Sant Pau - Institut de Recerca

Main research lines

Identify new prognostic biomarkers and new therapeutic targets for risk and therapeutic stratification in endometrial cancer patients
Study the effect of the Nervous system in tumor progression and metastasis in gynecological and peritoneal cancers
Modeling gynecological and peritoneal cancers in animals to better understand tumor pathophysiology and the use for preclinical drug evaluation.
Development of new antitumor drugs, using nanotechnology, in cell lines and animal models for targeted delivery to cancer stem cells (in collaboration with the Oncogenesis and Antitumor Drugs group).

Scientific Challenges

Promote clinical and translational research into gynaecological cancers with a very large database and study relevant clinical issues.
Obtain funding from FIS, regional authorities and private companies.
Enhance cooperation with other clinical and research groups both in Sant Pau and extra-hospital, and attract predoctoral and postdoctoral fellows.
Develop molecular markers for therapeutic decision-making in endometrial cancer patients.
Identification and validation of novel therapeutic targets related to neuromodulation in tumour progression of gynaecological cancers.
Achieve antitumor and antimetastatic effects by targeting drugs at cancer stem cells in gynaecological and peritoneal cancers.

Group coordination

CESPEDES NAVARRO, M. VIRTUDES IR
mcespedes@santpau.cat

Members

Caruana Santiago, Pablo IR
Edwards, Maria Charlotte IR
Luna Guibourg, Rocio FGS
Magret Descamps, Eva FGS
Martin Lorente, Cristina FGS
Muñoz Sanchez, Raquel FGS
Rovira Negre, Ramon FGS
Soler Moreno, Cristina FGS
Teixeira, Natalia FGS
Zapater Enrique, Oscar FGS

Publications 2022

(JIF 2022)

Aznar AL, Lloret PE, Moreno CS, Luna-Guibourg R, Rovira R. Laparoscopic approach for symptomatic pelvic and para-aortic lymphoceles. Journal Of The Turkish-German Gynecological Association. 2022; 23(1). DOI:10.4274/jtgga.galenos.2021.2021.0028. PMID:34109774. Document type: Article.
Español P, Luna-Guibourg R, Soler-Moreno C, Caruana P, Altes A, Rodriguez F, Porta O, Sanchez O, Llurba E, Rovira R, Cespedes MV. Neural plasticity of the uterus: New targets for endometrial cancer?. Womens Health. 2022; 18:17455057221095537. DOI:10.1177/17455057221095537. PMID:35465787. Document type: Review.
Fernandez R, Carreno A, Mendoza R, Benito A, Ferrer N, Cespedes MV, Corchero JL. Escherichia coli as a New Platform for the Fast Production of Vault-like Nanoparticles: An Optimized Protocol. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(24):15543. DOI:10.3390/ijms232415543. PMID:36555185. IF:5,6 (Q1/3D). Document type: Article.
Francis KE, Kim SI, Friedlander M, Gebski V, Ray-Coquard I, Clamp A, Penson RT, Oza A, Perri T, Huzarski T, Martin-Lorente C, Cecere SC, Colombo N, Ataseven B, Fujiwara K, Sonke G, Vergote I, Pujade-Lauraine E, Kim J-W, Lee CK. The impact of olaparib dose reduction and treatment interruption on treatment outcome in the SOLO2/ENGOT-ov21 platinum-sensitive recurrent ovarian cancer. ANNALS OF ONCOLOGY. 2022; 33(6). DOI:10.1016/j.annonc.2022.02.222. PMID:35219776. IF:50,5 (Q1/1D). Document type: Article.
Lorca C, Laparra M, Cespedes MV, Casani L, Florit S, Jove M, Mota N, Vilella E, Gallart X, Serra A. Industrial By-Products As a Novel Circular Source of Biocompatible Extracellular Vesicles. ADVANCED FUNCTIONAL MATERIALS. 2022; 32(29):2202700. DOI:10.1002/adfm.202202700. IF:19 (Q1/1D). Document type: Article.
Luzarraga-Aznar A, Teixeira N, Luna-Guibourg R, Español P, Soler-Moreno C, Rovira R. Surgical treatment in older patients with endometrial cancer: A retrospective study. SURGICAL ONCOLOGY-OXFORD. 2022; 44:101852. DOI:10.1016/j.suronc.2022.101852. PMID:36126351. IF:2,3 (Q2/5D). Document type: Article.
Martin F, Carreno A, Mendoza R, Caruana P, Rodriguez F, Bravo M, Benito A, Ferrer N, Cespedes MV, Corchero JL. All-in-one biofabrication and loading of recombinant vaults in human cells. 2022; 14(2):025018. DOI:10.1088/1758-5090/ac584d. PMID:35203066. IF:9 (Q1/2D). Document type: Article.
Medina E, Cespedes MV, Gallardo A, Rioja E, Pavon MA, Asensio L, Farre L, Alba L, Unzueta U, Villaverde A, Vazquez E, Casanova I, Mangues R. Novel Endometrial Cancer Models Using Sensitive Metastasis Tracing for CXCR4-Targeted Therapy in Advanced Disease. 2022; 10(7):1680. DOI:10.3390/biomedicines10071680. PMID:35884987. IF:4,7 (Q1/3D). Document type: Article.
Rodríguez F, Caruana P, De la Fuente N, Español P, Gámez M, Balart J, Llurba E, Rovira R, Ruiz R, Martín C, Corchero JL, Céspedes MV. Nano-Based Approved Pharmaceuticals for Cancer Treatment: Present and Future Challenges. 2022; 12(6):784. DOI:10.3390/biom12060784. PMID:35740909. IF:5,5 (Q1/3D). Document type: Review.
Sala R, Rioja E, Serna N, Sanchez L, Alamo P, Alba L, Casanova I, Lopez A, Unzueta U, Cespedes MV, Vazquez E, Villaverde A, Mangues R. GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases. DRUG DELIVERY. 2022; 29(1). DOI:10.1080/10717544.2022.2069302. PMID:35532120. IF:6 (Q1/2D). Document type: Article.

Publications 2021

Castro RD, Olloquequi J, Etchetto M, Caruana P, Steele L, Leighton K-M, Ureña J, Beas C, Camins A, Verdaguer E, Auladell C. Dual mkk4 and mkk7 gene deletion in adult mouse causes an impairment of hippocampal immature granule cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021; 22(17):9545. DOI:10.3390/ijms22179545. PMID:34502457. IF:6,208.
COVIDSurg Collaborative [Sanchez-Lopez A, Balague MC, Targarona E, Sanchez-Cabus S, Molina V, Gonzalez-Lopez JA, Medrano R, Moral A]. Machine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: the COVIDSurg mortality score. BRITISH JOURNAL OF SURGERY. 2021;108(11):1274-1292. DOI:10.1093/bjs/znab183. PMID: 34227657. IF:11,122.
Iantsen A, Ferreira M, Lucia F, Jaouen V, Reinhold C, Bonaffini P, Alfieri J, RAMON N, Masson I, Robin P, Mervoyer A, Rousseau C, Kridelka F, Decuypere M, Lovinfosse P, Pradier O, Hustinx R, Schick U, Visvikis D, Hatt M. Convolutional neural networks for PET functional volume fully automatic segmentation: development and validation in a multi-center setting. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2021; 48(11). DOI:10.1007/s00259-021-05244-z. PMID:33772335. IF:10,057.
Luzarraga A, Mora I, Magret E, RAMON N. Laparoscopic Colposacropexy Mesh Excision Secondary to Severe Spondylodiscitis. Journal of Minimally Invasive Gynecology. 2021; 28(11). DOI:10.1016/j.jmig.2021.08.029. PMID:34500066. IF:4,314.
Redondo A, Guerra E, Manso L, Martin C, Martinez J, Perez JA, Varela MQ, Rubio MJ, Barretina MP, Gonzalez A. SEOM clinical guideline in ovarian cancer (2020). Clinical & Translational Oncology. 2021; 23(5). DOI:10.1007/s12094-020-02545-x. PMID:33515422. IF:3,340.
Redondo A, Oaknin A, Rubio MJ, Barretina MP, de Juan A, Manso L, Romero I, Martin C, Poveda A, Gonzalez A. Management of advanced ovarian cancer in Spain: an expert Delphi consensus. Journal of Ovarian Research. 2021; 14(1):72. DOI:10.1186/s13048-021-00816-x. PMID:34039386. IF:5,506.
Tattersall HL, Hodson J, Cardona K, Lee RM, Nessim C, Gladdy R, Van Der Hage J, Schrage Y, Tseng WW, van Houdt W, Novak M, Grignani G, Tolomeo F, Goel N, Ryon E, Gyorki D, Bagaria SP, Gonzalez JA, Arnau ABM, Sayyed R, Tirotta F, Evenden C, Desai A, Almond M, Glasbey J, Fiore M, Gronchi A, Ford SJ. Primary mesenteric sarcomas: Collaborative experience from the Trans-Atlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG). JOURNAL OF SURGICAL ONCOLOGY. 2021;123(4):1057-1066. DOI:10.1002/jso.26353. Erratum in: JOURNAL OF SURGICAL ONCOLOGY. 2021;124(3):457. PMID: 33368277. IF:2,885.
Zapardiel I, Alvarez J, Barahona M, Barri P, Boldo A, Bresco P, Gasca I, Jaunarena I, Kucukmetin A, Mancebo G, Otero B, Roldan F, Rovira R, Suarez E, Tejerizo A, Torrent A, Gorostidi M. Utility of Intraoperative Fluorescence Imaging in Gynecologic Surgery: Systematic Review and Consensus Statement. ANNALS OF SURGICAL ONCOLOGY. 2021;28(6):3266-3278. DOI:10.1245/s10434-020-09222-x. PMID: 33095359. IF:4,339.

Introduction

Main research lines

Identify new prognostic biomarkers and new therapeutic targets for risk and therapeutic stratification in endometrial cancer patients
Study the effect of the Nervous system in tumor progression and metastasis in gynecological and peritoneal cancers
Modeling gynecological and peritoneal cancers in animals to better understand tumor pathophysiology and the use for preclinical drug evaluation.
Development of new antitumor drugs, using nanotechnology, in cell lines and animal models for targeted delivery to cancer stem cells (in collaboration with the Oncogenesis and Antitumor Drugs group).

Scientific Challenges

Promote clinical and translational research into gynaecological cancers with a very large database and study relevant clinical issues.
Obtain funding from FIS, regional authorities and private companies.
Enhance cooperation with other clinical and research groups both in Sant Pau and extra-hospital, and attract predoctoral and postdoctoral fellows.
Develop molecular markers for therapeutic decision-making in endometrial cancer patients.
Identification and validation of novel therapeutic targets related to neuromodulation in tumour progression of gynaecological cancers.
Achieve antitumor and antimetastatic effects by targeting drugs at cancer stem cells in gynaecological and peritoneal cancers.

Team

Group coordination

CESPEDES NAVARRO, M. VIRTUDES IR
mcespedes@santpau.cat

Members

Scientific output

Publications 2022

(JIF 2022)

Aznar AL, Lloret PE, Moreno CS, Luna-Guibourg R, Rovira R. Laparoscopic approach for symptomatic pelvic and para-aortic lymphoceles. Journal Of The Turkish-German Gynecological Association. 2022; 23(1). DOI:10.4274/jtgga.galenos.2021.2021.0028. PMID:34109774. Document type: Article.
Español P, Luna-Guibourg R, Soler-Moreno C, Caruana P, Altes A, Rodriguez F, Porta O, Sanchez O, Llurba E, Rovira R, Cespedes MV. Neural plasticity of the uterus: New targets for endometrial cancer?. Womens Health. 2022; 18:17455057221095537. DOI:10.1177/17455057221095537. PMID:35465787. Document type: Review.
Fernandez R, Carreno A, Mendoza R, Benito A, Ferrer N, Cespedes MV, Corchero JL. Escherichia coli as a New Platform for the Fast Production of Vault-like Nanoparticles: An Optimized Protocol. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(24):15543. DOI:10.3390/ijms232415543. PMID:36555185. IF:5,6 (Q1/3D). Document type: Article.
Francis KE, Kim SI, Friedlander M, Gebski V, Ray-Coquard I, Clamp A, Penson RT, Oza A, Perri T, Huzarski T, Martin-Lorente C, Cecere SC, Colombo N, Ataseven B, Fujiwara K, Sonke G, Vergote I, Pujade-Lauraine E, Kim J-W, Lee CK. The impact of olaparib dose reduction and treatment interruption on treatment outcome in the SOLO2/ENGOT-ov21 platinum-sensitive recurrent ovarian cancer. ANNALS OF ONCOLOGY. 2022; 33(6). DOI:10.1016/j.annonc.2022.02.222. PMID:35219776. IF:50,5 (Q1/1D). Document type: Article.
Lorca C, Laparra M, Cespedes MV, Casani L, Florit S, Jove M, Mota N, Vilella E, Gallart X, Serra A. Industrial By-Products As a Novel Circular Source of Biocompatible Extracellular Vesicles. ADVANCED FUNCTIONAL MATERIALS. 2022; 32(29):2202700. DOI:10.1002/adfm.202202700. IF:19 (Q1/1D). Document type: Article.
Luzarraga-Aznar A, Teixeira N, Luna-Guibourg R, Español P, Soler-Moreno C, Rovira R. Surgical treatment in older patients with endometrial cancer: A retrospective study. SURGICAL ONCOLOGY-OXFORD. 2022; 44:101852. DOI:10.1016/j.suronc.2022.101852. PMID:36126351. IF:2,3 (Q2/5D). Document type: Article.
Martin F, Carreno A, Mendoza R, Caruana P, Rodriguez F, Bravo M, Benito A, Ferrer N, Cespedes MV, Corchero JL. All-in-one biofabrication and loading of recombinant vaults in human cells. 2022; 14(2):025018. DOI:10.1088/1758-5090/ac584d. PMID:35203066. IF:9 (Q1/2D). Document type: Article.
Medina E, Cespedes MV, Gallardo A, Rioja E, Pavon MA, Asensio L, Farre L, Alba L, Unzueta U, Villaverde A, Vazquez E, Casanova I, Mangues R. Novel Endometrial Cancer Models Using Sensitive Metastasis Tracing for CXCR4-Targeted Therapy in Advanced Disease. 2022; 10(7):1680. DOI:10.3390/biomedicines10071680. PMID:35884987. IF:4,7 (Q1/3D). Document type: Article.
Rodríguez F, Caruana P, De la Fuente N, Español P, Gámez M, Balart J, Llurba E, Rovira R, Ruiz R, Martín C, Corchero JL, Céspedes MV. Nano-Based Approved Pharmaceuticals for Cancer Treatment: Present and Future Challenges. 2022; 12(6):784. DOI:10.3390/biom12060784. PMID:35740909. IF:5,5 (Q1/3D). Document type: Review.
Sala R, Rioja E, Serna N, Sanchez L, Alamo P, Alba L, Casanova I, Lopez A, Unzueta U, Cespedes MV, Vazquez E, Villaverde A, Mangues R. GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases. DRUG DELIVERY. 2022; 29(1). DOI:10.1080/10717544.2022.2069302. PMID:35532120. IF:6 (Q1/2D). Document type: Article.

Publications 2021

Castro RD, Olloquequi J, Etchetto M, Caruana P, Steele L, Leighton K-M, Ureña J, Beas C, Camins A, Verdaguer E, Auladell C. Dual mkk4 and mkk7 gene deletion in adult mouse causes an impairment of hippocampal immature granule cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021; 22(17):9545. DOI:10.3390/ijms22179545. PMID:34502457. IF:6,208.
COVIDSurg Collaborative [Sanchez-Lopez A, Balague MC, Targarona E, Sanchez-Cabus S, Molina V, Gonzalez-Lopez JA, Medrano R, Moral A]. Machine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: the COVIDSurg mortality score. BRITISH JOURNAL OF SURGERY. 2021;108(11):1274-1292. DOI:10.1093/bjs/znab183. PMID: 34227657. IF:11,122.
Iantsen A, Ferreira M, Lucia F, Jaouen V, Reinhold C, Bonaffini P, Alfieri J, RAMON N, Masson I, Robin P, Mervoyer A, Rousseau C, Kridelka F, Decuypere M, Lovinfosse P, Pradier O, Hustinx R, Schick U, Visvikis D, Hatt M. Convolutional neural networks for PET functional volume fully automatic segmentation: development and validation in a multi-center setting. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2021; 48(11). DOI:10.1007/s00259-021-05244-z. PMID:33772335. IF:10,057.
Luzarraga A, Mora I, Magret E, RAMON N. Laparoscopic Colposacropexy Mesh Excision Secondary to Severe Spondylodiscitis. Journal of Minimally Invasive Gynecology. 2021; 28(11). DOI:10.1016/j.jmig.2021.08.029. PMID:34500066. IF:4,314.
Redondo A, Guerra E, Manso L, Martin C, Martinez J, Perez JA, Varela MQ, Rubio MJ, Barretina MP, Gonzalez A. SEOM clinical guideline in ovarian cancer (2020). Clinical & Translational Oncology. 2021; 23(5). DOI:10.1007/s12094-020-02545-x. PMID:33515422. IF:3,340.
Redondo A, Oaknin A, Rubio MJ, Barretina MP, de Juan A, Manso L, Romero I, Martin C, Poveda A, Gonzalez A. Management of advanced ovarian cancer in Spain: an expert Delphi consensus. Journal of Ovarian Research. 2021; 14(1):72. DOI:10.1186/s13048-021-00816-x. PMID:34039386. IF:5,506.
Tattersall HL, Hodson J, Cardona K, Lee RM, Nessim C, Gladdy R, Van Der Hage J, Schrage Y, Tseng WW, van Houdt W, Novak M, Grignani G, Tolomeo F, Goel N, Ryon E, Gyorki D, Bagaria SP, Gonzalez JA, Arnau ABM, Sayyed R, Tirotta F, Evenden C, Desai A, Almond M, Glasbey J, Fiore M, Gronchi A, Ford SJ. Primary mesenteric sarcomas: Collaborative experience from the Trans-Atlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG). JOURNAL OF SURGICAL ONCOLOGY. 2021;123(4):1057-1066. DOI:10.1002/jso.26353. Erratum in: JOURNAL OF SURGICAL ONCOLOGY. 2021;124(3):457. PMID: 33368277. IF:2,885.
Zapardiel I, Alvarez J, Barahona M, Barri P, Boldo A, Bresco P, Gasca I, Jaunarena I, Kucukmetin A, Mancebo G, Otero B, Roldan F, Rovira R, Suarez E, Tejerizo A, Torrent A, Gorostidi M. Utility of Intraoperative Fluorescence Imaging in Gynecologic Surgery: Systematic Review and Consensus Statement. ANNALS OF SURGICAL ONCOLOGY. 2021;28(6):3266-3278. DOI:10.1245/s10434-020-09222-x. PMID: 33095359. IF:4,339.

ONCOHEMATOLOGIC DISEASES

Gynecologic and Peritoneal Oncology

Main research lines

Scientific Challenges

Group coordination

Members

Publications 2022

Publications 2021

Main research lines

Scientific Challenges

Group coordination

Members

Publications 2022

Publications 2021

Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau