Regulation of Cardiac Rhythm and Contraction

Main lines of research

  • Receptor-mediated changes in intracellular calcium homeostasis in atrial fibrillation.
  • Contribution of genetic variants to electrical remodelling and arrhythmogenesis.
  • Effects of development and ageing on calcium handling in cardiac myocytes.
  • Functional effects of lipid accumulation in cardiomyocytes.


The goal is to consolidate the group as a reference in research on calcium handling in atrial fibrillation and to establish it within other lines of research by including emerging technology and fields of research. Specifically we aim to:

  • Develop computational tools and models to improve the analysis and understanding of intracellular calcium handling in cardiac myocytes.
  • Incorporate emerging technology such as stretching and measurements of force development in single cardiomyocytes.
  • Consolidate current national and international collaborations and establish new strategic collaborations within emerging fields of research such as the use of super-resolution fluorescence imaging (STORM, STED-techniques), the detection and role of Reactive Oxygen Species in diseased cardiomyocytes, and the role of telomere length in cardiac senescence and regeneration.
  • Achieve international funding for incorporation of scientific expertise and participation in multidisciplinary international research projects.

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