HAEMATOLOGICAL AND ONCOLOGICAL DISEASES

Haematological Diagnosis

Main Lines of Research

Malignant Haemopathologies

  • ADiagnostic activities: morphological, immunophenotyping, cytogenetic and molecular characterization (particularly of acute leukaemias).
  • Biological characteristics responding to therapy.
  • New treatments using cell line models aimed at molecular targets.
  • Genomic (microarrays) and proteomic platforms for diagnosis.
  • Murine models development.

Noncancerous Haemopathologies

  • Diagnosis and characterization of thrombocytopenias, thrombocytopathies and other platelet pathologies, especially complex pathologies (of genetic, mixed or unknown origin) and including unusual presentations of common diseases.
  • In the framework of the GAIT-2 (genetic analysis of idiopathic thrombophilia, phase 2) project, to seek new phenotypes that favour the development of thrombosis, specifically related to the structure and function of platelets and other blood cells.

Challenges

  • Consolidate characterization of haematological tumours and complex, rare and genetic noncancerous haematopathologies.
  • Include the results of mass-analysis genomic and proteomic platforms in diagnostic algorithms and establish prognostic factors for haematological disorders, preferably complex or genetic neoplasms and noncancerous pathologies.
  • Develop functional cell culture and animal (murine) models.
  • Consolidate cooperation with the GAIT-2 project, especially regarding platelet and other blood cell participation in thrombosis generation.
  • Promote interaction and stable links with internal groups (clinical haematology, pathology, gastrointestinal, haemostasis and thrombosis, complex disease genomics areas) and with other groups in Spain and abroad, especially those with complementary technologies.

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