Sant Pau - Institut de Recerca

Main lines of research

RESEARCH LINE: PARKINSON’S DISEASE, PARKINSONISM, TREMOR, DYSTONIAS AND TICS

Line Leaders: Pagonabarraga Mora, Javier, and Martínez-Fernández, Raul

Within this line, the main research areas are:

COGNITIVE DECLINE AND BEHAVIORAL ALTERATIONS IN PARKINSON’S DISEASE

Study and in-depth analysis of the neural correlates of cognitive and behavioral alterations in the disease using neurophysiological techniques and structural and functional neuroimaging.
Development of sensitive neuropsychological tools for cognitive and functional assessment in Parkinson’s disease.

NEUROMODULATION IN PARKINSON’S DISEASE

Definition, description, and prospective follow-up of patients with Parkinson’s disease who are candidates for HIFU or deep brain stimulation, and imaging analysis of changes at the neural network level associated with different types of neuromodulation (TMS, HIFU, DBS).

ATYPICAL PARKINSONISM

Study of the neural correlates of neuropsychiatric and cognitive alterations in atypical parkinsonism using structural and functional neuroimaging techniques, as well as biomarkers that facilitate differential diagnosis.

ESSENTIAL TREMOR, DYSTONIAS AND TICS

Clinical, neurophysiological, and neuroimaging assessment of patients with essential tremor undergoing HIFU therapy.
Neuroimaging, neurophysiological, and genetic studies of patients with primary segmental and generalized dystonias, and patients with Tourette syndrome, and their application to the identification of neuromodulation targets.

TRANSLATIONAL RESEARCH – BIOMARKERS AND CELLULAR MODELS

Study of biomarkers in different fluids (CSF and plasma) and skin biopsies for the analysis and correlation of pathological and molecular alterations associated with cognitive and neuropsychiatric disorders in Parkinson’s disease and atypical parkinsonism.

RESEARCH LINE: HUNTINGTON’S DISEASE, OTHER CHOREAS AND ATAXIAS

Line Leader: Martínez-Horta, Saül .

Within this line, the main research areas are:

HUNTINGTON’S DISEASE

Study of metabolic correlates (¹⁸F-FDG PET) of disease progression from the presymptomatic phase to the early stage, and of cognitive, affective, and motivational alterations.
Determination of the prevalence and clinical significance of neuropsychiatric features in Huntington’s disease.
Development of new instruments for cognitive and functional assessment in Huntington’s disease, and characterization of differentiated cognitive phenotypes.
Prospective observational study of Huntington’s disease in a European cohort (Registry Study) and an international cohort (Enroll-HD).
Collaboration in coordinated multicenter projects and coordinated Spanish projects.

TRANSLATIONAL RESEARCH – BIOMARKERS AND CELLULAR MODELS

Identification of progression biomarkers in both premanifest and manifest phases, based on neuroimaging, biological samples (blood, muscle tissue, cerebrospinal fluid), and clinical data.
Molecular, clinical, behavioral, and cognitive characterization of the BACHD rat model of Huntington’s disease.

Challenges

Cognitive and Behavioural Dysfunctions in Parkinson Disease

Study and understanding of the neural substrates of cognitive impairment in Parkinson disease so as to improve diagnostic and therapeutic approaches.
Development of specific tools to assess and track cognitive changes in Parkinson disease.

Huntington’s Disease

Study of the dynamics of mutant Htt protein aggregation and related neural and cognitive correlates along disease stages in Huntington’s disease.
Validation of new instruments to assess and track subtle cognitive changes in pre-manifested and early-stage Huntington’s disease population.

Essential Tremor and Other Movement Disorders

Genetic studies and genotype-phenotype correlations in essential tremor.
Development of new therapeutic interventions in essential tremor.
Neurochemical and structural neuroimaging studies on the pathophysiological bases of essential tremor.

Translational Research – Animal Models of Parkinsonism

Behavioural, physiological and pharmacological characterization of animal models of parkinsonism with combined dopaminergic and noradrenergic lesions.
Physiopathology of motor, cognitive and behavioural complications linked to antiparkinsonian drugs in animal models of parkinsonism.

Group coordination

KULISEVSKY BOJARSKI, JAIME FGS
jkulisevsky@santpau.cat

Members

Aracil Bolanos, Ignacio FGS
Bojtos, Lidia IR
Bonavita, Sofia IR
Borrell Pichot, Maria FGS
Campolongo Perillo, Antonia FGS
Franch Marti, Carla IR
Garcia Sanchez, Carmen FGS
Gironell Carrero, Alexandre FGS
Gonzalez Castillo, Diego IR
Ji, Yi IR
Martinez Horta, Saul Indra FGS
Olmedo Saura, Gonzalo FGS
Pagonabarraga Mora, Javier FGS
Pascual Sedano, Berta Marta FGS
Perez Carasol, Laura IR
Perez Perez, Jesus FGS
Puig Davi, Arnau IR
Rivas Asensio, Elisa Maria IR
Rodriguez-Antigüedad Muñoz, Jon IR
Rubio Romera, Margarita IR
Ruiz Barrio, Iñigo IR
Sampedro Santalo, Frederic Vicenç FGS
Soler Almendros, Judit IR

Publications 2024

(JIF 2024)

-Aibar JÁ, Villalba G, Freixer B, Araus E, Morollón Sanchez N, Belvis R, Revuelta M, Molet J, García C, de Quintana C, Muñoz F, Rodríguez R. Long-Term Results of Cortical Motor Stimulation for Neuropathic Peripheral and Central Pain: Real-World Evidence From Two Independent Centers. Neurosurgery. 2024; 94(1). DOI:10.1227/neu.0000000000002638. PMID:37638720. IF:3,900 (Q1/1D). Document type: Article.

-Aracil-Bolaños I, Pérez-Pérez J, Martínez-Horta S, Horta-Barba A, Puig-Davi A, García-Cornet J, Olmedo-Saura G, Campolongo A, Pagonabarraga J, Kulisevsky J. Baseline Large-Scale Network Dynamics Associated with Disease Progression in Huntington’s Disease. Mov Disord. 2024; 39(1):197-203. DOI:10.1002/mds.29655. PMID:38148511. IF:7,600 (Q1/1D). Document type: Article.

-Berzosa I, Martinez S, Pérez J, Kulisevsky J, Pagonabarraga J. Therapeutic Approach to Primary Tic Disorders and Associated Psychiatric Comorbidities. Brain Sciences. 2024; 14(12):1231. DOI:10.3390/brainsci14121231. PMID:39766430. IF:2,800 (Q3/6D). Document type: Article.

-Busteed L, García C, Pascual B, Grunden N, Gironell A, Kulisevsky J, Pagonabarraga J. Impact of Stimulation Frequency on Verbal Fluency Following Bilateral Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease. ARCHIVES OF CLINICAL NEUROPSYCHOLOGY. 2024; DOI:10.1093/arclin/acae062. PMID:39127889. IF:2,100 (Q2/5D). Document type: Article.

-Chia R, Ray A, Shah Z, Ding J, Ruffo P, Fujita M, Menon V, Saez S, Reho P, Kaivola K, Walton RL, Reynolds RH, Karra R, Sait S, Akcimen F, Diez M, Alvarez I, Fanciulli A, Stefanova N, Seppi K, Duerr S, Leys F, Krismer F, Sidoroff V, Zimprich A, Pirker W, Rascol O, Foubert A, Meissner WG, Tison F, Pavy A, Pellecchia MT, Barone P, Russillo MC, Marín J, Kulisevsky J, Torres S, Mir P, Periñán MT, Proukakis C, Chelban V, Wu L, Goh YY, Parkkinen L, Hu MT, Kobylecki C, Saxon JA, Rollinson S, Garland E, Biaggioni I, Litvan I, Rubio I, Alcalay RN, Kwei KT, Lubbe SJ, Mao QW, Flanagan ME, Castellani RJ, Khurana V, Ndayisaba A, Calvo A, Mora G, Canosa A, Floris G, Bohannan RC, Moore A, Norcliffe L, Palma JA, Kaufmann H, Kim C, Iba M, Masliah E, Dawson TM, Rosenthal LS, Pantelyat A, Albert MS, Pletnikova O, Troncoso JC, Infante J, Lage C, Sánchez P, Serrano GE, Beach TG, Pastor P, Morris HR, Albani D, Clarimon J, Wenning GK, Hardy JA, Ryten M, Topol E, Torkamani A, Chio A, Bennett DA, De Jager PL, Low PA, Singer W, Cheshire WP, Wszolek ZK, Dickson DW, Traynor BJ, Gibbs JR, Dalgard CL, Ross OA, Houlden H, Scholz SW. Genome sequence analyses identify novel risk loci for multiple system atrophy. NEURON. 2024; 112(13). DOI:10.1016/j.neuron.2024.04.002. PMID:38701790. IF:15,000 (Q1/1D). Document type: Article.

-Daniels C, Rodríguez-Antigüedad J, Jentschke E, Kulisevsky J, Volkmann J. Cognitive disorders in advanced Parkinson’s disease: challenges in the diagnosis of delirium. Neurol Res Pract. 2024; 6(1):14. DOI:10.1186/s42466-024-00309-4. PMID:38481336. IF:3,200 (Q2/4D). Document type: Review.

-de la Riva P, Marta J, Rodríguez J, Bergareche A, de Munain AL. Understanding Endothelial Dysfunction and Its Role in Ischemic Stroke After the Outbreak of Recanalization Therapies. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024; 25(21):11631. DOI:10.3390/ijms252111631. PMID:39519182. IF:4,900 (Q1/3D). Document type: Review.

-Dellarole IL, Vacchi E, Ruiz I, Pinton S, Raimondi A, Rossi S, Morandi S, Bianco G, Bacinoglu MB, Lombardo A, Celauro L, Staedler C, Galati S, Pagonabarraga J, Kulisevsky J, Legname G, Gobbi C, Kaelin A, Moda F, Melli G. Tau seeding activity in skin biopsy differentiates tauopathies from synucleinopathies. npj Parkinsons Disease. 2024; 10(1):116. DOI:10.1038/s41531-024-00728-9. PMID:38879633. IF:8,200 (Q1/1D). Document type: Article.

-Fernández JM, Aracil I, García C, Campolongo A, Curell M, Rodríguez R, Aibar JA, Kulisevsky J, Pascual B. Cognitive phenotyping of GBA1-Parkinson’s disease: A study on deep brain stimulation outcomes. PARKINSONISM & RELATED DISORDERS. 2024; 128:107127. DOI:10.1016/j.parkreldis.2024.107127. PMID:39357432. IF:3,400 (Q2/4D). Document type: Article.

-Fernández JM, Olmedo G, Querol LA, Kulisevsky J, Pérez J. Crossed-reflex in antiphospholipid chorea. NEUROLOGICAL SCIENCES. 2024; 45(9). DOI:10.1007/s10072-024-07622-5. PMID:38896185. IF:2,400 (Q3/6D). Document type: Article.

-Garon M, Weis L, Siquier A, Fiorenzato E, Pistonesi F, Cianci V, Canesi M, Pesce F, Reali E, Pozzi B, Isaias IU, Siri C, Santangelo G, Cuoco S, Barone P, Kulisevsky J, Antonini A, Biundo R. Validation of the Italian version of the Parkinson’s Disease- Cognitive Functional Rating Scale. JOURNAL OF NEURAL TRANSMISSION. 2024; 131(4). DOI:10.1007/s00702-024-02746-6. PMID:38280057. IF:4,000 (Q1/2D). Document type: Article.

-Gironell A, Marín J, Póveda S. Essential Tremor: Update of Therapeutic Strategies. MEDICINA CLINICA. 2024; 162(12). DOI:10.1016/j.medcli.2023.12.013. PMID:38553256. IF:2,100 (Q2/3D). Document type: Article.

-Gonzalez B, Happé F, Nicholson TR, Morgante F, Pagonabarraga J, Deeley Q, Edwards MJ. Functional Neurological Disorder and Autism Spectrum Disorder: A Complex and Potentially Significant Relationship. Brain and Behavior. 2024; 14(12):e70168. DOI:10.1002/brb3.70168. PMID:39705515. IF:2,700 (Q2/3D). Document type: Review.

-Grunden N, Calabria M, García C, Pons C, Arroyo JA, Gómez B, Estévez MD, Belvís R, Morollón N, Cordero M, Mur I, Pomar V, Domingo P. Evolving trends in neuropsychological profiles of post COVID-19 condition: A 1-year follow-up in individuals with cognitive complaints. PLoS One. 2024; 19(8):e0302415. DOI:10.1371/journal.pone.0302415. PMID:39116061. IF:2,600 (Q2/4D). Document type: Article.

-Herrero M, Pérez J, Escaramís G, Martínez S, Pérez R, Rivas E, Kulisevsky J, Gámez A, Martí E. Small RNAs in plasma extracellular vesicles define biomarkers of premanifest changes in Huntington’s disease. Journal of Extracellular Vesicles. 2024; 13(10):e12522. DOI:10.1002/jev2.12522. PMID:39377487. IF:14,500 (Q1/1D). Document type: Article.

-Kassubek J, Factor SA, Balaguer E, Schwarz J, Chaudhuri KR, Isaacson SH, Wu S, Muhr CD, Kulisevsky J. Long-term safety, tolerability and efficacy of apomorphine sublingual film in patients with Parkinson’s disease complicated by OFF episodes: a phase 3, open-label study. JOURNAL OF NEUROLOGY. 2024; 271(6). DOI:10.1007/s00415-024-12323-2. PMID:38546829. IF:4,600 (Q1/2D). Document type: Article.

-Kulisevsky J, Ferraz HB, Suppa A, Reichmann H. Effects of Safinamide on Motor and Non-Motor Symptoms in Patients with Parkinson’s Disease and Motor Fluctuations. EUROPEAN NEUROLOGY. 2024; 87(5-6). DOI:10.1159/000541362. PMID:39342935. IF:2,400 (Q3/6D). Document type: Review.

-Martinez S, Perez J, Perez R, Sampedro F, Horta A, Campolongo A, Rivas E, Puig A, Pagonabarraga J, Kulisevsky J. Cognitive phenotype and neurodegeneration associated with Tau in Huntington's disease. Annals of Clinical and Translational Neurology. 2024; 11(5). DOI:10.1002/acn3.52031. PMID:38544341. IF:3,900 (Q1/3D). Document type: Article.

-Pagonabarraga J, Bejr H, Martinez S, Kulisevsky J. Parkinson disease psychosis: from phenomenology to neurobiological mechanisms. Nature Reviews Neurology. 2024; 20(3). DOI:10.1038/s41582-023-00918-8. PMID:38225264. IF:33,100 (Q1/1D). Document type: Review.

-Pérez J, García S, Valle TF, Painous C, Querol MR, Ruiz PJG, Diago EB, Delgado EC, Pastor BV, Villaplana MCP, Santana IM, Estrada MB, Garride MC, Ribera PM, Alvarez C, Maurino J, de Prado A, López JL. Huntington Disease Health Related Quality of Life, Function and Well Being: The Patient’s Perspective. Neurology and Therapy. 2024; DOI:10.1007/s40120-024-00655-0. PMID:39370480. IF:4,800 (Q1/2D). Document type: Article.

-Puig A, Martinez S, Pérez L, Horta A, Ruiz I, Aracil I, Pérez R, Rivas E, Sampedro F, Campolongo A, Pagonabarraga J, Kulisevsky J. Prediction of Cognitive Heterogeneity in Parkinson’s Disease: A 4-Year Longitudinal Study Using Clinical, Neuroimaging, Biological and Electrophysiological Biomarkers. ANNALS OF NEUROLOGY. 2024; 96(5). DOI:10.1002/ana.27035. PMID:39099459. IF:7,700 (Q1/1D). Document type: Article.

-Rodríguez J, Martínez S, Horta A, Puig A, Campolongo A, Sampedro F, Bejr H, Marín J, Pagonabarraga J, Kulisevsky J. Facial emotion recognition deficits are associated with hypomimia and related brain correlates in Parkinson’s disease. JOURNAL OF NEURAL TRANSMISSION. 2024; 131(12). DOI:10.1007/s00702-023-02725-3. PMID:38206439. IF:4,000 (Q1/2D). Document type: Article.

-Ruiz I, Horta A, Aracil I, Martinez S, Kulisevsky J, Pagonabarraga J. Predicting Disability in Progressive Supranuclear Palsy Using Bedside Frontal-Lobe Signs. Movement Disorders Clinical Practice. 2024; 11(3). DOI:10.1002/mdc3.13958. PMID:38164060. IF:2,700 (Q2/5D). Document type: Article.

-Ruiz I, Vázquez A, Puig A, Rivas E, Perez J, Fernandez C, Horta A, Olmedo G, Salvat N, Sampedro F, Vacchi E, Melli G, Pagonabarraga J, Kulisevsky J, Martinez S. Skin Tau Quantification as a Novel Biomarker in Huntington’s Disease. MOVEMENT DISORDERS. 2024; 39(11). DOI:10.1002/mds.29989. PMID:39192729. IF:7,600 (Q1/1D). Document type: Article.

-Salvat N, Vazquez A, Rivas E, Herrero M, Gámez A, Pérez J, Izquierdo C, Campolongo A, Marti E, Kulisevsky J, Pérez R. Methodological Assessment of ExoGAG for Isolation of Cerebrospinal Fluid Extracellular Vesicles as a Source of Biomarkers. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024; 25(24):13705. DOI:10.3390/ijms252413705. PMID:39769471. IF:4,900 (Q1/3D). Document type: Article.

-Santos D, de Deus T, Cores C, Painceiras MJF, Alvarado M, Samaniego LB, Maside AL, Jesus S, Cosgaya M, Caldentey JG, Caballol N, Legarda I, Hernandez J, Lopez IC, Manzanares LL, Gonzalez I, Avila A, Gomez V, Nogueira V, Garcia JD, Borrue C, Solano B, Sauco MA, Vela L, Escalante S, Cubo E, Mendoza Z, Parees I, Alonso PS, Losada M, Lopez N, Gaston I, Kulisevsky J, Seijo M, Valero C, Redondo RA, Buongiorno MT, Ordas C, Menendez M, Mcafee D, Martinez P, Mir P. Levodopa-Induced Dyskinesias are Frequent and Impact Quality of Life in Parkinson’s Disease: A 5-Year Follow-Up Study. Movement Disorders Clinical Practice. 2024; 11(7). DOI:10.1002/mdc3.14056. PMID:38747234. IF:2,700 (Q2/5D). Document type: Article.

Publications 2023

(JIF 2023)

-Alonso A, Kurtis MM, Gomez V, Macias D, Viedma AG, Rezola EM, Pagonabarraga J, Orgaz LA, Masjuan J, Martinez JC, Parees I. Functional neurological disorders after COVID-19 and SARS-CoV-2 vaccines: a national multicentre observational study. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. 2023; 94(9). DOI:10.1136/jnnp-2022-330885. PMID:36889911. IF:8,700 (Q1/1D). Document type: Article.

-Aracil I, Pérez J, Martínez S, Horta A, Puig A, Garcia J, Olmedo G, Campolongo A, Pagonabarraga J, Kulisevsky J. Baseline Large-Scale Network Dynamics Associated with Disease Progression in Huntington's Disease. MOVEMENT DISORDERS. 2023; DOI:10.1002/mds.29655. PMID:38148511. IF:7,400 (Q1/1D). Document type: Letter.

-Barrio IR, Miki Y, Jaunmuktane ZT, Warner T, De Pablo E. Association Between Orthostatic Hypotension and Dementia in Patients With Parkinson Disease and Multiple System Atrophy. NEUROLOGY. 2023; 100(10):e998-e1008. DOI:10.1212/WNL.0000000000201659. PMID:36526431. IF:8,400 (Q1/1D). Document type: Article.

-Brandao PRD, Pereira DA, Grippe TC, Bispo DDD, Maluf FB, Yunes MP, Nunes G, Alves CHL, Pagonabarraga J, Kulisevsky J, da A, Serafim CFD, Ferreira A, Bastos A, Belchior A, de Almeida BLC, Castro B, Matos MS, de Matos RC, Rios GD, Carneiro LO, da BCC, Castro L, Rocha VLS, Tavares MCH, Cardoso F. Parkinson’s Disease-Cognitive Rating Scale (PD-CRS): Normative Data and Mild Cognitive Impairment Assessment in Brazil. Movement Disorders Clinical Practice. 2023; 10(3). DOI:10.1002/mdc3.13657. PMID:36949793. IF:2,600 (Q2/5D). Document type: Article.

-Calabria M, Ciongoli F, Grunden N, Ordás C, García C. Background Music and Memory in Mild Cognitive Impairment: The Role of Interindividual Differences. JOURNAL OF ALZHEIMERS DISEASE. 2023; 92(3). DOI:10.3233/JAD-221051. PMID:36806508. IF:3,400 (Q2/4D). Document type: Article.

-Cattaneo C, Kulisevsky J. The Effects of Safinamide in Chinese and Non-Chinese Patients with Parkinson’s Disease. ADVANCES IN THERAPY. 2023; DOI:10.1007/s12325-023-02736-2. PMID:38070039. IF:3,400 (Q2/3D). Document type: Article.

-Collerton D, Barnes J, Diederich NJ, Dudley R, Ffytche D, Friston K, Goetz CG, Goldman JG, Jardri R, Kulisevsky J, Lewis SJG, Naral S, O’Callaghan C, Onofrj M, Pagonabarraga J, Parr T, Shine JM, Stebbins G, Taylor JP, Tsuda I, Weil RS. Understanding visual hallucinations: A new synthesis. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS. 2023; 150:105208. DOI:10.1016/j.neubiorev.2023.105208. PMID:37141962. IF:7,600 (Q1/1D). Document type: Article.

-Collet R, Olmedo G, Ruiz I, Martinez A, Rodriguez B, Bernal S, Kulisevsky J, Pagonabarraga J. Late-Onset Beta-Propeller Protein-Associated Neurodegeneration: A Case Report. Movement Disorders Clinical Practice. 2023; 10(8). DOI:10.1002/mdc3.13811. PMID:37635772. IF:2,600 (Q2/5D). Document type: Article.

-Constantin VA, Szász JA, Dulamea AO, Valkovic P, Kulisevsky J. Impact of Infusion Therapies on Quality of Life in Advanced Parkinson’s Disease. Neuropsychiatric Disease and Treatment. 2023; 19. DOI:10.2147/NDT.S422717. PMID:37727253. IF:2,500 (Q2/5D). Document type: Article.

-Gamez J, Calopa M, Munoz E, Ferre A, Huertas O, McAllister K, Reig N, Scart C, Insa R, Kulisevsky J. A proof-of-concept study with SOM3355 (bevantolol hydrochloride) for reducing chorea in Huntington’s disease. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 2023; 89(5). DOI:10.1111/bcp.15635. PMID:36494329. IF:3,100 (Q2/4D). Document type: Correction.

-Garcia M, Castany C, Golbano A, Perez J, Brito V, Kulisevsky J, Perez E. Lamin B1 and nuclear morphology in peripheral cells as new potential biomarkers to follow treatment response in Huntington’s disease. Clinical and Translational Medicine. 2023; 13(2):e1154. DOI:10.1002/ctm2.1154. PMID:36781300. IF:7,900 (Q1/1D). Document type: Article.

-Gil C, Martinez SI, Santalo FS, Martin M, Gundin S, Alvarez P, Maza L, Calvo S, Collazo C, Alonso E, Rinones E, Arrabal A, Rodriguez JN, Saiz M, Aguado L, Mariscal N, Munoz I, Pineiro D, Rivadeneyra J, Diez M, Miguel I, Cubo E. Association Between Insulin-Like Growth Factor-1 and Social Cognition in Huntington’s Disease. Movement Disorders Clinical Practice. 2023; 10(2). DOI:10.1002/mdc3.13613. PMID:36825059. IF:2,600 (Q2/5D). Document type: Letter.

-Gironell A, Pascual B, Marín J, Pérez J, Pagonabarraga J. Non-Persistence of Tremorolytic Effect of Perampanel in Essential Tremor: Real-World Experience with 50 Patients. Movement Disorders Clinical Practice. 2023; 10(1). DOI:10.1002/mdc3.13576. PMID:36704076. IF:2,600 (Q2/5D). Document type: Article.

-Gironell A. Essential tremor: are we just splitting hairs? Non-motor symptoms and essential tremor-plus. REVISTA DE NEUROLOGIA. 2023; 76(12). DOI:10.33588/rn.7612.2023083. PMID:37303101. IF:0,800 (Q4/9D). Document type: Article.

-Gonzalez B, Morgante F, Pagonabarraga J, Stanton B, Edwards MJ. Autism Spectrum Disorder May Be Highly Prevalent in People with Functional Neurological Disorders. Journal of Clinical Medicine. 2023; 12(1):299. DOI:10.3390/jcm12010299. PMID:36615098. IF:3,000 (Q1/2D). Document type: Review.

-Horta A, Martinez S, Perez J, Puig A, de Lucia N, de Michele G, Salvatore E, Kehrer S, Priller J, Migliore S, Squitieri F, Castaldo A, Mariotti C, Mananes V, Lopez JL, Rodriguez N, Martinez A, Julio F, Januaario C, Delussi M, de Tommaso M, Noguera S, Ruiz J, Sitek EJ, Wallner R, Nuzzi A, Pagonabarraga J, Kulisevsky J. Measuring cognitive impairment and monitoring cognitive decline in Huntington’s disease: a comparison of assessment instruments. JOURNAL OF NEUROLOGY. 2023; 270(11). DOI:10.1007/s00415-023-11804-0. PMID:37462754. IF:4,800 (Q1/2D). Document type: Article.

-Horta A, Martinez S, Sampedro F, Pérez J, Pagonabarraga J, Kulisevsky J. Structural and metabolic brain correlates of arithmetic word-problem solving in Huntington’s disease. JOURNAL OF NEUROSCIENCE RESEARCH. 2023; 101(6). DOI:10.1002/jnr.25174. PMID:36807154. IF:2,900 (Q2/5D). Document type: Article.

-Jost WH, Kulisevsky J, LeWitt PA. Inhaled levodopa for threatening impending OFF episodes in managing Parkinson’s disease. JOURNAL OF NEURAL TRANSMISSION. 2023; 130(6). DOI:10.1007/s00702-023-02636-3. PMID:37087697. IF:3,200 (Q2/3D). Document type: Article.

-Kulisevsky J, Esquivel A, Freire E, Gómez JC, Legarda I, Mata M. SYNAPSES. A European observational study to evaluate the safety and the effectiveness of safinamide in routine clinical practice: post-hoc analysis of the Spanish study population. REVISTA DE NEUROLOGIA. 2023; 77(s02). DOI:10.33588/rn.77s02.2023217. PMID:37752685. IF:0,800 (Q4/9D). Document type: Review.

-Kulisevsky J, Falup C, Santens P, Jost WH. Towards improved access to device-aided therapies in advanced PD: the importance of cooperation of different disciplines. JOURNAL OF NEURAL TRANSMISSION. 2023; 130(11). DOI:10.1007/s00702-023-02664-z. PMID:37439943. IF:3,200 (Q2/3D). Document type: Article.

-Kulisevsky J, Martinez S, Campolongo A, Pascual B, Marin J, Bejr H, Labandeira JL, Lanciego JL, Puig A, Horta A, Pagonabarraga J, Rodriguez J. A randomized clinical trial of candesartan for cognitive impairment in Parkinson’s disease. PARKINSONISM & RELATED DISORDERS. 2023; 110:105367. DOI:10.1016/j.parkreldis.2023.105367. PMID:36963339. IF:3,100 (Q2/4D). Document type: Review.

-Martinez A, Xuclà T, Collet R, Olmedo G, Martí J, Izquierdo A, Martínez A, Prats L, Guasch M, Guisado D, Ramos A, Camps P. Clinical characteristics and outcome of amaurosis fugax due to transient retinal ischemia: Results from a contemporary cohort. Journal of Stroke & Cerebrovascular Diseases. 2023; 32(11):107335. DOI:10.1016/j.jstrokecerebrovasdis.2023.107335. PMID:37748428. IF:2,000 (Q3/6D). Document type: Article.

-Martínez M, Ariz M, Alvarez I, Castellanos G, Aguilar M, Hernández J, Caballol N, Garrido A, Bayés À, Vilas D, Marti MJ, Pascual B, Marin J, Avila A, Buongiorno M, Tartari JP, Puente V, Ezquerra M, Valldeoriola F, Compta Y, Tolosa E, Pont C, Pastor P, de Solórzano CO, Pastor MA, the Catalonian Neuroimaging Parkinson’s disease C. Brainstem neuromelanin and iron MRI reveals a precise signature for idiopathic and LRRK2 Parkinson’s disease. npj Parkinsons Disease. 2023; 9(1):62. DOI:10.1038/s41531-023-00503-2. PMID:37061532. IF:6,700 (Q1/1D). Document type: Article.

-Martinez S, Aracil I, Perez J, Perez L, Garcia J, Campolongo A, Aibar JA, Rodriguez R, Pascual B, Kulisevsky J. Theta/Alpha Band Suppression and Clinical Outcomes During Globus Pallidus Internus Deep Brain Stimulation in Huntington’s Disease. Movement Disorders Clinical Practice. 2023; 10(3). DOI:10.1002/mdc3.13644. PMID:36949795. IF:2,600 (Q2/5D). Document type: Article.

-Martinez S, Marzal CN, Cuso S, Aracil I, Kulisevsky J. Reduplicative paramnesia as an atypical form of presentation of a Heidenhain variant of Creutzfeldt-Jakob disease: A case report. JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY. 2023; 29(6):PII S1355617722000583. DOI:10.1017/S1355617722000583. PMID:36062534. IF:2,600 (Q2/4D). Document type: Letter.

-Martinez S, Perez J, Oltra J, Sampedro F, Horta A, Puig A, Pagonabarraga J, Kulisevsky J. Divergent cognitive trajectories in early stage Huntington’s disease: A 3-year longitudinal study. EUROPEAN JOURNAL OF NEUROLOGY. 2023; 30(7). DOI:10.1111/ene.15806. PMID:36994811. IF:4,500 (Q1/2D). Document type: Article.

-Olmedo G, Perez J, Xucla T, Collet R, Martinez A, Kulisevsky J. Cerebellar Syndrome Induced by Hypomagnesemia: A Treatable Cause of Ataxia Not to be Missed. Report of Three Cases and a Review of the Literature. Movement Disorders Clinical Practice. 2023; 10(6). DOI:10.1002/mdc3.13739. PMID:37332648. IF:2,600 (Q2/5D). Document type: Article.

-Olszewska DA, Shetty A, Rajalingam R, Rodriguez J, Hamed M, Huang JA, Breza M, Rasheed A, Bahr N, Madoev H, Westenberger A, Trinh J, Lohmann K, Klein C, Marras C, Waln O. Genotype-phenotype relations for episodic ataxia genes: MDSGene systematic review. EUROPEAN JOURNAL OF NEUROLOGY. 2023; 30(10). DOI:10.1111/ene.15969. PMID:37422902. IF:4,500 (Q1/2D). Document type: Review.

-Pagonabarraga J, Alamo C, Castellanos M, Diaz S, Manzano S. Depression in Major Neurodegenerative Diseases and Strokes: A Critical Review of Similarities and Differences among Neurological Disorders. Brain Sciences. 2023; 13(2):318. DOI:10.3390/brainsci13020318. PMID:36831861. IF:2,700 (Q3/6D). Document type: Review.

-Rossi M, Hamed M, Rodríguez J, Cornejo M, Breza M, Lohmann K, Klein C, Rajalingam R, Marras C, van de Warrenburg BP. Genotype-Phenotype Correlations for ATX-TBP (SCA17): MDSGene Systematic Review. MOVEMENT DISORDERS. 2023; 38(3). DOI:10.1002/mds.29278. PMID:36374860. IF:7,400 (Q1/1D). Document type: Review.

-Sampedro F, Puig A, Martinez S, Pagonabarraga J, Horta A, Aracil I, Kulisevsky J. Cortical macro and microstructural correlates of cognitive and neuropsychiatric symptoms in Parkinson’s disease. CLINICAL NEUROLOGY AND NEUROSURGERY. 2023; 224:107531. DOI:10.1016/j.clineuro.2022.107531. PMID:36455303. IF:1,800 (Q2/5D). Document type: Review.

-Sampedro F. The success of assessing cortical microstructure through surface-based diffusion-weighted neuroimaging. CLINICAL NEUROLOGY AND NEUROSURGERY. 2023; 234:107990. DOI:10.1016/j.clineuro.2023.107990. PMID:37806052. IF:1,800 (Q2/5D). Document type: Article.

-Santos D, Cores C, Feal MJ, García I, Íñiguez MC, Paz JM, García J, Hernández J, Cabo I, López L, González I, Ávila MA, Gómez V, Dotor García J, Borrué C, Solano B, Álvarez M, Mendoza Z, Martínez JC, Sánchez P, Alonso MG, López N, Alonso R, Menéndez M, Adarmes AD, Almeria M, Losada MGA, Cánovas AA, Frech FA, Redondo RA, Álvarez I, Sauco MÁ, Díaz AA, Arnáiz S, Arribas S, Vidondo AA, Aguilar M, Ávila MA, Lambrich NN, Bejr H, Estrada MB, Botí M, Borrue C, Buongiorno MT, González CC, López IC, Caballol N, Lorenzo AC, Medina HC, Pendón EC, Carrillo F, Padilla FJC, Casas E, Catalán MJ, Clavero P, Fernández AC, Cosgaya M, Foraster AC, Cuevas AC, Cubo E, de Deus T, de Fábregues O, Díez M, García JD, Erro E, Escalante S, Peyret EE, Guillán NF, Gámez P, Gallego M, Caldentey JG, Campos CG, Díez CG, Moreno JMG, Gastón I, Garre MPG, Mayordomo VG, Aloy JG, González I, Ardura JG, García BG, Palmás MJG, Toledo GRG, Díaz AG, Solá MG, Guardia G, Vara JH, Horta A, Calderón DI, Infante J, Jesús S, Kulisevsky J, Kurtis M, Labandeira C, Labrador MA, Lacruz F, Castro ML, Gómez SL, Legarda I, Ariztegui NL, Díaz LML, Domínguez DL, Manzanares LL, Seoane BL, del Pozo SL, Macías Y, Mata M, Andres GM, Martí MJ, Castrillo JCM, Martinez P, McAfee D, Meitín MT, Plasencia ZM, González MM, del Barrio CM, Mir P, Santiago JM, Casado MIM, Diéguez AM, García IM, Nogueira V, Amado AN, Ponte SN, Ordás C, Pagonabarraga J, Pareés I, Pascual B, Pastor P, Fuertes AP, Noguera RP, Planas A, Planellas L, Prats MA, Jurczynska CP, Puente V, Morlans MP, Daví AP, Rafales NR, Méndez LR, Pérez ABR, Roldán F, De Arcos MR, Martínez JR, Alonso PS, Sánchez M, Díez GS, Rodríguez AS, Santacruz P, García DS, Rodríguez JCS, Seijo M, Peña MS, Vila BS, Castro ES, Tartari JP, Valero C, Vargas L, Vela L, Villanueva C, COPPADIS G. Cognitive impairment and dementia in young onset Parkinson’s disease. JOURNAL OF NEUROLOGY. 2023; DOI:10.1007/s00415-023-11921-w. PMID:37578489. IF:4,800 (Q1/2D). Document type: Letter.

-Santos D, de Deus T, Cores C, Castro ES, Hernández J, Jesús S, Mir P, Cosgaya M, Martí MJ, Pastor P, Cabo I, Seijo M, Legarda I, Vives B, Caballol N, Rúiz J, Croitoru I, Cubo E, Miranda J, Alonso MG, Labandeira C, López N, Morales M, González I, Infante J, Escalante S, Bernardo N, Blázquez M, Menéndez M, Caldentey JG, Borrué C, Vela L, Catalán MJ, Gómez V, Kurtis M, Prieto C, Ordás C, Nogueira V, López L, Ávila MA, Puente V, García JM, Solano B, Álvarez M, Carrillo F, Carlos Martínez Castrillo J, Sánchez P, Gastón I, Kulisevsky J, Valero C, de Fábregues O, González J, López LM, Martinez P, COPPADIS G. Falls Predict Acute Hospitalization in Parkinson’s Disease. Journal of Parkinsons Disease. 2023; 13(1). DOI:10.3233/JPD-212539. PMID:33843696. IF:4,000 (Q2/3D). Document type: Article.

-Santos D, Fonticoba TD, Bartolomé CC, Painceiras MJF, Díaz IG, Alvarado M, Paz JM, Jesús S, Cosgaya M, Caldentey JG, Caballol N, Legarda I, Vara JH, Cabo I, Manzanares LL, Aramburu IG, Rivera M, Mayordomo VG, Nogueira V, García JD, Borrué C, Vila BS, Sauco MA, Vela L, Escalante S, Cubo E, Mendoza Z, Castrillo JCM, Alonso PS, Losada M, Ariztegui NL, Gastón I, Kulisevsky J, Seijo M, Valero C, Redondo RA, Buongiorno MT, Ordás C, Menéndez M, Mcafee D, Martinez P, Mir P, COPPADIS GRP. Staging Parkinson's disease according to the MNCD classification correlates with caregiver burden. Brain and Behavior. 2023; 13(12). DOI:10.1002/brb3.3295. PMID:37939322. IF:2,600 (Q2/3D). Document type: Article.

-Santos D, Fonticoba TD, Bartolome CC, Painceiras MJF, Gonzalez JMP, Miro CM, Jesus S, Aguilar M, Pastor P, Planellas L, Cosgaya M, Caldentey JG, Caballol N, Legarda I, Vara JH, Cabo I, Manzanares LL, Aramburu IG, Rivera M, Mayordomo VG, Nogueira V, Puente V, Garcia JD, Borrue C, Vila BS, Sauco MA, Vela L, Escalante S, Cubo E, Padilla FC, Castrillo JCM, Alonso PS, Losada M, Ariztegui NL, Gaston I, Kulisevsky J, Estrada MB, Seijo M, Martinez JR, Valero C, Kurtis M, de Fabregues O, Ardura JG, Redondo RA, Ordas C, Diaz LMLL, McAfee D, Martinez P, Mir P, COPPADIS GRP. Risk of Cognitive Impairment in Patients With Parkinson’s Disease With Visual Hallucinations and Subjective Cognitive Complaints. Journal of Clinical Neurology. 2023; 19(4). DOI:10.3988/jcn.2022.0186. PMID:36647231. IF:2,900 (Q2/4D). Document type: Article.

-Santos D, Fonticoba TD, Bartolome CC, Painceiras MJF, Iniguez MC, Diaz IG, Jesus S, Buongiorno MT, Planellas L, Cosgaya M, Caldentey JG, Caballol N, Legarda I, Vara JH, Cabo I, Manzanares LL, Aramburu IG, Rivera M, Mayordomo VG, Nogueira V, Puente V, Garcia JD, Borrue C, Vila BS, Sauco MA, Vela L, Escalante S, Cubo E, Padilla FC, Castrillo JCM, Alonso PS, Losada M, Ariztegui NL, Gaston I, Kulisevsky J, Gonzalez MM, Seijo M, Martinez JR, Valero C, Kurtis M, Ardura JG, Redondo RA, Ordas C, Diaz LML, McAfee D, Calopa M, Carrillo F, Sevilla FE, Freire E, Esteban JCG, Ramos RG, Luquin M, Martinez I, Ignacio AS, Martinez P, Mir P, COPPADIS GRP. Staging Parkinson’s Disease According to the MNCD (Motor/Non-motor/Cognition/ Dependency) Classification Correlates with Disease Severity and Quality of Life. Journal of Parkinsons Disease. 2023; 13(3). DOI:10.3233/JPD-225073. PMID:36911948. IF:4,000 (Q2/3D). Document type: Article.

-Santos D, Fonticoba TD, Bartolome CC, Painceiras MJF, Iniguez MC, Diaz IG, Jesús S, Buongiorno MT, Planellas L, Cosgaya M, Caldentey JG, Caballol N, Legarda I, Vara JH, Cabo I, Manzanares LL, Aramburu IG, Rivera M, Mayordomo VG, Nogueira V, Puente V, Garcia JD, Borrué C, Vila BS, Sauco MA, Vela L, Escalante S, Cubo E, Padilla FC, Castrillo JCM, Alonso PS, Losada M, Ariztegui NL, Gastón I, Kulisevsky J, Gonzalez MM, Seijo M, Martinez JR, Valero C, Kurtis M, Ardura JG, Redondo RA, Ordás C, Diaz LML, McAfee D, Martinez P, Mir P, COPPADIS GRP. Changes in Principal Caregiver Mood Affects the Mood of the Parkinson’s Disease Patient: The Vicious Cycle of Illness. Journal of Parkinsons Disease. 2023; 13(2). DOI:10.3233/JPD-225014. PMID:36683517. IF:4,000 (Q2/3D). Document type: Article.

-Santos D, Fonticoba TD, Bartolome CC, Painceiras MJF, Iniguez MC, Jesús S, Buongiorno MT, Planellas L, Cosgaya M, Caldentey JG, Caballol N, Legarda I, Vara JH, Cabo I, Manzanares LL, Aramburu IG, Rivera M, Mayordomo VG, Nogueira V, Puente V, Garcia JD, Borrué C, Vila BS, Sauco MA, Vela L, Escalante S, Cubo E, Padilla FC, Castrillo JCM, Alonso PS, Losada M, Ariztegui NL, Gastón I, Kulisevsky J, Estrada MB, Seijo M, Martinez JR, Valero C, Kurtis M, De Fábregues O, Ardura JG, Redondo RA, Ordás C, Diaz LMLL, McAfee D, Martinez P, Mir P, Coppadis SG. Prevalence and Factors Associated with Drooling in Parkinson’s Disease: Results from a Longitudinal Prospective Cohort and Comparison with a Control Group. Parkinsons Disease. 2023; 2023:3104425. DOI:10.1155/2023/3104425. PMID:37065970. IF:2,100 (Q3/6D). Document type: Article.

-Santos D, Fonticoba TD, Bartolome CC, Panceiras MJF, Diaz IG, Alvarado M, Jesus S, Boungiorno MT, Planellas L, Cosgaya M, Caldentey JG, Caballol N, Legarda I, Vara JH, Cabo I, Manzanares LL, Aramburu IG, Rivera M, Mayordomo VG, Nogueira V, Puente V, Garcia JD, Borrue C, Vila BS, Sauco MA, Vela L, Escalante S, Cubo E, Padilla FC, Castrillo JCM, Alonso PS, Losada M, Ariztegui NL, Gaston I, Kulisevsky J, Estrada MB, Seijo M, Martinez JR, Valero C, Kurtis M, de Fabregues O, Ardura JG, Redondo RA, Ordas C, Diaz LML, McAfee D, Martinez P, Mir P, COPPADIS GRP. Suicidal ideation among people with Parkinson’s disease and comparison with a control group. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY. 2023; 38(5):e5919. DOI:10.1002/gps.5919. PMID:37147900. IF:3,600 (Q1/3D). Document type: Article.

-Santos D, Laguna A, Hernandez J, Fonticoba TD, Bartolome CC, Painceiras MJF, Iniguez MC, Diaz IG, Jesus S, Boungiorno MT, Planellas L, Cosgaya M, Caldentey JG, Caballol N, Legarda I, Cabo I, Manzanares LL, Aramburu IG, Rivera M, Mayordomo VG, Nogueira V, Puente V, Garcia JD, Borrue C, Vila BS, Sauco MA, Vela L, Escalante S, Cubo E, Padilla FC, Castrillo JCM, Alonso PS, Losada M, Ariztegui NL, Gaston I, Kulisevsky J, Gonzalez MM, Seijo M, Martinez JR, Valero C, Kurtis M, Ardura JG, Redondo RA, Ordas C, Diaz LML, McAfee D, Martinez P, Mir P, COPPADIS GRP. Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson’s Disease. Journal of Clinical Medicine. 2023; 12(4):1329. DOI:10.3390/jcm12041329. PMID:36835866. IF:3,000 (Q1/2D). Document type: Article.

Publications 2022

(JIF 2022)

Abdelnour C, Ferreira D, van de Beek M, Cedres N, Oppedal K, Cavallin L, Blanc F, Bousiges O, Wahlund LO, Pilotto A, Padovani A, Boada M, Pagonabarraga J, Kulisevsky J, Aarsland D, Lemstra AW, Westman E. Parsing heterogeneity within dementia with Lewy bodies using clustering of biological, clinical, and demographic data. Alzheimers Research & Therapy. 2022; 14(1):14. DOI:10.1186/s13195-021-00946-w. PMID:35063023. IF:9 (Q1/1D). Document type: Article.
Aracil I, Martinez S, Gonzalez JM, Sampedro F, Perez J, Horta A, Campolongo A, Izquierdo C, Gomez B, Pagonabarraga J, Kulisevsky J. Structure and Dynamics of Large-Scale Cognitive Networks in Huntington’s Disease. MOVEMENT DISORDERS. 2022; 37(2). DOI:10.1002/mds.28839. PMID:34752656. IF:8,6 (Q1/1D). Document type: Article.
Aracil I, Sampedro F, Marin J, Horta A, Martinez S, Gonzalez JM, Perez J, Bejr H, Pascual B, Boti M, Campolongo A, Izquierdo C, Gironell A, Gomez B, Kulisevsky J, Pagonabarraga J. Tipping the scales: how clinical assessment shapes the neural correlates of Parkinson’s disease mild cognitive impairment. Brain Imaging and Behavior. 2022; 16(2). DOI:10.1007/s11682-021-00543-3. PMID:34553331. IF:3,2 (Q2/5D). Document type: Article.
Aretouli E, Chondrogiorgi M, Dede O, Koutsonida M, Lafi C, Konstantinopoulou E, Kulisevsky J, Kosmidis MH, Konitsiotis S. The Parkinson’s Disease-Cognitive Rating Scale: Greek Normative Data, Clinical Utility and Cultural Considerations. JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY. 2022; 35(5):08919887211049110. DOI:10.1177/08919887211049110. PMID:34663111. IF:2,6 (Q3/7D). Document type: Article.
Asl AM, Mehdizadeh M, Kulisevsky J, Sabet A, Sharabiani P, Mehdizadeh H, Ashayeri H, Taghizadeh G. Reliability, validity, and diagnostic accuracy of Parkinson’s Disease-Cognitive Rating Scale in Iranian patients with idiopathic Parkinson’s disease. DISABILITY AND REHABILITATION. 2022; 44(10). DOI:10.1080/09638288.2020.1813337. PMID:32924645. IF:2,2 (Q2/4D). Document type: Article.
Bach L, Boccalatte F, DeRosa A, Devos D, Garcia C, Inglese M, Droby A. Functional changes in prefrontal cortex following frequency-specific training. Scientific Reports. 2022; 12(1):20316. DOI:10.1038/s41598-022-24088-7. PMID:36434008. IF:4,6 (Q2/3D). Document type: Article.
Bejr H, Martinez S, Pagonabarraga J, Marin J, Horta A, Sampedro F, Aracil I, Perez J, Campolongo A, Izquierdo C, Pascual B, Kulisevsky J. The role of attentional control over interference in minor hallucinations in Parkinson’s disease. PARKINSONISM & RELATED DISORDERS. 2022; 102. DOI:10.1016/j.parkreldis.2022.07.009. PMID:35987038. IF:4,1 (Q2/3D). Document type: Article.
Calabria M, Garcia C, Grunden N, Pons C, Arroyo JA, Gomez B, Garcia M, Belvis R, Morollon N, Igual JV, Mur I, Pomar V, Domingo P. Post-COVID-19 fatigue: the contribution of cognitive and neuropsychiatric symptoms. JOURNAL OF NEUROLOGY. 2022; 269(8). DOI:10.1007/s00415-022-11141-8. PMID:35488918. IF:6 (Q1/2D). Document type: Article.
De la Riva P, Rodriguez J, Gomez V, Arenaza G, Gorostidi A, Diez N, De Arce A, Martinez M, Gonzalez F, Luttich A, Garmendia E, Sola A, Larrea JA, Bergareche A, Sobrino T. Endothelial NO synthase 786T/T polymorphism increases hemorrhagic transformation after endovascular thrombectomy. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. 2022; 129. DOI:10.1016/j.niox.2022.08.006. PMID:36067953. IF:3,9 (Q2/5D). Document type: Article.
De Paepe AE, Garcia C, Martinez S, Perez JP, Kulisevsky J, Rodriguez N, Vaquer I, Subira S, Calopa M, Santacruz P, Munoz E, Mareca C, Ruiz J, De Diego R, Camara E. Delineating apathy profiles in Huntington’s disease with the short-Lille Apathy Rating Scale. PARKINSONISM & RELATED DISORDERS. 2022; 105. DOI:10.1016/j.parkreldis.2022.10.025. PMID:36395542. IF:4,1 (Q2/3D). Document type: Article.
Devos D, Labreuche J, Rascol O, Corvol JC, Duhamel A, Delannoy PG, Poewe W, Compta Y, Pavese N, Ruzicka E, Dusek P, Post B, Bloem BR, Berg D, Maetzler W, Otto M, Habert MO, Lehericy S, Ferreira J, Dodel R, Tranchant C, Eusebio A, Thobois S, Marques AR, Meissner WG, Ory F, Walter U, de Bie R, Gago M, Vilas D, Kulisevsky J, Januario C, Coelho MVS, Behnke S, et al. Trial of Deferiprone in Parkinson’s Disease. NEW ENGLAND JOURNAL OF MEDICINE. 2022; 387(22). DOI:10.1056/NEJMoa2209254. PMID:36449420. IF:158,5 (Q1/1D). Document type: Article.
Ferraro PM, Spotorno N, Finegan E, Sampedro F, Caso F. Editorial: Genotype-phenotype correlations in neurodegenerative diseases: From clinical features to neuroimaging signatures. Frontiers in Neurology. 2022; 13:1100953. DOI:10.3389/fneur.2022.1100953. PMID:36588898. IF:3,4 (Q2/5D). Document type: Editorial material.
Ferreira JJ, Rodrigues FB, Duarte GS, Mestre TA, Bachoud AC, Bentivoglio AR, Burgunder JM, Cardoso F, Claassen DO, Landwehrmeyer GB, Kulisevsky J, Nirenberg MJ, Rosser A, Roth J, Seppi K, Slawek J, Furr E, Tabrizi SJ, Walker FO, Vandenberghe W, Costa J, Sampaio C. An MDS Evidence-Based Review on Treatments for Huntington’s Disease. MOVEMENT DISORDERS. 2022; 37(1). DOI:10.1002/mds.28855. PMID:34842303. IF:8,6 (Q1/1D). Document type: Review.
Garcia C, Calabria M, Grunden N, Pons C, Arroyo JA, Gomez B, Lleo A, Alcolea D, Belvis R, Morollon N, Mur I, Pomar V, Domingo P. Neuropsychological deficits in patients with cognitive complaints after COVID-19. Brain and Behavior. 2022; 12(3):e2508. DOI:10.1002/brb3.2508. PMID:35137561. IF:3,1 (Q2/3D). Document type: Article.
Garcia DS, Roca LG, Fonticoba TD, Bartolome CC, Rios LN, Canfield H, Gonzalez JMP, Miro CM, Jesus S, Aguilar M, Pastor P, Planellas L, Cosgaya M, Caldentey JG, Caballol N, Legarda I, Vara JH, Cabo I, Manzanares LL, Aramburu IG, Rivera M, Mayordomo VG, Nogueira V, Puente V, Garcia JD, Borrue C, Vila BS, Sauco MA, Vela L, Escalante S, Cubo E, Padilla FC, et al. [Kulisevsky J]. Constipation Predicts Cognitive Decline in Parkinson’s Disease: Results from the COPPADIS Cohort at 2-Year Follow-up and Comparison with a Control Group. Journal of Parkinsons Disease. 2022; 12(1). DOI:10.3233/JPD-212868. PMID:34602501. IF:5,2 (Q1/3D). Document type: Article.
Garcia DS, Sauco MA, Calopa M, Carrillo F, Sevilla FE, Freire E, Ramos RG, Kulisevsky J, Esteban JCG, Legarda I, Luquin M, Castrillo JCM, Martinez P, Martinez I, Mir P, Ignacio AS. MNCD: A New Tool for Classifying Parkinson’s Disease in Daily Clinical Practice. 2022; 12(1):55. DOI:10.3390/diagnostics12010055. PMID:35054222. IF:3,6 (Q2/4D). Document type: Article.
Horta A, Martinez S, Perez J, Sampedro F, Puig A, Pagonabarraga J, Kulisevsky J. Measuring the functional impact of cognitive impairment in Huntington’s disease. JOURNAL OF NEUROLOGY. 2022; 269(7). DOI:10.1007/s00415-021-10955-2. PMID:35061089. IF:6 (Q1/2D). Document type: Article.
Illan I, Nigro S, VandeVrede L, Falgas N, Heuer HW, Painous C, Compta Y, Marti MJ, Montal V, Pagonabarraga J, Kulisevsky J, Lleo A, Fortea J, Logroscino G, Quattrone A, Quattrone A, Perry DC, Gorno ML, Rosen HJ, Grinberg LT, Spina S, La Joie R, Rabinovici GD, Miller BL, Rojas JC, Seeley WW, Boxer AL. Diagnostic Accuracy of Magnetic Resonance Imaging Measures of Brain Atrophy Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Degeneration. JAMA Network Open. 2022; 5(4):e229588. DOI:10.1001/jamanetworkopen.2022.9588. PMID:35486397. IF:13,8 (Q1/1D). Document type: Article.
Kulisevsky J, Martinez S, Campolongo A, Pascual B, Marin J, Bejr H, Aracil I, Horta A, Puig A, Pagonabarraga J. A Randomized Clinical Trial to Evaluate the Effects of Safinamide on Apathetic Non-demented Patients With Parkinson’s Disease. Frontiers in Neurology. 2022; 13:866502. DOI:10.3389/fneur.2022.866502. PMID:35720066. IF:3,4 (Q2/5D). Document type: Article.
Kulisevsky J. Pharmacological management of Parkinson’s disease motor symptoms: update and recommendations from an expert. REVISTA DE NEUROLOGIA. 2022; 75(s04):S1-S10. DOI:10.33588/rn.75s04.2022217. PMID:36342310. IF:1,2 (Q4/10D). Document type: Review.
Marin J, Martinez S, Pagonabarraga J, Horta A, Aracil I, Bejr H, Sampedro F, Campolongo A, Kulisevsky J. Predicting Impulse Control Disorders in Parkinson Disease through Incentive Biomarkers. ANNALS OF NEUROLOGY. 2022; 92(6). DOI:10.1002/ana.26486. PMID:36054656. IF:11,2 (Q1/1D). Document type: Article.
Mauricio D, Vlacho B, de la Puente JB, Mundet X, Real J, Kulisevsky J, Ortega E, Castelblanco E, Julve J, Franch J. Associations Between Diabetic Retinopathy and Parkinson’s Disease: Results From the Catalonian Primary Care Cohort Study. Frontiers in Medicine. 2022; 8:800973. DOI:10.3389/fmed.2021.800973. PMID:35118094. IF:8,1 (Q1/2D). Document type: Article.
Pagonabarraga J, Perez R, Bejr H, Marin J, Horta A, Martinez S, Aracil I, Sampedro F, Campolongo A, Rivas E, Puig A, Ruiz I, Perez J, Pascual B, Kulisevsky J. Dissociable contribution of plasma NfL and p-tau181 to cognitive impairment in Parkinson’s disease. PARKINSONISM & RELATED DISORDERS. 2022; 105. DOI:10.1016/j.parkreldis.2022.05.020. PMID:35752549. IF:4,1 (Q2/3D). Document type: Article.
Pérez C, Hernández J, Caballol N, Bayes À, Buongiorno M, Lopez N, Gironell A, López J, Martínez JC, Sauco A, López L, Escalante S, Pérez DA, Rodríguez A, The MoMoPa G. Comparison of the Results of a Parkinson’s Holter Monitor With Patient Diaries, in Real Conditions of Use: A Sub-analysis of the MoMoPa-EC Clinical Trial. Frontiers in Neurology. 2022; 13:835249. DOI:10.3389/fneur.2022.835249. PMID:35651347. IF:3,4 (Q2/5D). Document type: Article.
Pou MA, Orfila F, Pagonabarraga J, Ferrer S, Corominas H, Diaz C. Le risque de maladie de Parkinson dans une population méditerranéenne de patients goutteux : étude cas-témoins. Revue Du Rhumatisme (edition Francaise). 2022; 89(6). DOI:10.1016/j.rhum.2022.09.019. Document type: Article.
Pou MA, Orfila F, Pagonabarraga J, Ferrer S, Corominas H, Diaz C. Risk of Parkinson’s disease in a gout Mediterranean population: A case-control study. JOINT BONE SPINE. 2022; 89(6):105402. DOI:10.1016/j.jbspin.2022.105402. PMID:35504516. IF:4,2 (Q2/4D). Document type: Article.
Rodríguez F, Beltrán Á, Chico JL, Parra P, Baena B, Pagonabarraga J, Pérez P, Pareés I, López JL, Martínez JC, Alonso A. Efficacy and safety of high doses of safinamide in advanced Parkinson disease. PARKINSONISM & RELATED DISORDERS. 2022; 97. DOI:10.1016/j.parkreldis.2022.03.010. PMID:35344893. IF:4,1 (Q2/3D). Document type: Letter.
Rosas I, Morís G, Coto E, Blázquez M, Suárez E, García C, Martínez C, Herrera ID, Pérez S, Álvarez V, Menéndez M, Adarmes AD, Aguilar M, Alvarez I, Barrero FJ, Bergareche JA, Bonilla M, Botía JA, Boungiorno MT, Buiza D, Cámara A, Carrillo F, Cerdan D, Clarimón J, Compta Y, Diez M, Dols-Icardo O, de Fabregues O, Cartagena PS, Duarte J, Duran R, Escamilla F, et al. [Kulisevsky J, Pagonabarraga J, Pascual Sedano B, ]. Smoking is associated with age at disease onset in Parkinson’s disease. PARKINSONISM & RELATED DISORDERS. 2022; 97. DOI:10.1016/j.parkreldis.2022.03.005. PMID:35364453. IF:4,1 (Q2/3D). Document type: Article.
Ruiz I, Horta A, Illan I, Kulisevsky J, Pagonabarraga J. Genotype-Phenotype Correlation in Progressive Supranuclear Palsy Syndromes: Clinical and Radiological Similarities and Specificities. Frontiers in Neurology. 2022; 13:861585. DOI:10.3389/fneur.2022.861585. PMID:35557621. IF:3,4 (Q2/5D). Document type: Review.
Saiz M, Gil C, Diez M, Martinez SI, Santalo FS, Calvo S, Alonso E, Rinones E, Aguado L, Mariscal N, Munoz I, Pineiro D, Rivadeneyra J, Cubo E. Polymorphisms in the oxytocin receptor and their association with apathy and impaired social cognition in Huntington’s disease. NEUROLOGICAL SCIENCES. 2022; 43(10). DOI:10.1007/s10072-022-06226-1. PMID:35725858. IF:3,3 (Q2/5D). Document type: Article.
Sampedro F, Aracil I, Farres C, Soler J, Schmidt C, Elices M, Pomarol E, Salvador R, Vega D, Pascual JC. A Functional Connectivity Study to Investigate the Role of the Right Anterior Insula in Modulating Emotional Dysfunction in Borderline Personality Disorder. PSYCHOSOMATIC MEDICINE. 2022; 84(1). DOI:10.1097/PSY.0000000000001019. PMID:34611112. IF:3,3 (Q2/4D). Document type: Article.
Sampedro F, Camara E, Kulisevsky J. Editorial: Neuroimaging of Cognitive and Neuropsychiatric Symptoms in Movement Disorders. Frontiers in Neurology. 2022; 13:843440. DOI:10.3389/fneur.2022.843440. PMID:35173676. IF:3,4 (Q2/5D). Document type: Editorial material.
Sampedro F, Kulisevsky J. Intracortical surface-based MR diffusivity to investigate neurologic and psychiatric disorders: a review. JOURNAL OF NEUROIMAGING. 2022; 32(1). DOI:10.1111/jon.12930. PMID:34506674. IF:2,4 (Q3/6D). Document type: Review.
Sampedro F, Martinez S, Horta A, Grothe MJ, Labrador MA, Jesus S, Adarmes A, Carrillo F, Puig A, Lora FR, Barbera MA, Pastor P, Arroyo SE, Vila BS, Foraster AC, Martinez JR, Padilla FC, Morlans MP, Aramburu IG, Ceberio JI, Vara JH, de Fabregues O, de Deus T, Avila A, Martinez JC, Bejr H, Campolongo A, Pascual B, Martinez P, Santos D, Mir P, Kulisevsky J. Increased homocysteine levels correlate with cortical structural damage in Parkinson’s disease. JOURNAL OF THE NEUROLOGICAL SCIENCES. 2022; 434:120148. DOI:10.1016/j.jns.2022.120148. PMID:35085959. IF:4,4 (Q2/3D). Document type: Article.
Sampedro F, Martinez S, Horta A, Grothe MJ, Labrador MA, Jesus S, Adarmes A, Carrillo F, Puig A, Roldan F, Aguilar M, Pastor P, Arroyo SE, Vila BS, Cots A, Ruiz J, Carrillo F, Pueyo M, Gonzalez I, Infante J, Hernandez J, de Fabregues O, Fonticoba TD, Avila A, Martinez JC, Bejr H, Campolongo A, Pascual B, Martinez P, Santos D, Mir P, Garcia PJ, Kulisevsky J. Clinical and structural brain correlates of hypomimia in early-stage Parkinson’s disease. EUROPEAN JOURNAL OF NEUROLOGY. 2022; 29(12). DOI:10.1111/ene.15513. PMID:35852918. IF:5,1 (Q1/2D). Document type: Article.
Sampedro F, Martínez S, Kulisevsky J. Response to letter: “Association of elevated blood homocysteine with cognitive decline in early, untreated Parkinson’s disease”. JOURNAL OF THE NEUROLOGICAL SCIENCES. 2022; 438:120272. DOI:10.1016/j.jns.2022.120272. PMID:35576640. IF:4,4 (Q2/3D). Document type: Letter.
Sampedro F, Martinez S, Marin J, Pagonabarraga J, Kulisevsky J. Apathy Reflects Extra-Striatal Dopaminergic Degeneration in de novo Parkinson’s Disease. Journal of Parkinsons Disease. 2022; 12(5). DOI:10.3233/JPD-223223. PMID:35491803. IF:5,2 (Q1/3D). Document type: Article.
Sampedro F, Martinez S, Perez J, Perez R, Horta A, Campolongo A, Izquierdo C, Aracil I, Rivas E, Puig A, Pagonabarraga J, Gomez B, Kulisevsky J. Plasma TDP-43 Reflects Cortical Neurodegeneration and Correlates with Neuropsychiatric Symptoms in Huntington’s Disease. Clinical Neuroradiology. 2022; 32(4). DOI:10.1007/s00062-022-01150-5. PMID:35238950. IF:2,8 (Q2/5D). Document type: Article.
Santos D, Canfield H, de Deus T, Cores C, Naya L, García L, Martínez C, Jesús S, Aguilar M, Pastor P, Cosgaya M, García J, Caballol N, Legarda I, Hernández J, Cabo I, López L, González I, Ávila MA, Gómez V, Nogueira V, Puente V, Dotor J, Borrué C, Solano B, Álvarez M, Vela L, Escalante S, Cubo E, Carrillo F, Martínez JC, Sánchez P, Alonso MG, López N, Gastón I, Kulisevsky J, et al. Parkinson’s Disease Motor Subtypes Change with the Progression of the Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up. Journal of Parkinsons Disease. 2022; 12(3). DOI:10.3233/JPD-213004. PMID:34957949. IF:5,2 (Q1/3D). Document type: Article.
Santos D, Fonticoba TD, Bartolome CC, Alvarado M, Panceiras MJF, Castro ES, Canfield H, Miro CM, Jesus S, Aguilar M, Pastor P, Planellas L, Cosgaya M, Caldentey JG, Caballol N, Legarda I, Vara JH, Cabo I, Manzanares LL, Aramburu IG, Rivera M, Mayordomo VG, Nogueira V, Puente V, Garcia JD, Borrue C, Vila BS, Sauco MA, Vela L, Escalante S, Cubo E, et al. [Kulisevsky J]. Predictors of the change in burden, strain, mood, and quality of life among caregivers of Parkinson’s disease patients. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY. 2022; 37(6):GPS5761. DOI:10.1002/gps.5761. PMID:35633051. IF:4 (Q2/5D). Document type: Article.
Santos D, Fonticoba TD, Bartolome CC, Painceiras MJF, Castro ES, Canfield H, Miro CM, Jesus S, Aguilar M, Pastor P, Planellas L, Cosgaya M, Caldentey JG, Caballol N, Legarda I, Hernandez J, Cabo I, Manzanares LL, Aramburu IG, Rivera M, Mayordomo VG, Nogueira V, Puente V, Garcia JD, Borrue C, Vila BS, Sauco MA, Vela L, Escalante S, Cubo E, Padilla FC, et al. [Kulisevsky J]. Motor Fluctuations Development Is Associated with Non-Motor Symptoms Burden Progression in Parkinson’s Disease Patients: A 2-Year Follow-Up Study. 2022; 12(5):1147. DOI:10.3390/diagnostics12051147. PMID:35626303. IF:3,6 (Q2/4D). Document type: Article.
Stocchi F, Antonini A, Berg D, Bergmans B, Jost W, Katzenschlager R, Kulisevsky J, Odin P, Valldeoriola F, Chaudhuri KR. Safinamide in the treatment pathway of Parkinson’s Disease: a European Delphi Consensus. npj Parkinsons Disease. 2022; 8(1):17. DOI:10.1038/s41531-022-00277-z. PMID:35190544. IF:8,7 (Q1/1D). Document type: Article.
Valle N, Pérez R, Chiva G, Belbin O, Serrano S, Sirisi S, González AC, Giró O, Sánchez É, Dols O, Alcolea D, Carmona M, Jimenez A, Lleó A, Fortea J, Iulita MF. Enrichment of Astrocyte-Derived Extracellular Vesicles from Human Plasma. Jove-Journal of Visualized Experiments. 2022; 2022(186):e64107. DOI:10.3791/64107. PMID:35993755. IF:1,2 (Q3/8D). Document type: Article.

Publications 2021

Abbruzzese G, Kulisevsky J, Bergmans B, Gomez JC, Kagi G, Raw J, Stefani A, Warnecke T, Jost WH, SYNAPSES Study Investigators GRP. A European Observational Study to Evaluate the Safety and the Effectiveness of Safinamide in Routine Clinical Practice: The SYNAPSES Trial. Journal of Parkinsons Disease. 2021; 11(1). DOI:10.3233/JPD-202224. PMID:33104040. IF: 5,520
Aracil I, Sampedro F, Pujol J, Soriano C, Gonzalez JM, Kulisevsky J, Pagonabarraga J. The impact of dopaminergic treatment over cognitive networks in Parkinson’s disease: Stemming the tide?. HUMAN BRAIN MAPPING. 2021; 42(17). DOI:10.1002/hbm.25650. PMID:34510640. IF: 5,399
Bejr-Kasem H, Sampedro F, Marín-Lahoz J, Martínez-Horta S, Pagonabarraga J, Kulisevsky J. Minor hallucinations reflect early gray matter loss and predict subjective cognitive decline in Parkinson’s disease. European Journal of Neurology. 2021;28(2):438-447. DOI:10.1111/ene.14576. PMID: 33032389. IF: 6,288
Bernasconi F, Blondiaux E, Potheegadoo J, Stripeikyte G, Pagonabarraga J, Bejr H, Bassolino M, Akselrod M, Martinez S, Sampedro F, Hara M, Horvath J, Franza M, Konik S, Bereau M, Ghika JA, Burkhard PR, Van de Ville D, Faivre N, Rognini G, Krack P, Kulisevsky J, Blanke O. Robot-induced hallucinations in Parkinson’s disease depend on altered sensorimotor processing in fronto-temporal network. Science Translational Medicine. 2021; 13(591):eabc8362. DOI:10.1126/scitranslmed.abc8362. PMID:33910980. IF: 19,319
Blauwendraat C, Iwaki H, Makarious MB, Bandres S, Leonard HL, Grenn FP, Lake J, Krohn L, Tan M, Kim JJ, Gibbs JR, Hernandez DG, Ruskey JA, Pihlstrom L, Toft M, van JJ, Marinus J, Schulte C, Brockmann K, Sharma M, Siitonen A, Majamaa K, Eerola J, Tienari PJ, Grosset DG, Lesage S, Corvol JC, Brice A, Wood N, et al. [Clarimón J, Dols O, Kulisevsky J, Pagonabarraga J]. Investigation of Autosomal Genetic Sex Differences in Parkinson’s Disease. ANNALS OF NEUROLOGY. 2021; 90(1). DOI:10.1002/ana.26090. PMID:33901317. IF: 11,274
Calabria M, Perez JP, Martinez S, Horta A, Carceller M, Kulisevsky J, Costa A. Language reconfiguration in bilinguals A study with Huntington’s disease patients. Linguistic Approaches to Bilingualism. 2021; 11(4). DOI:10.1075/lab.18022.cal. IF: 1,815
Chen ZB, Zhang D, Reynolds RH, Gustavsson EK, Garcia S, D’Sa K, Fairbrother A, Vandrovcova J, Hardy J, Houlden H, Taliun S, Botia J, Ryten M, Clarimón J, Dols O, Kulisevsky J, Pagonabarraga J, Int Parkinson’s Dis Genomics C. Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage. Nature Communications. 2021; 12(1):2076. DOI:10.1038/s41467-021-22262-5. PMID:33824317. IF: 17,694
De Paepe AE, Ara A, Garcia C, Martinez S, Perez J, Kulisevsky J, Rodriguez N, Vaquer I, Subira S, Calopa M, Munoz E, Santacruz P, Ruiz J, Mareca C, de Diego R, Camara E. Gray Matter Vulnerabilities Predict Longitudinal Development of Apathy in Huntington’s Disease. MOVEMENT DISORDERS. 2021; 36(9). DOI:10.1002/mds.28638. PMID:33998063. IF: 9,698
Diez M, Houle G, Ortega S, Bandres S, Alvarez I, Carcel M, Ibanez L, Fernandez MV, Budde JP, Trotta JR, Tonda R, Chong JX, Bamshad MJ, Nickerson DA, Aguilar M, Tartari JP, Gironell A, Garcia E, Agundez J, Alonso H, Jimenez FJ, Fernandez M, Valldeoriola F, Marti MJ, Tolosa E, Coria F, Pastor MA, Vilarino C, Rajput A, Dion PA, Cruchaga C, Rouleau GA, Pastor P, U. Exome-wide rare variant analysis in familial essential tremor. PARKINSONISM & RELATED DISORDERS. 2021; 82. DOI:10.1016/j.parkreldis.2020.11.021. PMID:33279834. IF: 4,402
Gaig C, Compta Y, Heidbreder A, Marti MJ, Titulaer MJ, Crijnen Y, Hogl B, Lewerenz J, Erro ME, Garcia JC, Nigro P, Tambasco N, Patalong M, Erdler M, Macher S, Berger E, Hoftberger R, Geis C, Hutterer M, Milan A, Martin A, Manzanares LL, Quintas S, Hoglinger GU, Mohn N, Schoberl F, Thaler FS, Asioli GM, Provini F, Plazzi G, Berganzo K, Blaabjerg M, et al. [Perez JP]. Frequency and Characterization of Movement Disorders in Anti-IgLON5 Disease. NEUROLOGY. 2021; 97(14). DOI:10.1212/WNL.0000000000012639. PMID:34380749. IF: 11,800
Garcia R, Santos D, Alonso A, Alvarez M, Ares B, Avila A, Caballol N, Carrillo F, Sevilla FE, Freire E, Esteban JCG, Legarda I, Manzanares LL, Valdes EL, Martinez I, Mata M, Parees I, Pascual B, Mir P, Castrillo JCM. Management of Parkinson’s disease and other movement disorders in woman of childbearing age: Part 1. NEUROLOGIA. 2021; 36(2). DOI:10.1016/j.nrl.2020.05.010. PMID:32718872. IF: 5,486
Garcia R, Santos D, Alonso A, Alvarez M, Ares B, Avila A, Caballol N, Carrillo F, Sevilla FE, Freire E, Esteban JCG, Legarda I, Manzanares LL, Valdes EL, Martinez I, Mata M, Parees I, Pascual B, Castrillo JCM, Mir P. Management of Parkinson’s disease and other movement disorders in women of childbearing age: Part 2. NEUROLOGIA. 2021; 36(2). DOI:10.1016/j.nrl.2020.05.012. PMID:32980194. IF: 5,486
Gialluisi A, Reccia MG, Modugno N, Nutile T, Lombardi A, Di LG, Pietracupa S, Ruggiero D, Scala S, Gambardella S, Iacoviello L, Gianfrancesco F, Acampora D, D’Esposito M, Simeone A, Ciullo M, Esposito T, Kulisevsky J, Pagonabarraga J, Int Parkinsons Dis Genomics C. Identification of sixteen novel candidate genes for late onset Parkinson’s disease. Molecular Neurodegeneration. 2021; 16(1):35. DOI:10.1186/s13024-021-00455-2. PMID:34148545. IF: 18,879
Grothe MJ, Labrador MA, Jesus S, Macias D, Adarmes A, Carrillo F, Camacho EI, Franco P, Lora FR, Martin JF, Barbera MA, Pastor P, Arroyo SE, Vila BS, Foraster AC, Martinez JR, Padilla FC, Morlans MP, Aramburu IG, Ceberio JI, Vara JH, de Fabregues O, Fonticoba TD, Pascual B, Kulisevsky J, Martinez P, Santos D, Mir P. In vivo cholinergic basal forebrain degeneration and cognition in Parkinson’s disease: Imaging results from the COPPADIS study. PARKINSONISM & RELATED DISORDERS. 2021; 88. DOI:10.1016/j.parkreldis.2021.05.027. PMID:34144230. IF: 4,402
Horta A, Pagonabarraga J, Martinez S, Busteed L, Pascual B, Illan I, Marin J, Aracil I, Perez J, Sampedro F, Bejr H, Kulisevsky J. Cognitive and behavioral profile of progressive supranuclear palsy and its phenotypes. JOURNAL OF NEUROLOGY. 2021; 268(9). DOI:10.1007/s00415-021-10511-y. PMID:33704556. IF: 6,682
Jost ST, Visser V, Rizos A, Loehrer PA, Silverdale M, Evans J, Samuel M, Petry JN, Sauerbier A, Gronostay A, Barbe MT, Fink GR, Ashkan K, Antonini A, Martinez P, Chaudhuri KR, Timmermann L, Dafsari HS, Pagonabarraga J, Walker RW. Non-motor predictors of 36-month quality of life after subthalamic stimulation in Parkinson disease. npj Parkinsons Disease. 2021; 7(1):48. DOI:10.1038/s41531-021-00174-x. PMID:34103534. IF: 9,304
Kia DA, Zhang D, Guelfi S, Manzoni C, Hubbard L, Reynolds RH, Botia J, Ryten M, Ferrari R, Lewis PA, Williams N, Trabzuni D, Hardy J, Wood NW, Clarimón J, Dols O, Kulisevsky J, Pagonabarraga J, United B, Int Parkinsons Dis G. Identification of Candidate Parkinson Disease Genes by Integrating Genome-Wide Association Study, Expression, and Epigenetic Data Sets. JAMA Neurology. 2021; 78(4). DOI:10.1001/jamaneurol.2020.5257. PMID:33523105. IF: 29,907
Lage C, Lopez S, Bejanin A, Kazimierczak M, Aracil I, Calvo A, Pozueta A, Garcia M, Fernandez A, Bravo M, Jimenez J, Banzo I, Irure J, Pegueroles J, Illan I, Fortea J, Rodriguez E, Lleo A, Garcia CE, Sanchez P. Distinctive Oculomotor Behaviors in Alzheimer’s Disease and Frontotemporal Dementia. Frontiers in Aging Neuroscience. 2021; 12:603790. DOI:10.3389/fnagi.2020.603790. PMID:33613262. IF: 5,702
Leon P, Pagonabarraga J, Moris J, Martinez S, Marin J, Horta A, Bejr H, Kulisevsky J, Rodriguez A. Neural signatures of predictive language processing in Parkinson’s disease with and without mild cognitive impairment. CORTEX. 2021; 141. DOI:10.1016/j.cortex.2021.03.032. PMID:34049254. IF: 4,644
Martinez S, Bejr H, Horta A, Pascual B, Santos D, De Deus T, Jesus S, Aguilar M, Planellas L, Garcia J, Caballol N, Vives B, Hernandez J, Cabo I, Lopez L, Gonzalez I, Avila MA, Catalan MJ, Lopez LM, Puente V, Garcia JM, Borrue C, Solano B, Alvarez M, Vela L, Escalante S, Cubo E, Carrillo F, Martinez JC, Sanchez P, Alonso MG, Lopez N, Gaston I, et al. [Kulisevsky J]. Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease. BMC Neurology. 2021; 21(1):477. DOI:10.1186/s12883-021-02485-1. PMID:34879838. IF: 2,903
Martinez S, Ivanir E, Perrinjaquet T, Keuter MH, Kulisevsky J. Effects of a Green Oat Herb Extract on Cognitive Performance and Neurophysiological Activity: A Randomized Double-Blind Placebo-Controlled Study. Frontiers in Neuroscience. 2021; 15:748188. DOI:10.3389/fnins.2021.748188. PMID:34658781. IF: 5,152
Martinez-Horta S, Sampedro F, Horta-Barba A, Perez-Perez J, Pagonabarraga J, Gomez-Anson B, Kulisevsky J. Structural brain correlates of irritability and aggression in early manifest Huntington’s disease. Brain Imaging and Behavior. 2021;15(1):107-113. DOI:10.1007/s11682-019-00237-x. PMID: 31898092. IF: 3,224
Pagano G, Boess FG, Taylor KI, Ricci B, Mollenhauer B, Poewe W, Boulay A, Anzures J, Vogt A, Marchesi M, Post A, Nikolcheva T, Kinney GG, Zago WM, Ness DK, Svoboda H, Britschgi M, Ostrowitzki S, Simuni T, Marek K, Koller M, Sevigny J, Doody R, Fontoura P, Umbricht D, Bonni A, PASADENA I, Bejr H, Bojarsky JK, Prasinezumab GRP. A Phase II Study to Evaluate the Safety and Efficacy of Prasinezumab in Early Parkinson’s Disease (PASADENA): Rationale, Design, and Baseline Data. Frontiers in Neurology. 2021; 12:705407. DOI:10.3389/fneur.2021.705407. PMID:34659081. IF: 4,086
Pagonabarraga J, Horta A, Busteed L, Bejr H, Illan I, Aracil I, Marin J, Pascual B, Perez J, Campolongo A, Izquierdo C, Martinez S, Sampedro F, Kulisevsky J. Quantitative evaluation of oculomotor disturbances in progressive supranuclear palsy. PARKINSONISM & RELATED DISORDERS. 2021; 85. DOI:10.1016/j.parkreldis.2021.03.002. PMID:33744691. IF: 4,402
Pagonabarraga J, Tinazzi M, Caccia C, Jost WH. The role of glutamatergic neurotransmission in the motor and non-motor symptoms in Parkinson’s disease: Clinical cases and a review of the literature. JOURNAL OF CLINICAL NEUROSCIENCE. 2021; 90. DOI:10.1016/j.jocn.2021.05.056. PMID:34275546. IF: 2,116
Perez A, Giraldo DM, Rios J, Munoz E, Compta Y, Marti MJ, Pagonabarraga J. Progression of Motor and Non-Motor Symptoms in Multiple System Atrophy: A Prospective Study from the Catalan-MSA Registry. Journal of Parkinsons Disease. 2021; 11(2). DOI:10.3233/JPD-202332. PMID:33492245. IF: 5,520
Pezzoli S, Sanchez R, Solanes A, Kempton MJ, Bandmann O, Il J, Cagnin A, Goldman JG, Merkitch D, Firbank MJ, Taylor JP, Pagonabarraga J, Kulisevsky J, Blanc F, Verdolini N, Venneri A, Radua J. Neuroanatomical and cognitive correlates of visual hallucinations in Parkinson’s disease and dementia with Lewy bodies: Voxel-based morphometry and neuropsychological meta-analysis. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS. 2021; 128. DOI:10.1016/j.neubiorev.2021.06.030. PMID:34171324. IF: 9,052
Rodriguez A, Hernandez J, Minarro A, Perez C, Bayes A, Martinez JC, Perez DA, Gironell A, Monitoring Parkinsons Patients M. Multicentre, randomised, single-blind, parallel group trial to compare the effectiveness of a Holter for Parkinson’s symptoms against other clinical monitoring methods: study protocol. BMJ Open. 2021; 11(7):e045272. DOI:10.1136/bmjopen-2020-045272. PMID:34281918. IF: 3,006
Sampedro F, Farres C, Soler J, Elices M, Schmidt C, Corripio I, Dominguez E, Pomarol E, Salvador R, Pascual JC. Structural brain abnormalities in borderline personality disorder correlate with clinical severity and predict psychotherapy response. Brain Imaging and Behavior. 2021; 15(5). DOI:10.1007/s11682-021-00451-6. PMID:33634348. IF: 3,224
Sampedro F, Kulisevsky J. Intracortical surface-based MR diffusivity to investigate neurologic and psychiatric disorders: a review. JOURNAL OF NEUROIMAGING. 2022; 32(1). DOI:10.1111/jon.12930. PMID:34506674. IF: 3,870
Sampedro F, Marin J, Martinez S, Camacho V, Lopez DA, Pagonabarraga J, Kulisevsky J. Extrastriatal SPECT-DAT uptake correlates with clinical and biological features of de novo Parkinson’s disease. NEUROBIOLOGY OF AGING. 2021; 97. DOI:10.1016/j.neurobiolaging.2020.10.016. PMID:33212336. IF: 5,133
Sampedro F, Martinez S, Perez J, Perez R, Horta A, Campolongo A, Aracil I, Gomez B, Kulisevsky J. Interaction between sex and neurofilament light chain on brain structure and clinical severity in Huntington’s disease. Annals of Clinical and Translational Neurology. 2021; 8(12). DOI:10.1002/acn3.51460. PMID:34761569. IF: 5,430
Sampedro F, Perez J, Martinez S, Perez R, Horta A, Campolongo A, Izquierdo C, Pagonabarraga J, Gomez B, Kulisevsky J. Cortical microstructural correlates of plasma neurofilament light chain in Huntington’s disease. PARKINSONISM & RELATED DISORDERS. 2021; 85. DOI:10.1016/j.parkreldis.2021.03.008. PMID:33770670. IF: 4,402
Sampedro F, Roldan A, Alonso A, Grasa E, Portella MJ, Aguilar EJ, Nunez F, Gomez B, Corripio I. Grey matter microstructural alterations in schizophrenia patients with treatment-resistant auditory verbal hallucinations. JOURNAL OF PSYCHIATRIC RESEARCH. 2021; 138. DOI:10.1016/j.jpsychires.2021.03.037. PMID:33852993. IF: 5,250
Santos D, Fonticoba TD, Bartolome CC, Castro ES, Jesus S, Mir P, Pascual B, Pagonabarraga J, Kulisevsky J, Hernandez J, Planellas LL, Cabo I, Seijo M, Legarda I, Padilla FC, Caballol N, Cubo E, Nogueira V, Losada M, Ariztegui NL, Aramburu IG, Caldentey JG, Borrue C, Valero C, Alonso PS. Depression is Associated with Impulse-compulsive Behaviors in Parkinson’s disease. JOURNAL OF AFFECTIVE DISORDERS. 2021; 280. DOI:10.1016/j.jad.2020.11.075. PMID:33242731. IF: 6,533
Santos-Garcia D, Blazquez M, Calopa M, Escamilla F, Freire E, Ruiz PJG, Grandas F, Kulisevsky J, Lopez L, Castrillo JCM, Mir P, Pagonabarraga J, Perez F, Salom JM, Tijero B, Valldeoriola F, Yanez R, Aviles A, Luquin MR. Present and Future of Parkinson’s Disease in Spain: PARKINSON-2030 Delphi Project. Brain Sciences. 2021; 11(8):1027. DOI:10.3390/brainsci11081027. PMID:34439646. IF: 3,333
Santos-García D, Castro ES, de Deus Fonticoba T, Panceiras MJF, Enriquez JGM, González JMP, Bartolomé CC, Planellas LL, Caldentey JG, Caballol N, Legarda I, López IC, Manzanares LL, Rivera MAÁ, Catalán MJ, Nogueira V, Borrué C, Sauco MÁ, Vela L, Cubo E, Castrillo JCM, Alonso PS, Losada MGA, Ariztegui NL, Gastón MI, Kulisevsky J, Pagonabarraga J, et al. Sleep Problems Are Related to a Worse Quality of Life and a Greater Non-Motor Symptoms Burden in Parkinson’s Disease. JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY. 2021;34(6):642-658. DOI:10.1177/0891988720964250. PMID: 33043810. IF: 2,718
Santos-García D, De Deus FT, Cores BC, Valdés AL, Suárez CE, Aneiros Á, Jesús S, Aguilar M, Pastor P, Planellas L, Cosgaya M, García CJ, Caballol N, Legarda I, Hernández VJ, Cabo I, López ML, González AI, Ávila RMA, José CM, Nogueira V, Puente V, García MJM, Borrué C, Solano VB, Álvarez SM, Vela L, Escalante S, Cubo E, Carrillo PF, Martínez CJC, et al.; COPPADIS Study Group [Kulisevsky J]. Mood in Parkinson’s disease: From early- to late-stage disease. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY. 2021;36(5):627-646. DOI:10.1002/gps.5461. PMID: 33169885. IF: 3,850
Santos-Garcia D, Fonticoba TD, Cores C, Munoz G, Gonzalez JMP, Miro CM, Suarez E, Jesus S, Aguilar M, Pastor P, Planellas L, Cosgaya M, Caldentey JG, Caballol N, Legarda I, Vara JH, Cabo I, Manzanares LL, Aramburu IG, Rivera M, Catalan MJ, Nogueira V, Puente V, de Arcos MR, Borrue C, Vila BS, Sauco MA, Vela L, Escalante S, Cubo E, Padilla FC, et al. [Kulisevsky J]. Predictors of clinically significant quality of life impairment in Parkinson’s disease. NPJ Parkinsons Disease. 2021; 7(1):118. DOI:10.1038/s41531-021-00256-w. PMID:34916528. IF: 9,304
Santos-Garcia D, Fonticoba TDD, Gonzalez JMP, Bartolome CC, Aymerich LV, Enriquez JGM, Suarez E, Jesus S, Aguilar M, Pastor P, Planellas LL, Cosgaya M, Caldentey JG, Caballol N, Legarda I, Vara JH, Cabo I, Manzanares LL, Aramburu IG, Rivera M, Catalan MJ, Nogueira V, Puente V, Moreno JMG, Borrue C, Vila BS, Sauco MA, Vela L, Escalante S, et al.; COPPADIS GRP [Kulisevsky J. Staging Parkinson’s Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life. Parkinsons Disease. 2021; 2021. DOI:10.1155/2021/8871549. PMID:34094501. IF: 3,170
Santos-Garcia D, Rios LN, Fonticoba TD, Bartolome CC, Roca LG, Painceiras MF, Miro CM, Canfield H, Jesus S, Aguilar M, Pastor P, Cosgaya M, Caldentey JG, Caballol N, Legarda I, Vara JH, Cabo I, Manzanares LL, Aramburu IG, Rivera M, Mayordomo VG, Nogueira V, Puente V, Dotor J, Borrue C, Vila BS, Sauco MA, Vela L, Escalante S, Cubo E, Padilla FC, et al. [Kulisevsky J]. Diplopia Is Frequent and Associated with Motor and Non-Motor Severity in Parkinson’s Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up. Diagnostics. 2021; 11(12):2380. DOI:10.3390/diagnostics11122380. PMID:34943619. IF: 3,992
Santos-García D, de Deus T, Cores C, Canfield H, Paz González JM, Martínez Miró C, Valdés Aymerich L, Suárez E, Jesús S, Aguilar M, Pastor P, Planellas L, Cosgaya M, García Caldentey J, Caballol N, Legarda I, Hernández-Vara J, Cabo I, López Manzanares L, González Aramburu I, Ávila Rivera MA, Catalán MJ, Nogueira V, Puente V, Dotor J, Borrué C, et al.; Coppadis Study Group [Kulisevsky J]. Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson’s Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up. Journal of Personalized Medicine. 2021; 11(7):626. DOI:10.3390/jpm11070626. PMID:34209166. IF: 3,508
Stantonyonge N, Martinez S, Sampedro F, Sanchez MB, Chico A. Defective involuntary attention to novelty in type 1 diabetes and impaired awareness of hypoglycaemia. DIABETES RESEARCH AND CLINICAL PRACTICE. 2021; 177:108898. DOI:10.1016/j.diabres.2021.108898. PMID:34098058. IF: 8,180
Stantonyonge N, Sampedro F, Mendez J, Martinez S, Chico A, Gomez B. Structural Gray and White Matter Differences in Patients With Type 1 Diabetes and Impaired Awareness of Hypoglycemia. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2021; 106(2). DOI:10.1210/clinem/dgaa832. PMID:33180907. IF: 6,134
Storm CS, Kia DA, Almramhi MM, Bandres S, Finan C, Hingorani AD, Wood NW, Clarimón J, Dols O, Kulisevsky J, Marín J, Pagonabarraga J, Lynch TL. Finding genetically-supported drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome. Nature Communications. 2021; 12(1):7342. DOI:10.1038/s41467-021-26280-1. PMID:34930919. IF: 17,694

2017 Scientific Report – Parkinson Diseases and Movement disorders

Introduction

Main lines of research

RESEARCH LINE: PARKINSON’S DISEASE, PARKINSONISM, TREMOR, DYSTONIAS AND TICS

Line Leaders: Pagonabarraga Mora, Javier, and Martínez-Fernández, Raul

Within this line, the main research areas are:

COGNITIVE DECLINE AND BEHAVIORAL ALTERATIONS IN PARKINSON’S DISEASE

Study and in-depth analysis of the neural correlates of cognitive and behavioral alterations in the disease using neurophysiological techniques and structural and functional neuroimaging.
Development of sensitive neuropsychological tools for cognitive and functional assessment in Parkinson’s disease.

NEUROMODULATION IN PARKINSON’S DISEASE

Definition, description, and prospective follow-up of patients with Parkinson’s disease who are candidates for HIFU or deep brain stimulation, and imaging analysis of changes at the neural network level associated with different types of neuromodulation (TMS, HIFU, DBS).

ATYPICAL PARKINSONISM

Study of the neural correlates of neuropsychiatric and cognitive alterations in atypical parkinsonism using structural and functional neuroimaging techniques, as well as biomarkers that facilitate differential diagnosis.

ESSENTIAL TREMOR, DYSTONIAS AND TICS

Clinical, neurophysiological, and neuroimaging assessment of patients with essential tremor undergoing HIFU therapy.
Neuroimaging, neurophysiological, and genetic studies of patients with primary segmental and generalized dystonias, and patients with Tourette syndrome, and their application to the identification of neuromodulation targets.

TRANSLATIONAL RESEARCH – BIOMARKERS AND CELLULAR MODELS

Study of biomarkers in different fluids (CSF and plasma) and skin biopsies for the analysis and correlation of pathological and molecular alterations associated with cognitive and neuropsychiatric disorders in Parkinson’s disease and atypical parkinsonism.

RESEARCH LINE: HUNTINGTON’S DISEASE, OTHER CHOREAS AND ATAXIAS

Line Leader: Martínez-Horta, Saül .

Within this line, the main research areas are:

HUNTINGTON’S DISEASE

Study of metabolic correlates (¹⁸F-FDG PET) of disease progression from the presymptomatic phase to the early stage, and of cognitive, affective, and motivational alterations.
Determination of the prevalence and clinical significance of neuropsychiatric features in Huntington’s disease.
Development of new instruments for cognitive and functional assessment in Huntington’s disease, and characterization of differentiated cognitive phenotypes.
Prospective observational study of Huntington’s disease in a European cohort (Registry Study) and an international cohort (Enroll-HD).
Collaboration in coordinated multicenter projects and coordinated Spanish projects.

TRANSLATIONAL RESEARCH – BIOMARKERS AND CELLULAR MODELS

Identification of progression biomarkers in both premanifest and manifest phases, based on neuroimaging, biological samples (blood, muscle tissue, cerebrospinal fluid), and clinical data.
Molecular, clinical, behavioral, and cognitive characterization of the BACHD rat model of Huntington’s disease.

Challenges

Cognitive and Behavioural Dysfunctions in Parkinson Disease

Study and understanding of the neural substrates of cognitive impairment in Parkinson disease so as to improve diagnostic and therapeutic approaches.
Development of specific tools to assess and track cognitive changes in Parkinson disease.

Huntington’s Disease

Study of the dynamics of mutant Htt protein aggregation and related neural and cognitive correlates along disease stages in Huntington’s disease.
Validation of new instruments to assess and track subtle cognitive changes in pre-manifested and early-stage Huntington’s disease population.

Essential Tremor and Other Movement Disorders

Genetic studies and genotype-phenotype correlations in essential tremor.
Development of new therapeutic interventions in essential tremor.
Neurochemical and structural neuroimaging studies on the pathophysiological bases of essential tremor.

Translational Research – Animal Models of Parkinsonism

Behavioural, physiological and pharmacological characterization of animal models of parkinsonism with combined dopaminergic and noradrenergic lesions.
Physiopathology of motor, cognitive and behavioural complications linked to antiparkinsonian drugs in animal models of parkinsonism.

Team

Group coordination

KULISEVSKY BOJARSKI, JAIME FGS
jkulisevsky@santpau.cat

Members

Scientific output

Abdelnour C, Ferreira D, van de Beek M, Cedres N, Oppedal K, Cavallin L, Blanc F, Bousiges O, Wahlund LO, Pilotto A, Padovani A, Boada M, Pagonabarraga J, Kulisevsky J, Aarsland D, Lemstra AW, Westman E. Parsing heterogeneity within dementia with Lewy bodies using clustering of biological, clinical, and demographic data. Alzheimers Research & Therapy. 2022; 14(1):14. DOI:10.1186/s13195-021-00946-w. PMID:35063023. IF:9 (Q1/1D). Document type: Article.
Aracil I, Martinez S, Gonzalez JM, Sampedro F, Perez J, Horta A, Campolongo A, Izquierdo C, Gomez B, Pagonabarraga J, Kulisevsky J. Structure and Dynamics of Large-Scale Cognitive Networks in Huntington’s Disease. MOVEMENT DISORDERS. 2022; 37(2). DOI:10.1002/mds.28839. PMID:34752656. IF:8,6 (Q1/1D). Document type: Article.
Aracil I, Sampedro F, Marin J, Horta A, Martinez S, Gonzalez JM, Perez J, Bejr H, Pascual B, Boti M, Campolongo A, Izquierdo C, Gironell A, Gomez B, Kulisevsky J, Pagonabarraga J. Tipping the scales: how clinical assessment shapes the neural correlates of Parkinson’s disease mild cognitive impairment. Brain Imaging and Behavior. 2022; 16(2). DOI:10.1007/s11682-021-00543-3. PMID:34553331. IF:3,2 (Q2/5D). Document type: Article.
Aretouli E, Chondrogiorgi M, Dede O, Koutsonida M, Lafi C, Konstantinopoulou E, Kulisevsky J, Kosmidis MH, Konitsiotis S. The Parkinson’s Disease-Cognitive Rating Scale: Greek Normative Data, Clinical Utility and Cultural Considerations. JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY. 2022; 35(5):08919887211049110. DOI:10.1177/08919887211049110. PMID:34663111. IF:2,6 (Q3/7D). Document type: Article.
Asl AM, Mehdizadeh M, Kulisevsky J, Sabet A, Sharabiani P, Mehdizadeh H, Ashayeri H, Taghizadeh G. Reliability, validity, and diagnostic accuracy of Parkinson’s Disease-Cognitive Rating Scale in Iranian patients with idiopathic Parkinson’s disease. DISABILITY AND REHABILITATION. 2022; 44(10). DOI:10.1080/09638288.2020.1813337. PMID:32924645. IF:2,2 (Q2/4D). Document type: Article.
Bach L, Boccalatte F, DeRosa A, Devos D, Garcia C, Inglese M, Droby A. Functional changes in prefrontal cortex following frequency-specific training. Scientific Reports. 2022; 12(1):20316. DOI:10.1038/s41598-022-24088-7. PMID:36434008. IF:4,6 (Q2/3D). Document type: Article.
Bejr H, Martinez S, Pagonabarraga J, Marin J, Horta A, Sampedro F, Aracil I, Perez J, Campolongo A, Izquierdo C, Pascual B, Kulisevsky J. The role of attentional control over interference in minor hallucinations in Parkinson’s disease. PARKINSONISM & RELATED DISORDERS. 2022; 102. DOI:10.1016/j.parkreldis.2022.07.009. PMID:35987038. IF:4,1 (Q2/3D). Document type: Article.
Calabria M, Garcia C, Grunden N, Pons C, Arroyo JA, Gomez B, Garcia M, Belvis R, Morollon N, Igual JV, Mur I, Pomar V, Domingo P. Post-COVID-19 fatigue: the contribution of cognitive and neuropsychiatric symptoms. JOURNAL OF NEUROLOGY. 2022; 269(8). DOI:10.1007/s00415-022-11141-8. PMID:35488918. IF:6 (Q1/2D). Document type: Article.
De la Riva P, Rodriguez J, Gomez V, Arenaza G, Gorostidi A, Diez N, De Arce A, Martinez M, Gonzalez F, Luttich A, Garmendia E, Sola A, Larrea JA, Bergareche A, Sobrino T. Endothelial NO synthase 786T/T polymorphism increases hemorrhagic transformation after endovascular thrombectomy. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. 2022; 129. DOI:10.1016/j.niox.2022.08.006. PMID:36067953. IF:3,9 (Q2/5D). Document type: Article.
De Paepe AE, Garcia C, Martinez S, Perez JP, Kulisevsky J, Rodriguez N, Vaquer I, Subira S, Calopa M, Santacruz P, Munoz E, Mareca C, Ruiz J, De Diego R, Camara E. Delineating apathy profiles in Huntington’s disease with the short-Lille Apathy Rating Scale. PARKINSONISM & RELATED DISORDERS. 2022; 105. DOI:10.1016/j.parkreldis.2022.10.025. PMID:36395542. IF:4,1 (Q2/3D). Document type: Article.
Devos D, Labreuche J, Rascol O, Corvol JC, Duhamel A, Delannoy PG, Poewe W, Compta Y, Pavese N, Ruzicka E, Dusek P, Post B, Bloem BR, Berg D, Maetzler W, Otto M, Habert MO, Lehericy S, Ferreira J, Dodel R, Tranchant C, Eusebio A, Thobois S, Marques AR, Meissner WG, Ory F, Walter U, de Bie R, Gago M, Vilas D, Kulisevsky J, Januario C, Coelho MVS, Behnke S, et al. Trial of Deferiprone in Parkinson’s Disease. NEW ENGLAND JOURNAL OF MEDICINE. 2022; 387(22). DOI:10.1056/NEJMoa2209254. PMID:36449420. IF:158,5 (Q1/1D). Document type: Article.
Ferraro PM, Spotorno N, Finegan E, Sampedro F, Caso F. Editorial: Genotype-phenotype correlations in neurodegenerative diseases: From clinical features to neuroimaging signatures. Frontiers in Neurology. 2022; 13:1100953. DOI:10.3389/fneur.2022.1100953. PMID:36588898. IF:3,4 (Q2/5D). Document type: Editorial material.
Ferreira JJ, Rodrigues FB, Duarte GS, Mestre TA, Bachoud AC, Bentivoglio AR, Burgunder JM, Cardoso F, Claassen DO, Landwehrmeyer GB, Kulisevsky J, Nirenberg MJ, Rosser A, Roth J, Seppi K, Slawek J, Furr E, Tabrizi SJ, Walker FO, Vandenberghe W, Costa J, Sampaio C. An MDS Evidence-Based Review on Treatments for Huntington’s Disease. MOVEMENT DISORDERS. 2022; 37(1). DOI:10.1002/mds.28855. PMID:34842303. IF:8,6 (Q1/1D). Document type: Review.
Garcia C, Calabria M, Grunden N, Pons C, Arroyo JA, Gomez B, Lleo A, Alcolea D, Belvis R, Morollon N, Mur I, Pomar V, Domingo P. Neuropsychological deficits in patients with cognitive complaints after COVID-19. Brain and Behavior. 2022; 12(3):e2508. DOI:10.1002/brb3.2508. PMID:35137561. IF:3,1 (Q2/3D). Document type: Article.
Garcia DS, Roca LG, Fonticoba TD, Bartolome CC, Rios LN, Canfield H, Gonzalez JMP, Miro CM, Jesus S, Aguilar M, Pastor P, Planellas L, Cosgaya M, Caldentey JG, Caballol N, Legarda I, Vara JH, Cabo I, Manzanares LL, Aramburu IG, Rivera M, Mayordomo VG, Nogueira V, Puente V, Garcia JD, Borrue C, Vila BS, Sauco MA, Vela L, Escalante S, Cubo E, Padilla FC, et al. [Kulisevsky J]. Constipation Predicts Cognitive Decline in Parkinson’s Disease: Results from the COPPADIS Cohort at 2-Year Follow-up and Comparison with a Control Group. Journal of Parkinsons Disease. 2022; 12(1). DOI:10.3233/JPD-212868. PMID:34602501. IF:5,2 (Q1/3D). Document type: Article.
Garcia DS, Sauco MA, Calopa M, Carrillo F, Sevilla FE, Freire E, Ramos RG, Kulisevsky J, Esteban JCG, Legarda I, Luquin M, Castrillo JCM, Martinez P, Martinez I, Mir P, Ignacio AS. MNCD: A New Tool for Classifying Parkinson’s Disease in Daily Clinical Practice. 2022; 12(1):55. DOI:10.3390/diagnostics12010055. PMID:35054222. IF:3,6 (Q2/4D). Document type: Article.
Horta A, Martinez S, Perez J, Sampedro F, Puig A, Pagonabarraga J, Kulisevsky J. Measuring the functional impact of cognitive impairment in Huntington’s disease. JOURNAL OF NEUROLOGY. 2022; 269(7). DOI:10.1007/s00415-021-10955-2. PMID:35061089. IF:6 (Q1/2D). Document type: Article.
Illan I, Nigro S, VandeVrede L, Falgas N, Heuer HW, Painous C, Compta Y, Marti MJ, Montal V, Pagonabarraga J, Kulisevsky J, Lleo A, Fortea J, Logroscino G, Quattrone A, Quattrone A, Perry DC, Gorno ML, Rosen HJ, Grinberg LT, Spina S, La Joie R, Rabinovici GD, Miller BL, Rojas JC, Seeley WW, Boxer AL. Diagnostic Accuracy of Magnetic Resonance Imaging Measures of Brain Atrophy Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Degeneration. JAMA Network Open. 2022; 5(4):e229588. DOI:10.1001/jamanetworkopen.2022.9588. PMID:35486397. IF:13,8 (Q1/1D). Document type: Article.
Kulisevsky J, Martinez S, Campolongo A, Pascual B, Marin J, Bejr H, Aracil I, Horta A, Puig A, Pagonabarraga J. A Randomized Clinical Trial to Evaluate the Effects of Safinamide on Apathetic Non-demented Patients With Parkinson’s Disease. Frontiers in Neurology. 2022; 13:866502. DOI:10.3389/fneur.2022.866502. PMID:35720066. IF:3,4 (Q2/5D). Document type: Article.
Kulisevsky J. Pharmacological management of Parkinson’s disease motor symptoms: update and recommendations from an expert. REVISTA DE NEUROLOGIA. 2022; 75(s04):S1-S10. DOI:10.33588/rn.75s04.2022217. PMID:36342310. IF:1,2 (Q4/10D). Document type: Review.
Marin J, Martinez S, Pagonabarraga J, Horta A, Aracil I, Bejr H, Sampedro F, Campolongo A, Kulisevsky J. Predicting Impulse Control Disorders in Parkinson Disease through Incentive Biomarkers. ANNALS OF NEUROLOGY. 2022; 92(6). DOI:10.1002/ana.26486. PMID:36054656. IF:11,2 (Q1/1D). Document type: Article.
Mauricio D, Vlacho B, de la Puente JB, Mundet X, Real J, Kulisevsky J, Ortega E, Castelblanco E, Julve J, Franch J. Associations Between Diabetic Retinopathy and Parkinson’s Disease: Results From the Catalonian Primary Care Cohort Study. Frontiers in Medicine. 2022; 8:800973. DOI:10.3389/fmed.2021.800973. PMID:35118094. IF:8,1 (Q1/2D). Document type: Article.
Pagonabarraga J, Perez R, Bejr H, Marin J, Horta A, Martinez S, Aracil I, Sampedro F, Campolongo A, Rivas E, Puig A, Ruiz I, Perez J, Pascual B, Kulisevsky J. Dissociable contribution of plasma NfL and p-tau181 to cognitive impairment in Parkinson’s disease. PARKINSONISM & RELATED DISORDERS. 2022; 105. DOI:10.1016/j.parkreldis.2022.05.020. PMID:35752549. IF:4,1 (Q2/3D). Document type: Article.
Pérez C, Hernández J, Caballol N, Bayes À, Buongiorno M, Lopez N, Gironell A, López J, Martínez JC, Sauco A, López L, Escalante S, Pérez DA, Rodríguez A, The MoMoPa G. Comparison of the Results of a Parkinson’s Holter Monitor With Patient Diaries, in Real Conditions of Use: A Sub-analysis of the MoMoPa-EC Clinical Trial. Frontiers in Neurology. 2022; 13:835249. DOI:10.3389/fneur.2022.835249. PMID:35651347. IF:3,4 (Q2/5D). Document type: Article.
Pou MA, Orfila F, Pagonabarraga J, Ferrer S, Corominas H, Diaz C. Le risque de maladie de Parkinson dans une population méditerranéenne de patients goutteux : étude cas-témoins. Revue Du Rhumatisme (edition Francaise). 2022; 89(6). DOI:10.1016/j.rhum.2022.09.019. Document type: Article.
Pou MA, Orfila F, Pagonabarraga J, Ferrer S, Corominas H, Diaz C. Risk of Parkinson’s disease in a gout Mediterranean population: A case-control study. JOINT BONE SPINE. 2022; 89(6):105402. DOI:10.1016/j.jbspin.2022.105402. PMID:35504516. IF:4,2 (Q2/4D). Document type: Article.
Rodríguez F, Beltrán Á, Chico JL, Parra P, Baena B, Pagonabarraga J, Pérez P, Pareés I, López JL, Martínez JC, Alonso A. Efficacy and safety of high doses of safinamide in advanced Parkinson disease. PARKINSONISM & RELATED DISORDERS. 2022; 97. DOI:10.1016/j.parkreldis.2022.03.010. PMID:35344893. IF:4,1 (Q2/3D). Document type: Letter.
Rosas I, Morís G, Coto E, Blázquez M, Suárez E, García C, Martínez C, Herrera ID, Pérez S, Álvarez V, Menéndez M, Adarmes AD, Aguilar M, Alvarez I, Barrero FJ, Bergareche JA, Bonilla M, Botía JA, Boungiorno MT, Buiza D, Cámara A, Carrillo F, Cerdan D, Clarimón J, Compta Y, Diez M, Dols-Icardo O, de Fabregues O, Cartagena PS, Duarte J, Duran R, Escamilla F, et al. [Kulisevsky J, Pagonabarraga J, Pascual Sedano B, ]. Smoking is associated with age at disease onset in Parkinson’s disease. PARKINSONISM & RELATED DISORDERS. 2022; 97. DOI:10.1016/j.parkreldis.2022.03.005. PMID:35364453. IF:4,1 (Q2/3D). Document type: Article.
Ruiz I, Horta A, Illan I, Kulisevsky J, Pagonabarraga J. Genotype-Phenotype Correlation in Progressive Supranuclear Palsy Syndromes: Clinical and Radiological Similarities and Specificities. Frontiers in Neurology. 2022; 13:861585. DOI:10.3389/fneur.2022.861585. PMID:35557621. IF:3,4 (Q2/5D). Document type: Review.
Saiz M, Gil C, Diez M, Martinez SI, Santalo FS, Calvo S, Alonso E, Rinones E, Aguado L, Mariscal N, Munoz I, Pineiro D, Rivadeneyra J, Cubo E. Polymorphisms in the oxytocin receptor and their association with apathy and impaired social cognition in Huntington’s disease. NEUROLOGICAL SCIENCES. 2022; 43(10). DOI:10.1007/s10072-022-06226-1. PMID:35725858. IF:3,3 (Q2/5D). Document type: Article.
Sampedro F, Aracil I, Farres C, Soler J, Schmidt C, Elices M, Pomarol E, Salvador R, Vega D, Pascual JC. A Functional Connectivity Study to Investigate the Role of the Right Anterior Insula in Modulating Emotional Dysfunction in Borderline Personality Disorder. PSYCHOSOMATIC MEDICINE. 2022; 84(1). DOI:10.1097/PSY.0000000000001019. PMID:34611112. IF:3,3 (Q2/4D). Document type: Article.
Sampedro F, Camara E, Kulisevsky J. Editorial: Neuroimaging of Cognitive and Neuropsychiatric Symptoms in Movement Disorders. Frontiers in Neurology. 2022; 13:843440. DOI:10.3389/fneur.2022.843440. PMID:35173676. IF:3,4 (Q2/5D). Document type: Editorial material.
Sampedro F, Kulisevsky J. Intracortical surface-based MR diffusivity to investigate neurologic and psychiatric disorders: a review. JOURNAL OF NEUROIMAGING. 2022; 32(1). DOI:10.1111/jon.12930. PMID:34506674. IF:2,4 (Q3/6D). Document type: Review.
Sampedro F, Martinez S, Horta A, Grothe MJ, Labrador MA, Jesus S, Adarmes A, Carrillo F, Puig A, Lora FR, Barbera MA, Pastor P, Arroyo SE, Vila BS, Foraster AC, Martinez JR, Padilla FC, Morlans MP, Aramburu IG, Ceberio JI, Vara JH, de Fabregues O, de Deus T, Avila A, Martinez JC, Bejr H, Campolongo A, Pascual B, Martinez P, Santos D, Mir P, Kulisevsky J. Increased homocysteine levels correlate with cortical structural damage in Parkinson’s disease. JOURNAL OF THE NEUROLOGICAL SCIENCES. 2022; 434:120148. DOI:10.1016/j.jns.2022.120148. PMID:35085959. IF:4,4 (Q2/3D). Document type: Article.
Sampedro F, Martinez S, Horta A, Grothe MJ, Labrador MA, Jesus S, Adarmes A, Carrillo F, Puig A, Roldan F, Aguilar M, Pastor P, Arroyo SE, Vila BS, Cots A, Ruiz J, Carrillo F, Pueyo M, Gonzalez I, Infante J, Hernandez J, de Fabregues O, Fonticoba TD, Avila A, Martinez JC, Bejr H, Campolongo A, Pascual B, Martinez P, Santos D, Mir P, Garcia PJ, Kulisevsky J. Clinical and structural brain correlates of hypomimia in early-stage Parkinson’s disease. EUROPEAN JOURNAL OF NEUROLOGY. 2022; 29(12). DOI:10.1111/ene.15513. PMID:35852918. IF:5,1 (Q1/2D). Document type: Article.
Sampedro F, Martínez S, Kulisevsky J. Response to letter: “Association of elevated blood homocysteine with cognitive decline in early, untreated Parkinson’s disease”. JOURNAL OF THE NEUROLOGICAL SCIENCES. 2022; 438:120272. DOI:10.1016/j.jns.2022.120272. PMID:35576640. IF:4,4 (Q2/3D). Document type: Letter.
Sampedro F, Martinez S, Marin J, Pagonabarraga J, Kulisevsky J. Apathy Reflects Extra-Striatal Dopaminergic Degeneration in de novo Parkinson’s Disease. Journal of Parkinsons Disease. 2022; 12(5). DOI:10.3233/JPD-223223. PMID:35491803. IF:5,2 (Q1/3D). Document type: Article.
Sampedro F, Martinez S, Perez J, Perez R, Horta A, Campolongo A, Izquierdo C, Aracil I, Rivas E, Puig A, Pagonabarraga J, Gomez B, Kulisevsky J. Plasma TDP-43 Reflects Cortical Neurodegeneration and Correlates with Neuropsychiatric Symptoms in Huntington’s Disease. Clinical Neuroradiology. 2022; 32(4). DOI:10.1007/s00062-022-01150-5. PMID:35238950. IF:2,8 (Q2/5D). Document type: Article.
Santos D, Canfield H, de Deus T, Cores C, Naya L, García L, Martínez C, Jesús S, Aguilar M, Pastor P, Cosgaya M, García J, Caballol N, Legarda I, Hernández J, Cabo I, López L, González I, Ávila MA, Gómez V, Nogueira V, Puente V, Dotor J, Borrué C, Solano B, Álvarez M, Vela L, Escalante S, Cubo E, Carrillo F, Martínez JC, Sánchez P, Alonso MG, López N, Gastón I, Kulisevsky J, et al. Parkinson’s Disease Motor Subtypes Change with the Progression of the Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up. Journal of Parkinsons Disease. 2022; 12(3). DOI:10.3233/JPD-213004. PMID:34957949. IF:5,2 (Q1/3D). Document type: Article.
Santos D, Fonticoba TD, Bartolome CC, Alvarado M, Panceiras MJF, Castro ES, Canfield H, Miro CM, Jesus S, Aguilar M, Pastor P, Planellas L, Cosgaya M, Caldentey JG, Caballol N, Legarda I, Vara JH, Cabo I, Manzanares LL, Aramburu IG, Rivera M, Mayordomo VG, Nogueira V, Puente V, Garcia JD, Borrue C, Vila BS, Sauco MA, Vela L, Escalante S, Cubo E, et al. [Kulisevsky J]. Predictors of the change in burden, strain, mood, and quality of life among caregivers of Parkinson’s disease patients. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY. 2022; 37(6):GPS5761. DOI:10.1002/gps.5761. PMID:35633051. IF:4 (Q2/5D). Document type: Article.
Santos D, Fonticoba TD, Bartolome CC, Painceiras MJF, Castro ES, Canfield H, Miro CM, Jesus S, Aguilar M, Pastor P, Planellas L, Cosgaya M, Caldentey JG, Caballol N, Legarda I, Hernandez J, Cabo I, Manzanares LL, Aramburu IG, Rivera M, Mayordomo VG, Nogueira V, Puente V, Garcia JD, Borrue C, Vila BS, Sauco MA, Vela L, Escalante S, Cubo E, Padilla FC, et al. [Kulisevsky J]. Motor Fluctuations Development Is Associated with Non-Motor Symptoms Burden Progression in Parkinson’s Disease Patients: A 2-Year Follow-Up Study. 2022; 12(5):1147. DOI:10.3390/diagnostics12051147. PMID:35626303. IF:3,6 (Q2/4D). Document type: Article.
Stocchi F, Antonini A, Berg D, Bergmans B, Jost W, Katzenschlager R, Kulisevsky J, Odin P, Valldeoriola F, Chaudhuri KR. Safinamide in the treatment pathway of Parkinson’s Disease: a European Delphi Consensus. npj Parkinsons Disease. 2022; 8(1):17. DOI:10.1038/s41531-022-00277-z. PMID:35190544. IF:8,7 (Q1/1D). Document type: Article.
Valle N, Pérez R, Chiva G, Belbin O, Serrano S, Sirisi S, González AC, Giró O, Sánchez É, Dols O, Alcolea D, Carmona M, Jimenez A, Lleó A, Fortea J, Iulita MF. Enrichment of Astrocyte-Derived Extracellular Vesicles from Human Plasma. Jove-Journal of Visualized Experiments. 2022; 2022(186):e64107. DOI:10.3791/64107. PMID:35993755. IF:1,2 (Q3/8D). Document type: Article.

Publications 2021

Abbruzzese G, Kulisevsky J, Bergmans B, Gomez JC, Kagi G, Raw J, Stefani A, Warnecke T, Jost WH, SYNAPSES Study Investigators GRP. A European Observational Study to Evaluate the Safety and the Effectiveness of Safinamide in Routine Clinical Practice: The SYNAPSES Trial. Journal of Parkinsons Disease. 2021; 11(1). DOI:10.3233/JPD-202224. PMID:33104040. IF: 5,520
Aracil I, Sampedro F, Pujol J, Soriano C, Gonzalez JM, Kulisevsky J, Pagonabarraga J. The impact of dopaminergic treatment over cognitive networks in Parkinson’s disease: Stemming the tide?. HUMAN BRAIN MAPPING. 2021; 42(17). DOI:10.1002/hbm.25650. PMID:34510640. IF: 5,399
Bejr-Kasem H, Sampedro F, Marín-Lahoz J, Martínez-Horta S, Pagonabarraga J, Kulisevsky J. Minor hallucinations reflect early gray matter loss and predict subjective cognitive decline in Parkinson’s disease. European Journal of Neurology. 2021;28(2):438-447. DOI:10.1111/ene.14576. PMID: 33032389. IF: 6,288
Bernasconi F, Blondiaux E, Potheegadoo J, Stripeikyte G, Pagonabarraga J, Bejr H, Bassolino M, Akselrod M, Martinez S, Sampedro F, Hara M, Horvath J, Franza M, Konik S, Bereau M, Ghika JA, Burkhard PR, Van de Ville D, Faivre N, Rognini G, Krack P, Kulisevsky J, Blanke O. Robot-induced hallucinations in Parkinson’s disease depend on altered sensorimotor processing in fronto-temporal network. Science Translational Medicine. 2021; 13(591):eabc8362. DOI:10.1126/scitranslmed.abc8362. PMID:33910980. IF: 19,319
Blauwendraat C, Iwaki H, Makarious MB, Bandres S, Leonard HL, Grenn FP, Lake J, Krohn L, Tan M, Kim JJ, Gibbs JR, Hernandez DG, Ruskey JA, Pihlstrom L, Toft M, van JJ, Marinus J, Schulte C, Brockmann K, Sharma M, Siitonen A, Majamaa K, Eerola J, Tienari PJ, Grosset DG, Lesage S, Corvol JC, Brice A, Wood N, et al. [Clarimón J, Dols O, Kulisevsky J, Pagonabarraga J]. Investigation of Autosomal Genetic Sex Differences in Parkinson’s Disease. ANNALS OF NEUROLOGY. 2021; 90(1). DOI:10.1002/ana.26090. PMID:33901317. IF: 11,274
Calabria M, Perez JP, Martinez S, Horta A, Carceller M, Kulisevsky J, Costa A. Language reconfiguration in bilinguals A study with Huntington’s disease patients. Linguistic Approaches to Bilingualism. 2021; 11(4). DOI:10.1075/lab.18022.cal. IF: 1,815
Chen ZB, Zhang D, Reynolds RH, Gustavsson EK, Garcia S, D’Sa K, Fairbrother A, Vandrovcova J, Hardy J, Houlden H, Taliun S, Botia J, Ryten M, Clarimón J, Dols O, Kulisevsky J, Pagonabarraga J, Int Parkinson’s Dis Genomics C. Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage. Nature Communications. 2021; 12(1):2076. DOI:10.1038/s41467-021-22262-5. PMID:33824317. IF: 17,694
De Paepe AE, Ara A, Garcia C, Martinez S, Perez J, Kulisevsky J, Rodriguez N, Vaquer I, Subira S, Calopa M, Munoz E, Santacruz P, Ruiz J, Mareca C, de Diego R, Camara E. Gray Matter Vulnerabilities Predict Longitudinal Development of Apathy in Huntington’s Disease. MOVEMENT DISORDERS. 2021; 36(9). DOI:10.1002/mds.28638. PMID:33998063. IF: 9,698
Diez M, Houle G, Ortega S, Bandres S, Alvarez I, Carcel M, Ibanez L, Fernandez MV, Budde JP, Trotta JR, Tonda R, Chong JX, Bamshad MJ, Nickerson DA, Aguilar M, Tartari JP, Gironell A, Garcia E, Agundez J, Alonso H, Jimenez FJ, Fernandez M, Valldeoriola F, Marti MJ, Tolosa E, Coria F, Pastor MA, Vilarino C, Rajput A, Dion PA, Cruchaga C, Rouleau GA, Pastor P, U. Exome-wide rare variant analysis in familial essential tremor. PARKINSONISM & RELATED DISORDERS. 2021; 82. DOI:10.1016/j.parkreldis.2020.11.021. PMID:33279834. IF: 4,402
Gaig C, Compta Y, Heidbreder A, Marti MJ, Titulaer MJ, Crijnen Y, Hogl B, Lewerenz J, Erro ME, Garcia JC, Nigro P, Tambasco N, Patalong M, Erdler M, Macher S, Berger E, Hoftberger R, Geis C, Hutterer M, Milan A, Martin A, Manzanares LL, Quintas S, Hoglinger GU, Mohn N, Schoberl F, Thaler FS, Asioli GM, Provini F, Plazzi G, Berganzo K, Blaabjerg M, et al. [Perez JP]. Frequency and Characterization of Movement Disorders in Anti-IgLON5 Disease. NEUROLOGY. 2021; 97(14). DOI:10.1212/WNL.0000000000012639. PMID:34380749. IF: 11,800
Garcia R, Santos D, Alonso A, Alvarez M, Ares B, Avila A, Caballol N, Carrillo F, Sevilla FE, Freire E, Esteban JCG, Legarda I, Manzanares LL, Valdes EL, Martinez I, Mata M, Parees I, Pascual B, Mir P, Castrillo JCM. Management of Parkinson’s disease and other movement disorders in woman of childbearing age: Part 1. NEUROLOGIA. 2021; 36(2). DOI:10.1016/j.nrl.2020.05.010. PMID:32718872. IF: 5,486
Garcia R, Santos D, Alonso A, Alvarez M, Ares B, Avila A, Caballol N, Carrillo F, Sevilla FE, Freire E, Esteban JCG, Legarda I, Manzanares LL, Valdes EL, Martinez I, Mata M, Parees I, Pascual B, Castrillo JCM, Mir P. Management of Parkinson’s disease and other movement disorders in women of childbearing age: Part 2. NEUROLOGIA. 2021; 36(2). DOI:10.1016/j.nrl.2020.05.012. PMID:32980194. IF: 5,486
Gialluisi A, Reccia MG, Modugno N, Nutile T, Lombardi A, Di LG, Pietracupa S, Ruggiero D, Scala S, Gambardella S, Iacoviello L, Gianfrancesco F, Acampora D, D’Esposito M, Simeone A, Ciullo M, Esposito T, Kulisevsky J, Pagonabarraga J, Int Parkinsons Dis Genomics C. Identification of sixteen novel candidate genes for late onset Parkinson’s disease. Molecular Neurodegeneration. 2021; 16(1):35. DOI:10.1186/s13024-021-00455-2. PMID:34148545. IF: 18,879
Grothe MJ, Labrador MA, Jesus S, Macias D, Adarmes A, Carrillo F, Camacho EI, Franco P, Lora FR, Martin JF, Barbera MA, Pastor P, Arroyo SE, Vila BS, Foraster AC, Martinez JR, Padilla FC, Morlans MP, Aramburu IG, Ceberio JI, Vara JH, de Fabregues O, Fonticoba TD, Pascual B, Kulisevsky J, Martinez P, Santos D, Mir P. In vivo cholinergic basal forebrain degeneration and cognition in Parkinson’s disease: Imaging results from the COPPADIS study. PARKINSONISM & RELATED DISORDERS. 2021; 88. DOI:10.1016/j.parkreldis.2021.05.027. PMID:34144230. IF: 4,402
Horta A, Pagonabarraga J, Martinez S, Busteed L, Pascual B, Illan I, Marin J, Aracil I, Perez J, Sampedro F, Bejr H, Kulisevsky J. Cognitive and behavioral profile of progressive supranuclear palsy and its phenotypes. JOURNAL OF NEUROLOGY. 2021; 268(9). DOI:10.1007/s00415-021-10511-y. PMID:33704556. IF: 6,682
Jost ST, Visser V, Rizos A, Loehrer PA, Silverdale M, Evans J, Samuel M, Petry JN, Sauerbier A, Gronostay A, Barbe MT, Fink GR, Ashkan K, Antonini A, Martinez P, Chaudhuri KR, Timmermann L, Dafsari HS, Pagonabarraga J, Walker RW. Non-motor predictors of 36-month quality of life after subthalamic stimulation in Parkinson disease. npj Parkinsons Disease. 2021; 7(1):48. DOI:10.1038/s41531-021-00174-x. PMID:34103534. IF: 9,304
Kia DA, Zhang D, Guelfi S, Manzoni C, Hubbard L, Reynolds RH, Botia J, Ryten M, Ferrari R, Lewis PA, Williams N, Trabzuni D, Hardy J, Wood NW, Clarimón J, Dols O, Kulisevsky J, Pagonabarraga J, United B, Int Parkinsons Dis G. Identification of Candidate Parkinson Disease Genes by Integrating Genome-Wide Association Study, Expression, and Epigenetic Data Sets. JAMA Neurology. 2021; 78(4). DOI:10.1001/jamaneurol.2020.5257. PMID:33523105. IF: 29,907
Lage C, Lopez S, Bejanin A, Kazimierczak M, Aracil I, Calvo A, Pozueta A, Garcia M, Fernandez A, Bravo M, Jimenez J, Banzo I, Irure J, Pegueroles J, Illan I, Fortea J, Rodriguez E, Lleo A, Garcia CE, Sanchez P. Distinctive Oculomotor Behaviors in Alzheimer’s Disease and Frontotemporal Dementia. Frontiers in Aging Neuroscience. 2021; 12:603790. DOI:10.3389/fnagi.2020.603790. PMID:33613262. IF: 5,702
Leon P, Pagonabarraga J, Moris J, Martinez S, Marin J, Horta A, Bejr H, Kulisevsky J, Rodriguez A. Neural signatures of predictive language processing in Parkinson’s disease with and without mild cognitive impairment. CORTEX. 2021; 141. DOI:10.1016/j.cortex.2021.03.032. PMID:34049254. IF: 4,644
Martinez S, Bejr H, Horta A, Pascual B, Santos D, De Deus T, Jesus S, Aguilar M, Planellas L, Garcia J, Caballol N, Vives B, Hernandez J, Cabo I, Lopez L, Gonzalez I, Avila MA, Catalan MJ, Lopez LM, Puente V, Garcia JM, Borrue C, Solano B, Alvarez M, Vela L, Escalante S, Cubo E, Carrillo F, Martinez JC, Sanchez P, Alonso MG, Lopez N, Gaston I, et al. [Kulisevsky J]. Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease. BMC Neurology. 2021; 21(1):477. DOI:10.1186/s12883-021-02485-1. PMID:34879838. IF: 2,903
Martinez S, Ivanir E, Perrinjaquet T, Keuter MH, Kulisevsky J. Effects of a Green Oat Herb Extract on Cognitive Performance and Neurophysiological Activity: A Randomized Double-Blind Placebo-Controlled Study. Frontiers in Neuroscience. 2021; 15:748188. DOI:10.3389/fnins.2021.748188. PMID:34658781. IF: 5,152
Martinez-Horta S, Sampedro F, Horta-Barba A, Perez-Perez J, Pagonabarraga J, Gomez-Anson B, Kulisevsky J. Structural brain correlates of irritability and aggression in early manifest Huntington’s disease. Brain Imaging and Behavior. 2021;15(1):107-113. DOI:10.1007/s11682-019-00237-x. PMID: 31898092. IF: 3,224
Pagano G, Boess FG, Taylor KI, Ricci B, Mollenhauer B, Poewe W, Boulay A, Anzures J, Vogt A, Marchesi M, Post A, Nikolcheva T, Kinney GG, Zago WM, Ness DK, Svoboda H, Britschgi M, Ostrowitzki S, Simuni T, Marek K, Koller M, Sevigny J, Doody R, Fontoura P, Umbricht D, Bonni A, PASADENA I, Bejr H, Bojarsky JK, Prasinezumab GRP. A Phase II Study to Evaluate the Safety and Efficacy of Prasinezumab in Early Parkinson’s Disease (PASADENA): Rationale, Design, and Baseline Data. Frontiers in Neurology. 2021; 12:705407. DOI:10.3389/fneur.2021.705407. PMID:34659081. IF: 4,086
Pagonabarraga J, Horta A, Busteed L, Bejr H, Illan I, Aracil I, Marin J, Pascual B, Perez J, Campolongo A, Izquierdo C, Martinez S, Sampedro F, Kulisevsky J. Quantitative evaluation of oculomotor disturbances in progressive supranuclear palsy. PARKINSONISM & RELATED DISORDERS. 2021; 85. DOI:10.1016/j.parkreldis.2021.03.002. PMID:33744691. IF: 4,402
Pagonabarraga J, Tinazzi M, Caccia C, Jost WH. The role of glutamatergic neurotransmission in the motor and non-motor symptoms in Parkinson’s disease: Clinical cases and a review of the literature. JOURNAL OF CLINICAL NEUROSCIENCE. 2021; 90. DOI:10.1016/j.jocn.2021.05.056. PMID:34275546. IF: 2,116
Perez A, Giraldo DM, Rios J, Munoz E, Compta Y, Marti MJ, Pagonabarraga J. Progression of Motor and Non-Motor Symptoms in Multiple System Atrophy: A Prospective Study from the Catalan-MSA Registry. Journal of Parkinsons Disease. 2021; 11(2). DOI:10.3233/JPD-202332. PMID:33492245. IF: 5,520
Pezzoli S, Sanchez R, Solanes A, Kempton MJ, Bandmann O, Il J, Cagnin A, Goldman JG, Merkitch D, Firbank MJ, Taylor JP, Pagonabarraga J, Kulisevsky J, Blanc F, Verdolini N, Venneri A, Radua J. Neuroanatomical and cognitive correlates of visual hallucinations in Parkinson’s disease and dementia with Lewy bodies: Voxel-based morphometry and neuropsychological meta-analysis. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS. 2021; 128. DOI:10.1016/j.neubiorev.2021.06.030. PMID:34171324. IF: 9,052
Rodriguez A, Hernandez J, Minarro A, Perez C, Bayes A, Martinez JC, Perez DA, Gironell A, Monitoring Parkinsons Patients M. Multicentre, randomised, single-blind, parallel group trial to compare the effectiveness of a Holter for Parkinson’s symptoms against other clinical monitoring methods: study protocol. BMJ Open. 2021; 11(7):e045272. DOI:10.1136/bmjopen-2020-045272. PMID:34281918. IF: 3,006
Sampedro F, Farres C, Soler J, Elices M, Schmidt C, Corripio I, Dominguez E, Pomarol E, Salvador R, Pascual JC. Structural brain abnormalities in borderline personality disorder correlate with clinical severity and predict psychotherapy response. Brain Imaging and Behavior. 2021; 15(5). DOI:10.1007/s11682-021-00451-6. PMID:33634348. IF: 3,224
Sampedro F, Kulisevsky J. Intracortical surface-based MR diffusivity to investigate neurologic and psychiatric disorders: a review. JOURNAL OF NEUROIMAGING. 2022; 32(1). DOI:10.1111/jon.12930. PMID:34506674. IF: 3,870
Sampedro F, Marin J, Martinez S, Camacho V, Lopez DA, Pagonabarraga J, Kulisevsky J. Extrastriatal SPECT-DAT uptake correlates with clinical and biological features of de novo Parkinson’s disease. NEUROBIOLOGY OF AGING. 2021; 97. DOI:10.1016/j.neurobiolaging.2020.10.016. PMID:33212336. IF: 5,133
Sampedro F, Martinez S, Perez J, Perez R, Horta A, Campolongo A, Aracil I, Gomez B, Kulisevsky J. Interaction between sex and neurofilament light chain on brain structure and clinical severity in Huntington’s disease. Annals of Clinical and Translational Neurology. 2021; 8(12). DOI:10.1002/acn3.51460. PMID:34761569. IF: 5,430
Sampedro F, Perez J, Martinez S, Perez R, Horta A, Campolongo A, Izquierdo C, Pagonabarraga J, Gomez B, Kulisevsky J. Cortical microstructural correlates of plasma neurofilament light chain in Huntington’s disease. PARKINSONISM & RELATED DISORDERS. 2021; 85. DOI:10.1016/j.parkreldis.2021.03.008. PMID:33770670. IF: 4,402
Sampedro F, Roldan A, Alonso A, Grasa E, Portella MJ, Aguilar EJ, Nunez F, Gomez B, Corripio I. Grey matter microstructural alterations in schizophrenia patients with treatment-resistant auditory verbal hallucinations. JOURNAL OF PSYCHIATRIC RESEARCH. 2021; 138. DOI:10.1016/j.jpsychires.2021.03.037. PMID:33852993. IF: 5,250
Santos D, Fonticoba TD, Bartolome CC, Castro ES, Jesus S, Mir P, Pascual B, Pagonabarraga J, Kulisevsky J, Hernandez J, Planellas LL, Cabo I, Seijo M, Legarda I, Padilla FC, Caballol N, Cubo E, Nogueira V, Losada M, Ariztegui NL, Aramburu IG, Caldentey JG, Borrue C, Valero C, Alonso PS. Depression is Associated with Impulse-compulsive Behaviors in Parkinson’s disease. JOURNAL OF AFFECTIVE DISORDERS. 2021; 280. DOI:10.1016/j.jad.2020.11.075. PMID:33242731. IF: 6,533
Santos-Garcia D, Blazquez M, Calopa M, Escamilla F, Freire E, Ruiz PJG, Grandas F, Kulisevsky J, Lopez L, Castrillo JCM, Mir P, Pagonabarraga J, Perez F, Salom JM, Tijero B, Valldeoriola F, Yanez R, Aviles A, Luquin MR. Present and Future of Parkinson’s Disease in Spain: PARKINSON-2030 Delphi Project. Brain Sciences. 2021; 11(8):1027. DOI:10.3390/brainsci11081027. PMID:34439646. IF: 3,333
Santos-García D, Castro ES, de Deus Fonticoba T, Panceiras MJF, Enriquez JGM, González JMP, Bartolomé CC, Planellas LL, Caldentey JG, Caballol N, Legarda I, López IC, Manzanares LL, Rivera MAÁ, Catalán MJ, Nogueira V, Borrué C, Sauco MÁ, Vela L, Cubo E, Castrillo JCM, Alonso PS, Losada MGA, Ariztegui NL, Gastón MI, Kulisevsky J, Pagonabarraga J, et al. Sleep Problems Are Related to a Worse Quality of Life and a Greater Non-Motor Symptoms Burden in Parkinson’s Disease. JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY. 2021;34(6):642-658. DOI:10.1177/0891988720964250. PMID: 33043810. IF: 2,718
Santos-García D, De Deus FT, Cores BC, Valdés AL, Suárez CE, Aneiros Á, Jesús S, Aguilar M, Pastor P, Planellas L, Cosgaya M, García CJ, Caballol N, Legarda I, Hernández VJ, Cabo I, López ML, González AI, Ávila RMA, José CM, Nogueira V, Puente V, García MJM, Borrué C, Solano VB, Álvarez SM, Vela L, Escalante S, Cubo E, Carrillo PF, Martínez CJC, et al.; COPPADIS Study Group [Kulisevsky J]. Mood in Parkinson’s disease: From early- to late-stage disease. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY. 2021;36(5):627-646. DOI:10.1002/gps.5461. PMID: 33169885. IF: 3,850
Santos-Garcia D, Fonticoba TD, Cores C, Munoz G, Gonzalez JMP, Miro CM, Suarez E, Jesus S, Aguilar M, Pastor P, Planellas L, Cosgaya M, Caldentey JG, Caballol N, Legarda I, Vara JH, Cabo I, Manzanares LL, Aramburu IG, Rivera M, Catalan MJ, Nogueira V, Puente V, de Arcos MR, Borrue C, Vila BS, Sauco MA, Vela L, Escalante S, Cubo E, Padilla FC, et al. [Kulisevsky J]. Predictors of clinically significant quality of life impairment in Parkinson’s disease. NPJ Parkinsons Disease. 2021; 7(1):118. DOI:10.1038/s41531-021-00256-w. PMID:34916528. IF: 9,304
Santos-Garcia D, Fonticoba TDD, Gonzalez JMP, Bartolome CC, Aymerich LV, Enriquez JGM, Suarez E, Jesus S, Aguilar M, Pastor P, Planellas LL, Cosgaya M, Caldentey JG, Caballol N, Legarda I, Vara JH, Cabo I, Manzanares LL, Aramburu IG, Rivera M, Catalan MJ, Nogueira V, Puente V, Moreno JMG, Borrue C, Vila BS, Sauco MA, Vela L, Escalante S, et al.; COPPADIS GRP [Kulisevsky J. Staging Parkinson’s Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life. Parkinsons Disease. 2021; 2021. DOI:10.1155/2021/8871549. PMID:34094501. IF: 3,170
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NEUROLOGICAL DISEASES, NEUROSCIENCE & MENTAL HEALTH

Parkinson Disease and Movement Disorders

Main lines of research

RESEARCH LINE: PARKINSON’S DISEASE, PARKINSONISM, TREMOR, DYSTONIAS AND TICS

RESEARCH LINE: HUNTINGTON’S DISEASE, OTHER CHOREAS AND ATAXIAS

Challenges

Cognitive and Behavioural Dysfunctions in Parkinson Disease

Huntington’s Disease

Essential Tremor and Other Movement Disorders

Translational Research – Animal Models of Parkinsonism

Group coordination

Members

Publications 2024

Publications 2023

Publications 2022

Publications 2021

Main lines of research

RESEARCH LINE: PARKINSON’S DISEASE, PARKINSONISM, TREMOR, DYSTONIAS AND TICS

RESEARCH LINE: HUNTINGTON’S DISEASE, OTHER CHOREAS AND ATAXIAS

Challenges

Cognitive and Behavioural Dysfunctions in Parkinson Disease

Huntington’s Disease

Essential Tremor and Other Movement Disorders

Translational Research – Animal Models of Parkinsonism

Group coordination

Members

Publications 2024

Publications 2023

Publications 2022

Publications 2021

Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau