An international team of researchers has demonstrated that the tetravalent dengue vaccine Qdenga provides significant protection against the disease under real-world conditions during the major 2024 epidemic in São Paulo, Brazil. The study, published in the journal The Lancet Infectious Diseases and led by Dr. Otavio Ranzani, head of the DataHealth Lab group at the Sant Pau Research Institute (IR Sant Pau). Together with Dr. Julio Croda, Fiocruz, Brazil, provides the first evidence of the vaccine’s effectiveness following its approval.

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A team of researchers at the Sant Pau Research Institute (IR Sant Pau) has demonstrated that the plasma biomarker p-tau217, obtained through a simple blood test, can predict the clinical progression of Alzheimer’s disease even in its earliest stages. This is when symptoms are not yet evident. The study, published in the journal Neurology, reinforces the role of blood tests in the future of diagnosing and monitoring dementias.

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Physicians from the Intensive Care Medicine Department at Hospital Sant Pau, members of the Sant Pau Research Institute (IR Sant Pau), have participated in the international PROMIZING study. This is one of the most ambitious clinical trials to date aimed at optimizing the discontinuation of mechanical ventilation in patients with severe respiratory failure.

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Researchers at the Sant Pau Research Institute (IR Sant Pau), in collaboration with the Hospital de Sant Pau and the Josep Carreras Leukaemia Research Institute, have developed an innovative CAR-T cell therapy targeting the CD30 protein (HSP-CAR30). This therapy has shown high efficacy in patients with refractory CD30+ lymphoma.

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A study led by Víctor Montal, researcher at the Research Institute of the Hospital de Santa Creu i Sant Pau – IIB Sant Pau and Jorge Sepulcre, of the Massachusetts General Hospital and Harvard Medical School, in Boston (United States ) has described the association between the accumulation of the TAU protein in certain areas of the brain and the overexpression of the APOE and SLC1A2 genes in the same areas. The work has been published in the journal Science Translational Medicine.

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Alzheimer’s disease has become the leading medical problem in adults with Down syndrome due to the chromosomal alteration and the increase in life expectancy of this population, with a risk of more than 90% of developing dementia throughout their lives.

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An international macro-study in which researchers from the Hospital de la Santa Creu i Sant Pau Research Institute – IIB Sant Pau have participated has located 11 new chromosomal regions involved in susceptibility to SARS-CoV-2 infection and in severity COVID-19 clinic. The work is published in the journal Nature.

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Researchers from the Research Institute of the Hospital de la Santa Creu i Sant Pau – IIB Sant Pau, the Immunology Department and the Geriatrics Unit of the Internal Medicine Department of the same hospital have identified that the increased levels of CD28+ CD27+ T lymphocytes early differentiated is associated with a better prognosis in patients older than 65 years who are admitted for pneumonia.

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Researchers at the Research Institute of Sant Pau (IIB Sant Pau) and CIBER, led by Eugenia Mato of the Endocrinology, Diabetes and Nutrition Research Group and Joan Carles Escolà-Gil of the Risk Metabolic Basis Research Group Cardiovascular, have shown the role of cholesterol and one of its main metabolites, 27-hydroxycholesterol (27HC) in the growth of the thyroid tumor, as well as in its aggressiveness. The work has been published in Scientific Report.

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“1 in 6 people will suffer a stroke in their lifetime”.
“In Catalonia, stroke is the first cause of death in women and the third in men, the first cause of disability and the second cause of dementia”.
“Time is brain”.

Joan Martí Fàbregas

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