Sant Pau - Institut de Recerca

Molecular mechanisms involved in the modulation of the receptor LRP1 by cardiovascular risk factors.
Impact of LRP1 in the vascular and myocardial cholesterol entrapment.
Impact of atherogenic dyslipemia in LRP1 intracellular signaling in cardiovascular cells exposed to normoxic and hypoxic conditions and in vivo models of ischemia.
Lipoproteins and diabetic myocardiopathy.
Lipoproteins and breast cancer.
LRP1 and inflammation.
Non-coding RNAs as circulating biomarkers of atherosclerosis and myocardiopathies.
Non-coding RNAs as biomarkers of vascular and myocardial lipid accumulation.

Challenges
To perform in vivo and clinical studies useful to demonstrate the role of LRP1 in the cardiovascular system.
To maintain and expand our collaborative network with IIB-SantPau groups and with clinical, academic and entrepreneur institutions required to increase the traslationality of our research area.
To expand our international collaborations.
To establish new collaborations with companies able to strategically contribute to develop innovative products essential to advance in the diagnostic and treatment of cardiovascular diseases.

LLORENTE CORTES, CONCEPCION VICENTA CSIC
cllorente@santpau.cat

Garcia Rodriguez, Jesus Eduardo IR
La Chica Lhoest, Maria Teresa CSIC
Martinez Jimenez, Andrea IR

(JIF 2022)

Benitez A, Martinez N, Manero N, Claudi L, Lhoest MTL, Soler M, Ros L, Navarro P, Llorente V. Peptides against Low Density Lipoprotein (LDL) Aggregation Inhibit Intracellular Cholesteryl Ester Loading and Proliferation of Pancreatic Tumor Cells. 2022; 14(4):890. DOI:10.3390/cancers14040890. PMID:35205638. IF:5,2 (Q2/3D). Document type: Article.
Dato VA, Benitez A, Garcia E, Claudi L, Lhoest MTL, Iborra A, Guerra JM, Escola JC, Samouillan V, Enrich C, Chiabrando G, Llorente V. Targeting cholesteryl ester accumulation in the heart improves cardiac insulin response. BIOMEDICINE & PHARMACOTHERAPY. 2022; 152:113270. DOI:10.1016/j.biopha.2022.113270. PMID:35709652. IF:7,5 (Q1/1D). Document type: Article.

Amaro AB, Curco AS, Garcia E, Julve J, Rives J, Benitez S, Cortes VL. Apolipoprotein and LRP1-Based Peptides as New Therapeutic Tools in Atherosclerosis. Journal of Clinical Medicine. 2021; 10(16):3571. DOI:10.3390/jcm10163571. PMID:34441867. IF:4,964.
Gamboa R, Jaramillo MJ, Martinez MD, Soto ME, Torres YE, de Gonzalo D, Del Valle L, Lopez R, Llorente VC, Huesca C. Monocyte Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Expression Correlates with cIMT in Mexican Hypertensive Patients. Arquivos Brasileiros de Cardiologia. 2021; 116(1). DOI:10.36660/abc.20190535. PMID:33566965. IF:2,667.
Lopez JN, Couselo M, Baluja A, Gonzalez L, Rozados A, Llorente V, de Gonzalo D, Guerra JM, Vilades D, Leta R, Martinez JL, Garcia FJ, Fernandez XA, Gonzalez JR, Eiras S, Rodriguez M. Sex-related differences of fatty acid-binding protein 4 and leptin levels in atrial fibrillation. EUROPACE. 2021; 23(5). DOI:10.1093/europace/euaa284. PMID:33319222. IF:5,486.

Introduction

Molecular mechanisms involved in the modulation of the receptor LRP1 by cardiovascular risk factors.
Impact of LRP1 in the vascular and myocardial cholesterol entrapment.
Impact of atherogenic dyslipemia in LRP1 intracellular signaling in cardiovascular cells exposed to normoxic and hypoxic conditions and in vivo models of ischemia.
Lipoproteins and diabetic myocardiopathy.
Lipoproteins and breast cancer.
LRP1 and inflammation.
Non-coding RNAs as circulating biomarkers of atherosclerosis and myocardiopathies.
Non-coding RNAs as biomarkers of vascular and myocardial lipid accumulation.

Challenges
To perform in vivo and clinical studies useful to demonstrate the role of LRP1 in the cardiovascular system.
To maintain and expand our collaborative network with IIB-SantPau groups and with clinical, academic and entrepreneur institutions required to increase the traslationality of our research area.
To expand our international collaborations.
To establish new collaborations with companies able to strategically contribute to develop innovative products essential to advance in the diagnostic and treatment of cardiovascular diseases.

Team

LLORENTE CORTES, CONCEPCION VICENTA CSIC
cllorente@santpau.cat

Garcia Rodriguez, Jesus Eduardo IR
La Chica Lhoest, Maria Teresa CSIC
Martinez Jimenez, Andrea IR

Scientific output

(JIF 2022)

Benitez A, Martinez N, Manero N, Claudi L, Lhoest MTL, Soler M, Ros L, Navarro P, Llorente V. Peptides against Low Density Lipoprotein (LDL) Aggregation Inhibit Intracellular Cholesteryl Ester Loading and Proliferation of Pancreatic Tumor Cells. 2022; 14(4):890. DOI:10.3390/cancers14040890. PMID:35205638. IF:5,2 (Q2/3D). Document type: Article.
Dato VA, Benitez A, Garcia E, Claudi L, Lhoest MTL, Iborra A, Guerra JM, Escola JC, Samouillan V, Enrich C, Chiabrando G, Llorente V. Targeting cholesteryl ester accumulation in the heart improves cardiac insulin response. BIOMEDICINE & PHARMACOTHERAPY. 2022; 152:113270. DOI:10.1016/j.biopha.2022.113270. PMID:35709652. IF:7,5 (Q1/1D). Document type: Article.

Amaro AB, Curco AS, Garcia E, Julve J, Rives J, Benitez S, Cortes VL. Apolipoprotein and LRP1-Based Peptides as New Therapeutic Tools in Atherosclerosis. Journal of Clinical Medicine. 2021; 10(16):3571. DOI:10.3390/jcm10163571. PMID:34441867. IF:4,964.
Gamboa R, Jaramillo MJ, Martinez MD, Soto ME, Torres YE, de Gonzalo D, Del Valle L, Lopez R, Llorente VC, Huesca C. Monocyte Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Expression Correlates with cIMT in Mexican Hypertensive Patients. Arquivos Brasileiros de Cardiologia. 2021; 116(1). DOI:10.36660/abc.20190535. PMID:33566965. IF:2,667.
Lopez JN, Couselo M, Baluja A, Gonzalez L, Rozados A, Llorente V, de Gonzalo D, Guerra JM, Vilades D, Leta R, Martinez JL, Garcia FJ, Fernandez XA, Gonzalez JR, Eiras S, Rodriguez M. Sex-related differences of fatty acid-binding protein 4 and leptin levels in atrial fibrillation. EUROPACE. 2021; 23(5). DOI:10.1093/europace/euaa284. PMID:33319222. IF:5,486.

CARDIOVASCULAR DISEASES