Experts agree that today we are much closer to defeating Alzheimer’s and that we are living through a historic paradigm shift. There is still no cure, but for the first time it has been possible to slow the course of the disease thanks to a turning point: a new generation of drugs that remove the beta-amyloid protein that accumulates in patients’ brains and slow the progression of Alzheimer’s by 30%. Plasma biomarkers are also highlighted as a revolution in diagnosis at all stages of the disease through a simple blood test. They also deliver a public health message to society: 45% of dementia cases could be prevented or delayed by addressing 14 modifiable risk factors. These are some key conclusions from the recent meeting marking the 20th anniversary of the Memory Unit (MU) at Hospital de Sant Pau, which brought together world experts, patients, and families.