Sant Pau - Institut de Recerca

Summary

The Group of Genomics of Complex Diseases of the Sant Pau Hospital Research Institute is an interdisciplinary translational research team, with expertise in several scientific domains: Omics Big Data, Molecular Biology, Statistics and Bioinformatics.To complement and enhance our current research lines on Genomics of Thrombosis and Sports Medicine, we have recently integrated the Vascular Biology Group (LABVI) together with the Vascular Surgery and Angiology clinical team of Sant Pau Hospital. This means new capabilities to the group (expertise in cellular and tissue biology, biochemistry of inflammation mediators and functional analysis), creating a unique Vascular Research line with more competitive orientation and big scientific potential. The resulting group constitutes a consolidated basic and clinical team with translational and groundbreaking research lines, with the aim of transfer all the new knowledge that will be generated in Omics and molecular basic research to the clinical practice, working in the different areas of research with special focus on Personalized and Precision Medicine.

Main lines of Research

Angiology and Vascular Biology.

TAGA Project: Genomic basis of Abdominal Aortic Aneurysm.

Venous Thrombosis and Thrombosis and cancer

GAIT Project: Genetic Analysis of Idiopathic Thrombophilia
RETROVE Project: Risk of Venous Thromboembolic Disease.
OncoThromb Project: New biomarkers related with Thrombosis and Cancer.
AIRTOP and MIRTO Projects: Assesment of the Individual Risk of Thrombosis in Oncology Patients.

Genomics in Sport Medicine

SUMMIT Project (Health in sport and its limits): Marathons and Ultra-trail races. Biological, genetic and clinical impact.

SHERPA_Everest’2017 Project. Exposition to extreme environmental hypoxia and its effect on the inflammatory and cardiopulmonar response: Biological, genetic and clinical impact.
Xtreme-Genetics K2 project. Expedition to K2 peak. Biological, genetic and clinical impact.

Transversal Research Areas

Bioinformatics and Epigenetics.
Translational Research and Personalized Medicine

Scientific Challenges

Analysis of Omics data (Genomics, transcriptomics, epigenomics) in the field of complex diseases with translational approach in cooperation with clinical groups.
Identify new biomarkers (genetic, epigenetic and/or plasmatic) that determine the susceptibility to complex diseases.
Identify new mechanisms involved in the development and progression of complex diseases.
Development of predictive algorithms that integrate the genetic, biological and clinical information of the patients (Personalized Medicine).

Scientific Collaborations

With other IIB Sant Pau Groups and Sant Pau Hospital

Thrombosis and Haemostasis, Dr. JC Souto: GAIT, MIRTO, RETROVE Projects.
Clinical Hematology, Dr. J Sierra: MIRTO Project.
Neurology, Dr. J. Marti: MIRTO Project. Elena Jimenez: Lipoproteic biomarkers. ICTUS.
Otorhinolaryngology. Dr. M Quer and Dr. X Leon. Prediction of response to head and neck cancer.
Regulatory Mechanisms of Cardiovascular Remodeling. Dra. C. Rodriguez and Dra. M Galán.
Participation en CIBERCV (CIBER of cardiovascular diseases). Dr. J González.
General and Digestive Surgery. Dra. C Balaguer
Clinical Pharmacology. Dra. MA Mangues and Dra. M Gomis. AIRTOP Project.
Neumology Service, Dr. O Sibila: SUMMIT, SHERPA Projects.

External

Clinical Oncology Department, Hospital Gregorio Marañón, Madrid,Dr. A Muñoz: ONCOTHROMB, AIRTOP Projects.
Clinical Department of Hematology and Hemostasis. University of Wien, Austria. Dra. I Pabinger. ONCOTHROMB, MIRTO Projects.
Dr. J Schwenk. SciLifeLab, Sweeden: GAIT Project
Department of Genetics, University of Genève, Switzerland, Dr. M Dermitzakis and Dr. A Viñuela: GAIT Project.
Institute of Biological Psychiatry, Sankt Hans Hospital. Roskilde, Denmark, Dr. A Buil: Bioinformatics of Complex diseases, GAIT Project.
Laboratory Haematology, Hospital Timone Marseille, France, Dr. P Morange: GAIT, VEREMA Projects.
INSERM UMR_S1219 – Bordeaux Public Health Center. Bordeaux, France. Dr. DA Tregouet: GAIT, VEREMA Projects.
Haematology Department, Karolinska Hospital, Sweden, Dr. J Odeberg: VEREMA Project.
Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid. Dr. JM Redondo.
Hospital Clínic de Barcelona. Otorhinolaryngology Service. Prediction of response to head and neck cancer. Dr. FX Avilés.
Hospital Vall d’Hebron, Barcelona. Vascular Surgery Service. Dr. S Bellmunt.
Bac de Sang i Teixits (BST). Dr. F Vidal.
Centre de Recerca en Enginyeria Biomèdica, Universitat Politècnica de Catalunya, Barcelona, Dr. A Perera: SUMMIT Project.
CAR, Centre d’Alt Rendiment Sportiu, Sant Cugat. Dr. F Drobnic: Sport Medicine Projects.
CHARGE, International network consortium. Hemostatic factors studies.
GIANT, International network consortium. Anthropometric factors studies.
GLGC, International network consortium. Lipidic factors research.

With Biopharma companies

GenIncode. Development of Genetic Diagnostics in Thrombosis.
Leo-Pharma. Prediction of Thrombosis Risk in cancer patients.

Group coordination

SORIA FERNANDEZ, JOSE MANUEL IR
jsoria@santpau.cat

Members

Aloy Ortiz, Carme H. DOS MAIG
Camacho Perez De Madrid, Maria Mercedes IR
De la Rosa Estadella, Mireia IR
Dilme Muñoz, Jaume Felix FGS
Escudero Rodriguez, Jose Roman FGS
Ezquerra Condeminas, Pol CIBER
Fite Matamoros, Joan FGS
Garcia Garcia, Irina IR
Lloret Cano, Maria Dolores H. DOS MAIG
Lobato Delgado, Barbara IR
Martinez Perez, Angel IR
Romero Carro, Josep Maria FGS
Sabater Lleal, Maria IR
Sanchez Garcia, Laia FGS
Soto Carricas, Begoña Dolores FGS
Tejedor Millos, Robert FGS
Uribezubia Azpitarte, Ager IR

Publications 2024

(JIF 2024)

-Arqueros C, Gallardo A, Vidal S, Osuna R, Tibau A, Bell OL, Cajal T, Lerma E, Lobato B, Salazar J, Barnadas A. Clinical Relevance of Tumour-Infiltrating Immune Cells in HER2-Negative Breast Cancer Treated with Neoadjuvant Therapy. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024; 25(5):2627. DOI:10.3390/ijms25052627. PMID:38473874. IF:4,900 (Q1/3D). Document type: Article.

-Balagué L, Esko T, de Heredia ML, Abellán J, Acosta R, Aguado JM, Aguilar C, Aguilera S, Sabbagh AA, Alba J, Albu S, Alcalá K, Alcoba J, Batres SA, Algarin HR, Almadana V, Medeiros KA, Almeida J, Almoguera B, Alonso MR, Alvarez N, Walther R, Alvarez Y, Alvarez F, dos KA, Andreu A, Antonijoan MR, Martínez E, Arana E, Aranda C, Arango C, Araque C, Araujo NK, Arcanjo AC, Arnaiz A, Fernández FA, Arranz MJ, López J, Artiga MJ, Avello Y, Ayuso C, Martín BB, Baptista RC, Baldion AM, Barranco A, Barreda M, Barrera V, Belhassen M, Bernal D, Bernal E, Bezerra JF, Bezerra M, Blanca N, Blancas R, Boix L, Borobia A, Bravo E, Brion M, Brochado O, Brugada R, Bustos M, Cabello A, Cáceres A, Cáceres JJ, Calbo E, Calderón EJ, Camacho S, Ceballos FC, Cañadas Y, Carbonell C, Cardona S, Abad MSC, Segura CC, Carrillo JA, Campos MC, Casasnovas C, Castaño L, Castaño CF, Castelao JE, Candalija AC, Castillo MA, Chaves WG, Chiquillo S, Cid MA, Cienfuegos O, Conde R, Cunha GCR, Cordero ML, Corella D, Corrales A, Cortés JL, Corton M, Souza KSC, Silva FTC, Cruz R, Cuesta L, Tavares N, Carvalho MCC, Dalmau D, Dantas RCS, Darnaude MT, de Andrés R, de Juan C, Troca JJD, de la Horra C, de la Hoz AB, De Martino A, Cruz MS, Neri J, del Campo V, Delgado J, de Bustamante AD, Díaz A, Dietl B, Diz S, Alves MD, Domínguez E, Rosa LS, Luchessi AD, Echave J, Eiros R, Enciso CO, Escudero G, España PP, Sanabria GE, Fariñas MC, Fernández R, Fernández L, Fernández A, Fernández S, Martínez YF, Fernandez MJ, Fernández U, Fernández A, Fernández M, Fernández R, Fernández T, Fernández C, Carioca A, Flores P, Fuenmayor L, Fuertes M, Fumadó V, Gadea I, Gagliardi L, Gago M, Gallego N, Galoppo C, García A, García C, García A, Garcia J, García I, García C, García AC, García L, García M, Torrejón MCG, García I, García E, Garza E, Gentile A, Gil B, de Araújo JNG, Gómez M, Gómez J, Carrera LG, García MG, Sacristán AG, González A, Alvarez BG, de Quirós FGB, González R, González J, Gonzalez M, Gonzalo H, Gorgojo O, Górgolas M, Guaragna F, Chaux JG, Guillén E, Guillén B, Guisado P, Gutiérrez LD, Gutiérrez JF, Heili S, Jacomo RH, Hernández E, Hernández C, Hernández LD, Hernández G, Hernández R, Herráez B, Herranz MT, Herrera M, Herrero MJ, Herrero A, Horcajada JP, Imaz N, Intxausti M, Iñigo A, Iñiguez M, Jara R, Jiménez A, Jiménez I, Jiménez P, Jiménez MA, Jordan I, Laguna R, Laorden D, Lasa M, Lattig MC, Lauriente A, Borja AL, Llanos L, López A, de Heredia ML, Lopez E, López E, Lopez R, López MA, Lorente L, Lorenzo J, Lozano JE, Lozano M, Mahillo I, Mancebo E, Mar C, Calvo CM, Marcos A, Marcos M, Marín A, Mariscal P, Martin L, Martin M, Martín C, Martín JA, Martín MD, Martín V, Martín MM, Martín M, Martinez A, Martínez O, Martínez R, Martinez P, Díaz CM, Martínez O, Martínez I, Martínez MF, Martínez S, Martínez JJ, Martínez A, Martínez A, Martínez V, Marzal L, Mazzeu JF, Medrano FJ, Meijome XM, Mejuto N, Mendes I, Duarte AL, Méndez A, Charris HM, Macías EM, Mercadillo F, Mercado AR, Mínguez P, Molina E, Molina AJ, Montoya JJ, Pinho SMT, Moreira P, Morelos X, Moreno R, Cuerda VM, Moreno A, Moreno J, Fernández AM, Garcia PM, Neira P, Nevado J, Nieto I, Silbiger VN, Nuñez R, Obrador A, Ocejo JG, Virginia O, Oliveira SF, Ondo L, Orfao A, Ortega E, Ortega L, Ortiz R, Ortiz F, Oteo JA, Pacheco M, Pacheco FJ, Padilla I, Panadero S, Parellada M, Pariente R, Friaza V, Paz E, Peces G, Kus MSP, Perales C, Santos NPC, Guegel GP, Pérez MJ, Pérez A, Pérez P, Pérez C, Pérez G, Pérez F, Pérez P, Pérez LA, Pérez ME, Perucho T, Pichardo LA, Ribeiro AP, Pinsach ML, Pinzón LA, Medeiros JFP, Pita G, Pla F, Planas L, Pompa EN, Porras GL, Pujol A, Quevedo ME, Quijada MA, Quintela I, Ramiro S, Sedes PR, Nunes JFR, Recalde D, Recio E, Resino S, Sousa RR, Rivadeneira CS, Roa D, Pardo MR, Fernandes MR, Rodríguez MA, Rodriguez A, Rodríguez E, Rodriguez MJ, Rodríguez F, Rodríguez M, Rodríguez C, Rodríguez JA, Maya BR, Rodriguez A, Rodríguez GE, Rodriguez PA, Rojo F, Romero A, Morilla R, Rondón F, Rosales A, Rubio C, Olivera MR, Ruiz F, Ruiz E, Ruiz JJ, Ruiz J, Ruiz M, Ryan P, Salamanca HD, Salazar L, Salgueiro GG, Sangil A, Sánchez O, Sánchez PL, López A, Sánchez C, Sanchez MC, Sanchez J, Sanchez J, Sancho C, Sande E, Santos A, Schlüter A, Segovia S, Serra A, Sevil F, Sevilla M, Sicolo MA, Silván C, Moraes VMS, Souza VS, Solé J, Soria JM, Sorlí JV, Silva NS, Souto JC, Sprockel JJ, Suárez JJ, Suárez DA, Taboada X, Tamayo E, Tamayo A, Taracido JC, Vasconcelos RHT, Tellería C, Carratto TMT, Tenorio JA, Teper A, Araujo I, Torres J, Torres L, Torres RP, Troya J, Urioste M, Valencia J, Valido A, Vargas JP, Varón B, Vega T, Velasco S, Vélez V, Víctor V, Vidán J, Silva GV, Vieitez M, Vilches C, Villalobos L, Villar F, Villar J, Villaverde C, Villoslada P, Virseda A, Costa TX, Yáñez Z, Zapatero A, Zarate R, Zazo S, Flores C, Riancho JA, Rojas A, Lapunzina P, Carracedo A, González JR, SCOURGE GRP. Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2. Communications Biology. 2024; 7(1):202. DOI:10.1038/s42003-024-05805-6. PMID:38374351. IF:5,100 (Q1/1D). Document type: Article.

-Camacho M, Vazquez C, Valero C, Holgado A, Terra X, Avilés FX, León X. Transcriptional expression of SLC16A7 as a biomarker of occult lymph node metastases in patients with head and neck squamous cell carcinoma. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. 2024; 281(12). DOI:10.1007/s00405-024-08882-9. PMID:39215860. IF:2,200 (Q1/3D). Document type: Article.

-Condeminas PE, Mallol M, Font R, Tremps V, Gutiérrez JA, Rodas G, Lluna AP, Soria JM. Unraveling athletic performance: Transcriptomics and external load monitoring in handball competition. PLoS One. 2024; 19(3):e0299556. DOI:10.1371/journal.pone.0299556. PMID:38466679. IF:2,600 (Q2/4D). Document type: Article.

-de Vries PS, Reventun P, Brown MR, Heath AS, Huffman JE, Le NQ, Bebo A, Brody JA, Temprano G, Raffield LM, Ozel AB, Thibord F, Jain D, Lewis JP, Rodriguez B, Pankratz N, Taylor KD, Polasek O, Chen MH, Yanek LR, Carrasquilla GD, Marioni RE, Kleber ME, Trégouët DA, Yao J, Li R, Joshi PK, Trompet S, Martinez A, Ghanbari M, Howard TE, Reiner AP, Arvanitis M, Ryan KA, Bartz TM, Rudan I, Faraday N, Linneberg A, Ekunwe L, Davies G, Delgado GE, Suchon P, Guo XQ, Rosendaal FR, Klaric L, Noordam R, van F, Curran JE, Wheeler MM, Osburn WO, O’Connell JR, Boerwinkle E, Beswick A, Psaty BM, Kolcic I, Souto JC, Becker LC, Hansen T, Doyle MF, Harris SE, Moissl AP, Deleuze JF, Rich SS, Vlieg AV, Campbell H, Stott DJ, Soria JM, de Maat MPM, Almasy L, Brody LC, Auer PL, Mitchell BD, Ben Y, Fornage M, Hayward C, Mathias RA, Kilpelaeinen TO, Lange LA, Cox SR, März W, Morange PE, Rotter JI, Mook DO, Wilson JF, van der Harst P, Jukema JW, Ikram MA, Blangero J, Kooperberg C, Desch KC, Johnson AD, Sabater M, Lowenstein CJ, Smith NL, Morrison AC, Trans Omics Precision Med TOPMed P, INVENT C. A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels. BLOOD. 2024; 143(18). DOI:10.1182/blood.2023021452. PMID:38320121. IF:23,100 (Q1/1D). Document type: Article.

-Diz-de Almeida S, Cruz R, Luchessi AD, Lorenzo-Salazar JM, de Heredia ML, Quintela I, González-Montelongo R, Nogueira Silbiger V, Porras MS, Tenorio Castaño JA, Nevado J, Aguado JM, Aguilar C, Aguilera-Albesa S, Almadana V, Almoguera B, Alvarez N, Andreu-Bernabeu Á, Arana-Arri E, Arango C, Arranz MJ, Artiga MJ, Baptista-Rosas RC, Barreda-Sánchez M, Belhassen-Garcia M, Bezerra JF, Bezerra MAC, Boix-Palop L, Brion M, Brugada R, Bustos M, Calderón EJ, Carbonell C, Castano L, Castelao JE, Conde-Vicente R, Cordero-Lorenzana ML, Cortes-Sanchez JL, Corton M, Darnaude MT, De Martino-Rodríguez A, Del Campo-Pérez V, de Bustamante AD, Domínguez-Garrido E, Eirós R, Fariñas MC, Fernandez-Nestosa MJ, Fernández-Robelo U, Fernández-Rodríguez A, Fernández-Villa T, Gago-Dominguez M, Gil-Fournier B, Gómez-Arrue J, Álvarez BG, Bernaldo de Quirós FG, González-Neira A, González-Peñas J, Gutiérrez-Bautista JF, Herrero MJ, Herrero-Gonzalez A, Jimenez-Sousa MA, Lattig MC, Borja AL, Lopez-Rodriguez R, Mancebo E, Martín-López C, Martín V, Martinez-Nieto O, Martinez-Lopez I, Martinez-Resendez MF, Martinez-Perez A, Mazzeu JF, Macías EM, Minguez P, Cuerda VM, Oliveira SF, Ortega-Paino E, Parellada M, Paz-Artal E, Santos NPC, Pérez-Matute P, Perez P, Pérez-Tomás ME, Perucho T, Pinsach-Abuin M, Pita G, Pompa-Mera EN, Porras-Hurtado GL, Pujol A, León SR, Resino S, Fernandes MR, Rodríguez-Ruiz E, Rodriguez-Artalejo F, Rodriguez-Garcia JA, Ruiz-Cabello F, Ruiz-Hornillos J, Ryan P, Soria JM, Souto JC, Tamayo E, Tamayo-Velasco A, Taracido-Fernandez JC, Teper A, Torres-Tobar L, Urioste M, Valencia-Ramos J, Yáñez Z, Zarate R, de Rojas I, Ruiz A, Sánchez P, Real LM; SCOURGE Cohort Group; Guillen-Navarro E, Ayuso C, Parra E, Riancho JA, Rojas-Martinez A, Flores C, Lapunzina P, Carracedo Á. Novel risk loci for COVID-19 hospitalization among admixed American populations. Elife. 2024; 13:RP93666. DOI:10.7554/eLife.93666. PMID:39361370. Document type: Article.

-Gallego C, Temprano G, Cárcel J, Muiño E, Cullell N, Lledós M, Llucià L, Martin JM, Sobrino T, Castillo J, Millán M, Muñoz L, López E, Ribó M, Alvarez J, Jiménez J, Roquer J, Tur S, Obach V, Arenillas JF, Segura T, Serrano G, Marti J, Freijo M, Moniche F, Castellanos MDM, Morrison AC, Smith NL, de Vries PS, Fernández I, Sabater M, Dehghan A, Heath AS, Reiner AP, Johnson A, Richmond A, Peters A, van Hylckama Vlieg A, McKnight B, Psaty BM, Hayward C, Ward C, O’Donnell C, Chasman D, Strachan DP, Tregouet DA, Mook D, Gill D, Thibord F, Asselbergs FW, Leebeek FWG, Rosendaal FR, Davies G, Homuth G, Temprano G, Campbell H, Taylor HA, Bressler J, Huffman JE, Rotter JI, Yao J, Wilson JF, Bis JC, Hahn JM, Desch KC, Wiggins KL, Díez L, Raffield LM, Bielak LF, Yanek LR, Kleber ME, Mueller M, Kavousi M, Mangino M, Conomos MP, Liu M, Brown MR, Jhun M-A, Chen M-H, de Maat MPM, Pankratz N, Peyser PA, Elliot P, Wei P, Wild PS, Morange PE, van der Harst P, Yang Q, Marioni R, Li R, Damrauer SM, Cox SR, Trompet S, Felix SB, Völker U, Tang W, Koenig W, Jukema JW, Guo X. A multitrait genetic study of hemostatic factors and hemorrhagic transformation after stroke treatment. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2024; 22(4). DOI:10.1016/j.jtha.2023.11.027. PMID:38103737. IF:5,000 (Q1/2D). Document type: Article.

-Gendre B, Martinez A, Kleber ME, Vlieg AV, Boland A, Olaso R, Germain M, Munsch G, Moissl AP, Suchon P, Souto JC, Soria JM, Deleuze JF, März W, Rosendaal FR, Sabater M, Morange PE, Tregouët DA, CHARGE Hemostasis Working GRP. Genome-Wide Search for Nonadditive Allele Effects Identifies PSKH2 as Involved in the Variability of Factor V Activity. Journal of the American Heart Association. 2024; 13(21):e034943. DOI:10.1161/JAHA.124.034943. PMID:39424413. IF:5,300 (Q1/2D). Document type: Article.

-Hahn J, Temprano-Sagrera G, Hasbani NR, Ligthart S, Dehghan A, Wolberg AS, Smith NL, Sabater-Lleal M, Morrison AC, de Vries PS. Bivariate genome-wide association study of circulating fibrinogen and C-reactive protein levels. J Thromb Haemost. 2024; 22(12):3448-3459. DOI:10.1016/j.jtha.2024.08.021. PMID:39299614. IF:5,000 (Q1/2D). Document type: Article.

-Huffman JE, Nicholas J, Hahn J, Heath AS, Raffield LM, Yanek LR, Brody JA, Thibord F, Almasy L, Bartz TM, Bielak LF, Bowler RP, Carrasquilla GD, Chasman DI, Chen MH, Emmert DB, Ghanbari M, Haessler J, Hottenga JJ, Kleber ME, Le NQ, Lee J, Lewis JP, Li R, Luan J, Malmberg A, Mangino M, Marioni RE, Martinez A, Pankratz N, Polasek O, Richmond A, Rodriguez B, Rotter JI, Steri M, Suchon P, Trompet S, Weiss S, Zare M, Auer P, Cho MH, Christofidou P, Davies G, de Geus E, Deleuze JF, Delgado GE, Ekunwe L, Faraday N, Gögele M, Greinacher A, Gao H, Howard T, Joshi PK, Kilpeläinen TO, Lahti J, Linneberg A, Naitza S, Noordam R, Paüls F, Rich SS, Rosendaal FR, Rudan I, Ryan KA, Souto JC, van F, Wang HM, Zhao W, Becker LC, Beswick A, Brown MR, Cade BE, Campbell H, Cho K, Crapo JD, Curran JE, de Maat MPM, Doyle M, Elliott P, Floyd JS, Fuchsberger C, Grarup N, Guo XQ, Harris SE, Hou LF, Kolcic I, Kooperberg C, Menni C, Nauck M, O’Connell JR, Orrú V, Psaty BM, Räikkönen K, Smith JA, Soria JM, Stott DJ, Vlieg AV, Watkins H, Willemsen G, Wilson PWF, Ben Y, Blangero J, Boomsma D, Cox SR, Dehghan A, Eriksson JG, Fiorillo E, Fornage M, Hansen T, Hayward C, Ikram MA, Jukema JW, Kardia SLR, Lange LA, März W, Mathias RA, Mitchell BD, Mook DO, Morange PE, Pedersen O, Pramstaller PP, Redline S, Reiner A, Ridker PM, Silverman EK, Spector TD, Völker U, Wareham NJ, Wilson JF, Yao J, Trégouët DA, Johnson AD, Wolberg AS, de Vries PS, Sabater M, Morrison AC, Smith NL, Va Million Vet P, Nhlbi Trans T. Whole-genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles. BLOOD. 2024; 144(21). DOI:10.1182/blood.2023022596. PMID:39226462. IF:23,100 (Q1/1D). Document type: Article.

-Leon X, Valero C, Fuster G, Bragado P, Camacho M, Aviles FX. Predictive capacity for local disease control of neogenin-1 (NEO1) transcriptional expression in patients with head and neck squamous cell carcinoma. Clinical & Translational Oncology. 2024; DOI:10.1007/s12094-024-03535-z. PMID:38898351. IF:2,500 (Q3/6D). Document type: Article.

-Martinez J, Torramade S, Moreno AB, Llobet D, Jerez D, Sanchez P, Carrasco M, Mojal S, Moret C, Camacho M, Soria JM, Palomo M, Martin L, Vidal F, Escolar G, Diaz M, Souto JC. Increased Platelet Adhesiveness in Patients with Venous Thromboembolic Disease. TH OPEN. 2024; 08(04). DOI:10.1055/s-0044-1800798. PMID:39619107. IF:1,800 (Q3/7D). Document type: Article.

-Pérez-Fernández X, Ulsamer A, Cámara-Rosell M, Sbraga F, Boza-Hernández E, Moret-Ruíz E, Plata-Menchaca E, Santiago-Bautista D, Boronat-García P, Gumucio-Sanguino V, Peñafiel-Muñoz J, Camacho-Pérez M, Betbesé-Roig A, Forni L, Campos-Gómez A, Sabater-Riera J; SIRAKI02 Study Group. Extracorporeal Blood Purification and Acute Kidney Injury in Cardiac Surgery: The SIRAKI02 Randomized Clinical Trial. JAMA. 2024; 332(17):1446-1454. DOI:10.1001/jama.2024.20630. PMID:39382234. IF:55,000 (Q1/1D). Document type: Article.

-Puertas L, Puig N, Camacho M, Dantas AP, Marin R, Marti J, Jimenez E, Benitez S, Camps P, Jimenez F. Serum from Stroke Patients with High-Grade Carotid Stenosis Promotes Cyclooxygenase-Dependent Endothelial Dysfunction in Non-ischemic Mice Carotid Arteries. Translational Stroke Research. 2024; 15(1). DOI:10.1007/s12975-022-01117-1. PMID:36536168. IF:4,300 (Q1/2D). Document type: Article.

-Temprano G, Peypoch O, Soto B, Dilmé J, Juscafresa LC, Davtian D, Estadella MD, Nieto L, Brown A, Escudero JR, Viñuela A, Camacho M, Sabater M. Differential Expression Analyses on Human Aortic Tissue Reveal Novel Genes and Pathways Associated With Abdominal Aortic Aneurysm Onset and Progression. Journal of the American Heart Association. 2024; 13(24):e036082. DOI:10.1161/JAHA.124.036082. PMID:39655704. IF:5,300 (Q1/2D). Document type: Article.

Publications 2023

(JIF 2023)

-Gené A, Casasa A, Puig T, de La Figuera M, Jimenez MJ, Fité J, Roman J, Bellmunt S. Normal Infrarenal Aortic Diameter in Men and Women in a Mediterranean Area. ANNALS OF VASCULAR SURGERY. 2023; 92. DOI:10.1016/j.avsg.2022.12.087. PMID:36639098. IF:1,400 (Q3/6D). Document type: Article.

-Hahn J, Bressler J, Domingo A, Chen MH, McCartney DL, Teumer A, van J, Kleber ME, Aissi D, Swenson BR, Yao J, Zhao W, Huang J, Xia YJ, Brown MR, Costeira R, de Geus E, Delgado GE, Dobson DA, Elliott P, Grabe HJ, Guo XQ, Harris SE, Huffman JE, Kardia SLR, Liu YM, Lorkowski S, Marioni RE, Nauck M, Ratliff SM, Sabater M, Spector TD, Suchon P, Taylor KD, Thibord F, Tregouet DA, Wiggins KL, Willemsen G, Bell JT, Boomsma DI, Cole SA, Cox SR, Dehghan A, Greinacher A, Haack K, Marz W, Morange PE, Rotter JI, Sotoodehnia N, Tellez M, Navas A, Smith JA, Johnson AD, Fornage M, Smith NL, Wolberg AS, Morrison AC, de Vries PS. DNA methylation analysis is used to identify novel genetic loci associated with circulating fibrinogen levels in blood. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2023; 21(5). DOI:10.1016/j.jtha.2023.01.015. PMID:36716967. IF:5,5000 (Q1/2D). Document type: Article.

-Iglesias MJ, Sanchez L, Ibrahim M, Naudin C, Munsch G, Goumidi L, Farm M, Smith PM, Thibord F, Kral JB, Hong M-G, Suchon P, Germain M, Schottmaier W, Dusart P, Boland A, Kotol D, Edfors F, Koprulu M, Pietzner M, Langenberg C, Damrauer SM, Johnson AD, Klarin DM, Smith NL, Smadja DM, Holmström M, Magnusson M, Silveira A, Uhlén M, Renné T, Martinez A, Emmerich J, Deleuze J-F, Antovic J, Soria JM, Assinger A, Schwenk JM, Souto JC, Morange P-E, Butler LM, Trégouët D-A, Odeberg J. Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism. Nature Communications. 2023; 14(1):3280. DOI:10.1038/s41467-023-38383-y. PMID:37286573. IF:14,700 (Q1/1D). Document type: Article.

-Ji YK, Temprano G, Holle LA, Bebo A, Brody JA, Le NQ, Kangro K, Brown MR, Martinez A, Sitlani CM, Suchon P, Kleber ME, Emmert DB, Ozel AB, Dobson DA, Tang WH, Llobet D, Tracy RP, Deleuze JF, Delgado GE, Gogele M, Wiggins KL, Souto JC, Pankow JS, Taylor KD, Tregouet DA, Moissl AP, Fuchsberger C, Rosendaal FR, Morrison AC, Soria JM, Cushman M, Morange PE, Marz W, Hicks AA, Desch KC, Johnson AD, de Vries PS, Wolberg AS, Smith NL, Sabater M, INVENT C, CHARGE Consortium Hemostasis W, INVENT C. Antithrombin, Protein C, and Protein S: Genome and Transcriptome-Wide Association Studies Identify 7 Novel Loci Regulating Plasma Levels. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2023; 43(7):e254-e269. DOI:10.1161/ATVBAHA.122.318213. PMID:37128921. IF:7,400 (Q1/1D). Document type: Article.

-León X, Bagué S, Holgado A, Quer M, Terra X, Camacho M, Avilés FX. Relationship between transcriptional expression of pyruvate dehydrogenase and local control of disease in patients with oral cavity carcinomas. Acta Otorrinolaringologica Espanola. 2023; 74(6). DOI:10.1016/j.otoeng.2023.05.006. PMID:37730160. IF:0,900 (Q3/8D). Document type: Article.

-León X, Bague S, Holgado A, Quer M, Terra X, Camacho M, Aviltes FX. Relationship between transcriptional expression of pyruvate dehydrogenase and local control of disease in patients with oral cavity carcinomas. Acta Otorrinolaringologica Espanola. 2023; 74(6). DOI:10.1016/j.otorri.2023.05.001. IF:0,900 (Q3/8D). Document type: Article.

-León X, Llansana A, Pérez L, García J, Valero C, Quer M, Camacho M. Predictive capacity of FAT1 transcriptional expression in patients with head and neck squamous cell carcinomas treated with radiotherapy. Acta Otorrinolaringologica Espanola. 2023; 74(6). DOI:10.1016/j.otorri.2023.03.003. PMID:37931687. IF:0,900 (Q3/8D). Document type: Article.

-Martin L, Garcia I, Lopez S, Martinez A, Vilalta N, Plaza M, Moret C, Vinuela A, Brown AA, Panousis NI, Buil A, Dermitzakis ET, Corrales I, Souto JC, Vidal F, Soria JM. Multiallelic Copy Number Variation in ORM1 is Associated with Plasma Cell-Free DNA Levels as an Intermediate Phenotype for Venous Thromboembolism. THROMBOSIS AND HAEMOSTASIS. 2023; 123(04). DOI:10.1055/s-0043-1760844. PMID:36696913. IF:5,000 (Q1/2D). Document type: Article.

-Matamoros JF. Latest report from the ALTAMIRA study of emergency management of vein thrombosis: our departments’ strengths and weaknesses. Emergencias. 2023; 35(2). PMID:37038937. IF:5,400 (Q1/1D). Document type: Editorial Material.

-Molina JM, Munoz JD. Blood pool in a patient with intramural aortic hematoma. Angiologia. 2023; 75(3). DOI:10.20960/angiologia.00492. IF:0,100 (Q4/10D). Document type: Article.

-Muñoz A, Ay C, Grilz E, López S, Font C, Pachón V, Castellón V, Martínez V, Salgado M, Martínez E, Calzas J, Ortega L, Rupérez A, Salas E, Pabinger I, Soria JM. A Clinical-Genetic Risk Score for Predicting Cancer-Associated Venous Thromboembolism: A Development and Validation Study Involving Two Independent Prospective Cohorts. JOURNAL OF CLINICAL ONCOLOGY. 2023; 41(16). DOI:10.1200/JCO.22.00255. PMID:36730884. IF:42,100 (Q1/1D). Document type: Article.

-Muñoz A, Salas E, Soria JM. Reply to FI Mulder et al. JOURNAL OF CLINICAL ONCOLOGY. 2023; 41(36). DOI:10.1200/JCO.23.00817. PMID:37816210. IF:42,100 (Q1/1D). Document type: Letter.

-Muñoz AJ, Ortega L, Gutiérrez A, Gallardo E, Rubio D, Rubio C, Morón B, García P, Soria JM. Cost-effectiveness of apixaban and rivaroxaban in thromboprophylaxis of cancer patients treated with chemotherapy in Spain. JOURNAL OF MEDICAL ECONOMICS. 2023; 26(1). DOI:10.1080/13696998.2023.2248839. PMID:37602646. IF:2,900 (Q1/2D). Document type: Article.

-Puig N, Camps P, Sole A, Aguilera A, Jimenez E, Fernandez A, Camacho M, Guasch M, Marin R, Marti J, Martinez A, Prats L, Casoni F, Perez B, Jimenez F, Sanchez JL, Benitez S. Electronegative LDL Is Associated with Plaque Vulnerability in Patients with Ischemic Stroke and Carotid Atherosclerosis. Antioxidants. 2023; 12(2):438. DOI:10.3390/antiox12020438. PMID:36829998. IF:6,000 (Q1/2D). Document type: Article.

-Puig N, Rives J, Estruch M, Aguilera A, Rotllan N, Camacho M, Colomé N, Canals F, Sánchez JL, Benitez S. Presence of Ceramidase Activity in Electronegative LDL. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023; 24(1):165. DOI:10.3390/ijms24010165. PMID:36613609. IF:4,900 (Q1/3D). Document type: Article.

-Rodríguez A, Tello C, Vergara AC, Fernández C, Moustafa AH, Pinilla CA, Ginel A, Barros AJ, Dilme JF. Case Report: Kommerell's diverticulum and left aberrant subclavian artery stenosis hybrid treatment with branched aortic stent-graft. Frontiers in Cardiovascular Medicine. 2023; 10:1309839. DOI:10.3389/fcvm.2023.1309839. PMID:38155991. IF:2,800 (Q2/4D). Document type: Article.

-Roychowdhury T, Klarin D, Levin MG, Spin JM, Rhee YH, Deng A, Headley CA, Tsao NL, Gellatly C, Zuber V, Shen F, Hornsby WE, Laursen IH, Verma SS, Locke AE, Einarsson G, Thorleifsson G, Graham SE, Dikilitas O, Pattee JW, Judy RL, Pauls F, Nielsen JB, Wolford BN, Brumpton BM, Dilmé J, Peypoch O, Juscafresa LC, Edwards TL, Li D, Banasik K, Brunak S, Jacobsen RL, Garcia MT, Zhang J, Rasmussen LM, Lee R, Handa A, Wanhainen A, Mani K, Lindholt JS, Obel LM, Strauss E, Oszkinis G, Nelson CP, Saxby KL, van JA, van der Laan SW, van J, Camacho M, Davis FM, Wasikowski R, Tsoi LC, Gudjonsson JE, Eliason JL, Coleman DM, Henke PK, Ganesh SK, Chen YE, Guan W, Pankow JS, Pankratz N, Pedersen OB, Erikstrup C, Tang W, Hveem K, Gudbjartsson D, Gretarsdottir S, Thorsteinsdottir U, Holm H, Stefansson K, Ferreira MA, Baras A, Kullo IJ, Ritchie MD, Christensen AH, Iversen KK, Eldrup N, Sillesen H, Ostrowski SR, Bundgaard H, Ullum H, Burgess S, Gill D, Gallagher K, Sabater M, Dudbridge F, Samani NJ, Surakka I, Jones GT, Bown MJ, Tsao PS, Willer CJ, Damrauer SM. Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target. NATURE GENETICS. 2023; DOI:10.1038/s41588-023-01510-y. PMID:37845353. IF:31,700 (Q1/1D). Document type: Article.

-Tello C, Dilmé JF. An Uncommon Cause of Congestive Heart Failure. EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. 2023; 66(4). DOI:10.1016/j.ejvs.2023.07.042. PMID:37506872. IF:4,200 (Q1/2D). Document type: Article.

-Tello C, Romero JM, Soto B, Moreno J, Aloy C, Dilmé JF. Type Ib endoleak repaired with a thoracic endovascular graft inside previous visceral debranching bypass in a patient with chronic type B aortic dissection. Journal Of Vascular Surgery Cases, Innovations And Techniques. 2023; 9(2):101186. DOI:10.1016/j.jvscit.2023.101186. PMID:37305360. IF:0,700 (Q4/8D). Document type: Case Reports.

-Torres JK, Niño J, Martinez P, Diarte EMG, Méndez KA, del Olmo TV, Rotllan N, Julián MT, Alonso N, Mauricio D, Camacho M, Muñoz JP, Rossell J, Julve J. Nicotinamide Prevents Diabetic Brain Inflammation via NAD+-Dependent Deacetylation Mechanisms. Nutrients. 2023; 15(14):3083. DOI:10.3390/nu15143083. PMID:37513501. IF:4,800 (Q1/2D). Document type: Article.

-Trallero J, Camacho M, Marín M, Álvarez E, Benseny N, Barnadas R. Properties and cellular uptake of photo-triggered mixed metallosurfactant vesicles intended for controlled CO delivery in gas therapy. COLLOIDS AND SURFACES B-BIOINTERFACES. 2023; 228:113422. DOI:10.1016/j.colsurfb.2023.113422. PMID:37356136. IF:5,400 (Q1/2D). Document type: Article.

-Ward J, Le NQ, Suryakant S, Brody JA, Amouyel P, Boland A, Bown R, Cullen B, Debette S, Deleuze JF, Emmerich J, Graham N, Germain M, Anderson JJ, Pell JP, Lyall DM, Lyall LM, Smith DJ, Wiggins KL, Soria JM, Souto JC, Morange PE, Smith NL, Trégouët DA, Sabater M, Strawbridge RJ. Polygenic risk of major depressive disorder as a risk factor for venous thromboembolism. Blood Advances. 2023; 7(18). DOI:10.1182/bloodadvances.2023010562. PMID:37399490. IF:7,400 (Q1/2D). Document type: Article.

Publications 2022

(JIF 2022)

Bague S, Leon X, Terra X, Lejeune M, Camacho M, Aviles FX. Prognostic capacity of the transcriptional expression of lactate dehydrogenase A in patients with head and neck squamous cell carcinoma. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK. 2022; 44(11). DOI:10.1002/hed.27161. PMID:36207788. IF:2,9 (Q1/2D). Document type: Article.
Camacho M, Leon X, Pujol A, Montezuma L, Quer M, Garcia J. Prognostic value of transcriptional expression of fibronectin type III domain-containing 4 (FNDC4) in head and neck carcinoma patients treated with chemoradiotherapy. Clinical & Translational Oncology. 2022; 24(11). DOI:10.1007/s12094-022-02870-3. PMID:35752749. IF:3,4 (Q3/6D). Document type: Article.
Canyelles M, Plaza M, Rotllan N, Llobet D, Julve J, Mojal S, Diaz M, Soria JM, Escola JC, Tondo M, Blanco F, Souto JC. TMAO and Gut Microbial-Derived Metabolites TML and gamma BB Are Not Associated with Thrombotic Risk in Patients with Venous Thromboembolism. Journal of Clinical Medicine. 2022; 11(5):1425. DOI:10.3390/jcm11051425. PMID:35268516. IF:3,9 (Q2/4D). Document type: Article.
Corrochano M, Acosta R, Mojal S, Miqueleiz S, Rodriguez D, Quijada MA, Fraga E, Castillo M, Amaro K, Albiol N, Soria JM, Antonijoan RM, Souto JC. Impact of pre-admission antithrombotic therapy on disease severity and mortality in patients hospitalized for COVID-19. JOURNAL OF THROMBOSIS AND THROMBOLYSIS. 2022; 53(1). DOI:10.1007/s11239-021-02507-2. PMID:34138399. IF:4 (Q2/4D). Document type: Article.
Cruz R, Díaz S, López de Heredia M, Quintela I, Ceballos FC, Lorenzo GM, Gonzalez R, Gago M, Porras MS, Castano J, Nevado J, Aguado JM, Aguilar C, Aguilera S, Almadana V, Almoguera B, Alvarez N, Andreu A, Arana E, Arango C, Arranz MJ, Artiga MJ, Baptista RC, Barreda M, Belhassen M, Bezerra JF, Bezerra M, Boix L, Brion M, Brugada R, Bustos M, Calderon EJ, et al. [Martínez-Pérez A, Soria JM, Souto JC, Fernández-Cadenas I]. Novel genes and sex differences in COVID-19 severity. HUMAN MOLECULAR GENETICS. 2022; 31(22). DOI:10.1093/hmg/ddac132. PMID:35708486. IF:3,5 (Q2/4D). Document type: Article.
Garcia LS, Munoz JFD. Steerable sheath for cannulation of target visceral vessels in complex endoprosthesis. Angiologia. 2022; 74(5). DOI:10.20960/angiologia.00401. Document type: Article.
Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Clarke SL, Bhatti KF, Vedantam S, Winkler TW, Locke AE, Marouli E, Zajac GJM, Wu K-HH, Ntalla I, Hui Q, Klarin D, Hilliard AT, Xue C, Thorleifsson G, Helgadottir A, Gudbjartsson DF, Holm H, Olafsson I, Hwang MY, Han S, Akiyama M, Sakaue S, Terao C, Kanai M, Zhou W, Brumpton BM, Rasheed H, Havulinna AS, et al. [Sabater-Lleal M]. Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis. GENOME BIOLOGY. 2022; 23(1):268. DOI:10.1186/s13059-022-02837-1. PMID:36575460. IF:12,3 (Q1/1D). Document type: Article.
Leon X, Garcia J, Pujol A, de Juan J, Vasquez R, Quer M, Camacho M. Relationship between the transcriptional expression of PIM1 and local control in patients with head and neck squamous cell carcinomas treated with radiotherapy. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. 2022; 279(7). DOI:10.1007/s00405-021-07223-4. PMID:34993612. IF:2,6 (Q2/3D). Document type: Article.
Lobato B, Priego B, Sanchez D. Combining Molecular, Imaging, and Clinical Data Analysis for Predicting Cancer Prognosis. Cancers. 2022; 14(13):3215. DOI:10.3390/cancers14133215. PMID:35804988. IF:5,2 (Q2/3D). Document type: Review.
Lopez S, Martinez A, Rodriguez A, Vinuela A, Brown AA, Martin L, Vilalta N, Arus M, Panousis NI, Buil A, Sabater-Lleal M, Souto JC, Dermitzakis ET, Soria JM. Integrated GWAS and Gene Expression Suggest ORM1 as a Potential Regulator of Plasma Levels of Cell-Free DNA and Thrombosis Risk. THROMBOSIS AND HAEMOSTASIS. 2022; 122(06). DOI:10.1055/s-0041-1742169. PMID:35272364. IF:6,7 (Q1/2D). Document type: Article.
Marín-García M, Benseny-Cases N, Camacho M, Barnadas-Rodríguez R. Chapter 11: Metallosurfactants as Carbon Monoxide-Releasing Molecules. In: Surinder M, Ravneet K (Eds). Metallosurfactants: From Fundamentals to Catalytic and Biomedical Applications. Wiley, 2022. pp.195-222. DOI:10.1002/9783527831289.ch11. ISBN:9783527348688. Document Type: Book chapter.
Meler C, Aviles FX, Vilaseca I, Terra X, Bragado P, Fuster G, Vintro XL, Camacho M. Semaphorin-3F/Neuropilin-2 Transcriptional Expression as a Predictive Biomarker of Occult Lymph Node Metastases in HNSCC. 2022; 14(9):2259. DOI:10.3390/cancers14092259. PMID:35565388. IF:5,2 (Q2/3D). Document type: Article.
Puig N, Camps P, Camacho M, Aguilera A, Jimenez F, Fernandez A, Marin R, Marti J, Sanchez JL, Jimenez E, Benitez S. Plasma sICAM-1 as a Biomarker of Carotid Plaque Inflammation in Patients with a Recent Ischemic Stroke. Translational Stroke Research. 2022; 13(5). DOI:10.1007/s12975-022-01002-x. PMID:35237947. IF:6,9 (Q1/1D). Document type: Article.
Ramdas S, Judd J, Graham SE, Kanoni S, Wang YX, Surakka I, Wenz B, Clarke SL, Chesi A, Wells A, Bhatti KF, Vedantam S, Winkler TW, Locke AE, Marouli E, Zajac GJM, Wu KHH, Ntalla I, Hui Q, Klarin D, Hilliard AT, Wang ZY, Xue C, Thorleifsson G, Helgadottir A, Gudbjartsson DF, Holm H, Olafsson I, Hwang MY, Han S, Akiyama M, Sakaue S, Terao C, Kanai M, Zhou W, et al. [Sabater-Lleal M]. A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids. AMERICAN JOURNAL OF HUMAN GENETICS. 2022; 109(8). DOI:10.1016/j.ajhg.2022.06.012. PMID:35931049. IF:9,8(Q1/1D). Document type: Article.
Soria JM, Mojal S, Martinez A, Acosta FR, López S, Miqueleiz S, Rodriguez D, Quijada MA, Cardenas A, Vidal F, Remacha A, Antonijoan RM, Souto JC. A validated clinical-genetic score for assessing the risk of thrombosis in patients with COVID-19 receiving thromboprophylaxis. HAEMATOLOGICA. 2022; 107(9). DOI:10.3324/haematol.2022.281068. PMID:35545920. IF:10,1 (Q1/2D). Document type: Article.
Stacey D, Chen LY, Stanczyk PJ, Howson JMM, Mason AM, Burgess S, MacDonald S, Langdown J, McKinney H, Downes K, Farahi N, Peters JE, Bas S, Pankowf JS, Tang WH, Pankratz N, Sabater-Lleal M, de Vries PS, Smith NL, Gelinas AD, Schneider DJ, Janjic N, Samani NJ, Ye S, Summers C, Chilvers ER, Danesh J, Paul DS, CHARGE Hemostasis Working GRP. Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus. Nature Communications. 2022; 13(1):1222. DOI:10.1038/s41467-022-28729-3. PMID:35264566. IF:16,6 (Q1/1D). Document type: Article.
Temprano G, Sitlani CM, Bone WP, Martin M, Voight BF, Morrison AC, Damrauer SM, de Vries PS, Smith NL, Sabater-Lleal M. Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2022; 20(6). DOI:10.1111/jth.15698. PMID:35285134. IF:10,4 (Q1/1D). Document type: Article.
Thibord F, Klarin D, Brody JA, Chen MH, Levin MG, Chasman DI, Goode EL, Hveem K, Teder M, Martinez A, Aissi D, Daian D, Ito K, Natarajan P, Lutsey PL, Nadkarni GN, de Vries PS, Cuellar G, Wolford BN, Pattee JW, Kooperberg C, Braekkan SK, Li RF, Saut N, Sept C, Germain M, Judy RL, Wiggins KL, Ko D, O’Donnell CJ, Taylor KD, Giulianini F, De Andrade M, Nost TH, et al. [Soria JM, Souto JC, Sabater-Lleal M]. CIRCULATION. 2022; 146(16). DOI:10.1161/CIRCULATIONAHA.122.059675. PMID:36154123. IF:37,8 (Q1/1D). Document type: Article.
Vitiello G, Soto B, Martínez MC, Targarona E. Resection of the aortic bifurcation in the treatment of locally recurrent colorectal cancer. CIRUGIA ESPANOLA. 2022; 100(3). DOI:10.1016/j.ciresp.2020.12.009. PMID:33468362. IF:1,9 (Q3/6D). Document type: Letter.
Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen AU, Jiang YX, Raghavan S, Miao JK, Arias JD, Graham SE, Mukamel RE, Spracklen CN, Yin XY, Chen SH, Ferreira T, Highland HH, Ji YJ, Karaderi T, Lin K, Lull K, Malden DE, Medina C, Machado M, Moore A, Rueger S, Sim X, Vrieze S, Ahluwalia TS, Akiyama M, Allison MA, Alvarez M, et al. [Sabater-Lleal M]. A saturated map of common genetic variants associated with human height. NATURE. 2022; 610(7933). DOI:10.1038/s41586-022-05275-y. PMID:36224396. IF:64,8 (Q1/1D). Document type: Article.

Publications 2021

Ahluwalia TS, Prins BP, Abdollahi M, Armstrong NJ, Aslibekyan S, Bain L, Jefferis B, Baumert J, Beekman M, Ben Y, Bis JC, Mitchell BD, de Geus E, Delgado GE, Marek D, Eriksson J, Kajantie E, Kanoni S, Kemp JP, Lu C, Marioni RE, McLachlan S, Milaneschi Y, Nolte IM, Petrelis AM, Porcu E, Sabater M, Naderi E, Seppala I, Shah T, Singhal G, et al., CHARGE Inflammation Working GRP. Genome-wide association study of circulating interleukin 6 levels identifies novel loci. HUMAN MOLECULAR GENETICS. 2021; 30(5). DOI:10.1093/hmg/ddab023. PMID:33517400. IF:5,121.
Aviles-Jurado FX, Munoz C, Meler C, Flores JC, Guma J, Benaiges E, Mora J, Camacho M, Leon X, Vilaseca I, Terra X. Circulating microRNAs modulating glycolysis as non-invasive prognostic biomarkers of HNSCC. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. 2021; 278(5):1585-1594. DOI: 10.1007/s00405-020-06240-z. PMID: 32737645. IF:3,236.
Bastos M, Ortiz J, Pradillo V, Salas E, Marinez C, Munoz A, Buno I, Diez JL, Soria JM, Izquierdo CP. Incorporating genetic and clinical data into the prediction of thromboembolism risk in patients with lymphoma. Cancer Medicine. 2021; 10(21). DOI:10.1002/cam4.4280. PMID:34598309. IF:4,711.
Bonfill X, Quintana MJ, Escudero JR, Miralles M, Fite J, Mikelarena E, Castejon B, Garnica M, De Valderrama IF, Rodriguez A, Pijoan JI, Bellmunt S. Appropriateness of surgery performed for abdominal aortic aneurysm at tertiary hospitals in Spain. INTERNATIONAL ANGIOLOGY. 2021; 40(4). DOI:10.23736/S0392-9590.21.04654-X. PMID:34060282. IF:2,103.
Canes L, Alonso J, Ballester C, Varona S, Escudero JR, Andres V, Rodriguez C, Martinez J. Targeting Tyrosine Hydroxylase for Abdominal Aortic Aneurysm Impact on Inflammation, Oxidative Stress, and Vascular Remodeling. HYPERTENSION. 2021; 78(3). DOI:10.1161/HYPERTENSIONAHA.121.17517. PMID:34304581. IF:9,897.
Ellervik C, Mora S, Kus A, Asvold B, Marouli E, Deloukas P, Sterenborg RBTM, Teumer A, Burgess S, Sabater M, Huffman J, Johnson AD, Tregouet DA, Smith NL, Medici M, DeVries PS, Chasman DI, Kjaergaard AD. Effects of Thyroid Function on Hemostasis, Coagulation, and Fibrinolysis: A Mendelian Randomization Study. THYROID. 2021; 31(9). DOI:10.1089/thy.2021.0055. PMID:34210154. IF:6,506.
Fite J, Gayarre R, Puig T, Zamora S, Escudero JR, Roca JS, Bellmunt S. Feasibility and Efficiency Study of a Population-Based Abdominal Aortic Aneurysm Screening Program in Men and Women in Spain. ANNALS OF VASCULAR SURGERY. 2021; 73. DOI:10.1016/j.avsg.2020.11.042. PMID:33387620. IF:1,607.
Fite J, Gimenez E, Soto B, Artigas V, Escudero JR, Bellmunt S, Espallargues M. Systematic review on abdominal aortic aneurysm screening cost-efficiency and methodological quality assessment. INTERNATIONAL ANGIOLOGY. 2021; 40(1). DOI:10.23736/S0392-9590.20.04547-2. PMID:33086780. IF:2,103.
Goncalves G, Gil D, Tello C, Tenezaca X, Marrero C, Puig T, Gayarre R, Fite J, Bellmunt S. Prevalence of Peripheral Arterial Disease and Associated Vascular Risk Factors in 65-Years-Old People of Northern Barcelona. Journal of Clinical Medicine. 2021; 10(19):4467. DOI:10.3390/jcm10194467. PMID:34640483. IF:4,964.
Goumidi L, Thibord F, Wiggins KL, Li RF, Brown MR, Vlieg AV, Souto JC, Soria JM, Ibrahim M, Saut N, Daian D, Olaso R, Amouyel P, Debette S, Boland A, Bailly P, Morrison AC, Mook DO, Deleuze JF, Johnson A, de Vries PS, Sabater M, Chiaroni J, Smith NL, Rosendaal FR, Chasman DI, Tregouet DA, Morange PE. Association between ABO haplotypes and the risk of venous thrombosis: impact on disease risk estimation. BLOOD. 2021; 137(17). DOI:10.1182/blood.2020008997. PMID:33512453. IF:25,476.
Graham SE, Clarke SL, Wu KHH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I, Vedantam S, Winkler TW, Locke AE, Marouli E, Hwang MY, Han S, Narita A, Choudhury A, Bentley AR, Ekoru K, Verma A, Trivedi B, Martin HC, Hunt KA, Hui Q, Klarin D, Zhu X, Thorleifsson G, Helgadottir A, Gudbjartsson DF, Holm H, Olafsson I, et al. [Sabater M]. The power of genetic diversity in genome-wide association studies of lipids. NATURE. 2021; 600(7890). DOI:10.1038/s41586-021-04064-3. PMID:34887591. IF:69,504.
Guo YJ, Rist PM, Sabater M, de Vries P, Smith N, Ridker PM, Kurth T, Chasman DI. Association Between Hemostatic Profile and Migraine A Mendelian Randomization Analysis. NEUROLOGY. 2021; 96(20). DOI:10.1212/WNL.0000000000011931. PMID:33795393. IF:11,800.
Leon X, Venegas M, Pujol A, Bulboa C, Llansana A, Casasayas M, Quer M, Camacho M. Predictive value of transcriptional expression of Kruppel-like factor-6 (KLF6) in head and neck carcinoma patients treated with radiotherapy. Clinical & Translational Oncology. 2021; 23(12). DOI:10.1007/s12094-021-02651-4. PMID:34061320. IF:3,340.
Mendez KA, Rodriguez E, Sebastian D, Blanco R, Camacho M, Nan MN, Diarte E, Mato E, Lope S, Roglans N, Laguna JC, Alonso N, Mauricio D, Zorzano A, Villarroya F, Villena JA, Blanco F, Julve J. Nicotinamide Protects Against Diet-Induced Body Weight Gain, Increases Energy Expenditure, and Induces White Adipose Tissue Beiging. MOLECULAR NUTRITION & FOOD RESEARCH. 2021; 65(11):2100111. DOI:10.1002/mnfr.202100111. PMID:33870623. IF:6,575.
Paloschi V, Sabater M, Middelkamp H, Vivas A, Johansson S, van der Meer A, Tenje M, Maegdefessel L. Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases. CARDIOVASCULAR RESEARCH. 2021; 117(14). DOI:10.1093/cvr/cvab088. PMID:33729461. IF:13,081.
Rotllan N, Camacho M, Tondo M, Diarte E, Canyelles M, Mendez KA, Benitez S, Alonso N, Mauricio D, Escola JC, Blanco F, Julve J. Therapeutic Potential of Emerging NAD plus -Increasing Strategies for Cardiovascular Diseases. Antioxidants. 2021; 10(12):1939. DOI:10.3390/antiox10121939. IF:7,675.
Sanchez D, Nus M, Navas M, Fite J, Perez B, Barros AJ, Soto B, Martinez J, Camacho M, Rodriguez C, Mallat Z, Galan M. Oxidative Stress and Inflammatory Markers in Abdominal Aortic Aneurysm. Antioxidants. 2021; 10(4):602. DOI:10.3390/antiox10040602. PMID:33919749. IF:7,675.
Sanchez L, Fite J, Peypoch O, Moreno J, Jubert Q, Carricas BS, Dilme JF, Escudero JR. Preoperative geriatric assessment, a promising tool to improve outcomes in aortic pathology interventions. INTERNATIONAL ANGIOLOGY. 2021; 40(4). DOI:10.23736/S0392-9590.21.04643-5. PMID:33913311. IF:2,103.
Small AM, Huffman JE, Klarin D, Sabater M, Lynch JA, Assimes TL, Sun YV, Miller D, Freiberg MS, Morrison AC, Rader DJ, Wilson PWF, Cho K, Tsao PS, Chang KM, Smith NL, O’Donnell CJ, de Vries PS, Damrauer SM, Cohorts Heart Aging Res Genomic &, VA Million Veteran P. Mendelian Randomization Analysis of Hemostatic Factors and Their Contribution to Peripheral Artery Disease-Brief Report. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2021; 41(1). DOI:10.1161/ATVBAHA.119.313847. PMID:32847391. IF:10,514.
Thibord F, Song C, Pattee J, Rodriguez B, Chen MH, O’Donnell CJ, Kleber ME, Delgado GE, Guo XQ, Yao J, Taylor KD, Ozel AB, Brody JA, McKnight B, Gyorgy B, Simonsick E, Leonard HL, Carrasquilla GD, Guindo M, Silveira A, Temprano G, Yanek LR, Becker DM, Mathias RA, Becker LC, Raffield LM, Kilpelainen TO, Grarup N, Pedersen O, Hansen T, et al. [Sabater M]. FGL1 as a modulator of plasma D-dimer levels: Exome-wide marker analysis of plasma tPA, PAI-1, and D-dimer. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2021; 19(8). DOI:10.1111/jth.15345. PMID:33876560. IF:16,036.
Varona S, Puertas L, Galan M, Orriols M, Canes L, Aguilo S, Camacho M, Sirvent M, Andres V, Martinez J, Rodriguez C. Rolipram Prevents the Formation of Abdominal Aortic Aneurysm (AAA) in Mice: PDE4B as a Target in AAA. Antioxidants. 2021; 10(3):460. DOI:10.3390/antiox10030460. PMID:33809405. IF:7,675.

IIB-Sant-Pau-2020 Report. Genomics

Relevant Publications of the last 5 years

Plasma sICAM-1 as a Biomarker of Carotid Plaque Inflammation in Patients with a Recent Ischemic Stroke. Puig N, Camps-Renom P, Camacho M, Aguilera-Simón A, Jiménez-Altayó F, Fernández-León A, Marín R, Martí-Fàbregas J, Sánchez-Quesada JL, Jiménez-Xarrié E, Benitez S. Transl Stroke Res. 2022 Oct;13(5):745-756. doi: 10.1007/s12975-022-01002-x. Epub 2022 Mar 2. PMID: 35237947. IF:6.8. Q1
Combining Molecular, Imaging, and Clinical Data Analysis for Predicting Cancer Prognosis. Bárbara Lobato-Delgado, Blanca Priego-Torres, Daniel Sanchez-Morillo.Cancers (Basel). 022 Jun 30;14(13):3215. doi: 10.3390/cancers14133215. PMID: 35804988. IF: 6,575. Q1
A saturated map of common genetic variants associated with human height. Yengo L, et al. Nature. 2022 Oct 12. doi: 10.1038/s41586-022-05275-y. Online ahead of print.PMID: 36224396
Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus. Stacey D, Chen L, Stanczyk PJ, Howson JMM, Mason AM, Burgess S, MacDonald S, Langdown J, McKinney H, Downes K, Farahi N, Peters JE, Basu S, Pankow JS, Tang W, Pankratz N, Sabater-Lleal M, de Vries PS, Smith NL; CHARGE Hemostasis Working Group, Gelinas AD, Schneider DJ, Janjic N, Samani NJ, Ye S, Summers C, Chilvers ER, Danesh J, Paul DS. Nat Commun. 2022 Mar 9;13(1):1222. doi: 10.1038/s41467-022-28729-3. PMID: 35264566 IF: 17.694. D1.
Cross-Ancestr Investigation of Venous Thromboembolism Genomic Predictors. Florian Thibord et al. Circulation. 2022 Sep. 26.doi:10.1161/CIRCULATIONAHA.122.059675. Online ahead of print. PMID: 36154123 IF: 39.918. D1
Novel genes and sex differences in COVID-19 severity. Raquel Cruz et al. Hum Mol Genet. 2022 Jun 16;ddac132. doi: 10.1093/hmg/ddac132. PMID: 35708486. Online ahead of print. IF: 5.121, Q1.
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids. Ramdas S et al. Am J Hum Genet. 2022 Aug 4;109(8):1366-1387. doi: 10.1016/j.ajhg.2022.06.012. PMID: 35931049. IF: 11.043. D1.
A validated clinical-genetic score for assessing the risk of thrombosis in patients with COVID-19 receiving thromboprophylaxis. Jose Manuel Soria, Sergi Mojal, Angel Martinez-Perez, Francisco Rene Acosta, Sonia Lopez, Sara Miqueleiz, Diana Rodriguez, Maria Angeles Quijada, Antonio Cárdenas, Francisco Vidal, Angel Remacha, Rosa Maria Antonijoan, Juan Carlos Souto. Haematologica. 2022 Sep 1; 107(9):2244-2248. doi: 10.3324/haematol.2022.281068. PMID: 35545920, IF: 11.047. D1.
Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations. Temprano-Sagrera G, Sitlani CM, Bone WP, Martin-Bornez M, Voight BF, Morrison AC, Damrauer SM, de Vries PS, Smith NL, Sabater-Lleal M. J Thromb Haemost. 2022 Jun;20(6):1331-1349. doi: 10.1111/jth.15698. Epub 2022 Mar 29. PMID: 35285134. IF: 16.036. D1.
Integrated GWAS and Gene Expression Suggest ORM1 as a Potential Regulator of Plasma Levels of Cell-Free DNA and Thrombosis Risk. Lopez S, Martinez-Perez A, Rodriguez-Rius A, Viñuela A, Brown AA, Martin-Fernandez L, Vilalta N, Arús M, Panousis NI, Buil A, Sabater-Lleal M, Souto JC, Dermitzakis ET, Soria JM. Thromb Haemost. 2022 Mar 10. doi: 10.1055/s-0041-1742169. Online ahead of print. PMID: 35272364. IF: 6.681. Q1.
Plasma sICAM-1 as a Biomarker of Carotid Plaque Inflammation in Patients with a Recent Ischemic Stroke. Puig N, Camps-Renom P, Camacho M, Aguilera-Simón A, Jiménez-Altayó F, Fernández-León A, Marín R, Martí-Fàbregas J, Sánchez-Quesada JL, Jiménez-Xarrié E, Benitez S. Transl Stroke Res. 2022 Oct;13(5):745-756. doi: 10.1007/s12975-022-01002-x. Epub 2022 Mar 2. PMID: 35237947. IF:6.8. Q1
TMAO and gut microbial-derived metabolites TML and γBB are not associated with thrombotic risk in patients with venous thromboembolism. Marina Canyelles, Melania Plaza, Noemí Rotllan, Dolors Llobet, Josep Julve, Sergi Mojal, Maribel Diaz-Ricart, José Manuel Soria, Joan Carles Escolà-Gil, Mireia Tondo, Francisco Blanco-Vaca, Joan Carles Souto. Journal of Clinical Medicine. 2022 Mar 4; 11(5):1425. doi: 10.3390/jcm11051425. PMID: 35268516. IF: 4.964. Q2.
Semaphorin-3F/Neuropilin-2 Transcriptional Expression as a Predictive Biomarker of Occult Lymph Node Metastases in HNSCC. Carla Meler-Claramonte, Francesc Xavier Avilés-Jurado, Isabel Vilaseca, Ximena Terra, Paloma Bragado, Gemma Fuster, Xavier León Vintró, Mercedes Camacho. Cancers (Basel) 2022 Apr 30;14(9):2259. doi: 10.3390/cancers14092259. PMID: 35565388. IF:6.575. Q1.
Impact of pre-admission antithrombotic therapy on disease severity and mortality in patients hospitalized for COVID-19. Corrochano M, Acosta-Isaac R, Mojal S, Miqueleiz S, Rodriguez D, Quijada-Manuitt MA, Fraga E, Castillo-Ocaña M, Amaro-Hosey K, Albiol N, Soria JM, Antonijoan RM, Souto JC. J Thromb Thrombolysis. 2022 Jan;53(1):96-102. doi: 10.1007/s11239-021-02507-2. Epub 2021 Jun 17. PMID: 34138399 IF: 5.221. Q2
Incorporating Genetic and Clinical Data into the Prediction of Thromboembolism Risk in Patients with Lymphoma. Bastos Oreiro M, Ortiz J, Pradillo V, Martínez Laperche C, Salas E, Buño I, Díez JL, Soria JM, Pascual Izquierdo C. Cancer Medicine. 2021 Oct 1. doi: 10.1002/cam4.4280. Online ahead of print.PMID: 34598309. IF: 4.452. Q2.
Association of ABO haplotypes with the risk of venous thrombosis: impact on disease risks estimation. Goumidi L, Thibord F, Wiggins KL, Li-Gao R, Brown MR, Van Hylckama Vieg A, Souto JC, Soria JM, Ibrahim-Kosta M, Saut N, Dainan D, Olaso R, Amouyel P, Debette S, Boland A, Bailly P, Morrison, AC, Mook-Kanamori DO, Deleuze JF, Johnson A, De Vries P, Sabater-Lleal M, Chiaroni J, Smith NL, Rosendaal F, Chasman DI, Tré gouët DA, Morange PE. Blood. 2021 Apr 29;137(17):2394-2402 PMID: 33512453. IF: 17.794. D1.
Predictive Ability of a Clinical-Genetic Risk Score for Venous Thromboembolism iNorthern and Southern European Populations. Salas E, Farm M, Pich S, Onelöv L, Guillen K, Ortega I, Antovic JP, Soria JM. Thrombosis and Haemostasis. 2021. TH Open. 2021 Jul 8;5(3):e303-e311. doi: 10.1055/s-0041-1729626. eCollection 2021 Jul. PMID: 34263111. IF: 5.249. Q1
Impact of pre-admission antithrombotic therapy on disease severity and mortality in patients hospitalized for COVID-19. Corrochano M, Acosta-Isaac R, Mojal S, Miqueleiz S, Rodriguez D, Quijada-Manuitt MA, Fraga E, Castillo-Ocaña M, Amaro-Hosey K, Albiol N, Soria JM, Antonijoan RM, Souto JC. J Thromb Thrombolysis. 2021 Jun 17. doi: 10.1007/s11239-021-02507-2. Online ahead of print. PMID: 34138399. IF: 2.054. Q3.
Cell type specific genetic regulation of gene expression across human tissues. Kim-Hellmuth S, Aguet F, Oliva M, Muñoz-Aguirre M, Kasela S, Wucher V, Castel S, Hamel A, Viñuela A, Roberts A, Mangul A, Wen X, Wang G, Barbeira A, Garrido-Martín D, Nadel B, Zou Y, Bonazzola R, Quan J, Brown A, Martinez-Perez A, Soria JM, Getz G, Dermitzakis E, Small S, Stephens M, Xi H, Kyung Im H, Guigó R, Segrè A, Stranger B, Ardlie K, Lappalainen T. Science, Sept 2020 (DOI: https://doi.org/10.1126/science.aba3066). IF: 41.485. D1.
The impact of sex on gene expression across human tissues. Oliva M, Muñoz-Aguirre M, Kim-Hellmuth S, Wucher V, Gewirtz A, Cotter D, Parsana P, Kasela S, Balliu B, Viñuela A, Castel S, Mohammadi P, Aguet F, Zou Y, Khramtsova E, Skol A, Garrido-Martín D, Reverter F, Brown A, Evans P, Gamazon E, Payne A, Bonazzola R, Barbeira A, Hamel A, Martinez-Perez A, Soria JM, Pierce B, Stephens M, Eskin E, Dermitzakis E, Segrè A, Kyung Im H, Engelhardt B, Ardlie K, Montgomery S, Battle A, Lappalainen T, Guigó R, Stranger B. Science, Sept 2020 (DOI: https://doi.org/10.1126/science.aaz8528 ). IF: 41.485. D1.
Expression of microRNAs in human platelet-poor plasma: analysis of the factors affecting their expression and association with proximal genetic variants. Rodriguez-Rius A, Martinez-Perez A, López S, Sabater-Lleal M, Souto JC, Soria JM. Epigenetics. 2020 Jun 16. doi: 10.1080/15592294.2020.1783497. Online ahead of print. PMID: 32543954. IF: 4.173. Q1.
The TAGA Study: A Study of Factors Determining Aortic Diameter in Families at High Risk of Abdominal Aortic Aneurysm Reveal Two New Candidate Genes. Peypoch O, Paüls-Vergés F, Vázquez-Santiago M, Dilme J, Romero J, Giner J, Plaza V, Escudero JR, Soria JM, Camacho M, Sabater-Lleal M. J Clin Med. 2020 Apr 24;9(4). pii: E1242. doi: 10.3390/jcm9041242. PMID: 32344696. IF: 5.688, D1
Identification of a Plasma MicroRNA Profile Associated With Venous Thrombosis. Rodriguez-Rius A, Lopez S, Martinez-Perez A, Souto JC, Soria JM. Arterioscler Thromb Vasc Biol. 2020 Mar 12:ATVBAHA120314092. doi: 10.1161/ATVBAHA.120.314092. [Epub ahead of print].PMID: 32160777. IF: 6.618, D1

A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology. de Vries PS, Sabater-Lleal M, Huffman JE, Marten J, Song C, Pankratz N, Bartz TM, de Haan HG, Delgado GE, Eicher JD, Martinez-Perez A, Ward-Caviness CK, Brody JA, Chen MH, de Maat MPM, Frånberg M, Gill D, Kleber ME, Rivadeneira F, Soria JM, Tang W, Tofler GH, Uitterlinden AG, van Hylckama Vlieg A, Seshadri S, Boerwinkle E, Davies NM, Giese AK, Ikram MK, Kittner SJ, McKnight B, Psaty BM, Reiner AP, Sargurupremraj M, Taylor KD, Fornage M, Hamsten A, März W, Rosendaal FR, Souto JC, Dehghan A, Johnson AD, Morrison AC, O’Donnell CJ, Smith NL. Blood. 2019 Jan 14. pii: blood-2018-05-849240. doi: 10.1182/blood-2018-05-849240. [Epub ahead of print]. PMID: 30642921, D1. IF: 16.562
Breathless and dying on Mount Everest. Garrido E, Soria JM, Salisbury R. Lancet Respir Med. 2019 Nov;7(11):e36 PMID: 31645281. IF: 22.992. D1.

Genome-wide association trans-ethnic meta-analyses identifies novel associations regulating coagulation Factor VIII and von Willebrand Factor plasma level. Sabater-Lleal M et al. INVENT Consortium; MEGASTROKE consortium of the International Stroke Genetics Consortium (ISGC). Circulation. 2019 Jan 29;139(5):620-635. doi: 10.1161/CIRCULATIONAHA.118.034532. PMID: 30586737. IF: 23.054. D1.
Multivariable clinical-genetic risk model for predicting venous thromboembolic events in patients with cancer. Muñoz Martín A, Ortega I, Font C, Pachón V, Castellón V, Martínez-Marín V, Salgado M, Martínez de Castro E, Calzas J, Rupérez A, Souto JC, Martín M, Salas E, Soria JM. Br J Cancer. 2018 Mar 28. doi: 10.1038/s41416-018-0027-8. [Epub ahead of print]. PMID: 29588512. IF: 5.416. Q1.
Genome-wide association study with additional genetic and post-transcriptional analyses reveals novel regulators of plasma factor XI levels. Sennblad B, Basu S, Mazur J, Suchon P, Martinez-Perez A, van Hylckama Vlieg A, Truong V, Li Y, Gådin JR, Tang W, Grossman V, de Haan HG, Handin N, Silveira A, Souto JC, Franco-Cereceda A, Morange PE, Gagnon F, Soria JM, Eriksson P, Hamsten A, Maegdefessel L, Rosendaal FR, Wild P, Folsom AR, Trégouët DA, Sabater-Lleal M. Hum Mol Genet. 2017, 26(3):637-649. doi: 10.1093/hmg/ddw401. [Epub ahead of print]. PMID: 28053049. IF:4.902. D1.
The Unravelling of the Genetic Architecture of Plasminogen Deficiency and its Relation to Thrombotic Disease. Martin-Fernandez L, Marco P, Corrales I, Pérez R, Ramírez L, López S, Vidal F, Soria JM. Sci Rep. 2016 Dec 15;6:39255. doi: 10.1038/srep39255. PMID: 27976734. IF: 4.259. Q1.
Exploring correlation between bone metabolism markers and densitometric traits in extended families from Spain. Athanasiadis G, Arranz L, Ziyatdinov A, Brunel H, Camacho M, Malouf J, Sosa NH, Vila L, Casademont J, Soria JM. Bone. 2016 May 27. 90:1-6, doi: 10.1016/j.bone.2016.05.009. [Epub ahead of print]. PMID: 27241279. IF: 4.140. Q1.
Genome-wide association analysis of self-reported events in 6,135 individuals and 252,827 controls identifies 8 loci associated with thrombosis. Hinds DA, Buil A, Ziemek D, Martinez-Perez A, Malik R, Folkersen L, Mälarstig A, Soria JM, Bing N, Eriksson P, Souto JC, Hamsten A, Dermitzakis ET, Tung JY, METASTROKE, Sabater-Lleal M. Hum Mol Genet. 2016, 25(9):1867-74. PMID: 26908601. IF: 5.340. D1.
Solarius: An R Interface to SOLAR for Variance Component Analysis in Pedigrees. Ziyatdinov A, Brunel H, Martinez-Perez A, Buil A, Perera A, Soria JM. Bioinformatics 2016 Feb 15. 15;32(12):1901-2. PMID: 27153684.IF: 7.307.D1.
The European Hematology Association Roadmap for European Hematology Research. Consensus Document (European Vein Thrombosis Research: Genomics in Hemostasis). Reitsma PH, Soria JM, Morange P, Engert A. Haematologica 016 Feb;101(2):115-208. doi: 10.3324/haematol.2015.136739. Epub 2016 Jan 27. PMID: 26819058. IF: 7.702. D1.

Introduction

Summary

Main lines of Research

Angiology and Vascular Biology.

TAGA Project: Genomic basis of Abdominal Aortic Aneurysm.

Venous Thrombosis and Thrombosis and cancer

GAIT Project: Genetic Analysis of Idiopathic Thrombophilia
RETROVE Project: Risk of Venous Thromboembolic Disease.
OncoThromb Project: New biomarkers related with Thrombosis and Cancer.
AIRTOP and MIRTO Projects: Assesment of the Individual Risk of Thrombosis in Oncology Patients.

Genomics in Sport Medicine

SUMMIT Project (Health in sport and its limits): Marathons and Ultra-trail races. Biological, genetic and clinical impact.

SHERPA_Everest’2017 Project. Exposition to extreme environmental hypoxia and its effect on the inflammatory and cardiopulmonar response: Biological, genetic and clinical impact.
Xtreme-Genetics K2 project. Expedition to K2 peak. Biological, genetic and clinical impact.

Transversal Research Areas

Bioinformatics and Epigenetics.
Translational Research and Personalized Medicine

Scientific Challenges

Analysis of Omics data (Genomics, transcriptomics, epigenomics) in the field of complex diseases with translational approach in cooperation with clinical groups.
Identify new biomarkers (genetic, epigenetic and/or plasmatic) that determine the susceptibility to complex diseases.
Identify new mechanisms involved in the development and progression of complex diseases.
Development of predictive algorithms that integrate the genetic, biological and clinical information of the patients (Personalized Medicine).

Scientific Collaborations

With other IIB Sant Pau Groups and Sant Pau Hospital

Thrombosis and Haemostasis, Dr. JC Souto: GAIT, MIRTO, RETROVE Projects.
Clinical Hematology, Dr. J Sierra: MIRTO Project.
Neurology, Dr. J. Marti: MIRTO Project. Elena Jimenez: Lipoproteic biomarkers. ICTUS.
Otorhinolaryngology. Dr. M Quer and Dr. X Leon. Prediction of response to head and neck cancer.
Regulatory Mechanisms of Cardiovascular Remodeling. Dra. C. Rodriguez and Dra. M Galán.
Participation en CIBERCV (CIBER of cardiovascular diseases). Dr. J González.
General and Digestive Surgery. Dra. C Balaguer
Clinical Pharmacology. Dra. MA Mangues and Dra. M Gomis. AIRTOP Project.
Neumology Service, Dr. O Sibila: SUMMIT, SHERPA Projects.

External

Clinical Oncology Department, Hospital Gregorio Marañón, Madrid,Dr. A Muñoz: ONCOTHROMB, AIRTOP Projects.
Clinical Department of Hematology and Hemostasis. University of Wien, Austria. Dra. I Pabinger. ONCOTHROMB, MIRTO Projects.
Dr. J Schwenk. SciLifeLab, Sweeden: GAIT Project
Department of Genetics, University of Genève, Switzerland, Dr. M Dermitzakis and Dr. A Viñuela: GAIT Project.
Institute of Biological Psychiatry, Sankt Hans Hospital. Roskilde, Denmark, Dr. A Buil: Bioinformatics of Complex diseases, GAIT Project.
Laboratory Haematology, Hospital Timone Marseille, France, Dr. P Morange: GAIT, VEREMA Projects.
INSERM UMR_S1219 – Bordeaux Public Health Center. Bordeaux, France. Dr. DA Tregouet: GAIT, VEREMA Projects.
Haematology Department, Karolinska Hospital, Sweden, Dr. J Odeberg: VEREMA Project.
Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid. Dr. JM Redondo.
Hospital Clínic de Barcelona. Otorhinolaryngology Service. Prediction of response to head and neck cancer. Dr. FX Avilés.
Hospital Vall d’Hebron, Barcelona. Vascular Surgery Service. Dr. S Bellmunt.
Bac de Sang i Teixits (BST). Dr. F Vidal.
Centre de Recerca en Enginyeria Biomèdica, Universitat Politècnica de Catalunya, Barcelona, Dr. A Perera: SUMMIT Project.
CAR, Centre d’Alt Rendiment Sportiu, Sant Cugat. Dr. F Drobnic: Sport Medicine Projects.
CHARGE, International network consortium. Hemostatic factors studies.
GIANT, International network consortium. Anthropometric factors studies.
GLGC, International network consortium. Lipidic factors research.

With Biopharma companies

GenIncode. Development of Genetic Diagnostics in Thrombosis.
Leo-Pharma. Prediction of Thrombosis Risk in cancer patients.

Team

Group coordination

SORIA FERNANDEZ, JOSE MANUEL IR
jsoria@santpau.cat

Members

Scientific output

Publications 2024

(JIF 2024)

Publications 2023

(JIF 2023)

-Molina JM, Munoz JD. Blood pool in a patient with intramural aortic hematoma. Angiologia. 2023; 75(3). DOI:10.20960/angiologia.00492. IF:0,100 (Q4/10D). Document type: Article.

-Muñoz A, Salas E, Soria JM. Reply to FI Mulder et al. JOURNAL OF CLINICAL ONCOLOGY. 2023; 41(36). DOI:10.1200/JCO.23.00817. PMID:37816210. IF:42,100 (Q1/1D). Document type: Letter.

Publications 2022

(JIF 2022)

Bague S, Leon X, Terra X, Lejeune M, Camacho M, Aviles FX. Prognostic capacity of the transcriptional expression of lactate dehydrogenase A in patients with head and neck squamous cell carcinoma. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK. 2022; 44(11). DOI:10.1002/hed.27161. PMID:36207788. IF:2,9 (Q1/2D). Document type: Article.
Camacho M, Leon X, Pujol A, Montezuma L, Quer M, Garcia J. Prognostic value of transcriptional expression of fibronectin type III domain-containing 4 (FNDC4) in head and neck carcinoma patients treated with chemoradiotherapy. Clinical & Translational Oncology. 2022; 24(11). DOI:10.1007/s12094-022-02870-3. PMID:35752749. IF:3,4 (Q3/6D). Document type: Article.
Canyelles M, Plaza M, Rotllan N, Llobet D, Julve J, Mojal S, Diaz M, Soria JM, Escola JC, Tondo M, Blanco F, Souto JC. TMAO and Gut Microbial-Derived Metabolites TML and gamma BB Are Not Associated with Thrombotic Risk in Patients with Venous Thromboembolism. Journal of Clinical Medicine. 2022; 11(5):1425. DOI:10.3390/jcm11051425. PMID:35268516. IF:3,9 (Q2/4D). Document type: Article.
Corrochano M, Acosta R, Mojal S, Miqueleiz S, Rodriguez D, Quijada MA, Fraga E, Castillo M, Amaro K, Albiol N, Soria JM, Antonijoan RM, Souto JC. Impact of pre-admission antithrombotic therapy on disease severity and mortality in patients hospitalized for COVID-19. JOURNAL OF THROMBOSIS AND THROMBOLYSIS. 2022; 53(1). DOI:10.1007/s11239-021-02507-2. PMID:34138399. IF:4 (Q2/4D). Document type: Article.
Cruz R, Díaz S, López de Heredia M, Quintela I, Ceballos FC, Lorenzo GM, Gonzalez R, Gago M, Porras MS, Castano J, Nevado J, Aguado JM, Aguilar C, Aguilera S, Almadana V, Almoguera B, Alvarez N, Andreu A, Arana E, Arango C, Arranz MJ, Artiga MJ, Baptista RC, Barreda M, Belhassen M, Bezerra JF, Bezerra M, Boix L, Brion M, Brugada R, Bustos M, Calderon EJ, et al. [Martínez-Pérez A, Soria JM, Souto JC, Fernández-Cadenas I]. Novel genes and sex differences in COVID-19 severity. HUMAN MOLECULAR GENETICS. 2022; 31(22). DOI:10.1093/hmg/ddac132. PMID:35708486. IF:3,5 (Q2/4D). Document type: Article.
Garcia LS, Munoz JFD. Steerable sheath for cannulation of target visceral vessels in complex endoprosthesis. Angiologia. 2022; 74(5). DOI:10.20960/angiologia.00401. Document type: Article.
Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Clarke SL, Bhatti KF, Vedantam S, Winkler TW, Locke AE, Marouli E, Zajac GJM, Wu K-HH, Ntalla I, Hui Q, Klarin D, Hilliard AT, Xue C, Thorleifsson G, Helgadottir A, Gudbjartsson DF, Holm H, Olafsson I, Hwang MY, Han S, Akiyama M, Sakaue S, Terao C, Kanai M, Zhou W, Brumpton BM, Rasheed H, Havulinna AS, et al. [Sabater-Lleal M]. Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis. GENOME BIOLOGY. 2022; 23(1):268. DOI:10.1186/s13059-022-02837-1. PMID:36575460. IF:12,3 (Q1/1D). Document type: Article.
Leon X, Garcia J, Pujol A, de Juan J, Vasquez R, Quer M, Camacho M. Relationship between the transcriptional expression of PIM1 and local control in patients with head and neck squamous cell carcinomas treated with radiotherapy. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. 2022; 279(7). DOI:10.1007/s00405-021-07223-4. PMID:34993612. IF:2,6 (Q2/3D). Document type: Article.
Lobato B, Priego B, Sanchez D. Combining Molecular, Imaging, and Clinical Data Analysis for Predicting Cancer Prognosis. Cancers. 2022; 14(13):3215. DOI:10.3390/cancers14133215. PMID:35804988. IF:5,2 (Q2/3D). Document type: Review.
Lopez S, Martinez A, Rodriguez A, Vinuela A, Brown AA, Martin L, Vilalta N, Arus M, Panousis NI, Buil A, Sabater-Lleal M, Souto JC, Dermitzakis ET, Soria JM. Integrated GWAS and Gene Expression Suggest ORM1 as a Potential Regulator of Plasma Levels of Cell-Free DNA and Thrombosis Risk. THROMBOSIS AND HAEMOSTASIS. 2022; 122(06). DOI:10.1055/s-0041-1742169. PMID:35272364. IF:6,7 (Q1/2D). Document type: Article.
Marín-García M, Benseny-Cases N, Camacho M, Barnadas-Rodríguez R. Chapter 11: Metallosurfactants as Carbon Monoxide-Releasing Molecules. In: Surinder M, Ravneet K (Eds). Metallosurfactants: From Fundamentals to Catalytic and Biomedical Applications. Wiley, 2022. pp.195-222. DOI:10.1002/9783527831289.ch11. ISBN:9783527348688. Document Type: Book chapter.
Meler C, Aviles FX, Vilaseca I, Terra X, Bragado P, Fuster G, Vintro XL, Camacho M. Semaphorin-3F/Neuropilin-2 Transcriptional Expression as a Predictive Biomarker of Occult Lymph Node Metastases in HNSCC. 2022; 14(9):2259. DOI:10.3390/cancers14092259. PMID:35565388. IF:5,2 (Q2/3D). Document type: Article.
Puig N, Camps P, Camacho M, Aguilera A, Jimenez F, Fernandez A, Marin R, Marti J, Sanchez JL, Jimenez E, Benitez S. Plasma sICAM-1 as a Biomarker of Carotid Plaque Inflammation in Patients with a Recent Ischemic Stroke. Translational Stroke Research. 2022; 13(5). DOI:10.1007/s12975-022-01002-x. PMID:35237947. IF:6,9 (Q1/1D). Document type: Article.
Ramdas S, Judd J, Graham SE, Kanoni S, Wang YX, Surakka I, Wenz B, Clarke SL, Chesi A, Wells A, Bhatti KF, Vedantam S, Winkler TW, Locke AE, Marouli E, Zajac GJM, Wu KHH, Ntalla I, Hui Q, Klarin D, Hilliard AT, Wang ZY, Xue C, Thorleifsson G, Helgadottir A, Gudbjartsson DF, Holm H, Olafsson I, Hwang MY, Han S, Akiyama M, Sakaue S, Terao C, Kanai M, Zhou W, et al. [Sabater-Lleal M]. A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids. AMERICAN JOURNAL OF HUMAN GENETICS. 2022; 109(8). DOI:10.1016/j.ajhg.2022.06.012. PMID:35931049. IF:9,8(Q1/1D). Document type: Article.
Soria JM, Mojal S, Martinez A, Acosta FR, López S, Miqueleiz S, Rodriguez D, Quijada MA, Cardenas A, Vidal F, Remacha A, Antonijoan RM, Souto JC. A validated clinical-genetic score for assessing the risk of thrombosis in patients with COVID-19 receiving thromboprophylaxis. HAEMATOLOGICA. 2022; 107(9). DOI:10.3324/haematol.2022.281068. PMID:35545920. IF:10,1 (Q1/2D). Document type: Article.
Stacey D, Chen LY, Stanczyk PJ, Howson JMM, Mason AM, Burgess S, MacDonald S, Langdown J, McKinney H, Downes K, Farahi N, Peters JE, Bas S, Pankowf JS, Tang WH, Pankratz N, Sabater-Lleal M, de Vries PS, Smith NL, Gelinas AD, Schneider DJ, Janjic N, Samani NJ, Ye S, Summers C, Chilvers ER, Danesh J, Paul DS, CHARGE Hemostasis Working GRP. Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus. Nature Communications. 2022; 13(1):1222. DOI:10.1038/s41467-022-28729-3. PMID:35264566. IF:16,6 (Q1/1D). Document type: Article.
Temprano G, Sitlani CM, Bone WP, Martin M, Voight BF, Morrison AC, Damrauer SM, de Vries PS, Smith NL, Sabater-Lleal M. Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2022; 20(6). DOI:10.1111/jth.15698. PMID:35285134. IF:10,4 (Q1/1D). Document type: Article.
Thibord F, Klarin D, Brody JA, Chen MH, Levin MG, Chasman DI, Goode EL, Hveem K, Teder M, Martinez A, Aissi D, Daian D, Ito K, Natarajan P, Lutsey PL, Nadkarni GN, de Vries PS, Cuellar G, Wolford BN, Pattee JW, Kooperberg C, Braekkan SK, Li RF, Saut N, Sept C, Germain M, Judy RL, Wiggins KL, Ko D, O’Donnell CJ, Taylor KD, Giulianini F, De Andrade M, Nost TH, et al. [Soria JM, Souto JC, Sabater-Lleal M]. CIRCULATION. 2022; 146(16). DOI:10.1161/CIRCULATIONAHA.122.059675. PMID:36154123. IF:37,8 (Q1/1D). Document type: Article.
Vitiello G, Soto B, Martínez MC, Targarona E. Resection of the aortic bifurcation in the treatment of locally recurrent colorectal cancer. CIRUGIA ESPANOLA. 2022; 100(3). DOI:10.1016/j.ciresp.2020.12.009. PMID:33468362. IF:1,9 (Q3/6D). Document type: Letter.
Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen AU, Jiang YX, Raghavan S, Miao JK, Arias JD, Graham SE, Mukamel RE, Spracklen CN, Yin XY, Chen SH, Ferreira T, Highland HH, Ji YJ, Karaderi T, Lin K, Lull K, Malden DE, Medina C, Machado M, Moore A, Rueger S, Sim X, Vrieze S, Ahluwalia TS, Akiyama M, Allison MA, Alvarez M, et al. [Sabater-Lleal M]. A saturated map of common genetic variants associated with human height. NATURE. 2022; 610(7933). DOI:10.1038/s41586-022-05275-y. PMID:36224396. IF:64,8 (Q1/1D). Document type: Article.

Publications 2021

Ahluwalia TS, Prins BP, Abdollahi M, Armstrong NJ, Aslibekyan S, Bain L, Jefferis B, Baumert J, Beekman M, Ben Y, Bis JC, Mitchell BD, de Geus E, Delgado GE, Marek D, Eriksson J, Kajantie E, Kanoni S, Kemp JP, Lu C, Marioni RE, McLachlan S, Milaneschi Y, Nolte IM, Petrelis AM, Porcu E, Sabater M, Naderi E, Seppala I, Shah T, Singhal G, et al., CHARGE Inflammation Working GRP. Genome-wide association study of circulating interleukin 6 levels identifies novel loci. HUMAN MOLECULAR GENETICS. 2021; 30(5). DOI:10.1093/hmg/ddab023. PMID:33517400. IF:5,121.
Aviles-Jurado FX, Munoz C, Meler C, Flores JC, Guma J, Benaiges E, Mora J, Camacho M, Leon X, Vilaseca I, Terra X. Circulating microRNAs modulating glycolysis as non-invasive prognostic biomarkers of HNSCC. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. 2021; 278(5):1585-1594. DOI: 10.1007/s00405-020-06240-z. PMID: 32737645. IF:3,236.
Bastos M, Ortiz J, Pradillo V, Salas E, Marinez C, Munoz A, Buno I, Diez JL, Soria JM, Izquierdo CP. Incorporating genetic and clinical data into the prediction of thromboembolism risk in patients with lymphoma. Cancer Medicine. 2021; 10(21). DOI:10.1002/cam4.4280. PMID:34598309. IF:4,711.
Bonfill X, Quintana MJ, Escudero JR, Miralles M, Fite J, Mikelarena E, Castejon B, Garnica M, De Valderrama IF, Rodriguez A, Pijoan JI, Bellmunt S. Appropriateness of surgery performed for abdominal aortic aneurysm at tertiary hospitals in Spain. INTERNATIONAL ANGIOLOGY. 2021; 40(4). DOI:10.23736/S0392-9590.21.04654-X. PMID:34060282. IF:2,103.
Canes L, Alonso J, Ballester C, Varona S, Escudero JR, Andres V, Rodriguez C, Martinez J. Targeting Tyrosine Hydroxylase for Abdominal Aortic Aneurysm Impact on Inflammation, Oxidative Stress, and Vascular Remodeling. HYPERTENSION. 2021; 78(3). DOI:10.1161/HYPERTENSIONAHA.121.17517. PMID:34304581. IF:9,897.
Ellervik C, Mora S, Kus A, Asvold B, Marouli E, Deloukas P, Sterenborg RBTM, Teumer A, Burgess S, Sabater M, Huffman J, Johnson AD, Tregouet DA, Smith NL, Medici M, DeVries PS, Chasman DI, Kjaergaard AD. Effects of Thyroid Function on Hemostasis, Coagulation, and Fibrinolysis: A Mendelian Randomization Study. THYROID. 2021; 31(9). DOI:10.1089/thy.2021.0055. PMID:34210154. IF:6,506.
Fite J, Gayarre R, Puig T, Zamora S, Escudero JR, Roca JS, Bellmunt S. Feasibility and Efficiency Study of a Population-Based Abdominal Aortic Aneurysm Screening Program in Men and Women in Spain. ANNALS OF VASCULAR SURGERY. 2021; 73. DOI:10.1016/j.avsg.2020.11.042. PMID:33387620. IF:1,607.
Fite J, Gimenez E, Soto B, Artigas V, Escudero JR, Bellmunt S, Espallargues M. Systematic review on abdominal aortic aneurysm screening cost-efficiency and methodological quality assessment. INTERNATIONAL ANGIOLOGY. 2021; 40(1). DOI:10.23736/S0392-9590.20.04547-2. PMID:33086780. IF:2,103.
Goncalves G, Gil D, Tello C, Tenezaca X, Marrero C, Puig T, Gayarre R, Fite J, Bellmunt S. Prevalence of Peripheral Arterial Disease and Associated Vascular Risk Factors in 65-Years-Old People of Northern Barcelona. Journal of Clinical Medicine. 2021; 10(19):4467. DOI:10.3390/jcm10194467. PMID:34640483. IF:4,964.
Goumidi L, Thibord F, Wiggins KL, Li RF, Brown MR, Vlieg AV, Souto JC, Soria JM, Ibrahim M, Saut N, Daian D, Olaso R, Amouyel P, Debette S, Boland A, Bailly P, Morrison AC, Mook DO, Deleuze JF, Johnson A, de Vries PS, Sabater M, Chiaroni J, Smith NL, Rosendaal FR, Chasman DI, Tregouet DA, Morange PE. Association between ABO haplotypes and the risk of venous thrombosis: impact on disease risk estimation. BLOOD. 2021; 137(17). DOI:10.1182/blood.2020008997. PMID:33512453. IF:25,476.
Graham SE, Clarke SL, Wu KHH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I, Vedantam S, Winkler TW, Locke AE, Marouli E, Hwang MY, Han S, Narita A, Choudhury A, Bentley AR, Ekoru K, Verma A, Trivedi B, Martin HC, Hunt KA, Hui Q, Klarin D, Zhu X, Thorleifsson G, Helgadottir A, Gudbjartsson DF, Holm H, Olafsson I, et al. [Sabater M]. The power of genetic diversity in genome-wide association studies of lipids. NATURE. 2021; 600(7890). DOI:10.1038/s41586-021-04064-3. PMID:34887591. IF:69,504.
Guo YJ, Rist PM, Sabater M, de Vries P, Smith N, Ridker PM, Kurth T, Chasman DI. Association Between Hemostatic Profile and Migraine A Mendelian Randomization Analysis. NEUROLOGY. 2021; 96(20). DOI:10.1212/WNL.0000000000011931. PMID:33795393. IF:11,800.
Leon X, Venegas M, Pujol A, Bulboa C, Llansana A, Casasayas M, Quer M, Camacho M. Predictive value of transcriptional expression of Kruppel-like factor-6 (KLF6) in head and neck carcinoma patients treated with radiotherapy. Clinical & Translational Oncology. 2021; 23(12). DOI:10.1007/s12094-021-02651-4. PMID:34061320. IF:3,340.
Mendez KA, Rodriguez E, Sebastian D, Blanco R, Camacho M, Nan MN, Diarte E, Mato E, Lope S, Roglans N, Laguna JC, Alonso N, Mauricio D, Zorzano A, Villarroya F, Villena JA, Blanco F, Julve J. Nicotinamide Protects Against Diet-Induced Body Weight Gain, Increases Energy Expenditure, and Induces White Adipose Tissue Beiging. MOLECULAR NUTRITION & FOOD RESEARCH. 2021; 65(11):2100111. DOI:10.1002/mnfr.202100111. PMID:33870623. IF:6,575.
Paloschi V, Sabater M, Middelkamp H, Vivas A, Johansson S, van der Meer A, Tenje M, Maegdefessel L. Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases. CARDIOVASCULAR RESEARCH. 2021; 117(14). DOI:10.1093/cvr/cvab088. PMID:33729461. IF:13,081.
Rotllan N, Camacho M, Tondo M, Diarte E, Canyelles M, Mendez KA, Benitez S, Alonso N, Mauricio D, Escola JC, Blanco F, Julve J. Therapeutic Potential of Emerging NAD plus -Increasing Strategies for Cardiovascular Diseases. Antioxidants. 2021; 10(12):1939. DOI:10.3390/antiox10121939. IF:7,675.
Sanchez D, Nus M, Navas M, Fite J, Perez B, Barros AJ, Soto B, Martinez J, Camacho M, Rodriguez C, Mallat Z, Galan M. Oxidative Stress and Inflammatory Markers in Abdominal Aortic Aneurysm. Antioxidants. 2021; 10(4):602. DOI:10.3390/antiox10040602. PMID:33919749. IF:7,675.
Sanchez L, Fite J, Peypoch O, Moreno J, Jubert Q, Carricas BS, Dilme JF, Escudero JR. Preoperative geriatric assessment, a promising tool to improve outcomes in aortic pathology interventions. INTERNATIONAL ANGIOLOGY. 2021; 40(4). DOI:10.23736/S0392-9590.21.04643-5. PMID:33913311. IF:2,103.
Small AM, Huffman JE, Klarin D, Sabater M, Lynch JA, Assimes TL, Sun YV, Miller D, Freiberg MS, Morrison AC, Rader DJ, Wilson PWF, Cho K, Tsao PS, Chang KM, Smith NL, O’Donnell CJ, de Vries PS, Damrauer SM, Cohorts Heart Aging Res Genomic &, VA Million Veteran P. Mendelian Randomization Analysis of Hemostatic Factors and Their Contribution to Peripheral Artery Disease-Brief Report. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2021; 41(1). DOI:10.1161/ATVBAHA.119.313847. PMID:32847391. IF:10,514.
Thibord F, Song C, Pattee J, Rodriguez B, Chen MH, O’Donnell CJ, Kleber ME, Delgado GE, Guo XQ, Yao J, Taylor KD, Ozel AB, Brody JA, McKnight B, Gyorgy B, Simonsick E, Leonard HL, Carrasquilla GD, Guindo M, Silveira A, Temprano G, Yanek LR, Becker DM, Mathias RA, Becker LC, Raffield LM, Kilpelainen TO, Grarup N, Pedersen O, Hansen T, et al. [Sabater M]. FGL1 as a modulator of plasma D-dimer levels: Exome-wide marker analysis of plasma tPA, PAI-1, and D-dimer. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2021; 19(8). DOI:10.1111/jth.15345. PMID:33876560. IF:16,036.
Varona S, Puertas L, Galan M, Orriols M, Canes L, Aguilo S, Camacho M, Sirvent M, Andres V, Martinez J, Rodriguez C. Rolipram Prevents the Formation of Abdominal Aortic Aneurysm (AAA) in Mice: PDE4B as a Target in AAA. Antioxidants. 2021; 10(3):460. DOI:10.3390/antiox10030460. PMID:33809405. IF:7,675.

CARDIOVASCULAR DISEASES

Genomics of Complex Diseases

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Publications 2022

Publications 2021

IIB-Sant-Pau-2020 Report. Genomics

Relevant Publications of the last 5 years

Summary

Main lines of Research

Scientific Challenges

Scientific Collaborations

Group coordination

Members

Publications 2024

Publications 2023

Publications 2022

Publications 2021

Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau