Endocrinology, Diabetes and Nutrition

Lines of research

  • Diabetic complications: atherosclerosis and microvascular disease.
  • Diabetic epidemiology: primary care research, and research with large databases.
  • Endocrinological diseases and pregnancy.
  • Nodular disease and thyroid cancer.
  • Diabetes and cardiovascular risk factors.
  • Diabetes and obesity: biomarkers, physiopathology and effects of new therapies.

Diabetic complications: atherosclerosis and microvascular disease

    The main cause of morbidity and mortality in diabetes mellitus resides in chronic complications, especially atherosclerosis, but also in microvascular complications.This line includes clinical and translational studies that delve into research on pathogenesis, biomarkers, and early detection and treatment of these complications.

Diabetic epidemiology: primary care research, and research with large databases.

    The line of research includes research on diabetes mellitus in Primary Health Care in Catalonia.In recent years, the group has developed projects using the SIDIAP database, on various aspects of diabetes in real-world evidence.The group is a pioneer at the State level in this area, and has active collaborations with international groups.

Endocrinological diseases and pregnancy.

    Endocrinological diseases are a frequent disease during gestation with important repercussions for the mother and the child, both in the short and long term, and even for subsequent generations.Increasing knowledge about its prevalence, pathophysiological mechanisms and therapeutic options is very important for the health of the population.

Nodular disease and thyroid cancer

    The tumor pathology of the thyroid gland continues to pose a diagnostic and therapeutic challenge in endocrinology.There are clinical problems to be solved through clinical and translational research, the first aspect of diagnosis. To make an accurate diagnosis, avoiding highly unnecessary procedures and treatments, more knowledge is needed. Another important area is the adequate prognostic precision and application of the most personalized treatment in each type of tumor.

Diabetes and cardiovascular risk factors

    The main cause of morbidity and mortality in the population with diabetes is cardiovascular disease derived from both early arteriosclerosis and myocardial dysfunction. The development of these alterations is associated, among others, with dysfunction in lipoprotein metabolism, the inflammatory state, and excess and dysfunction of ectopic adipose tissue. Since the beginning of the 1990s, researchers from the Endocrinology and Nutrition Service of the Cardiovascular Biochemistry group have collaborated in the study of lipid metabolism and cardiovascular risk factors in patients with diabetes, dyslipidemia and obesity. Projects currently underway are aimed at studying the mechanisms that link diabetes, obesity, and dyslipidemia in cardiovascular disease, focusing especially on the role of epicardial adipose tissue and its relationship with adipokines and functional modifications of lipoproteins.

Diabetes and obesity: biomarkers, physiopathology and effects of new therapies

The line of basic and translational research, both in cellular and animal experimental models as well as in humans, is focused on the molecular basis of cell injury in diabetes and its associated metabolic conditions.

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