Researchers from the Lipids and Cardiovascular Pathology Group, from the Institute of Research of Sant Pau – IIB Sant Pau, led by Dr. Vicenta Llorente; from CSIC; from the Germans Trias i Pujol Research Institute; from the Institute of Biomedical Research of Barcelona and from the University of Barcelona have published an article in Metabolism. In their work, carried out in the context of different CIBER groups, they demonstrate in an experimental model that the preservation of low levels of the LRP1 receptor in cardiomyocytes (or in the heart) prevents the development of insulin resistance and obesity induced by the diet.
In the article “Low-density lipoprotein receptor-related protein 1 deficiency in cardiomyocytes reduce susceptibility to insulin resistance and Obesity” they state that it is due to the fact that the LRPI receptor controls the release of a protein in the bloodstream, the cardioquin or ANP hormone, which modulates the liver’s ability to burn or oxidize the fatty acids that the diet provides to the body. The increased ability of the liver to burn fatty acids prevents them from accumulating as fat and, therefore, LRP1-deficient animals gain less weight than controls even though they are fed a diet richer in fatty acids. These results open up a new therapeutic avenue to prevent cardiac and metabolic disorders in the context of diet-induced obesity and diabetes.
About the article
Benitez-Amaro A, Revuelta-López E, Bornachea O, Cedo L, See À, Herrero L, Roglans N, Soler-Botija C, de Gonzalo-Calvo D, Nasarre L, Camino-López S, García JE, Mato E, Blanco-Vaca F, Bayes-Genis A, Sebastian D, Laguna JC, Sierra D, Zorzano A, Escuela-Gil JC, Llorente-Cortes V. “Low-density lipoprotein receptor-related protein 1 deficiency in cardiomyocytes reducing susceptibility to insulin resistance and Obesity “. Metabolism. 2020 Feb 26: 154.191. doi: 10.1016 / j.metabol.2020.154191. PubMed PMID: 32112822.