in Aggressive Endometrial Cancer Models. Cancers. 2023; 15(1):85. DOI:10.3390/cancers15010085. PMID:36612081. IF:4,500 (Q1/3D). Document type: Article.

-Navarro M, Estadella I, Benavente A, Orellana R, Petit A, Ferreres JC, Felipe A. The Phosphorylation of Kv1.3: A Modulatory Mechanism for a Multifunctional Ion Channel. Cancers. 2023; 15(10):2716. DOI:10.3390/cancers15102716. PMID:37345053. IF:4,500 (Q1/3D). Document type: Review.

-Nunez Y, Garcia A, Falgas A, Serna N, Sanchez L, Garrido A, Sierra J, Gallardo A, Unzueta U, Vazquez E, Villaverde A, Mangues R, Casanova I. T22-PE24-H6 Nanotoxin Selectively Kills CXCR4-High Expressing AML Patient Cells In Vitro and Potently Blocks Dissemination In Vivo. Pharmaceutics. 2023; 15(3):727. DOI:10.3390/pharmaceutics15030727. PMID:36986589. IF:4,900 (Q1/2D). Document type: Article.

-Revilla G, Ruiz L, Vallverdu NF, Santamaria P, Moral A, Perez JI, Li CD, Fuste V, Lerma E, Corcoy R, Pitoia F, Escola JC, Mato E. Low-Density Lipoprotein Receptor Is a Key Driver of Aggressiveness in Thyroid Tumor Cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023; 24(13):11153. DOI:10.3390/ijms241311153. PMID:37446330. IF:4,900 (Q1/3D). Document type: Article.

-Rusiñol L, Mozos A, Yélamos O. Disseminated Monomorphic Pink Papules. JAMA Dermatology. 2023; 159(12). DOI:10.1001/jamadermatol.2023.3586. PMID:37938840. IF:11,500 (Q1/1D). Document type: Editorial Material.

-Sanchez L, Paul T, Martori C, Font J, Sanjurjo L, Aran G, Tellez E, Blanco J, Carrillo J, Ito M, Tuttolomondo M, Ditzel HJ, Fumagalli C, Tapia G, Sidorova J, Masnou H, Fernandez MA, Lozano JJ, Vilaplana C, Rodriguez A, Armengol C, Valledor AF, Kremer L, Sarriasa MR. Macrophage CD5L is a target for cancer immunotherapy. EBioMedicine. 2023; 91:104555. DOI:10.1016/j.ebiom.2023.104555. PMID:37054630. IF:9,700 (Q1/1D). Document type: Article.

-Serret Miralles P, Orellana Fernández R, Parra Parente T, García-Chamón Brígido RB, Carrera Salas R. Tumor de células gigantes óseo en arco costal, tratado con denosumab. Reporte de un caso [Giant cell tumour of bone in the rib cage treated with denosumab. A case report]. Rev Esp Patol. 2023; 56(2):119-123. DOI: 10.1016/j.patol.2021.04.002. PMID: 37061238. Document type: Article.

-Voltà E, Alba L, Serna N, Casanova I, López H, Gallardo A, Sánchez A, Villaverde A, Unzueta U, Vázquez E, Mangues R. High-precision targeting and destruction of cancer-associated PDGFR-ß(+) stromal fibroblasts through self-assembling, protein-only nanoparticles. Acta Biomaterialia. 2023; 170. DOI:10.1016/j.actbio.2023.09.001. PMID:37683965. IF:9,400 (Q1/1D). Document type: Article.

-Zampacorta C, Pasciuto MP, Ferro B, Lucidi A, Maestro AS, Espinosa I, D’Angelo E, Prat J. Placental site trophoblastic tumor (PSTT): a case report and review of the literature. Pathologica. 2023; 115(2)DOI:10.32074/1591-951X-873. PMID:37114629.Collet R, Olmedo G, Ruiz I, Martinez A, Rodriguez B, Bernal S, Kulisevsky J, Pagonabarraga J. Late-Onset Beta-Propeller Protein-Associated Neurodegeneration: A Case Report. Movement Disorders Clinical Practice. 2023; 10(8). DOI:10.1002/mdc3.13811. PMID:37635772. IF:2,600 (Q2/5D). Document type: Review.

Publications 2022

(JIF 2022)

Amat V, Yelamos O, Agut E, Dalmau J, Mozos A, Lopez S, Roe E. Spitzoid proliferative nodules arising in a congenital melanocytic naevus: A case report with clinical, dermoscopic and histologic correlation. AUSTRALASIAN JOURNAL OF DERMATOLOGY. 2022; 63(3). DOI:10.1111/ajd.13861. PMID:35510363. IF:2 (Q3/7D). Document type: Article.
Asla Q, Sarda H, Lerma E, Hanzu FA, Rodrigo MT, Urgell E, Perez JI, Webb SM, Aulinas A. 11-Deoxycorticosterone Producing Adrenal Hyperplasia as a Very Unusual Cause of Endocrine Hypertension: Case Report and Systematic Review of the Literature. Frontiers in Endocrinology. 2022; 13:846865. DOI:10.3389/fendo.2022.846865. PMID:35432204. IF:5,2 (Q1/3D). Document type: Review.
Bague S, Leon X, Terra X, Lejeune M, Camacho M, Aviles FX. Prognostic capacity of the transcriptional expression of lactate dehydrogenase A in patients with head and neck squamous cell carcinoma. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK. 2022; 44(11). DOI:10.1002/hed.27161. PMID:36207788. IF:2,9 (Q1/2D). Document type: Article.
Diaz E, Garcia M, Lopez L, Garcia X, Badimon L, Padro T. Urinary Proteomic Signature in Acute Decompensated Heart Failure: Advances into Molecular Pathophysiology. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(4):2344. DOI:10.3390/ijms23042344. PMID:35216460. IF:5,6 (Q1/3D). Document type: Article.
Diaz E, Garcia M, Lopez L, Garcia X, Badimon L, Padro T. Vitamin D Binding Protein and Renal Injury in Acute Decompensated Heart Failure. Frontiers in Cardiovascular Medicine. 2022; 9:829490. DOI:10.3389/fcvm.2022.829490. PMID:35757319. IF:3,6 (Q2/5D). Document type: Article.
Falgàs A, Garcia A, Núñez Y, Serna N, Sánchez L, Unzueta U, Voltà E, Aragó M, Álamo P, Alba L, Sierra J, Gallardo A, Villaverde A, Vázquez E, Mangues R, Casanova I. A diphtheria toxin-based nanoparticle achieves specific cytotoxic effect on CXCR4(+) lymphoma cells without toxicity in immunocompromised and immunocompetent mice. BIOMEDICINE & PHARMACOTHERAPY. 2022; 150:112940. DOI:10.1016/j.biopha.2022.112940. PMID:35421785. IF:7,5 (Q1/1D). Document type: Article.
Garcia C, Morales CE, Dalmau J, Cubiro X, Lopez C, Mozos A, Yelamos O. Extensive lichen planopilaris as exclusive lichenoid reaction secondary to pembrolizumab in a patient with metastatic melanoma. Dermatologic Therapy. 2022; 35(5):e15388. DOI:10.1111/dth.15388. PMID:35174945. IF:3,6 (Q1/3D). Document type: Letter.
Manrique A, Salazar J, Arranz MJ, Bague S, Orellana R, Lopez A, Cerda P, Gracia I, Majercakova K, Peiro A, Trullols L, Fernandez M, Valverde S, Quintana MJ, Bell O, Artigas A, Sebio A. Pharmacogenetic Profiling in High-Risk Soft Tissue Sarcomas Treated with Neoadjuvant Chemotherapy. Journal of Personalized Medicine. 2022; 12(4):618. DOI:10.3390/jpm12040618. PMID:35455734. Document type: Article.
Marsico S, Orellana R, Tizon H, Mas A, Solano A, Zuccarino F. Multimodality imaging evaluation of a primary cardiac epithelioid hemangioendothelioma. ACTA CARDIOLOGICA. 2022; 77(6). DOI:10.1080/00015385.2021.1908704. PMID:33827376. IF:1,6 (Q4/9D). Document type: Editorial material.
Medina E, Cespedes MV, Gallardo A, Rioja E, Pavon MA, Asensio L, Farre L, Alba L, Unzueta U, Villaverde A, Vazquez E, Casanova I, Mangues R. Novel Endometrial Cancer Models Using Sensitive Metastasis Tracing for CXCR4-Targeted Therapy in Advanced Disease. Biomedicines. 2022; 10(7):1680. DOI:10.3390/biomedicines10071680. PMID:35884987. IF:4,7 (Q1/3D). Document type: Article.
Pallares V, Unzueta U, Falgas A, Avino A, Nunez Y, Garcia A, Sanchez L, Serna N, Gallardo A, Alba L, Alamo P, Sierra J, Cedo L, Eritja R, Villaverde A, Vazquez E, Casanova I, Mangues R. A multivalent Ara-C-prodrug nanoconjugate achieves selective ablation of leukemic cells in an acute myeloid leukemia mouse model. 2022; 280:121258. DOI:10.1016/j.biomaterials.2021.121258. PMID:34847435. IF:14 (Q1/1D). Document type: Article.
Palones E, Pajares V, Lopez L, Castillo D, Torrego A. Sarcoidosis following SARS-CoV-2 infection: Cause or consequence?. Respirology Case Reports. 2022; 10(6):e0955. DOI:10.1002/rcr2.955. PMID:35505665. IF:0,8 (Q4/10D). Document type: Article.
Pasquali S, Palmerini E, Quagliuolo V, Martin J, Lopez A, Grignani G, Brunello A, Blay JY, Tendero O, Diaz R, Ferraresi V, Lugowska I, Infante G, Braglia L, Merlo DF, Fontana V, Marchesi E, Donati DM, Palassini E, Bianchi G, Marrari A, Morosi C, Stacchiotti S, Bague S, Coindre JM, Dei AP, Picci P, Bruzzi P, Miceli R, Casali PG, Gronchi A. Neoadjuvant chemotherapy in high-risk soft tissue sarcomas: A Sarculator-based risk stratification analysis of the ISG-STS 1001 randomized trial. CANCER. 2022; 128(1). DOI:10.1002/cncr.33895. PMID:34643947. IF:6,2 (Q1/3D). Document type: Article.
Revilla G,Moral A,Fuste V,Lerma E,Julve J,Escolà JC,Mato E,Pérez JI,Corcoy R,Paez EV. The role of ATP-binding cassette transporter genes in the metastatic process of epithelial thyroid carcinoma with aggressive behavior. In: Unraveling The Complexities Of Metastasis: Transition From A Segmented View To A Conceptual Continuum. Elsevier. 2022. p. 265-275. Document type: Book chapter.
Rioja E, Arroyo I, Alamo P, Casanova I, Gallardo A, Unzueta U, Serna N, Sanchez L, Quer M, Villaverde A, Vazquez E, Leon X, Alba L, Mangues R. CXCR4-targeted nanotoxins induce GSDME-dependent pyroptosis in head and neck squamous cell carcinoma. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2022; 41(1):49. DOI:10.1186/s13046-022-02267-8. PMID:35120582. IF:11,3 (Q1/1D). Document type: Article.
Rioja E, Arroyo I, Álamo P, Casanova I, Gallardo A, Unzueta U, Serna N, Sánchez L, Quer M, Villaverde A, Vázquez E, Mangues R, Alba L, León X. Self-assembling protein nanocarrier for selective delivery of cytotoxic polypeptides to CXCR4(+) head and neck squamous cell carcinoma tumors. Acta Pharmaceutica Sinica B. 2022; 12(5). DOI:10.1016/j.apsb.2021.09.030. PMID:35646535. IF:14,5 (Q1/1D). Document type: Article.
Rioja E, Gallardo A, Arroyo I, Alamo P, Casanova I, Unzueta U, Serna N, Sanchez L, Quer M, Villaverde A, Vazquez E, Leon X, Alba L, Mangues R. A Novel CXCR4-Targeted Diphtheria Toxin Nanoparticle Inhibits Invasion and Metastatic Dissemination in a Head and Neck Squamous Cell Carcinoma Mouse Model. 2022; 14(4):887. DOI:10.3390/pharmaceutics14040887. PMID:35456719. IF:5,4 (Q1/2D). Document type: Article.
Sanchez S, Leganes C, Bianchi F, Goruppi I, Boronat S, Fuste V, Lozano NB. Laparoscopic resection of a paediatric case of solid pseudopapillary tumour of the pancreas. Journal Of Pediatric Surgery Case Reports. 2022; 77:102141. DOI:10.1016/j.epsc.2021.102141. IF:0,4 (Q4/10D). Document type: Article.
Serda PC, Teres R, Sebio A, Bague S, Orellana R, Moreno ME, Riba M, Lopez A. Single-Center Experience with Trabectedin for the Treatment of Non-L-sarcomas. ADVANCES IN THERAPY. 2022; 39(4). DOI:10.1007/s12325-022-02051-2. PMID:35129790. IF:3,8 (Q2/4D). Document type: Article.
Serra C, Torrego A, Pajares V, Millan P, Barril S, Alonso A, Navarro M, Lopez L, Franquet T, Castillo D. Bronchoalveolar lavage complements transbronchial cryobiopsy diagnosis in diffuse interstitial lung diseases. Journal Of Bronchology And Interventional Pulmonology. 2022; 29(1). DOI:10.1097/LBR.0000000000000770. PMID:33828048. IF:3,3 (Q2/5D). Document type: Article.
Torrego A, Muñoz AM, Lucena CM, Castro P, López L, Badía JR, Betbesé A, Ramirez J, Andreo F, Fernández M-T, Fabra M, Pajares V, Agustí C. Safety and Feasibility of Transbronchial Cryobiopsy in Mechanically Ventilated Patients. ARCHIVOS DE BRONCONEUMOLOGIA. 2022; 58(8). DOI:10.1016/j.arbres.2021.11.005. PMID:35312520. IF:8 (Q1/2D). Document type: Letter.
Ventura M, Argemi J, Jones PD, Lackner C, El Hag M, Abraldes JG, Alvarado E, Clemente A, Ravi S, Alves A, Alboraie M, Altamirano J, Barace S, Bosques F, Brown R, Caballeria J, Cabezas J, Carvalhana S, Cortez H, Costa A, Degre D, Fernandez C, Ganne N, Garcia G, Genesca J, Koskinas J, Lanthier N, Louvet A, Lozano JJ, Lucey MR, Masson S, Mathurin P, Mendez N, et al. [Szafranska J]. Clinical, histological and molecular profiling of different stages of alcohol-related liver disease. GUT. 2022; 71(9):324295. DOI:10.1136/gutjnl-2021-324295. PMID:34992134. IF:24,5 (Q1/1D). Document type: Article.

Publications 2021

Aguado C, Teixido C, Román R, Reyes R, Gimenez-Capitan A, Marin E, Cabrera C, Viñolas N, Castillo S, Muñoz S, Arcocha A, Lopez-Vilaro L, Sullivan I, Aldeguer E, Rodriguez S, Moya I, Viteri S, Cardona AF, Palmero R, Sainz C, Mesa-Guzman M, Lozano MD, Aguilar-Hernandez A, Martinez-Bueno A, Gonzalez-Cao M, Gonzalvo E, Leenders WPJ, Rosell R, et al. Multiplex RNA-based detection of clinically relevant MET alterations in advanced non-small cell lung cancer. Molecular Oncology. 202115(2):350-363. DOI:10.1002/1878-0261.12861. PMID: 33236532. IF:7,449.
Alamo P, Cedano J, Conchillo O, Cano O, Alba L, Serna N, Avino A, Carrasco LM, Sanchez A, Martinez C, Gallardo A, Cano M, Eritja R, Villaverde A, Mangues R, Vazquez E, Unzueta U. Rational engineering of a human GFP-like protein scaffold for humanized targeted nanomedicines. Acta Biomaterialia. 2021; 130. DOI:10.1016/j.actbio.2021.06.001. PMID:34116228. IF:10,633.
Campos MC, Tubau C, Segura S, Gonzalez M, Iglesias M, Fernandez MT, Garcia MP, Mozos A. Oral submucous fibrosis presenting with histopathological lichenoid changes as predominant feature: Report of five cases and review of the literature. JOURNAL OF CUTANEOUS PATHOLOGY. 2021; 48(11). DOI:10.1111/cup.14084. PMID:34151457. IF:1,458.
Castillo D, Barril S, Rodrigo A, Millan P, Suarez G, Alonso A, Franquet T, Lopez L, Castellvi I, Plaza V, Sibila O. EARLY HOSPITAL READMISSION INCREASES SHORT AND LONG – TERM MORTALITY IN PATIENTS WITH INTERSTITIAL LUNG DISEASE. SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES. 2021; 38(2):e2021021. DOI:10.36141/svdld.v38i2.10709. PMID:34316260. IF:1,803.
D’Angelo E, Espinosa I, Cipriani V, Szafranska J, Barbareschi M, Prat J. Atypical Endometrial Hyperplasia, Low-grade “Much ADO About Nothing”. AMERICAN JOURNAL OF SURGICAL PATHOLOGY. 2021; 45(7). DOI:10.1097/PAS.0000000000001705. PMID:34105519. IF:6,298.
Escuin D, Lopez L, Mora J, Bell O, Moral A, Perez I, Arqueros C, Garcia B, Cajal TRY, Lerma E, Barnadas A. Circulating microRNAs in Early Breast Cancer Patients and Its Association With Lymph Node Metastases. Frontiers in Oncology. 2021; 11:627811. DOI:10.3389/fonc.2021.627811. PMID:34513655. IF:5,738.
Esteve A, Alameda F, Carrato C, Pineda E, Arpi O, Martinez M, Mallo M, Gut M, Dabad M, Tortosa A, Del Barco S, Capellades J, Puig J, Gallego O, Pujol T, Oleaga L, Gil M, de Quintana C, Valduvieco I, Martinez A, Bellosillo B, Munoz AM, Esteve A, Domenech M, Camins A, Craven J, Villa S, Marruecos J, Domenech S, de la Iglesia N, Balana C, Bagué S, Aldecoa I. RNA sequencing and Immunohistochemistry Reveal ZFN7 as a Stronger Marker of Survival than Molecular Subtypes in G-CIMP-negative Glioblastoma. CLINICAL CANCER RESEARCH. 2021; 27(2). DOI:10.1158/1078-0432.CCR-20-2141. PMID:33106291. IF:13,801.
Falgas A, Pallares V, Unzueta U, Nunez Y, Sierra J, Gallardo A, Alba L, Mangues MA, Alamo P, Villaverde A, Vazquez E, Mangues R, Casanova I. Specific Cytotoxic Effect of an Auristatin Nanoconjugate Towards CXCR4(+) Diffuse Large B-Cell Lymphoma Cells. International Journal of Nanomedicine. 2021; 16. DOI:10.2147/IJN.S289733. PMID:33716502. IF:7,033.
Iznardo H, Baselga E, Mozos A, Szafranska J, Orellana R, Roe E. Net-like superficial lymphatic malformation. PEDIATRIC DERMATOLOGY. 2021; 38(2). DOI:10.1111/pde.14526. PMID:33486776. IF:1,997.
Lopez C, Falla LM, Roe E, Arostegui JI, Mozos A, Bernal S, Iznardo H, Baselga E. Excellent response to secukinumab in an infant with severe generalized pustular psoriasis. JOURNAL OF DERMATOLOGY. 2021; 48(6). DOI:10.1111/1346-8138.15673. PMID:33543522. IF:3,468.
Martin J, Lopez M, Moura DS, Ramos R, Collini P, Romagosa C, Bague S, Renne SL, Barisella M, Velasco V, Coindre JM, Lopez D, Dopazo J, Gambarotti M, Braglia L, Merlo DF, Palmerini E, Stacchiotti S, Quagliuolo VL, Lopez A, Grignani G, Blay JY, Brunello A, Gutierrez A, Valverde C, Hindi N, Dei AP, Picci P, Casali PG, Gronchi A. Predictive Value of MRP-1 in Localized High-Risk Soft Tissue Sarcomas: A Translational Research Associated to ISG-STS 1001 Randomized Phase III Trial. MOLECULAR CANCER THERAPEUTICS. 2021; 20(12). DOI:10.1158/1535-7163.MCT-21-0315. PMID:34552008. IF:6,009.
Moura DS, Diaz J, Bague S, Orellana R, Sebio A, Mondaza JL, Salguero C, Rojo F, Hindi N, Fletcher CDM, Martin J. A Novel NFIX-STAT6 Gene Fusion in Solitary Fibrous Tumor: A Case Report. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021; 22(14):7514. DOI:10.3390/ijms22147514. PMID:34299133. IF:6,208.
Moura DS, Pena M, Varela J, Alvarez R, Agra C, Izquierdo F, Ramos R, Ortega L, Martin F, Castilla C, Hernandez CN, Romagosa C, Salgado M, Lavernia J, Bague S, Mayodormo E, Vicioso L, Barcelo J, Rubio J, de Juan A, Fiano MC, Hindi N, Lopez M, Lacerenza S, Dopazo J, Gutierrez A, Alvarez R, Valverde C, Martinez J, Martin J. A DNA damage repair gene-associated signature predicts responses of patients with advanced soft-tissue sarcoma to treatment with trabectedin. Molecular Oncology. 2021; 15(12). DOI:10.1002/1878-0261.12996. PMID:33983674. IF:7,449.
Pallares V, Nunez Y, Sanchez L, Falgas A, Serna N, Unzueta U, Gallardo A, Alba L, Alamo P, Sierra J, Villaverde A, Vazquez E, Casanova I, Mangues R. Antineoplastic effect of a diphtheria toxin-based nanoparticle targeting acute myeloid leukemia cells overexpressing CXCR4. JOURNAL OF CONTROLLED RELEASE. 2021; 335. DOI:10.1016/j.jconrel.2021.05.014. PMID:34004204. IF:11,467.
Revilla G, Cedo L, Tondo M, Moral A, Perez JI, Corcoy R, Lerma E, Fuste V, Reddy TS, Blanco F, Mato E, Escola JC. LDL, HDL and endocrine-related cancer: From pathogenic mechanisms to therapies. SEMINARS IN CANCER BIOLOGY. 2021; 73. DOI:10.1016/j.semcancer.2020.11.012. PMID:33249202. IF:17,012.
Vieites B, Lopez MA, Martin MD, Ramirez CL, Rezola R, Sancho M, Lopez L, Villardell F, Burgues O, Fernandez B, Alfaro L, Peg V. Predictive and prognostic value of total tumor load in sentinel lymph nodes in breast cancer patients after neoadjuvant treatment using one-step nucleic acid amplification: the NEOVATTL study. Clinical & Translational Oncology. 2021; 23(7). DOI:10.1007/s12094-020-02530-4. PMID:33517542. IF:3,340.

2017 Scientific Report – Molecular Pathology of Gynaecologic Cancer

Introduction

Main Lines of Research

Molecular Pathology of Gynaecologic Cancer

Pathogenic mechanisms of gynaecological cancer (endometrial/ovarian cancer).
Molecular mechanisms of stromal response and immunosuppression in endometrial cancer.
Clinical application of prognostic factors in common cancers (endometrial, ovarian, etc).
Clinical application of tumour markers.
Molecular biology of uterine and extra-uterine sarcomas.

Pathology of Lung Tumors

Challenges

Progress as a productive translational gynaecological cancer research group, capable of competing with other highly visible groups in Barcelona that publish regular articles in reputable journals.
Cooperate with other groups at the national and international levels.

Team

Group coordination

PIJUAN ANDUJAR, LARA FGS
lpijuan@santpau.cat

Members

Scientific output

Amat V, Yelamos O, Agut E, Dalmau J, Mozos A, Lopez S, Roe E. Spitzoid proliferative nodules arising in a congenital melanocytic naevus: A case report with clinical, dermoscopic and histologic correlation. AUSTRALASIAN JOURNAL OF DERMATOLOGY. 2022; 63(3). DOI:10.1111/ajd.13861. PMID:35510363. IF:2 (Q3/7D). Document type: Article.
Asla Q, Sarda H, Lerma E, Hanzu FA, Rodrigo MT, Urgell E, Perez JI, Webb SM, Aulinas A. 11-Deoxycorticosterone Producing Adrenal Hyperplasia as a Very Unusual Cause of Endocrine Hypertension: Case Report and Systematic Review of the Literature. Frontiers in Endocrinology. 2022; 13:846865. DOI:10.3389/fendo.2022.846865. PMID:35432204. IF:5,2 (Q1/3D). Document type: Review.
Bague S, Leon X, Terra X, Lejeune M, Camacho M, Aviles FX. Prognostic capacity of the transcriptional expression of lactate dehydrogenase A in patients with head and neck squamous cell carcinoma. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK. 2022; 44(11). DOI:10.1002/hed.27161. PMID:36207788. IF:2,9 (Q1/2D). Document type: Article.
Diaz E, Garcia M, Lopez L, Garcia X, Badimon L, Padro T. Urinary Proteomic Signature in Acute Decompensated Heart Failure: Advances into Molecular Pathophysiology. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(4):2344. DOI:10.3390/ijms23042344. PMID:35216460. IF:5,6 (Q1/3D). Document type: Article.
Diaz E, Garcia M, Lopez L, Garcia X, Badimon L, Padro T. Vitamin D Binding Protein and Renal Injury in Acute Decompensated Heart Failure. Frontiers in Cardiovascular Medicine. 2022; 9:829490. DOI:10.3389/fcvm.2022.829490. PMID:35757319. IF:3,6 (Q2/5D). Document type: Article.
Falgàs A, Garcia A, Núñez Y, Serna N, Sánchez L, Unzueta U, Voltà E, Aragó M, Álamo P, Alba L, Sierra J, Gallardo A, Villaverde A, Vázquez E, Mangues R, Casanova I. A diphtheria toxin-based nanoparticle achieves specific cytotoxic effect on CXCR4(+) lymphoma cells without toxicity in immunocompromised and immunocompetent mice. BIOMEDICINE & PHARMACOTHERAPY. 2022; 150:112940. DOI:10.1016/j.biopha.2022.112940. PMID:35421785. IF:7,5 (Q1/1D). Document type: Article.
Garcia C, Morales CE, Dalmau J, Cubiro X, Lopez C, Mozos A, Yelamos O. Extensive lichen planopilaris as exclusive lichenoid reaction secondary to pembrolizumab in a patient with metastatic melanoma. Dermatologic Therapy. 2022; 35(5):e15388. DOI:10.1111/dth.15388. PMID:35174945. IF:3,6 (Q1/3D). Document type: Letter.
Manrique A, Salazar J, Arranz MJ, Bague S, Orellana R, Lopez A, Cerda P, Gracia I, Majercakova K, Peiro A, Trullols L, Fernandez M, Valverde S, Quintana MJ, Bell O, Artigas A, Sebio A. Pharmacogenetic Profiling in High-Risk Soft Tissue Sarcomas Treated with Neoadjuvant Chemotherapy. Journal of Personalized Medicine. 2022; 12(4):618. DOI:10.3390/jpm12040618. PMID:35455734. Document type: Article.
Marsico S, Orellana R, Tizon H, Mas A, Solano A, Zuccarino F. Multimodality imaging evaluation of a primary cardiac epithelioid hemangioendothelioma. ACTA CARDIOLOGICA. 2022; 77(6). DOI:10.1080/00015385.2021.1908704. PMID:33827376. IF:1,6 (Q4/9D). Document type: Editorial material.
Medina E, Cespedes MV, Gallardo A, Rioja E, Pavon MA, Asensio L, Farre L, Alba L, Unzueta U, Villaverde A, Vazquez E, Casanova I, Mangues R. Novel Endometrial Cancer Models Using Sensitive Metastasis Tracing for CXCR4-Targeted Therapy in Advanced Disease. Biomedicines. 2022; 10(7):1680. DOI:10.3390/biomedicines10071680. PMID:35884987. IF:4,7 (Q1/3D). Document type: Article.
Pallares V, Unzueta U, Falgas A, Avino A, Nunez Y, Garcia A, Sanchez L, Serna N, Gallardo A, Alba L, Alamo P, Sierra J, Cedo L, Eritja R, Villaverde A, Vazquez E, Casanova I, Mangues R. A multivalent Ara-C-prodrug nanoconjugate achieves selective ablation of leukemic cells in an acute myeloid leukemia mouse model. 2022; 280:121258. DOI:10.1016/j.biomaterials.2021.121258. PMID:34847435. IF:14 (Q1/1D). Document type: Article.
Palones E, Pajares V, Lopez L, Castillo D, Torrego A. Sarcoidosis following SARS-CoV-2 infection: Cause or consequence?. Respirology Case Reports. 2022; 10(6):e0955. DOI:10.1002/rcr2.955. PMID:35505665. IF:0,8 (Q4/10D). Document type: Article.
Pasquali S, Palmerini E, Quagliuolo V, Martin J, Lopez A, Grignani G, Brunello A, Blay JY, Tendero O, Diaz R, Ferraresi V, Lugowska I, Infante G, Braglia L, Merlo DF, Fontana V, Marchesi E, Donati DM, Palassini E, Bianchi G, Marrari A, Morosi C, Stacchiotti S, Bague S, Coindre JM, Dei AP, Picci P, Bruzzi P, Miceli R, Casali PG, Gronchi A. Neoadjuvant chemotherapy in high-risk soft tissue sarcomas: A Sarculator-based risk stratification analysis of the ISG-STS 1001 randomized trial. CANCER. 2022; 128(1). DOI:10.1002/cncr.33895. PMID:34643947. IF:6,2 (Q1/3D). Document type: Article.
Revilla G,Moral A,Fuste V,Lerma E,Julve J,Escolà JC,Mato E,Pérez JI,Corcoy R,Paez EV. The role of ATP-binding cassette transporter genes in the metastatic process of epithelial thyroid carcinoma with aggressive behavior. In: Unraveling The Complexities Of Metastasis: Transition From A Segmented View To A Conceptual Continuum. Elsevier. 2022. p. 265-275. Document type: Book chapter.
Rioja E, Arroyo I, Alamo P, Casanova I, Gallardo A, Unzueta U, Serna N, Sanchez L, Quer M, Villaverde A, Vazquez E, Leon X, Alba L, Mangues R. CXCR4-targeted nanotoxins induce GSDME-dependent pyroptosis in head and neck squamous cell carcinoma. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2022; 41(1):49. DOI:10.1186/s13046-022-02267-8. PMID:35120582. IF:11,3 (Q1/1D). Document type: Article.
Rioja E, Arroyo I, Álamo P, Casanova I, Gallardo A, Unzueta U, Serna N, Sánchez L, Quer M, Villaverde A, Vázquez E, Mangues R, Alba L, León X. Self-assembling protein nanocarrier for selective delivery of cytotoxic polypeptides to CXCR4(+) head and neck squamous cell carcinoma tumors. Acta Pharmaceutica Sinica B. 2022; 12(5). DOI:10.1016/j.apsb.2021.09.030. PMID:35646535. IF:14,5 (Q1/1D). Document type: Article.
Rioja E, Gallardo A, Arroyo I, Alamo P, Casanova I, Unzueta U, Serna N, Sanchez L, Quer M, Villaverde A, Vazquez E, Leon X, Alba L, Mangues R. A Novel CXCR4-Targeted Diphtheria Toxin Nanoparticle Inhibits Invasion and Metastatic Dissemination in a Head and Neck Squamous Cell Carcinoma Mouse Model. 2022; 14(4):887. DOI:10.3390/pharmaceutics14040887. PMID:35456719. IF:5,4 (Q1/2D). Document type: Article.
Sanchez S, Leganes C, Bianchi F, Goruppi I, Boronat S, Fuste V, Lozano NB. Laparoscopic resection of a paediatric case of solid pseudopapillary tumour of the pancreas. Journal Of Pediatric Surgery Case Reports. 2022; 77:102141. DOI:10.1016/j.epsc.2021.102141. IF:0,4 (Q4/10D). Document type: Article.
Serda PC, Teres R, Sebio A, Bague S, Orellana R, Moreno ME, Riba M, Lopez A. Single-Center Experience with Trabectedin for the Treatment of Non-L-sarcomas. ADVANCES IN THERAPY. 2022; 39(4). DOI:10.1007/s12325-022-02051-2. PMID:35129790. IF:3,8 (Q2/4D). Document type: Article.
Serra C, Torrego A, Pajares V, Millan P, Barril S, Alonso A, Navarro M, Lopez L, Franquet T, Castillo D. Bronchoalveolar lavage complements transbronchial cryobiopsy diagnosis in diffuse interstitial lung diseases. Journal Of Bronchology And Interventional Pulmonology. 2022; 29(1). DOI:10.1097/LBR.0000000000000770. PMID:33828048. IF:3,3 (Q2/5D). Document type: Article.
Torrego A, Muñoz AM, Lucena CM, Castro P, López L, Badía JR, Betbesé A, Ramirez J, Andreo F, Fernández M-T, Fabra M, Pajares V, Agustí C. Safety and Feasibility of Transbronchial Cryobiopsy in Mechanically Ventilated Patients. ARCHIVOS DE BRONCONEUMOLOGIA. 2022; 58(8). DOI:10.1016/j.arbres.2021.11.005. PMID:35312520. IF:8 (Q1/2D). Document type: Letter.
Ventura M, Argemi J, Jones PD, Lackner C, El Hag M, Abraldes JG, Alvarado E, Clemente A, Ravi S, Alves A, Alboraie M, Altamirano J, Barace S, Bosques F, Brown R, Caballeria J, Cabezas J, Carvalhana S, Cortez H, Costa A, Degre D, Fernandez C, Ganne N, Garcia G, Genesca J, Koskinas J, Lanthier N, Louvet A, Lozano JJ, Lucey MR, Masson S, Mathurin P, Mendez N, et al. [Szafranska J]. Clinical, histological and molecular profiling of different stages of alcohol-related liver disease. GUT. 2022; 71(9):324295. DOI:10.1136/gutjnl-2021-324295. PMID:34992134. IF:24,5 (Q1/1D). Document type: Article.

Publications 2021

Aguado C, Teixido C, Román R, Reyes R, Gimenez-Capitan A, Marin E, Cabrera C, Viñolas N, Castillo S, Muñoz S, Arcocha A, Lopez-Vilaro L, Sullivan I, Aldeguer E, Rodriguez S, Moya I, Viteri S, Cardona AF, Palmero R, Sainz C, Mesa-Guzman M, Lozano MD, Aguilar-Hernandez A, Martinez-Bueno A, Gonzalez-Cao M, Gonzalvo E, Leenders WPJ, Rosell R, et al. Multiplex RNA-based detection of clinically relevant MET alterations in advanced non-small cell lung cancer. Molecular Oncology. 202115(2):350-363. DOI:10.1002/1878-0261.12861. PMID: 33236532. IF:7,449.
Alamo P, Cedano J, Conchillo O, Cano O, Alba L, Serna N, Avino A, Carrasco LM, Sanchez A, Martinez C, Gallardo A, Cano M, Eritja R, Villaverde A, Mangues R, Vazquez E, Unzueta U. Rational engineering of a human GFP-like protein scaffold for humanized targeted nanomedicines. Acta Biomaterialia. 2021; 130. DOI:10.1016/j.actbio.2021.06.001. PMID:34116228. IF:10,633.
Campos MC, Tubau C, Segura S, Gonzalez M, Iglesias M, Fernandez MT, Garcia MP, Mozos A. Oral submucous fibrosis presenting with histopathological lichenoid changes as predominant feature: Report of five cases and review of the literature. JOURNAL OF CUTANEOUS PATHOLOGY. 2021; 48(11). DOI:10.1111/cup.14084. PMID:34151457. IF:1,458.
Castillo D, Barril S, Rodrigo A, Millan P, Suarez G, Alonso A, Franquet T, Lopez L, Castellvi I, Plaza V, Sibila O. EARLY HOSPITAL READMISSION INCREASES SHORT AND LONG – TERM MORTALITY IN PATIENTS WITH INTERSTITIAL LUNG DISEASE. SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES. 2021; 38(2):e2021021. DOI:10.36141/svdld.v38i2.10709. PMID:34316260. IF:1,803.
D’Angelo E, Espinosa I, Cipriani V, Szafranska J, Barbareschi M, Prat J. Atypical Endometrial Hyperplasia, Low-grade “Much ADO About Nothing”. AMERICAN JOURNAL OF SURGICAL PATHOLOGY. 2021; 45(7). DOI:10.1097/PAS.0000000000001705. PMID:34105519. IF:6,298.
Escuin D, Lopez L, Mora J, Bell O, Moral A, Perez I, Arqueros C, Garcia B, Cajal TRY, Lerma E, Barnadas A. Circulating microRNAs in Early Breast Cancer Patients and Its Association With Lymph Node Metastases. Frontiers in Oncology. 2021; 11:627811. DOI:10.3389/fonc.2021.627811. PMID:34513655. IF:5,738.
Esteve A, Alameda F, Carrato C, Pineda E, Arpi O, Martinez M, Mallo M, Gut M, Dabad M, Tortosa A, Del Barco S, Capellades J, Puig J, Gallego O, Pujol T, Oleaga L, Gil M, de Quintana C, Valduvieco I, Martinez A, Bellosillo B, Munoz AM, Esteve A, Domenech M, Camins A, Craven J, Villa S, Marruecos J, Domenech S, de la Iglesia N, Balana C, Bagué S, Aldecoa I. RNA sequencing and Immunohistochemistry Reveal ZFN7 as a Stronger Marker of Survival than Molecular Subtypes in G-CIMP-negative Glioblastoma. CLINICAL CANCER RESEARCH. 2021; 27(2). DOI:10.1158/1078-0432.CCR-20-2141. PMID:33106291. IF:13,801.
Falgas A, Pallares V, Unzueta U, Nunez Y, Sierra J, Gallardo A, Alba L, Mangues MA, Alamo P, Villaverde A, Vazquez E, Mangues R, Casanova I. Specific Cytotoxic Effect of an Auristatin Nanoconjugate Towards CXCR4(+) Diffuse Large B-Cell Lymphoma Cells. International Journal of Nanomedicine. 2021; 16. DOI:10.2147/IJN.S289733. PMID:33716502. IF:7,033.
Iznardo H, Baselga E, Mozos A, Szafranska J, Orellana R, Roe E. Net-like superficial lymphatic malformation. PEDIATRIC DERMATOLOGY. 2021; 38(2). DOI:10.1111/pde.14526. PMID:33486776. IF:1,997.
Lopez C, Falla LM, Roe E, Arostegui JI, Mozos A, Bernal S, Iznardo H, Baselga E. Excellent response to secukinumab in an infant with severe generalized pustular psoriasis. JOURNAL OF DERMATOLOGY. 2021; 48(6). DOI:10.1111/1346-8138.15673. PMID:33543522. IF:3,468.
Martin J, Lopez M, Moura DS, Ramos R, Collini P, Romagosa C, Bague S, Renne SL, Barisella M, Velasco V, Coindre JM, Lopez D, Dopazo J, Gambarotti M, Braglia L, Merlo DF, Palmerini E, Stacchiotti S, Quagliuolo VL, Lopez A, Grignani G, Blay JY, Brunello A, Gutierrez A, Valverde C, Hindi N, Dei AP, Picci P, Casali PG, Gronchi A. Predictive Value of MRP-1 in Localized High-Risk Soft Tissue Sarcomas: A Translational Research Associated to ISG-STS 1001 Randomized Phase III Trial. MOLECULAR CANCER THERAPEUTICS. 2021; 20(12). DOI:10.1158/1535-7163.MCT-21-0315. PMID:34552008. IF:6,009.
Moura DS, Diaz J, Bague S, Orellana R, Sebio A, Mondaza JL, Salguero C, Rojo F, Hindi N, Fletcher CDM, Martin J. A Novel NFIX-STAT6 Gene Fusion in Solitary Fibrous Tumor: A Case Report. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021; 22(14):7514. DOI:10.3390/ijms22147514. PMID:34299133. IF:6,208.
Moura DS, Pena M, Varela J, Alvarez R, Agra C, Izquierdo F, Ramos R, Ortega L, Martin F, Castilla C, Hernandez CN, Romagosa C, Salgado M, Lavernia J, Bague S, Mayodormo E, Vicioso L, Barcelo J, Rubio J, de Juan A, Fiano MC, Hindi N, Lopez M, Lacerenza S, Dopazo J, Gutierrez A, Alvarez R, Valverde C, Martinez J, Martin J. A DNA damage repair gene-associated signature predicts responses of patients with advanced soft-tissue sarcoma to treatment with trabectedin. Molecular Oncology. 2021; 15(12). DOI:10.1002/1878-0261.12996. PMID:33983674. IF:7,449.
Pallares V, Nunez Y, Sanchez L, Falgas A, Serna N, Unzueta U, Gallardo A, Alba L, Alamo P, Sierra J, Villaverde A, Vazquez E, Casanova I, Mangues R. Antineoplastic effect of a diphtheria toxin-based nanoparticle targeting acute myeloid leukemia cells overexpressing CXCR4. JOURNAL OF CONTROLLED RELEASE. 2021; 335. DOI:10.1016/j.jconrel.2021.05.014. PMID:34004204. IF:11,467.
Revilla G, Cedo L, Tondo M, Moral A, Perez JI, Corcoy R, Lerma E, Fuste V, Reddy TS, Blanco F, Mato E, Escola JC. LDL, HDL and endocrine-related cancer: From pathogenic mechanisms to therapies. SEMINARS IN CANCER BIOLOGY. 2021; 73. DOI:10.1016/j.semcancer.2020.11.012. PMID:33249202. IF:17,012.
Vieites B, Lopez MA, Martin MD, Ramirez CL, Rezola R, Sancho M, Lopez L, Villardell F, Burgues O, Fernandez B, Alfaro L, Peg V. Predictive and prognostic value of total tumor load in sentinel lymph nodes in breast cancer patients after neoadjuvant treatment using one-step nucleic acid amplification: the NEOVATTL study. Clinical & Translational Oncology. 2021; 23(7). DOI:10.1007/s12094-020-02530-4. PMID:33517542. IF:3,340.

ONCOHEMATOLOGIC DISEASES

Molecular Pathology of Lung and Gynaecologic Cancers

Main Lines of Research

Pathology of Lung Tumors

Challenges

Group coordination

Members

Publications 2024

Publications 2023

Publications 2022

Publications 2021

Main Lines of Research

Pathology of Lung Tumors

Challenges

Group coordination

Members

Publications 2024

Publications 2023

Publications 2022

Publications 2021

Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau