Regulatory Mechanisms of Cardiovascular Remodelling

Main lines of researchThe  Group of “Regulatory mechanisms of cardiovascular remodeling” investigates key aspects of vascular biology, atherothrombosis and myocardial pathophysiology geared towards the characterization of the cellular and molecular mechanisms involved in the onset, progression and complication of ischemic heart disease, abdominal aortic aneurysm (AAA) and cardiac hypertrophy. The ultimate goal of the group is to identify novel therapeutic targets and biomarkers to better manage these highly prevalent cardiovascular diseases.

Main lines of research

  • Extracellular matrix remodeling in cardiovascular diseases.
  • Nuclear receptors in ischemic heart disease, vascular biology and cardiac hypertrophy.
  • Novel therapeutic targets in hypertensive disease


  • To analyze the molecular basis of abdominal aortic aneurysm and to identify novel therapeutic targets.
  • To study the pathophysiological and molecular mechanisms underlying the development of thoracic aortic aneurysm in syndromic patients.
  • To identify novel biomarkers and therapeutic targets for peripheral artery disease and vascular dysfunction.
  • To analyze the molecular mechanisms that involve nuclear receptors in the regulation of vascular calcification.
  • To identify and validate novel pharmacological tools in cardiovascular diseases.
  • To develop new animal models in cardiovascular disease.

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