New pathway discovered to improve the cardioprotective potential of HDL and which is diminished in familial hypercholesterolemia

Researchers in the research group on the Metabolic Basis of Cardiovascular Risk at the Sant Pau Research Institute, attached to CIBERDEM, led by Juan Carlos Escolà-Gil and Francisco Blanco-Vaca, have identified a new metabolic pathway that allows HDLs to transport cholesterol from macrophages in the artery wall and transfer it to LDLs for its subsequent elimination from the body through the liver. The work carried out in collaboration with other Spanish and Finnish researchers has been published in Circulation Research.

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